Browsing by Author "Rachelle Buchbinder"

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Erratum: Global, regional, and national comparative risk assessment of 84 behavioural, environmental and occupational, and metabolic risks or clusters of risks for 195 countries and territories, 1990–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1923–1994), (S0140673618322256), (10.1016/S0140-6736(18)32225-6))
(Lancet Publishing Group, 2019) Jeffrey D. Stanaway; Ashkan Afshin; Emmanuela Gakidou; Stephen S. Lim; Degu Abate; Kalkidan Hassen Abate; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Molla Abebe; Zegeye Abebe; Semaw F. Abera; Olifan Zewdie Abil; Haftom Niguse Abraha; Aklilu Roba Abrham; Laith Jamal Abu-Raddad; Niveen M.E. Abu-Rmeileh; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Pawan Acharya; Abdu A. Adamu; Akilew Awoke Adane; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Zanfina Ademi; Olatunji O. Adetokunboh; Mina G. Adib; Amha Admasie; Jose C. Adsuar; Kossivi Agbelenko Afanvi; Mohsen Afarideh; Gina Agarwal; Anju Aggarwal; Sargis Aghasi Aghayan; Anurag Agrawal; Sutapa Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Muktar Beshir Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Mohammad Esmaeil Akbari; Tomi Akinyemiju; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Hesham M. Al-Mekhlafi; Fares Alahdab; Khurshid Alam; Samiah Alam; Tahiya Alam; Alaa Alashi; Seyed Moayed Alavian; Kefyalew Addis Alene; Komal Ali; Syed Mustafa Ali; Mehran Alijanzadeh; Reza Alizadeh-Navaei; Syed Mohamed Aljunid; Ala’a Alkerwi; François Alla; Ubai Alsharif; Khalid Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Walid Ammar; Nahla Hamed Anber; Jason A. Anderson; Catalina Liliana Andrei; Sofia Androudi; Megbaru Debalkie Animut; Mina Anjomshoa; Mustafa Geleto Ansha; Josep M. Antó; Carl Abelardo T. Antonio; Palwasha Anwari; Lambert Tetteh Appiah; Seth Christopher Yaw Appiah; Jalal Arabloo; Olatunde Aremu; Johan Ärnlöv; Al Artaman; Krishna K. Aryal; Hamid Asayesh; Zerihun Ataro; Marcel Ausloos; Euripide F.G.A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Rakesh Ayer; Tambe B. Ayuk; Peter S. Azzopardi; Arefeh Babazadeh; Hamid Badali; Alaa Badawi; Kalpana Balakrishnan; Ayele Geleto Bali; Kylie Ball; Shoshana H. Ballew; Maciej Banach; Joseph Adel Mattar Banoub; Aleksandra Barac; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Sanjay Basu; Bernhard T. Baune; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Yannick Béjot; Bayu Begashaw Bekele; Eyasu Tamru Bekru; Ezra Belay; Yihalem Abebe Belay; Michelle L. Bell; Aminu K. Bello; Derrick A. Bennett; Isabela M. Bensenor; Gilles Bergeron; Adugnaw Berhane; Eduardo Bernabe; Robert S. Bernstein; Mircea Beuran; Tina Beyranvand; Neeraj Bhala; Ashish Bhalla; Suraj Bhattarai; Zulfiqar A. Bhutta; Belete Biadgo; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Donal Bisanzio; Tuhin Biswas; Tone Bjørge; Brigette F. Blacker; Archie Bleyer; Rohan Borschmann; Ibrahim R. Bou-Orm; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Michael Brauer; Alexandra Brazinova; Nicholas J.K. Breitborde; Hermann Brenner; Andrey Nikolaevich Briko; Gabrielle Britton; Traolach Brugha; Rachelle Buchbinder; Richard T. Burnett; Reinhard Busse; Zahid A. Butt; Leah E. Cahill; Lucero Cahuana-Hurtado; Ismael R. Campos-Nonato; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Félix Carvalho; Carlos A. Castañeda-Orjuela; Jacqueline Castillo Rivas; Franz Castro; Ferrán Catalá-López; Kate Causey; Kelly M. Cercy; Ester Cerin; Yazan Chaiah; Hsing-Yi Chang; Jung-Chen Chang; Kai-Lan Chang; Fiona J. Charlson; Aparajita Chattopadhyay; Vijay Kumar Chattu; Miao Li Chee; Ching-Yu Cheng; Adrienne Chew; Peggy Pei-Chia Chiang; Odgerel Chimed-Ochir; Ken Lee Chin; Abdulaal Chitheer; Jee-Young J. Choi; Rajiv Chowdhury; Hanne Christensen; Devasahayam J. Christopher; Sheng-Chia Chung; Flavia M. Cicuttini; Massimo Cirillo; Aaron J. Cohen; Daniel Collado-Mateo; Cyrus Cooper; Owen R. Cooper; Josef Coresh; Leslie Cornaby; Paolo Angelo Cortesi; Monica Cortinovis; Megan Costa; Ewerton Cousin; Michael H. Criqui; Elizabeth A. Cromwell; David K. Cundiff; Alemneh Kabeta Daba; Berihun Assefa Dachew; Abel Fekadu Dadi; Albertino Antonio Moura Damasceno; Lalit Dandona; Rakhi Dandona; Sarah C. Darby; Paul I. Dargan; Ahmad Daryani; Rajat Das Gupta; José Das Neves; Tamirat Tesfaye Dasa; Aditya Prasad Dash; Dragos Virgil Davitoiu; Kairat Davletov; Vanessa De la Cruz-Góngora; Fernando Pio De La Hoz; Diego De Leo; Jan-Walter De Neve; Louisa Degenhardt; Selina Deiparine; Robert P. Dellavalle; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Nikolaos Dervenis; Aniruddha Deshpande; Don C. Des Jarlais; Getenet Ayalew Dessie; Gabrielle Aline Deveber; Subhojit Dey; Samath Dhamminda Dharmaratne; Meghnath Dhimal; Mesfin Tadese Dinberu; Eric L. Ding; Helen Derara Diro; Shirin Djalalinia; Huyen Phuc Do; Klara Dokova; David Teye Doku; Kerrie E. Doyle; Tim R. Driscoll; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Bruce B. Duncan; Andre R. Duraes; Natalie Ebert; Hedyeh Ebrahimi; Soheil Ebrahimpour; David Edvardsson; Andem Effiong; Anne Elise Eggen; Charbel El Bcheraoui; Ziad El-Khatib; Iqbal Rf Elyazar; Ahmadali Enayati; Aman Yesuf Endries; Benjamin Er; Holly E. Erskine; Sharareh Eskandarieh; Alireza Esteghamati; Kara Estep; Hamed Fakhim; Mahbobeh Faramarzi; Mohammad Fareed; Talha A. Farid; Carla Sofia E. Sá Farinha; Andrea Farioli; Andre Faro; Maryam S. Farvid; Mohammad Hosein Farzaei; Batool Fatima; Kairsten A. Fay; Ali Akbar Fazaeli; Valery L. Feigin; Andrea B. Feigl; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Joao C. Fernandes; Giannina Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Irina Filip; Jonas David Finger; Florian Fischer; Nataliya A. Foigt; Kyle J. Foreman; Takeshi Fukumoto; Nancy Fullman; Thomas Fürst; João M. Furtado; Neal D. Futran; Seana Gall; Silvano Gallus; Amiran Gamkrelidze; Morsaleh Ganji; Alberto L. Garcia-Basteiro; William M. Gardner; Abadi Kahsu Gebre; Amanuel Tesfay Gebremedhin; Teklu Gebrehiwo Gebremichael; Tilayie Feto Gelano; Johanna M. Geleijnse; Yilma Chisha Dea Geramo; Peter W. Gething; Kebede Embaye Gezae; Reza Ghadimi; Keyghobad Ghadiri; Khalil Ghasemi Falavarjani; Maryam Ghasemi-Kasman; Mamata Ghimire; Rakesh Ghosh; Aloke Gopal Ghoshal; Simona Giampaoli; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Ibrahim Abdelmageed Ginawi; Giorgia Giussani; Elena V. Gnedovskaya; William W. Godwin; Srinivas Goli; Hector Gómez-Dantés; Philimon N. Gona; Sameer Vali Gopalani; Alessandra C. Goulart; Ayman Grada; Morgan E. Grams; Giuseppe Grosso; Harish Chander Gugnani; Yuming Guo; Rahul Gupta; Rajeev Gupta; Tanush Gupta; Reyna Alma Gutiérrez; Daniela S. Gutiérrez-Torres; Juanita A. Haagsma; Tesfa Dejenie Habtewold; Vladimir Hachinski; Nima Hafezi-Nejad; Tekleberhan B. Hagos; Tewodros Tesfa Hailegiyorgis; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Alexis J. Handal; Graeme J. Hankey; Yuantao Hao; Hilda L. Harb; Sivadasanpillai Harikrishnan; Josep Maria Haro; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Caitlin N. Hawley; Simon I. Hay; Akbar Hedayatizadeh-Omran; Behzad Heibati; Behnam Heidari; Mohsen