Browsing by Author "R. Tandon"

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A study of oxidative stress in leukaemia
(2002) R. Tandon; D. Behl; R. Khanna; H.D. Khanna
Free radicals produce persistent oxidative stress in biological system. Free radicals result in lipid peroxidation by attacking nucleic acids, proteins and membrane lipids. Lipid hydroperoxides decompose to form a variety of products including malondialdehyde (MOA) which is a stable product of lipid peroxidation. To determine the presence of oxidative stress in leukaemic patients, 56 proven cases of leukaemia of different category were taken and the results were compared with ten age and sex matched healthy individuals. The mean MDA levels were significantly raised in all the patients belonging to all the groups of leukaemia at the time of diagnosis. Total leucocyte count in all the patients was also raised. The observed values indicate the significant role of free radicals in the aetiopathogenesis of leukaemia. The degree of lipid peroxidation in these patients can be used a marker of the disease activity.
Analgesics: New vistas
(1997) A. Chakrabarti; R. Tandon; S.K. Bhattacharya
[No abstract available]
Clinically relevant adverse drug interactions
(1998) A. Chakrabarti; S.K. Tripathi; R. Tandon; S.K. Bhattacharya
[No abstract available]
Lipid peroxidation levels in peptic ulcer and gastric carcinoma [1]
(2006) R. Tandon; N. Mukherjee; V.K. Dixit; R. Khanna; H.D. Khanna
[No abstract available]
Management of malignant germ cell tumours of ovary.
(1992) R. Tandon; L. Kumar; A. Vaid; V. Kochupillai; S. Kumar; A. Kriplani; V.L. Bhargava
Ten patients of the advanced malignant germ cell tumours of the ovary were treated by cisplatin based combination chemotherapy after initial conservation surgery. Eight patients completed course containing cisplatinum, vinblastine and bleomycin. Five patients (62.5%) achieved CR while 2 (25%) attained PR. One patient died due to tumour lysis and respiratory infection. Rest two patients did not turn up in follow up. Long term follow up indicates above regimen to be highly effective. However poor performance status, advanced stage of disease and post operative gross residual disease were poor prognostic factors in our patients.
Oxidative stress and antioxidants status in peptic ulcer and gastric carcinoma
(2004) R. Tandon; H.D. Khanna; M. Dorababu; R.K. Goel
Oxidative stress is believed to initiate and aggravate many diseases including peptic ulcers and gastric carcinoma. We observed an increase in rat gastric mucosal lipid peroxidation (LPO) and superoxide dismutase (SOD) and a decrease in catalase (CAT) levels in cold restraint stress-induced gastric ulceration while, in clinical peptic ulceration and gastric carcinoma patients, an increase in serum LPO and a tendency to decrease in SOD and CAT levels were observed. The result thus, indicated a positive correlation between free radical-induced oxidative stress both in gastric and duodenal ulcers and gastric carcinoma.
Oxidative stress in hypertension: Association with antihypertensive treatment
(2008) H.D. Khanna; M.K. Sinha; S. Khanna; R. Tandon
There is growing evidence that oxidative stress contributes to the pathogenesis of hypertension. Our aim was to measure oxidative stress in hypertensive subjects, and assess the potential confounding influences of antihypertensive therapy. Serum malondialdehyde and antioxidant levels were estimated in patients at the time of presentation and also after a antihypertensive therapy for 3 months. During the period of study no antioxidant/s was given to the patients and control subjects. Mean blood pressure values were altered in the hypertensive patients following antihypertensive therapy from their respective values observed at the time of presentation. Serum malondialdehyde levels were significantly higher in the hypertensive patients in comparison to control cases. The antioxidant activity of enzymes super oxide dismutase, glutathione and non enzymatic antioxidant levels of vitamins E and C were significantly lower in patients compared to controls. After 3 months of antihypertensive treatment all the above parameters showed reversal in the respective levels of serum malondialdehyde and antioxidant activity. Antihypertensive medications lower the blood pressure and thereby results in reduced oxidative stress which indicates that oxidative stress is not the cause, but rather a consequence, of hypertension.
