Browsing by Author "R.M. Gupta"

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A noncryo-monoclonal IgM with auto anti-IgG activity in a case of lymphosarcoma
(1978) R.M. Gupta; T. Malati; M. Chakarvarty
[No abstract available]
Alfa-feto protein in liver disorders in Indians
(1977) R.M. Gupta; H.S. Bajpai; I.M. Gupta; C.V.S. Rao
A total of 150 cases of liver disorders were screened for AFP by Ouchterlony double diffusion technique using monospecific anti-AFP serum. AFP was detected in 45% cases of hepatoma, 37.5% cases of Indian childhood cirrhosis and one case each of viral hepatitis, adult cirrhosis and secondary deposits in liver. Presence of AFP could not be correlated to the histopathologic appearance of tumor, age and sex of the patient or liver function tests either in hepatoma or in Indian childhood cirrhosis. AFP produced in various disorders appeared to be antigenically identical.
Antilymphocytic serum (A brief review of current concepts)
(1979) R.M. Gupta; I.M. Gupta
[No abstract available]
Appraisal of maternal and neonatal cord serum immunoglobulins in Indians
(1978) R.M. Gupta; D. Sharma; G. Misra
Serum immunoglobulins IgG, IgA and IgM were estimated in paired maternal and cord serum samples collected from 100 mothers and their neonates (101 in number) at the time of normal vaginal delivery. Levels of the immunoglobulins in 20 non-pregnant age and socio-economically matched women served as the control. Factors such as parity, mild concurrent upper respiratory or urinary tract infection or anaemia seemed to be of little consequence. However, significantly low serum IgG levels were observed in the healthy primipara as well as healthy multigravida as compared to the non-pregnant women (mean 1139.5±148.3 mg percent). Cord serum IgG levels in neonates born to healthy primi and neonates of healthy multigravida were not significantly different. However, as compared to the respective maternal group these values were significantly low in cord sera in both the groups. It is proposed that transfer of IgG across placenta may not be as free as envisaged and there may be some subclass selectivity. Both preterm and low birth weight for term neonates showed significantly low IgG level as compared to the full term normal birth weight neonates. A critical analysis of data for IgA and IgM revealed the presence of IgM in six samples. Three of these neonates were born to multipara with a history of concurrent mild infection, and these had raised IgA and IgG levels. In 3 other neonates born to healthy primipara, with raised cord serum IgM, IgG level was not raised and IgA was present only in one case. It appears that detection of raised levels of all the three immunoglobulins in the cord might indicate intrauterine infection.
Cell mediated and humoral immunity in chronic suppurative otitis media
(1995) M.K. Agarwal; S.P. Rai; R.M. Gupta
The present study was carried out on 75 patients suffering from chronic otitis media and 25 healthy age and sex matched controls. The T. rosette percentage were depressed in malnourished pretreatment test cases and showed depressed cell mediated immunity (CMI), but once malnutrition was treated the CMI was improved. Anergy to challenge dose of 2:4 DNCB was not observed in any groups. Weak response was observed in 4% of controls, 18.7% of chronic otitis media patients and 5.7% of post treatment cases. Serum IgG, IgA and IgM levels were elevated in chronic otitis media patients from controls but once the infections were eliminated by treatment their values became insignificant (p 0.05) from controls. Presence of malnutrition significantly contributed to suppression of CMI response but no suppression of humoral immunity was observed. © 1995 Association of Otolaryngologists of India.
Cell mediated and humoral immunity in chronic suppurative otitis media
(1994) M.K. Agarwal; S.P. Rai; R.M. Gupta
The present study was carried out on 75 patients suffering from chronic otitis media and 25 healthy age and sex matched controls. The T. rosette percentage were depressed in malnouirished immunity (CMI), but once malnutrition was treated the CMI was improved. Anergy to challenge does of 2 : 4 DNCB was not observed in any groups. Weak response was observed in 4% of controls, 18.7% of chronic otitis media patients and 5.7% of post treatment cases. Serum IgG, IgA and IgM levels were elevated in chronic otitis media patients from controls but once the infections were eliminated by treatment their values became insignificant (p 0.05) from controls. Presence of Malnutrition significantly contributed to suppression of CMI response but no suppression of humoral immunity was observed. © 1994 Association of Otolaryngologists of India.