Heidari; Delia Hendrie; Andualem Henok; Ileana Heredia-Pi; Claudiu Herteliu; Fatemeh Heydarpour; Sousan Heydarpour; Desalegn T. Hibstu; Tarig B. Higazi; Esayas Haregot Hilawe; Hans W. Hoek; Howard J. Hoffman; Michael K. Hole; Enayatollah Homaie Rad; Praveen Hoogar; H. Dean Hosgood; Seyed Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Damian G. Hoy; Mohamed Hsairi; Thomas Hsiao; Guoqing Hu; Howard Hu; John J. Huang; Mamusha Aman Hussen; Chantal K. Huynh; Kim Moesgaard Iburg; Nayu Ikeda; Olayinka Stephen Ilesanmi; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; Sheikh Mohammed Shariful Islam; Farhad Islami; Maria D. Jackson; Kathryn H. Jacobsen; Leila Jahangiry; Nader Jahanmehr; Sudhir Kumar Jain; Mihajlo Jakovljevic; Spencer L. James; Simerjot K. Jassal; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Jost B. Jonas; Jitendra Jonnagaddala; Zahra Jorjoran Shushtari; Ankur Joshi; Jacek Jerzy Jozwiak; Mikk Jürisson; Zubair Kabir; Amaha Kahsay; Rizwan Kalani; Tanuj Kanchan; Surya Kant; Chittaranjan Kar; Manoochehr Karami; Behzad Karami Matin; André Karch; Corine Karema; Narges Karimi; Seyed M. Karimi; Amir Kasaeian; Dessalegn H. Kassa; Getachew Mullu Kassa; Tesfaye Dessale Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Anil Kaul; Norito Kawakami; Zhila Kazemi; Ali Kazemi Karyani; Adane Teshome Kefale; Peter Njenga Keiyoro; Grant Rodgers Kemp; Andre Pascal Kengne; Andre Keren; Chandrasekharan Nair Kesavachandran; Yousef Saleh Khader; Behzad Khafaei; Morteza Abdullatif Khafaie; Alireza Khajavi; Nauman Khalid; Ibrahim A. Khalil; Gulfaraz Khan; Muhammad Shahzeb Khan; Muhammad Ali Khan; Young-Ho Khang; Mona M. Khater; Mohammad Khazaei; Habibolah Khazaie; Abdullah T. Khoja; Ardeshir Khosravi; Mohammad Hossein Khosravi; Aliasghar A. Kiadaliri; Daniel N. Kiirithio; Cho-Il Kim; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Katarzyna Kissimova-Skarbek; Mika Kivimäki; Luke D. Knibbs; Ann Kristin Skrindo Knudsen; Sonali Kochhar; Yoshihiro Kokubo; Tufa Kolola; Jacek A. Kopec; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Michael A. Kravchenko; Kewal Krishan; Kristopher J. Krohn; Hans Kromhout; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Manasi Kumar; Igor Kuzin; Hmwe Hmwe Kyu; Carl Lachat; Deepesh P. Lad; Sheetal D. Lad; Alessandra Lafranconi; Ratilal Lalloo; Tea Lallukka; Faris Hasan Lami; Justin J. Lang; Van C. Lansingh; Samantha Leigh Larson; Arman Latifi; Jeffrey V. Lazarus; Paul H. Lee; James Leigh; Mostafa Leili; Cheru Tesema Leshargie; Janni Leung; Miriam Levi; Sonia Lewycka; Shanshan Li; Yichong Li; Juan Liang; Xiaofeng Liang; Yu Liao; Misgan Legesse Liben; Lee-Ling Lim; Shai Linn; Shiwei Liu; Rakesh Lodha; Giancarlo Logroscino; Alan D. Lopez; Stefan Lorkowski; Paulo A. Lotufo; Rafael Lozano; Tim C.D. Lucas; Raimundas Lunevicius; Stefan Ma; Erlyn Rachelle King Macarayan; Ísis Eloah Machado; Fabiana Madotto; Hue Thi Mai; Marek Majdan; Reza Majdzadeh; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Ana-Laura Manda; Helena Manguerra; Mohammad Ali Mansournia; Lorenzo Giovanni Mantovani; Joemer C. Maravilla; Wagner Marcenes; Ashley Marks; Randall V. Martin; Sheila C.O. Martins; Francisco Rogerlândio Martins-Melo; Winfried März; Melvin B. Marzan; Benjamin Ballard Massenburg; Manu Raj Mathur; Prashant Mathur; Kunihiro Matsushita; Pallab K. Maulik; Mohsen Mazidi; Colm McAlinden; John J. McGrath; Martin McKee; Ravi Mehrotra; Kala M. Mehta; Varshil Mehta; Toni Meier; Fantahun Ayenew Mekonnen; Yohannes A. Melaku; Addisu Melese; Mulugeta Melku; Peter T.N. Memiah; Ziad A. Memish; Walter Mendoza; Desalegn Tadese Mengistu; George A. Mensah; Gert B.M. Mensink; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Haftay Berhane Mezgebe; Bartosz Miazgowski; Tomasz Miazgowski; Anoushka I. Millear; Ted R. Miller; Molly Katherine Miller-Petrie; G.K. Mini; Mojde Mirarefin; Andreea Mirica; Erkin M. Mirrakhimov; Awoke Temesgen Misganaw; Habtamu Mitiku; Babak Moazen; Bahram Mohajer; Karzan Abdulmuhsin Mohammad; Moslem Mohammadi; Noushin Mohammadifard; Mousa Mohammadnia-Afrouzi; Shafiu Mohammed; Farnam Mohebi; Ali H. Mokdad; Mariam Molokhia; Fatemeh Momeniha; Lorenzo Monasta; Yoshan Moodley; Ghobad Moradi; Maziar Moradi-Lakeh; Mehdi Moradinazar; Paula Moraga; Lidia Morawska; Joana Morgado-Da-Costa; Shane Douglas Morrison; Marilita M. Moschos; Simin Mouodi; Seyyed Meysam Mousavi; Dariush Mozaffarian; Kalayu Brhane Mruts; Achenef Asmamaw Muche; Kindie Fentahun Muchie; Ulrich Otto Mueller; Oumer Sada Muhammed; Satinath Mukhopadhyay; Kate Muller; Kamarul Imran Musa; Ghulam Mustafa; Ashraf F. Nabhan; Mohsen Naghavi; Aliya Naheed; Azin Nahvijou; Gurudatta Naik; Nitish Naik; Farid Najafi; Vinay Nangia; Jobert Richie Nansseu; Bruno Ramos Nascimento; Bruce Neal; Nahid Neamati; Ionut Negoi; Ruxandra Irina Negoi; Subas Neupane; Charles Richard James Newton; Josephine W. Ngunjiri; Anh Quynh Nguyen; Grant Nguyen; Ha Thu Nguyen; Huong Lan Thi Nguyen; Huong Thanh Nguyen; Minh Nguyen; Nam Ba Nguyen; Emma Nichols; Jing Nie; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Nobuo Nishi; Molly R. Nixon; Marzieh Nojomi; Shuhei Nomura; Ole F. Norheim; Mehdi Noroozi; Bo Norrving; Jean Jacques Noubiap; Hamid Reza Nouri; Malihe Nourollahpour Shiadeh; Mohammad Reza Nowroozi; Elaine O. Nsoesie; Peter S. Nyasulu; Carla M. Obermeyer; Christopher M. Odell; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Olanrewaju Oladimeji; Andrew T. Olagunju; Tinuke O. Olagunju; Pedro R. Olivares; Helen Elizabeth Olsen; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Kanyin L. Ong; Sok King Ong; Eyal Oren; Heather M. Orpana; Alberto Ortiz; Erika Ota; Stanislav S. Otstavnov; Simon Øverland; Mayowa Ojo Owolabi; P.A. Mahesh; Rosana Pacella; Abhijit P. Pakhare; Amir H. Pakpour; Adrian Pana; Songhomitra Panda-Jonas; Eun-Kee Park; Charles D.H. Parry; Hadi Parsian; Shanti Patel; Sanghamitra Pati; Snehal T. Patil; Ajay Patle; George C. Patton; Deepak Paudel; Katherine R. Paulson; Wayra Citlali Paz Ballesteros; Neil Pearce; Alexandre Pereira; David M. Pereira; Norberto Perico; Konrad Pesudovs; Max Petzold; Hai Quang Pham; Michael R. Phillips; Julian David Pillay; Michael A. Piradov; Meghdad Pirsaheb; Tobias Pischon; Farhad Pishgar; Oleguer Plana-Ripoll; Dietrich Plass; Suzanne Polinder; Kevan R. Polkinghorne; Maarten J. Postma; Richie Poulton; Akram Pourshams; Hossein Poustchi; Dorairaj Prabhakaran; Swayam Prakash; Narayan Prasad; Caroline A. Purcell; Manorama B. Purwar; Mostafa Qorbani; Amir Radfar; Anwar Rafay; Alireza Rafiei; Fakher Rahim; Zohreh Rahimi; Afarin Rahimi-Movaghar; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Rajesh Kumar Rai; Fatemeh Rajati; Sasa Rajsic; Sree Bhushan Raju; Usha Ram; Chhabi Lal Ranabhat; Prabhat Ranjan; Goura Kishor Rath; David Laith Rawaf; Salman Rawaf; K. Srinath Reddy; Colin D. Rehm; Jürgen Rehm; Robert C. Reiner; Marissa B. Reitsma; Giuseppe Remuzzi; Andre M.N. Renzaho; Serge Resnikoff; Luz Myriam Reynales-Shigematsu; Satar Rezaei; Antonio Luiz P. Ribeiro; Juan A. Rivera; Kedir Teji Roba; Sonia Rodríguez-Ramírez; Leonardo Roever; Yesenia Román; Luca Ronfani; Gholamreza Roshandel; Ali Rostami; Gregory A. Roth; Dietrich Rothenbacher; Ambuj