Browsing by Author "R.K. Saran"

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Patterns and determinants of dyslipidaemia in 'Young' versus 'Not so Young' patients of coronary artery disease: A multicentric, randomised observational study in northern India
(Elsevier B.V., 2012) Nakul Sinha; Sudeep Kumar; Himanshu Rai; Neha Singh; Aditya Kapoor; Satyendra Tewari; R.K. Saran; V.S. Narain; R.P.S. Bharadwaj; R.K. Bansal; P.C. Saxena; P.R. Sinha; P.R. Gupta; Mukul Mishra; Praveen Jain; C.M. Pandey; Uttam Singh; S.S. Agarwal
Aims: The aims of the study were to ascertain difference in lipid levels of 'Young' onset of coronary artery disease (CAD) (≤ 45 years) vs. 'Not so Young' onset of CAD (≥ 55 years) among north Indians and also to investigate determinants of 'dyslipidaemia' in CAD patients. Methods: This was a prospective, multicentric, randomised, observational study carried in eight cen- tres of UP, India. All blood investigations were performed employing a central laboratory. Results: Out of a total 435 patients studied, 218 were in the 'young group' (YG) and 235 were in the 'Not so Young Group' (NSYG). Dyslipidaemia was more common in YG as evident by significantly higher levels of total cholesterol, triglycerides, low- and very low-density lipoprotein cholesterol as compared to NSYG. Diabetes, hypertension, urban lifestyle, and family history of CAD were found to be important determinants of dyslipidaemia in YG. Conclusion: We conclude that lipid levels among north Indians are significantly higher in younger patients with CAD when compared with elderly. © 2012, Cardiological Society of India. All rights reserved.
Pesticides in the environment: Degradation routes, pesticide transformation products and ecotoxicological considerations
(Elsevier B.V., 2024) Suchitra Mitra; R.K. Saran; Sudhakar Srivastava; Christopher Rensing
Among rising environmental concerns, emerging contaminants constitute a variety of different chemicals and biological agents. The composition, residence time in environmental media, chemical interactions, and toxicity of emerging contaminants are not fully known, and hence, their regulation becomes problematic. Some of the important groups of emerging contaminants are pesticides and pesticide transformation products (PTPs), which present a considerable obstacle to maintaining and preserving ecosystem health. This review article aims to thoroughly comprehend the occurrence, fate, and ecotoxicological importance of pesticide transformation products (PTPs). The paper provides an overview of pesticides and PTPs as contaminants of emerging concern and discusses the modes of degradation of pesticides, their properties and associated risks. The degradation of pesticides, however, does not lead to complete destruction but can instead lead to the generation of PTPs. The review discusses the properties and toxicity of PTPs and presents the methods available for their detection. Moreover, the present study examines the existing regulatory framework and suggests the need for the development of new technologies for easy, routine detection of PTPs to regulate them effectively in the environment. © 2024 Elsevier B.V.