Clinical and immunological study of patients of cancer cervix
(1979) D. Sharma; R.M. Gupta; V. Kadian
A detailed clinico-pathologic and immunologic study was carried out on 60 patients with cancer of the cervix and compared with normal controls (20) and cases of chronic cervicitis and erosion (20). Sensitivity to 2:4 dinitrochlorobenzene was 100% in both the control groups. Sensitivity to PPD and candida antigen was 80% in healthy controls and 85% in patients with chronic cervicitis. Cell-mediated immune response in cases of cancer of the cervix to 2:4 DNCB was 84% and to recall antigens was 57.9%. Reactivity to recall antigens of 2:4 DNCB was not much impaired in stages I and II but there was a progressive decrease in positive response and an increase in anergy in stages III and IV. There was a significant rise in the levels of serum IgG in cancer of the cervix, and this rise was parallel with the advancing stages of the disease. The IgA and IgM levels showed no significant change.
Delayed hypersensitivity reactions in hepatobiliary malignancy
(1982) N. Sud; R.M. Gupta; I.M. Gupta; S. Gupta
[No abstract available]
Effect of levamisole as an immunomodulating agent in trophoblastic lesions
(1993) A. Khanna; K.N. Ojha; Usha; R.M. Gupta
[No abstract available]
Evaluation of the effect of mode and duration of labor on maternofetal transfer of IgG at term in Indian mothers
(1984) R.M. Gupta; D. Sharma; K. Agarwal; M. Kumar
Paired maternal and cord serum IgG, IgA, and IgM were estimated in 100 full term normal birth weight neonates and their mothers delivered either per vaginum, by elective Caesarian section or by emergency Caesarian section. Neonates delivered per vaginum revealed significantly higher cord serum IgG levels (1168 ± 153 mg%, p<0.001) as compared to those delivered by emergency Caesarian section (956.25 ± 192.20) or elective Caesarian section (971.00 ± 245.12 mg%). Each group was further analyzed according to the duration of labor into those delivering in 10 hours or less, 11-20 hours, 21-30 hours, and more than 30 hours. The data revealed that labor of more than 20 hours significantly contributed to the materno-fetal transfer of IgG resulting in a lessening of the difference in cord serum IgG of neonates delivered per vaginum and by emergency Caesarian section. In the emergency Caesarian section group, patients delivering after 30 hours of labor had significantly higher levels of IgG (1050.00 ± 108.00 mg%) than the group delivering within 10 hours (880.77 ± 146.54 mg%). It appears that primarily the maternofetal transfer of IgG is modulated by the route of delivery but later uterine contractions may also contribute to it significantly.
Extramedullary plasmacytoma IgG type I presenting as mediastinal syndrome
(1974) R.M. Gupta; D.C. Roy; I.M. Gupta; S. Khanna
The case is reported of a young man with extramedullary plasmacytoma presenting with massive cervical lymphadenopathy, pleural effusion and purplish papules on the chest wall. Histopathology of a lymph node from the neck revealed a plasmacytoma. Immunochemical studies on serum and pleural fluid showed M paraprotein of IgG type I. © 1974.
Extramedullary plasmacytoma: Simulating a soft tissue sarcoma of the chest wall
(1980) B. Sanyal; G.C. Pant; K. Sahni; S. Khanna; R.M. Gupta; N.N. Khanna
Extramedullary plasmacytoma occurs infrequently as compared to osseous myoloma. A single case of extramedullary plasmacytoma was seen during the last 10 years whose initial presentation was that of a soft tissue sarcoma of the chest wall. Clinical data along with relevent investigation and treatment results are discussed with a review of the literature. Copyright © 1980 Wiley‐Liss, Inc., A Wiley Company
Hepatocellular injury in thermal burns
(1978) P.P. Vaidya; S.K. Roy; P.K. Shukla; R.M. Gupta
Twenty five patients with thermal burns, divided into 2 groups, were evaluated for their liver functions by estimation of certain specific serum enzymes to ascertain the possible mechanism of the clinically inexplicable late deaths. Serum enzyme alterations were evident in all cases suggesting hepatocellular damage, being proportional to the extent and severity of the injury and more profound between the post-burn days 6 to 16, i.e. the 2nd wk. However, no difference was noted in the enzyme levels in fatal burns as against the survivors having a comparable degree of burn-injury. The possible relation of RES depression to hepatocellular necrosis and the final outcome has been emphasized.