Roy; Enrico Rubagotti; Lesley Rushton; Charumathi Sabanayagam; Perminder S. Sachdev; Basema Saddik; Ehsan Sadeghi; Sahar Saeedi Moghaddam; Hosein Safari; Yahya Safari; Roya Safari-Faramani; Mahdi Safdarian; Sare Safi; Saeid Safiri; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; Haniye Sadat Sajadi; Nasir Salam; Payman Salamati; Zikria Saleem; Yahya Salimi; Hamideh Salimzadeh; Joshua A. Salomon; Devashri Digvijay Salvi; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Maria Dolores Sanchez-Niño; Tania G. Sánchez-Pimienta; Taren Sanders; Yingying Sang; Damian Francesco Santomauro; Itamar S. Santos; João Vasco Santos; Milena M. Santric Milicevic; Bruno Piassi Sao Jose; Mayank Sardana; Abdur Razzaque Sarker; Rodrigo Sarmiento-Suárez; Nizal Sarrafzadegan; Benn Sartorius; Shahabeddin Sarvi; Brijesh Sathian; Maheswar Satpathy; Arundhati R. Sawant; Monika Sawhney; Mete Saylan; Mehdi Sayyah; Elke Schaeffner; Maria Inês Schmidt; Ione J.C. Schneider; Ben Schöttker; Aletta Elisabeth Schutte; David C. Schwebel; Falk Schwendicke; James G. Scott; Soraya Seedat; Mario Sekerija; Sadaf G. Sepanlou; Marc L. Serre; Edson Serván-Mori; Seyedmojtaba Seyedmousavi; Hosein Shabaninejad; Gavin Shaddick; Azadeh Shafieesabet; Mehdi Shahbazi; Amira A. Shaheen; Masood Ali Shaikh; Teresa Shamah Levy; Mehran Shams-Beyranvand; Mohammadbagher Shamsi; Heidar Sharafi; Kiomars Sharafi; Mehdi Sharif; Mahdi Sharif-Alhoseini; Hamid Sharifi; Jayendra Sharma; Meenakshi Sharma; Rajesh Sharma; Jun She; Aziz Sheikh; Peilin Shi; Kenji Shibuya; Mekonnen Sisay Shiferaw; Mika Shigematsu; Min-Jeong Shin; Rahman Shiri; Reza Shirkoohi; Ivy Shiue; Farhad Shokraneh; Haitham Shoman; Mark G. Shrime; Matthew S. Shupler; Si Si; Soraya Siabani; Abla Mehio Sibai; Tariq J. Siddiqi; Inga Dora Sigfusdottir; Rannveig Sigurvinsdottir; Diego Augusto Santos Silva; João Pedro Silva; Dayane Gabriele Alves Silveira; Jasvinder A. Singh; Narinder Pal Singh; Virendra Singh; Dhirendra Narain Sinha; Eirini Skiadaresi; Vegard Skirbekk; David L. Smith; Mari Smith; Badr Hasan Sobaih; Soheila Sobhani; Ranjani Somayaji; Moslem Soofi; Reed J.D. Sorensen; Joan B. Soriano; Ireneous N. Soyiri; Angela Spinelli; Luciano A. Sposato; Chandrashekhar T. Sreeramareddy; Vinay Srinivasan; Vladimir I. Starodubov; Nadine Steckling; Dan J. Stein; Murray B. Stein; Goran Stevanovic; Leo Stockfelt; Mark A. Stokes; Lela Sturua; Michelle L. Subart; Agus Sudaryanto; Mu’awiyyah Babale Sufiyan; Gerhard Sulo; Bruno F. Sunguya; Patrick John Sur; Bryan L. Sykes; Cassandra E.I. Szoeke; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Santosh Kumar Tadakamadla; Ken Takahashi; Nikhil Tandon; Segen Gebremeskel Tassew; Mohammad Tavakkoli; Nuno Taveira; Arash Tehrani-Banihashemi; Tigist Gashaw Tekalign; Shishay Wahdey Tekelemedhin; Merhawi Gebremedhin Tekle; Habtamu Temesgen; Mohamad-Hani Temsah; Omar Temsah; Abdullah Sulieman Terkawi; Belay Tessema; Mebrahtu Teweldemedhin; Kavumpurathu Raman Thankappan; Andrew Theis; Sathish Thirunavukkarasu; Hannah J. Thomas; Matthew Lloyd Thomas; Nihal Thomas; George D. Thurston; Binyam Tilahun; Taavi Tillmann; Quyen G. To; Myriam Tobollik; Marcello Tonelli; Roman Topor-Madry; Anna E. Torre; Miguel Tortajada-Girbés; Mathilde Touvier; Marcos Roberto Tovani-Palone; Jeffrey A. Towbin; Bach Xuan Tran; Khanh Bao Tran; Thomas Clement Truelsen; Nu Thi Truong; Afewerki Gebremeskel Tsadik; Lorainne Tudor Car; E. Murat Tuzcu; Hayley D. Tymeson; Stefanos Tyrovolas; Kingsley N. Ukwaja; Irfan Ullah; Rachel L. Updike; Muhammad Shariq Usman; Olalekan A. Uthman; Muthiah Vaduganathan; Afsane Vaezi; Pascual R. Valdez; Aaron Van Donkelaar; Elena Varavikova; Santosh Varughese; Tommi Juhani Vasankari; Vidhya Venkateswaran; Narayanaswamy Venketasubramanian; Santos Villafaina; Francesco S. Violante
Background The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 comparative risk assessment (CRA) is a comprehensive approach to risk factor quantification that offers a useful tool for synthesising evidence on risks and risk–outcome associations. With each annual GBD study, we update the GBD CRA to incorporate improved methods, new risks and risk–outcome pairs, and new data on risk exposure levels and risk–outcome associations. Methods We used the CRA framework developed for previous iterations of GBD to estimate levels and trends in exposure, attributable deaths, and attributable disability-adjusted life-years (DALYs), by age group, sex, year, and location for 84 behavioural, environmental and occupational, and metabolic risks or groups of risks from 1990 to 2017. This study included 476 risk–outcome pairs that met the GBD study criteria for convincing or probable evidence of causation. We extracted relative risk and exposure estimates from 46 749 randomised controlled trials, cohort studies, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. Using the counterfactual scenario of theoretical minimum risk exposure level (TMREL), we estimated the portion of deaths and DALYs that could be attributed to a given risk. We explored the relationship between development and risk exposure by modelling the relationship between the Socio-demographic Index (SDI) and risk-weighted exposure prevalence and estimated expected levels of exposure and risk-attributable burden by SDI. Finally, we explored temporal changes in risk-attributable DALYs by decomposing those changes into six main component drivers of change as follows: (1) population growth; (2) changes in population age structures; (3) changes in exposure to environmental and occupational risks; (4) changes in exposure to behavioural risks; (5) changes in exposure to metabolic risks; and (6) changes due to all other factors, approximated as the risk-deleted death and DALY rates, where the risk-deleted rate is the rate that would be observed had we reduced the exposure levels to the TMREL for all risk factors included in GBD 2017. Findings In 2017, 34·1 million (95% uncertainty interval [UI] 33·3–35·0) deaths and 1·21 billion (1·14–1·28) DALYs were attributable to GBD risk factors. Globally, 61·0% (59·6–62·4) of deaths and 48·3% (46·3–50·2) of DALYs were attributed to the GBD 2017 risk factors. When ranked by risk-attributable DALYs, high systolic blood pressure (SBP) was the leading risk factor, accounting for 10·4 million (9·39–11·5) deaths and 218 million (198–237) DALYs, followed by smoking (7·10 million [6·83–7·37] deaths and 182 million [173–193] DALYs), high fasting plasma glucose (6·53 million [5·23–8·23] deaths and 171 million [144–201] DALYs), high body-mass index (BMI; 4·72 million [2·99–6·70] deaths and 148 million [98·6–202] DALYs), and short gestation for birthweight (1·43 million [1·36–1·51] deaths and 139 million [131–147] DALYs). In total, risk-attributable DALYs declined by 4·9% (3·3–6·5) between 2007 and 2017. In the absence of demographic changes (ie, population growth and ageing), changes in risk exposure and risk-deleted DALYs would have led to a 23·5% decline in DALYs during that period. Conversely, in the absence of changes in risk exposure and risk-deleted DALYs, demographic changes would have led to an 18·6% increase in DALYs during that period. The ratios