Oxidative stress in patients with essential hypertension
(2005) R. Tandon; M.K. Sinha; H. Garg; R. Khanna; H.D. Khanna
Background. Free oxygen radicals react with membrane lipids to form lipid hydroperoxides, a destructive process known as lipid peroxidation. Lipid hydroperoxides decompose to form a variety of products including malondialdehyde, which is used as an indicator of the oxidative damage of cells and tissues. Endogenous antioxidant enzymes such as superoxide dismutase counteract the oxidative damage from oxidative stress. There is increasing evidence that free radicals are involved in the pathogenesis of hypertension by altering endothelial function. We evaluated the oxidative stress and endogenous enzymatic antioxidant status in padents with essential hypertension before and 3 months after treatment with antihypertensives. Methods. Fifty patients with essential hypertension attending the outpatient services of the Department of Medicine, Institute of Medical Sciences, Banaras Hindu University and 20 age- and sex-matched healthy controls were studied. The serum malondialdehyde and superoxide dismutase levels were measured in patients at the time of presentation and after 3 months of antihypertensive treatment. No antioxidants were given to the patients during the period of the study. Results. The mean (SD) serum malondialdehyde level was found to be significantly higher (0.33 [0.07] mmol/L) in patients with hypertension compared with controls (0.21 [0.05] mmol/L; p < 0.001). This showed a significant decrease following antihypertensive therapy (0.23 [0.06] mmol/L; p < 0.001) compared with pre-treatment values. The serum superoxide dismutase activity was significantly lower in patients (6.93 [1.35] mg protein/ml of serum) compared with controls (20.12 [3.65] mg protein/ml serum; p < 0.001) at the time of presentation and, compared with the pre-treatment values, increased significantly after 3 months of treatment (10.66 [2.91] mg protein/ml of serum; p < 0.001). Conclusion. Our study shows that essential hypertension is associated with increased oxidative stress and reduced antioxidant status. Adequate control of blood pressure with antihypertensive therapy decreases oxidative stress and improves the antioxidant status in these patients. © The National Medical Journal of India 2005.
Pharmacological management of benign prostatic hyperplasia (BPH)
(1997) M. Aslam; A. Chakrbarti; R. Tandon; S.K. Bhattacharya
[No abstract available]
Pharmacological management of thyroid disorders
(1997) N. Sharma; A. Chakrabarti; R. Tandon; S.K. Bhattacharya
[No abstract available]
Primary amyloidosis presenting with predominant lymphnodal masses
(2005) D. Kumar; A.C. Singh; P. Neehar; Usha; R. Tandon; K. Tripathi
A 50year young farmer presented with clinical features of bilateral carpal tunnel syndrome and generalized lymphadenopathy including paratracheal and retroperitoneal lymphodes. The histological diagnosis confirmed primary amyloidosis of lymphnodes. Presentation of primary amyloidosis as lymphnodal mass with deposition of amyloid in carpal tunnel is extremely rare and can only be diagnosed by histochemistry. The clinical response to drugs is variable and needs surgical intervention for decompressive therapy which can improve the symptoms of carpal tunnel syndrome. © JAPI 2005.
Rational drug therapy in the elderly
(1999) M. Kumar; R. Tandon; S.K. Bhattacharya
[No abstract available]
Rational therapy in neonates and infants
(1998) R.R. Pathak; M. Kumar; R. Tandon; S.K. Bhattacharya
[No abstract available]
Rational therapy in pregnancy and lactation
(1998) M. Kumar; R. Tandon; S.K. Bhattacharya
[No abstract available]
Rational therapy in presence of renal and hepatic dysfunction
(1998) S.K. Bhattacharya; R. Tandon
[No abstract available]
Rational use of antibiotics
(1999) D. Behi; R.K. Singh; R. Tandon; S.K. Bhattacharya
[No abstract available]
Rational use of antihypertensive drugs
(1999) R.K. Singh; D. Behl; R. Tandon; S.K. Bhattacharya
[No abstract available]
Supportive therapy in cancer
(1991) R. Tandon; S.K. Bhattacharya
[No abstract available]