Humoral immune status in retinitis pigmentosa
(1983) M. Kumar; R.M. Gupta; H.V. Nema
[No abstract available]
Humoral immunity in pediatric Kalaazar patients in India
(1997) L. Usha; A. Dikshit; D.S. Singh; S. Sunder; Z. Ali; R.M. Gupta
The study included 20 patients of Kalaazar in children and 20 healthy children of same age group. Mostly patients were males (75%) and in age group of 3 to 10 years. Humoral immunity was assessed by total serum protein, immunoglobulin estimation and circulating immune complexes. Significant hyperproteinemia was found in patient group as compared to control (p<.001). Ninety percent children had increased IgG above 1600 mg/dl (Mean 2392 ± 715.11 mg/dl). Similarly serum IgM and IgA were also significantly raised in comparison to controls (IgA 178 ± 74 59 mg/dl IgM 194.5 ± 89.8 mg/dl). Except one patient almost all had significant increase in circulating immune complexes (79 78 ± 22.55%). None of the patients had glomerulonephritis, vasculitis or arthritis.
IgM type II dysimmunoglobulinemia associated with chronic biliary tract disease. Report of a case with a brief review of literature
(1972) R.M. Gupta; H.S. Bajpai; B. Dube; I.M. Gupta
Appearance of Ig 'M' type II dysimmunoglobulinemia in a 51 yr old Hindu male following cholecystitis with cholelithiasis is recorded. Patient's serum was strongly positive for rheumatoid activity. The significance of the absence of clinical features of rheumatoid disease has been discussed. Anemia was contributed to both by bleeding episodes and hemolysis.
Immunoglobulins in leprosy
(1978) R.M. Gupta; S.C. Gupta; G. Singh; S. Khanna
Serum immunoglobulins IgG, IgA and IgM were estimated in 22 lepromatous (LL) patients, 28 tuberculoid (TT), 9 borderline tuberculoid (BT), and 8 borderline lepromatous (BL), and compared with 50 normal healthy adult males belonging to a low socio-economic class. Immunoglobulin IgM was invariably significantly raised in TT, BT and LL subgroups of leprosy patients compared to the control but variation among different subgroups was statistically insignificant. Mean serum IgA levels were also raised in TT, BL and LL subgroups but statistically the rise was not significant. In the BT subgroup, significantly low IgA levels were observed both compared to the control and the other leprosy subgroups. Immunoglobulin G levels were significantly raised only in the LL subgroups compared to the control and the other subgroups of leprosy patients. It is proposed that persistently raised gamma globulins and immunoglobulin G, A and M levels observed in a lepromatous leprosy patients could be caused by macrophage blockade hindering the suppressor T-cell mediated homeostatic control for immunoglobulins.
Immunological evaluation of children undergoing tonsillectomy
(1979) D. Gogol; O.P. Gupta; M.K. Agarwal; R.M. Gupta
This study was carried out on 80 patients undergoing tonsillectomy for chronic tonsillitis. Twenty healthy school children in the same age group were investigated for control values. Ten children were also available for evaluation of any immunological change after tonsillectomy. No significant variation was seen in the serum IgG, IgA, and IgM levels before and after tonsillectomy. Peripheral absolute lymphocyte count was higher in the pre-operative cases as compared to the control group, and this count became near normal following tonsillectomy. Skin tests with recall antigens PPD and Candida and contact sensitizing agent 2:4 DNCB showed an improved cell mediated immune response following tonsillectomy.
Immunological status of trophoblastic neoplasia
(1985) A. Khanna; S. Khanna; R.M. Gupta; S. Gupta
Six cases of choriocarcinoma, 17 of vesicular mole, 20 normal pregnant females in the first trimester of pregnancy, and 20 normal nonpregnant women with previous normal obstetrical history were evaluated quantitatively for cell‐mediated immunity by response to 2:4 dinitrocholoroben‐zene and recall antigens. Serum immunoglobulins were estimated in all cases. Suppression of cell‐mediated immunity was marked in choriocarcinoma as compared to vesicular mole. Serum IgG levels were significantly diminished in cases of vesicular mole, indicating diminished humoral immunity. Follow‐up after 3 months of treatment with surgery and chemotherapy resulted in marked improvement of cell‐mediated immunity. Copyright © 1985 Wiley‐Liss, Inc., A Wiley Company
Immunosuppressive effects of Amura rohitaka and prednisolone on experimental allergic orchitis in guineapigs
(1978) A. Gupta; R.M. Gupta; I.M. Gupta
[No abstract available]