of observed risk exposure levels to exposure levels expected based on SDI (O/E ratios) increased globally for unsafe drinking water and household air pollution between 1990 and 2017. This result suggests that development is occurring more rapidly than are changes in the underlying risk structure in a population. Conversely, nearly universal declines in O/E ratios for smoking and alcohol use indicate that, for a given SDI, exposure to these risks is declining. In 2017, the leading Level 4 risk factor for age-standardised DALY rates was high SBP in four super-regions: central Europe, eastern Europe, and central Asia; north Africa and Middle East; south Asia; and southeast Asia, east Asia, and Oceania. The leading risk factor in the high-income super-region was smoking, in Latin America and Caribbean was high BMI, and in sub-Saharan Africa was unsafe sex. O/E ratios for unsafe sex in sub-Saharan Africa were notably high, and those for alcohol use in north Africa and the Middle East were notably low. Interpretation By quantifying levels and trends in exposures to risk factors and the resulting disease burden, this assessment offers insight into where past policy and programme efforts might have been successful and highlights current priorities for public health action. Decreases in behavioural, environmental, and occupational risks have largely offset the effects of population growth and ageing, in relation to trends in absolute burden. Conversely, the combination of increasing metabolic risks and population ageing will probably continue to drive the increasing trends in non-communicable diseases at the global level, which presents both a public health challenge and opportunity. We see considerable spatiotemporal heterogeneity in levels of risk exposure and risk-attributable burden. Although levels of development underlie some of this heterogeneity, O/E ratios show risks for which countries are overperforming or underperforming relative to their level of development. As such, these ratios provide a benchmarking tool to help to focus local decision making. Our findings reinforce the importance of both risk exposure monitoring and epidemiological research to assess causal connections between risks and health outcomes, and they highlight the usefulness of the GBD study in synthesising data to draw comprehensive and robust conclusions that help to inform good policy and strategic health planning. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Global burden of 369 diseases and injuries in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2020) Cristiana Abbafati; Kaja M. Abbas; Mohammad Abbasi; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Mohammad Abdollahi; Ibrahim Abdollahpour; Aidin Abedi; Parisa Abedi; Kedir Hussein Abegaz; Hassan Abolhassani; Akine Eshete Abosetugn; Victor Aboyans; Elissa M. Abrams; Lucas Guimarães Abreu; Michael R.M. Abrigo; Abdulaziz Khalid Abu Haimed; Ahmed Abualhasan; Eman Abu-Gharbieh; Laith Jamal Abu-Raddad; Abdelrahman I. Abushouk; Alyssa Acebedo; Ilana N. Ackerman; Maryam Adabi; Tim Adair; Abdu A. Adamu; Oladimeji M. Adebayo; Isaac Akinkunmi Adedeji; Victor Adekanmbi; Jaimie D. Adelson; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Shailesh M. Advani; Mohsen Afarideh; Mahdi Afshari; Ashkan Afshin; Emilie E. Agardh; Gina Agarwal; Pradyumna Agasthi; Kareha M. Agesa; Mohammad Aghaali; Seyed Mohammad Kazem Aghamir; Anurag Agrawal; Tauseef Ahmad; Alireza Ahmadi; Keivan Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Ehsan Ahmadpour; Muktar Beshir Ahmed; Budi Aji; Temesgen Yihunie Akalu; Rufus Olusola Akinyemi; Tomi Akinyemiju; Blessing Akombi; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Noore Alam; Samiah Alam; Tahiya Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Samuel B. Albertson; Jacqueline Elizabeth Alcalde-Rabanal; Niguse Meles Alema; Biresaw Wassihun Alemu; Yihun Mulugeta Alemu; Khalid F. Alhabib; Robert Kaba Alhassan; Muhammad Ali; Saqib Ali; Gianfranco Alicandro; Mehran Alijanzadeh; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; François Alla; Peter Allebeck; Majid Abdulrahman Hamad Almadi; Ali Almasi; Amir Almasi-Hashiani; Nihad A. Almasri; Hesham M. Al-Mekhlafi; Abdulaziz M. Almulhim; Jordi Alonso; Rajaa M. Al-Raddadi; Khalid A. Altirkawi; Arwa Khalid Alumran; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Bekalu Amare; Saeed Amini; Mostafa Amini-Rarani; Arya Aminorroaya; Fatemeh Amiri; Arianna Maever L. Amit; Dickson A. Amugsi; Gianna Gayle Herrera Amul; Etsay Woldu Anbesu; Robert Ancuceanu; Deanna Anderlini; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Sofia Androudi; Colin Angus; Mina Anjomshoa; Fereshteh Ansari; Iman Ansari; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Carl Abelardo T. Antonio; Catherine M. Antony; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Aleksandr Y. Aravkin; Aseb Arba Kinfe Arba; Olatunde Aremu; Filippo Ariani; Timur Aripov; Bahram Armoon; Johan Ärnlöv; Oluwaseyi Olalekan Arowosegbe; Krishna K. Aryal; Afsaneh Arzani; Malke Asaad; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Samaneh Asgari; Babak Asghari; Mohammad Asghari Jafarabadi; Charlie Ashbaugh; Michael Assmus; Zahra Atafar; Seyyed Shamsadin Athari; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Sachin R. Atre; Madhu Sudhan Atteraya; Floriane Ausloos; Marcel Ausloos; Leticia Avila-Burgos; Euripide Frinel Gbenato Arthur Avokpaho; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Getie Lake Aynalem; Yared Asmare Aynalem; Muluken Altaye Ayza; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Gulrez Azhar; Peter S. Azzopardi; B.B. Darshan; Ebrahim Babaee; Alaa Badawi; Ashish D. Badiye; Mojtaba Bagherzadeh; Eleni Bagli; Mohammad Amin Bahrami; Atif Amin Baig; Mohan Bairwa; Mohammad Hossein Bakhshaei; Ahad Bakhtiari; Shankar M. Bakkannavar; Arun Balachandran; Senthilkumar Balakrishnan; Shivanthi Balalla; Shelly Balassyano; Alberto Baldasseroni; Kylie Ball; Shoshana H. Ballew; Daniela Balzi; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Marlena S. Bannick; Agegnehu Bante Bante; Simachew Animen Bante; Adhanom Gebreegziabher Baraki; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Celine M. Barthelemy; Lingkan Barua; Akbar Barzegar; Huda Basaleem; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Bayisa Abdissa Baye; Gholamreza Bazmandegan; Jacob S. Becker; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Yannick Béjot; Tariku Tesfaye Tesfaye Bekuma; Michelle L. Bell; Aminu K. Bello; Rose G. Bender; Derrick A. Bennett; Fiona B. Bennitt; Isabela M. Bensenor; Catherine P. Benziger; Kidanemaryam Berhe; Adam E. Berman; Eduardo Bernabe; Robert S. Bernstein; Gregory J. Bertolacci; Akshaya Srikanth Bhagavathula; Reshmi Bhageerathy; Neeraj Bhala; Dinesh Bhandari; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Suraj Bhattarai; Zulfiqar A. Bhutta; Sadia Bibi; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Muhammad Shahdaat Bin Sayeed; Antonio Biondi; Binyam Minuye Birihane; Donal Bisanzio; Catherine Bisignano; Raaj Kishore Biswas; Helen Bitew; Tone Bjørge; Moses John Bockarie; Somayeh Bohlouli; Mehdi Bohluli; Hunduma Amensisa Bojia; Srinivasa