Browsing by Author "Rabinarayan Acharya"

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Ayurveda formulations: A roadmap to address the safety concerns
(Elsevier B.V., 2017) Kishor Patwardhan; Jigyasa Pathak; Rabinarayan Acharya
It is a matter of serious concern that the number of case reports pointing at a possible association between the clinical toxicity and the use of Ayurveda formulations is increasing significantly over the years in scientific medical literature. Though most of these cases are connected with the presence of heavy metals such as lead, mercury and arsenic in these formulations, there are also reports suggesting toxicity due to the presence of toxic chemicals of herbal origin. In the year 2008, the Government of India took an initiative of establishing the National Pharmacovigilance Programme for Ayurveda, Siddha and Unani drugs in a structured way. However, due to lack of sustained support, this program has now become defunct. This issue is of vital importance and needs to be addressed effectively on a priority basis. In this communication, we propose the following crucial policy interventions to be introduced at different levels: a. Amendments to Drug and Cosmetic Act, b. Issuing consumer guidelines, c. Issuing prescription guidelines, d. Issuing clinical monitoring guidelines, e. Implementation of good manufacturing guidelines, f. Promoting documentation of clinical safety, g. Identifying the sources of contamination, and, h. Provision for stringent punishment. If these policy interventions are taken up and implemented, a significant positive change in the scenario can be expected in the near future. © 2017 Transdisciplinary University, Bangalore and World Ayurveda Foundation
Exploring the potential of andrographis paniculata and its bioactive compounds in the management of liver diseases: A comprehensive food chemistry perspective
(Elsevier Ltd, 2024) Sunil Kumar; Kshirod Kumar Ratha; Sheetal Jaiswal; Meda Mruthyumjaya Rao; Rabinarayan Acharya
Background: Andrographis paniculata (AP) is a plant used in traditional medicines worldwide for its medicinal properties, and for liver disorders. Despite numerous studies on its efficacy, the precise mode of action responsible for its hepatoprotective potential remains unclear. Methods: In this review, traditional uses, bioactive compounds, and pharmacological activity of AP for hepatoprotection were investigated using ten databases and keywords such as Andrographis paniculata, Hepatoprotection of AP, and AP in liver disorders and results between 2000 and 2023. Results: The review found that AP has the potential to treat liver disorders, including cancer, and established its anti-inflammatory, antitumor, anti-fibrotic, antiviral potential, and hepatic protection activity through experimental and clinical studies. The review also discussed its safety aspects. Conclusion: AP can potentially treat liver disorders and the findings highlight the need for further research to elucidate the mode of action responsible for AP's hepatoprotective potential and validate its rational use in liver disorders. © 2024