Rao Bolla; Archith Boloor; Alexandra S. Boon-Dooley; Guilherme Borges; Antonio Maria Borzì; Shiva Borzouei; Dipan Bose; Cristina Bosetti; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Dejana Braithwaite; Michael Brauer; Carol Brayne; Nicholas J.K. Breitborde; Susanne Breitner; Hermann Brenner; Alexey V. Breusov; Paul Svitil Briant; Andrew M. Briggs; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Traolach Brugha; Dana Bryazka; Rachelle Buchbinder; Blair R. Bumgarner; Katrin Burkart; Richard Thomas Burnett; Sharath Burugina Nagaraja; Reinhard Busse; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Leah E. Cahill; Lucero Cahuana-Hurtado; Tianji Cai; Charlton S.K.H. Callender; Luis Alberto Cámera; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jackie Cao; Josip Car; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Chris D. Castle; Emma Castro; Franz Castro; Ferrán Catalá-López; Kate Causey; Christopher R. Cederroth; Kelly M. Cercy; Ester Cerin; Julian Chalek; Joht Singh Chandan; Alex R. Chang; Angela Y. Chang; Jung-Chen Chang; Kai-Lan Chang; Jaykaran Charan; Fiona J. Charlson; Vijay Kumar Chattu; Sarika Chaturvedi; Nicolas Cherbuin; Odgerel Chimed-Ochir; Ken Lee Chin; Jesus Lorenzo Chirinos-Caceres; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Hanne Christensen; Dinh-Toi Chu; Michael T. Chung; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Beniamino Cislaghi; Thomas Khaled Dwayne Classen; Aaron J. Cohen; Emma L. Collins; Haley Comfort; Kelly Compton; Sara Conti; Owen R. Cooper; Barbara Corso; Paolo Angelo Cortesi; Vera Marisa Costa; Ewerton Cousin; Richard G. Cowden; Benjamin C. Cowie; Elizabeth A. Cromwell; Andrew J. Croneberger; Di H. Cross; Marita Cross; Christopher Stephen Crowe; Jessica A. Cruz; Steven Cummins; Matthew Cunningham; Saad M.A. Dahlawi; Haijiang Dai; Hancheng Dai; Albertino Antonio Moura Damasceno; Giovanni Damiani; Emanuele D'Amico; Lalit Dandona; Rakhi Dandona; Parnaz Daneshpajouhnejad; William James Dangel; Anna-Karin Danielsson; Jiregna Darega Gela; Paul I. Dargan; Aso Mohammad Darwesh; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; José das Neves; Aditya Prasad Dash; Gail Davey; Claudio Alberto Dávila-Cervantes; Adrian C. Davis; Dragos Virgil Davitoiu; Kairat Davletov; Diego De Leo; Jan-Walter De Neve; Frances E. Dean; Nicole K. DeCleene; Amanda Deen; Louisa Degenhardt; Marissa DeLang; Robert Paul Dellavalle; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Edgar Denova-Gutiérrez; Nebiyu Dereje Dereje; Kebede Deribe; Nikolaos Dervenis; Rupak Desai; Assefa Desalew; Getenet Ayalew Dessie; Keshab Deuba; Samath Dhamminda Dharmaratne; Govinda Prasad Dhungana; Mostafa Dianatinasab; Diana Dias da Silva; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Martin Dichgans; Alireza Didarloo; Zachary V. Dingels; Ilse N. Dippenaar; M. Ashworth Dirac; Shirin Djalalinia; Hoa Thi Do; Klara Dokova; David Teye Doku; Christiane Dolecek; Andrew J. Dolgert; Fariba Dorostkar; Chirag P. Doshi; Pratik P. Doshi; Leila Doshmangir; Abdel Douiri; Matthew C. Doxey; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Susanna J. Dunachie; Bruce B. Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; Hedyeh Ebrahimi; Mohammad Ebrahimi Kalan; David Edvardsson; Andem Effiong; Joshua R. Ehrlich; Nevine El Nahas; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Hala Rashad Elhabashy; Shaimaa I. El-Jaafary; Aisha Elsharkawy; Iqbal R.F. Elyazar; Mohammad Hassan Emamian; Sophia Emmons-Bell; Holly E. Erskine; Babak Eshrati; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Firooz Esmaeilzadeh; Alireza Esteghamati; Sadaf Esteghamati; Kara Estep; Arash Etemadi; Atkilt Esaiyas Etisso; Oluchi Ezekannagha; Jessica Fanzo; Tamer Farag; Mohammad Farahmand; Anwar Faraj; Emerito Jose A. Faraon; Mohammad Fareed; Roghiyeh Faridnia; Carla Sofia e Sá Farinha; Andrea Farioli; Pawan Sirwan Faris; Andre Faro; Mithila Faruque; Farshad Farzadfar; Nazir Fattahi; Ali Akbar Fazaeli; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Giannina Ferrara; Pietro Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; James L. Fisher; Ryan Fitzgerald; Carsten Flohr; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Lisa M. Force; Carla Fornari; Masoud Foroutan; Jack T. Fox; Joel Msafiri Francis; Tahvi D. Frank; Richard Charles Franklin; Marisa Freitas; Weijia Fu; Takeshi Fukumoto; Kai Fukutaki; John E. Fuller; Nancy Fullman; João M. Furtado; Mohamed M. Gad; Abhay Motiramji Gaidhane; Emmanuela Gakidou; Natalie C. Galles; Silvano Gallus; Amiran Gamkrelidze; Alberto L. Garcia-Basteiro; William M. Gardner; Biniyam Sahiledengle Geberemariyam; Abiyu Mekonnen Gebrehiwot; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Leake G. Gebremeskel; Begashaw Melaku Gebresillassie; Assefa Ayalew Ayalew Ayalew Gebreslassie; Yilma Chisha Dea Geramo; Abraham Geremew; Anna Gershberg Hayoon; Hailay Abrha Gesesew; Peter W. Gething; Kebede Embaye Gezae; Maryam Ghadimi; Keyghobad Ghadiri; Fatemeh Ghaffarifar; Mansour Ghafourifard; Alireza Ghajar; Farhad Ghamari; Ahmad Ghashghaee; Hesam Ghiasvand; Nermin Ghith; Asadollah Gholamian; Rakesh Ghosh; Simona Giampaoli; Syed Amir Gilani; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Ibrahim Abdelmageed Ginawi; Themba G. Ginindza; Mojgan Gitimoghaddam; Giorgia Giussani; Mustefa Glagn; Ekaterina Vladimirovna Glushkova; Elena V. Gnedovskaya; Myron Anthony Godinho; Salime Goharinezhad; Mahaveer Golechha; Srinivas Goli; Ricardo Santiago Gomez; Philimon N. Gona; Sameer Vali Gopalani; Emily Goren; Giuseppe Gorini; Taren M. Gorman; Harrison Chase Gottlich; Houman Goudarzi; Amir Hossein Goudarzian; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Felix Greaves; Michal Grivna; Giuseppe Grosso; Mohammed Ibrahim Mohialdeen Gubari; Nachiket Gudi; Harish Chander Gugnani; Andre Luiz Sena Guimaraes; Rafael Alves Guimarães; Rashid Abdi Guled; Teklemariam Gultie; Gaorui Guo; Yuming Guo; Rahul Gupta; Rajeev Gupta; Subodh Sharan Gupta; Tarun Gupta; Juanita A. Haagsma; Vladimir Hachinski; Beatrix Haddock; Nima Hafezi-Nejad; Abdul Hafiz; Hailey Hagins; Lydia M. Haile; Teklehaimanot Gereziher Haile; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Kanaan Hamagharib Abdullah; Sajid Hameed; Samer Hamidi; Erin B. Hamilton; Melanie S. Hammer; Chieh Han; Hannah Han; Demelash Woldeyohannes Handiso; Asif Hanif; Graeme J. Hankey; Hamidreza Haririan; Josep Maria Haro; James D. Harvey; Ahmed I. Hasaballah; Md Mehedi Hasan; Edris Hasanpoor; Amir Hasanzadeh; Maryam Hashemian; Abdiwahab Hashi; Amr Hassan; Shoaib Hassan; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Roderick J. Hay; Simon I. Hay; Khezar Hayat; Behzad Heibati; Behnam Heidari; Golnaz Heidari; Reza Heidari-Soureshjani; Delia Hendrie; Kiana Henny; Andualem Henok; Hannah J. Henrikson; Nathaniel J. Henry; Molly E. Herbert; Claudiu Herteliu; Fatemeh Heydarpour; Thomas R. Hird; Hung Chak Ho; Hans W. Hoek; Michael K. Hole; Ramesh Holla; Bruce Hollingsworth; Praveen Hoogar; Kathleen Pillsbury Hopf; Nobuyuki Horita; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Damian G. Hoy; Mohamed Hsairi; Thomas Hsiao; Vivian Chia-Rong Hsieh; Guoqing Hu; Kejia Hu; Tanvir M. Huda; Fernando N. Hugo; Ayesha Humayun; Rabia Hussain; Chantal K. Huynh; Bing-Fang Hwang; Vincent C. Iannucci; Ivo Iavicoli; Charles Ugochukwu Ibeneme; Segun Emmanuel Ibitoye; Nayu Ikeda; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Mohammad Hasan Imani-Nasab; Leeberk Raja Inbaraj; Helen Ippolito; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; M. Mofizul Islam; Md. Mohaimenul Islam; Sheikh Mohammed Shariful Islam; Farhad Islami; Hiroyasu Iso; Rebecca Q. Ivers; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Jalil Jaafari; Kathryn H. Jacobsen; Farhad Jadidi-Niaragh; Hussain Jafari; Morteza Jafarinia; Deepa Jahagirdar; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Amir Jalali; Farzad Jalilian; Spencer L. James; Hosna Janjani; Manthan Dilipkumar Janodia; Tahereh Javaheri; Javad Javidnia; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Peng Jia; Lars Johansson; Oommen John; Yetunde O. John-Akinola; Catherine Owens Johnson; Sarah Charlotte Johnson; Jost B. Jonas; Tamas Joo; Ankur Joshi; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Hamed Kalani; Rizwan Kalani; Leila R. Kalankesh; Rohollah Kalhor; Aruna M. Kamath; Zahra Kamiab; Tanuj Kanchan; Neeti Kapoor; Behzad Karami Matin; Marina Karanikolos; André Karch; Mohd Anisul Karim; Salah Eddin Karimi; Seyed Asaad Karimi; Seyed M. Karimi; Ayele Semachew Kasa; Getachew Mullu Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Norito Kawakami; Gbenga A. Kayode; Ali Kazemi Karyani; Suzanne H. Keddie; Peter Njenga Keiyoro; Cathleen Keller; Laura Kemmer; Parkes J. Kendrick; Maia Kereselidze; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Mohammad Khammarnia; Ejaz Ahmad Khan; Gulfaraz Khan; Maseer Khan; Young-Ho Khang; Khaled Khatab; Amir M. Khater; Mona M. Khater; Mahalaqua Nazli Khatib; Maryam Khayamzadeh; Salman Khazaei; Habibolah Khazaie; Mohammad Taghi Khodayari; Abdullah T. Khoja; Jagdish Khubchandani; Roba Khundkar; Neda Kianipour; Christian Kieling; Cho-Il Kim; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Sezer Kisa; Katarzyna Kissimova-Skarbek; Niranjan Kissoon; Mika Kivimäki; Cameron J. Kneib; Luke D. Knibbs; Megan Knight; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; David S.Q. Koh; Stefan Kohler; Tufa Kolola; Hamidreza Komaki; Jacek A. Kopec; Anna V. Korotkova; Vladimir Andreevich Korshunov; Soewarta Kosen; Anirudh Kotlo; Parvaiz A. Koul; Ai Koyanagi; Moritz U.G. Kraemer; Michael A. Kravchenko; Kewal Krishan; Kris J. Krohn; Hans Kromhout; K.S. Shaji; Barthelemy Kuate Defo; Burcu Bicer Kucuk; Nuworza Kugbey; Vaman Kulkarni; G. Anil Kumar; Manasi Kumar; Nithin Kumar; Pushpendra Kumar; Vivek Kumar; Girikumar Kumaresh; Om P. Kurmi; Dian Kusuma; Hmwe Hmwe Kyu; Carlo La Vecchia; Ben Lacey; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Jennifer O. Lam; Faris Hasan Lami; Qing Lan; Iván Landires; Justin J. Lang; Sinéad M. Langan; Van Charles Lansingh; Sonia Lansky; Heidi Jane Larson; Samantha Leigh Larson; Anders O. Larsson; Savita Lasrado; Zohra S. Lassi; Kathryn Mei-Ming Lau; Paolo Lauriola; Pablo M. Lavados; Jeffrey V. Lazarus; Lisiane F. Leal; Janet L. Leasher; Jorge R. Ledesma; Paul H. Lee; Shaun Wen Huey Lee; Andrew T. Leever; Kate E. LeGrand; James Leigh; Matilde Leonardi; Haley Lescinsky; Janni Leung; Miriam Levi; Sarah Lewington; Bingyu Li; Shanshan Li; Lee-Ling Lim; Christine Lin; Ro-Ting Lin; Christine Linehan; Shai Linn; Stefan Listl; Hung-Chun Liu; Shiwei Liu; Simin Liu; Xuefeng Liu; Yang Liu; Zichen Liu; Justin Lo; Rakesh Lodha; Giancarlo Logroscino; Katharine J. Looker; Alan D. Lopez; Jaifred Christian F. Lopez; Platon D. Lopukhov; Stefan Lorkowski; Paulo A. Lotufo; Rafael Lozano; Alton Lu; Tim C.D. Lucas; Alessandra Lugo; Raimundas Lunevicius; Ronan A. Lyons; Jianing Ma; Daiane Borges Machado; Jennifer H. MacLachlan; Mohammed Madadin; Emilie R. Maddison; Ralph Maddison; Fabiana Madotto; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Phetole Walter Mahasha; Mokhtar Mahdavi Mahdavi; Morteza Mahmoudi; Hue Thi Mai; Azeem Majeed; Jeadran N. Malagón-Rojas; Venkatesh Maled; Afshin Maleki; Shokofeh Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Amir Manafi; Navid Manafi; Ana Laura Manda; Helena Manguerra; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Ana M. Mantilla Herrera; Chabila Christopher Mapoma; Joemer C. Maravilla; Ashley Marks; Randall V. Martin; Santi Martini; Francisco Rogerlândio Martins-Melo; Ira Martopullo; Anthony Masaka; Seyedeh Zahra Masoumi; João Massano; Benjamin Ballard Massenburg; Claudia I. Mastrogiacomo; Manu Raj Mathur; Kunihiro Matsushita; Pallab K. Maulik; Erin A. May; Mohsen Mazidi; Colm McAlinden; John J. McGrath; Martin McKee; Carlo Eduardo Medina-Solís; Birhanu Geta Meharie; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Fereshteh Mehri; Ravi Mehrotra; Kala M. Mehta; Wahengbam Bigyananda Meitei; Teferi Mekonnen; Addisu Melese; Peter T.N. Memiah; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; Meresa Berwo Mengesha; George A. Mensah; Alibek Mereke; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Irmina Maria Michalek; Kebadnew Mulatu Mihretie; Ted R. Miller; Edward J. Mills; George J. Milne; G.K. Mini; Mohammad Miri; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Roya Mirzaei; Mehdi Mirzaei-Alavijeh; Awoke Temesgen Misganaw; Philip B. Mitchell; Prasanna Mithra; Babak Moazen; Masoud Moghadaszadeh; Bahram Mohajer; Osama Mohamad; Efat Mohamadi; Dara K. Mohammad; Yousef Mohammad
Background: In an era of shifting global agendas and expanded emphasis on non-communicable diseases and injuries along with communicable diseases, sound evidence on trends by cause at the national level is essential. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) provides a systematic scientific assessment of published, publicly available, and contributed data on incidence, prevalence, and mortality for a mutually exclusive and collectively exhaustive list of diseases and injuries. Methods: GBD estimates incidence, prevalence, mortality, years of life lost (YLLs), years lived with disability (YLDs), and disability-adjusted life-years (DALYs) due to 369 diseases and injuries, for two sexes, and for 204 countries and territories. Input data were extracted from censuses, household surveys, civil registration and vital statistics, disease registries, health service use, air pollution monitors, satellite imaging, disease notifications, and other sources. Cause-specific death rates and cause fractions were calculated using the Cause of Death Ensemble model and spatiotemporal Gaussian process regression. Cause-specific deaths were adjusted to match the total all-cause deaths calculated as part of the GBD population, fertility, and mortality estimates. Deaths were multiplied by standard life expectancy at each age to calculate YLLs. A Bayesian meta-regression modelling tool, DisMod-MR 2.1, was used to ensure consistency between incidence, prevalence, remission, excess mortality, and cause-specific mortality for most causes. Prevalence estimates were multiplied by disability weights for mutually exclusive sequelae of diseases and injuries to calculate YLDs. We considered results in the context of the Socio-demographic Index (SDI), a composite indicator of income per capita, years of schooling, and fertility rate in females younger than 25 years. Uncertainty intervals (UIs) were generated for every metric using the 25th and 975th ordered 1000 draw values of the posterior distribution. Findings: Global health has steadily improved over the past 30 years as measured by age-standardised DALY rates. After taking into account population growth and ageing, the absolute number of DALYs has remained stable. Since 2010, the pace of decline in global age-standardised DALY rates has accelerated in age groups younger than 50 years compared with the 1990–2010 time period, with the greatest annualised rate of decline occurring in the 0–9-year age group. Six infectious diseases were among the top ten causes of DALYs in children younger than 10 years in 2019: lower respiratory infections (ranked second), diarrhoeal diseases (third), malaria (fifth), meningitis (sixth), whooping cough (ninth), and sexually transmitted infections (which, in this age group, is fully accounted for by congenital syphilis; ranked tenth). In adolescents aged 10–24 years, three injury causes were among the top causes of DALYs: road injuries (ranked first), self-harm (third), and interpersonal violence (fifth). Five of the causes that were in the top ten for ages 10–24 years were also in the top ten in the 25–49-year age group: road injuries (ranked first), HIV/AIDS (second), low back pain (fourth), headache disorders (fifth), and depressive disorders (sixth). In 2019, ischaemic heart disease and stroke were the top-ranked causes of DALYs in both the 50–74-year and 75-years-and-older age groups. Since 1990, there has been a marked shift towards a greater proportion of burden due to YLDs from non-communicable diseases and injuries. In 2019, there were 11 countries where non-communicable disease and injury YLDs constituted more than half of all disease burden. Decreases in age-standardised DALY rates have accelerated over the past decade in countries at the lower end of the SDI range, while improvements have started to stagnate or even reverse in countries with higher SDI. Interpretation: As disability becomes an increasingly large component of disease burden and a larger component of health expenditure, greater research and development investment is needed to identify new, more effective intervention strategies. With a rapidly ageing global population, the demands on health services to deal with disabling outcomes, which increase with age, will require policy makers to anticipate these changes. The mix of universal and more geographically specific influences on health reinforces the need for regular reporting on population health in detail and by underlying cause to help decision makers to identify success stories of disease control to emulate, as well as opportunities to improve. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
(Elsevier Ltd, 2023) Manuela L Ferreira; Katie De Luca; Lydia M Haile; Jaimie D Steinmetz; Garland T Culbreth; Marita Cross; Jacek A Kopec; Paulo H Ferreira; Fiona M Blyth; Rachelle Buchbinder; Jan Hartvigsen; Ai-Min Wu; Saeid Safiri; Anthony D Woolf; Gary S Collins; Kanyin Liane Ong; Stein Emil Vollset; Amanda E Smith; Jessica A Cruz; Kai Glenn Fukutaki; Semagn Mekonnen Abate; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Ahmed Abdelalim; Aidin Abedi; Hassan Abidi; Qorinah Estiningtyas Sakilah Adnani; Ali Ahmadi; Rufus Olusola Akinyemi; Abayneh Tadesse Alamer; Adugnaw Zeleke Alem; Yousef Alimohamadi; Mansour Abdullah Alshehri; Mohammed Mansour Alshehri; Hosam Alzahrani; Saeed Amini; Sohrab Amiri; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Benny Antony; Jalal Arabloo; Judie Arulappan; Ashokan Arumugam; Tahira Ashraf; Seyyed Shamsadin Athari; Nefsu Awoke; Sina Azadnajafabad; Till Winfried Bärnighausen; Lope H Barrero; Amadou Barrow; Akbar Barzegar; Lindsay M Bearne; Isabela M Bensenor; Alemshet Yirga Berhie; Bharti Bhandari Bhandari; Vijayalakshmi S Bhojaraja; Ali Bijani; Belay Boda Abule Bodicha; Srinivasa Rao Bolla; Javier Brazo-Sayavera; Andrew M Briggs; Chao Cao; Periklis Charalampous; Vijay Kumar Chattu; Flavia M Cicuttini; Benjamin Clarsen; Sarah Cuschieri; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Azizallah Dehghan; Takele Gezahegn G Demie; Edgar Denova-Gutiérrez; Syed Masudur Rahman Dewan; Samath Dhamminda Dharmaratne; Mandira Lamichhane Dhimal; Meghnath Dhimal; Daniel Diaz; Mojtaba Didehdar; Lankamo Ena Digesa; Mengistie Diress; Hoa Thi Do; Linh Phuong Doan; Michael Ekholuenetale; Muhammed Elhadi; Sharareh Eskandarieh; Shahriar Faghani; Jawad Fares; Ali Fatehizadeh; Getahun Fetensa; Irina Filip; Florian Fischer; Richard Charles Franklin; Balasankar Ganesan; Belete Negese Belete Gemeda; Motuma Erena Getachew; Ahmad Ghashghaee; Tiffany K Gill; Mahaveer Golechha; Pouya Goleij; Bhawna Gupta; Nima Hafezi-Nejad; Arvin Haj-Mirzaian; Pawan Kumar Hamal; Asif Hanif; Netanja I Harlianto; Hamidreza Hasani; Simon I Hay; Jeffrey J Hebert; Golnaz Heidari; Mohammad Heidari; Reza Heidari-Soureshjani; Mbuzeleni Mbuzeleni Hlongwa; Mohammad-Salar Hosseini; Alexander Kevin Hsiao; Ivo Iavicoli; Segun Emmanuel Ibitoye; Irena M Ilic; Milena D Ilic; Sheikh Mohammed Shariful Islam; Manthan Dilipkumar Janodia; Ravi Prakash Jha; Har Ashish Jindal; Jost B Jonas; Gebisa Guyasa Kabito; Himal Kandel; Rimple Jeet Kaur; Vikash Ranjan Keshri; Yousef Saleh Khader; Ejaz Ahmad Khan; Md Jobair Khan; Moien A B Khan; Hamid Reza Khayat Kashani; Jagdish Khubchandani; Yun Jin Kim; Adnan Kisa; Jitka Klugarová; Ali-Asghar Kolahi; Hamid Reza Koohestani; Ai Koyanagi; G Anil Kumar; Narinder Kumar; Tea Lallukka; Savita Lasrado; Wei-Chen Lee; Yo Han Lee; Ata Mahmoodpoor; Jeadran N Malagón-Rojas; Mohammad-Reza Malekpour; Reza Malekzadeh; Narges Malih; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Ritesh G Menezes; Alexios-Fotios A Mentis; Mohamed Kamal Mesregah; Ted R Miller; Mohammad Mirza-Aghazadeh-Attari; Maryam Mobarakabadi; Yousef Mohammad; Esmaeil Mohammadi; Shafiu Mohammed; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Mohammad Ali Moni; Ebrahim Mostafavi; Christopher J L Murray; Tapas Sadasivan Nair; Javad Nazari; Seyed Aria Nejadghaderi; Subas Neupane; Sandhya Neupane Kandel; Cuong Tat Nguyen; Ali Nowroozi; Hassan Okati-Aliabad; Emad Omer; Abderrahim Oulhaj; Mayowa O Owolabi; Songhomitra Panda-Jonas; Anamika Pandey; Eun-Kee Park; Shrikant Pawar; Paolo Pedersini; Jeevan Pereira; Mario F P Peres; Ionela-Roxana Petcu; Mohammadreza Pourahmadi; Amir Radfar; Shahram Rahimi-Dehgolan; Vafa Rahimi-Movaghar; Mosiur Rahman; Amir Masoud Rahmani; Nazanin Rajai; Chythra R Rao; Vahid Rashedi; Mohammad-Mahdi Rashidi; Zubair Ahmed Ratan; David Laith Rawaf; Salman Rawaf; Andre M N Renzaho; Negar Rezaei; Zahed Rezaei; Leonardo Roever; Guilherme De Andrade Ruela; Basema Saddik; Amirhossein Sahebkar; Sana Salehi; Francesco Sanmarchi; Sadaf G Sepanlou; Saeed Shahabi; Shayan Shahrokhi; Elaheh Shaker; Mohammad Bagher Shamsi; Mohammed Shannawaz; Saurab Sharma; Maryam Shaygan; Rahim Ali Sheikhi; Jeevan K Shetty; Rahman Shiri; Siddharudha Shivalli; Parnian Shobeiri; Migbar Mekonnen Sibhat; Ambrish Singh; Jasvinder A Singh; Helen Slater; Marco Solmi; Ranjani Somayaji; Ker-Kan Tan; Rekha Thapar; Seyed Abolfazl Tohidast; Sahel Valadan Tahbaz; Rohollah Valizadeh; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Vasily Vlassov; Bay Vo; Yuan-Pang Wang; Taweewat Wiangkham; Lalit Yadav; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Fereshteh Yazdanpanah; Naohiro Yonemoto; Mustafa Z Younis; Iman Zare; Armin Zarrintan; Mohammad Zoladl; Theo Vos; Lyn M March
Background: Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods: Population-based studies from 1980 to 2019 identified in a systematic review, international surveys, US medical claims data, and dataset contributions by collaborators were used to estimate the prevalence and YLDs for low back pain from 1990 to 2020, for 204 countries and territories. Low back pain was defined as pain between the 12th ribs and the gluteal folds that lasted a day or more; input data using alternative definitions were adjusted in a network meta-regression analysis. Nested Bayesian meta-regression models were used to estimate prevalence and YLDs by age, sex, year, and location. Prevalence was projected to 2050 by running a regression on prevalence rates using Socio-demographic Index as a predictor, then multiplying them by projected population estimates. Findings: In 2020, low back pain affected 619 million (95% uncertainty interval 554–694) people globally, with a projection of 843 million (759–933) prevalent cases by 2050. In 2020, the global age-standardised rate of YLDs was 832 per 100 000 (578–1070). Between 1990 and 2020, age-standardised rates of prevalence and YLDs decreased by 10·4% (10·9–10·0) and 10·5% (11·1–10·0), respectively. A total of 38·8% (28·7–47·0) of YLDs were attributed to occupational factors, smoking, and high BMI. Interpretation: Low back pain remains the leading cause of YLDs globally, and in 2020, there were more than half a billion prevalent cases of low back pain worldwide. While age-standardised rates have decreased modestly over the past three decades, it is projected that globally in 2050, more than 800 million people will have low back pain. Challenges persist in obtaining primary country-level data on low back pain, and there is an urgent need for more high-quality, primary, country-level data on both prevalence and severity distributions to improve accuracy and monitor change. Funding: Bill and Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national disability-adjusted life-years (DALYs) for 333 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
(Lancet Publishing Group, 2017) Simon I. Hay; Amanuel Alemu Abajobir; Kalkidan Hassen Abate; Cristiana Abbafati; Kaja M. Abbas; Foad Abd-Allah; Abdishakur M. Abdulle; Teshome Abuka Abebo; Semaw Ferede Abera; Victor Aboyans; Laith J. Abu-Raddad; Ilana N. Ackerman; Isaac A. Adedeji; Olatunji Adetokunboh; Ashkan Afshin; Rakesh Aggarwal; Sutapa Agrawal; Anurag Agrawal; Aliasghar Ahmad Kiadaliri; Muktar Beshir Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Sneha Aiyar; Tomi F. Akinyemiju; Nadia Akseer; Faris Hasan Al Lami; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Noore Alam; Tahiya Alam; Deena Alasfoor; Kefyalew Addis Alene; Raghib Ali; Reza Alizadeh-Navaei; Juma M. Alkaabi; Ala'a Alkerwi; François Alla; Peter Allebeck; Christine Allen; Fatma Al-Maskari; Mohammad Abdulaziz Almazroa; Rajaa Al-Raddadi; Ubai Alsharif; Shirina Alsowaidi; Benjamin M. Althouse; Khalid A. Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Erfan Amini; Walid Ammar; Yaw Ampem Amoako; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Palwasha Anwari; Johan Ärnlöv; Megha Arora; Al Artaman; Krishna Kumar Aryal; Solomon W. Asgedom; Tesfay Mehari Atey; Niguse Tadele Atnafu; Leticia Avila-Burgos; Euripide Frinel G. Arthur Avokpaho; Ashish Awasthi; Shally Awasthi; Beatriz Paulina Ayala Quintanilla; Mahmoud Reza Azarpazhooh; Peter Azzopardi; Tesleem Kayode Babalola; Umar Bacha; Alaa Badawi; Kalpana Balakrishnan; Marlena S. Bannick; Aleksandra Barac; Suzanne L. Barker-Collo; Till Bärnighausen; Simon Barquera; Lope H. Barrero; Sanjay Basu; Robert Battista; Katherine E. Battle; Bernhard T. Baune; Shahrzad Bazargan-Hejazi; Justin Beardsley; Neeraj Bedi; Yannick Béjot; Bayu Begashaw Bekele; Michelle L. Bell; Derrick A. Bennett; James R. Bennett; Isabela M. Bensenor; Jennifer Benson; Adugnaw Berhane; Derbew Fikadu Berhe; Eduardo Bernabé; Balem Demtsu Betsu; Mircea Beuran; Addisu Shunu Beyene; Anil Bhansali; Samir Bhatt; Zulfqar A. Bhutta; Sibhatu Biadgilign; Kelly Bienhof; Boris Bikbov; Charles Birungi; Stan Biryukov; Donal Bisanzio; Habtamu Mellie Bizuayehu; Fiona M. Blyth; Dube Jara Boneya; Dipan Bose; Ibrahim R. Bou-Orm; Rupert R. A. Bourne; Michael Brainin; Carol E. G. Brayne; Alexandra Brazinova; Nicholas J. K. Breitborde; Paul S. Briant; Gabrielle Britton; Traolach S. Brugha; Rachelle Buchbinder; Lemma Negesa Bulto Bulto; Blair Bumgarner; Zahid A. Butt; Lucero Cahuana-Hurtado; Ewan Cameron; Ismael Ricardo Campos-Nonato; Hélène Carabin; Rosario Cárdenas; David O. Carpenter; Juan Jesus Carrero; Austin Carter; Felix Carvalho; Daniel Casey; Carlos A. Castañeda-Orjuela; Jacqueline Castillo Rivas; Chris D. Castle; Ferrán Catalá-López; Jung-Chen Chang; Fiona J. Charlson; Pankaj Chaturvedi; Honglei Chen; Mirriam Chibalabala; Chioma Ezinne Chibueze; Vesper Hichilombwe Chisumpa; Abdulaal A. Chitheer; Rajiv Chowdhury; Devasahayam Jesudas Christopher; Liliana G. Ciobanu; Massimo Cirillo; Danny Colombara; Leslie Trumbull Cooper; Cyrus Cooper; Paolo Angelo Cortesi; Monica Cortinovis; Michael H. Criqui; Elizabeth A. Cromwell; Marita Cross; John A. Crump; Abel Fekadu Dadi; Koustuv Dalal; Albertino Damasceno; Lalit Dandona; Rakhi Dandona; José Das Neves; Dragos V. Davitoiu; Kairat Davletov; Barbora De Courten; Diego De Leo; Hans De Steur; Louisa Degenhardt; Selina Deiparine; Robert P. Dellavalle; Kebede Deribe; Amare Deribew; Don C. Das Jarlais; Subhojit Dey; Samath D. Dharmaratne; Preet K. Dhillon; Daniel Dicker; Shirin Djalalinia; Huyen Phuc Do; Klara Dokova; David Teye Doku; E. Ray Dorsey; Kadine Priscila Bender Dos Santos; Tim R. Driscoll; Manisha Dubey; Bruce Bartholow Duncan; Beth E. Ebel; Michelle Echko; Ziad Ziad El-Khatib; Ahmadali Enayati; Aman Yesuf Endries; Sergey Petrovich Ermakov; Holly E. Erskine; Setegn Eshetie; Babak Eshrati; Alireza Esteghamati; Kara Estep; Fanuel Belayneh Bekele Fanuel; Tamer Farag; Carla Sofa E Sa Farinha; André Faro; Farshad Farzadfar; Mir Sohail Fazeli; Valery L. Feigin; Andrea B. Feigl; Seyed-Mohammad Fereshtehnejad; João C. Fernandes; Alize J. Ferrari; Tesfaye Regassa Feyissa; Irina Filip; Florian Fischer; Christina Fitzmaurice; Abraham D. Flaxman; Nataliya Foigt; Kyle J. Foreman; Richard C. Franklin; Joseph J. Frostad; Nancy Fullman; Thomas Fürst; Joao M. Furtado; Neal D. Futran; Emmanuela Gakidou; Alberto L. Garcia-Basteiro; Teshome Gebre; Gebremedhin Berhe Gebregergs; Tsegaye Tewelde Gebrehiwot; Johanna M. Geleijnse; Ayele Geleto; Bikila Lencha Gemechu; Hailay Abrha Gesesew; Peter W. Gething; Alireza Ghajar; Katherine B. Gibney; Richard F. Gillum; Ibrahim Abdelmageem Mohamed Ginawi; Melkamu Dedefo Gishu; Giorgia Giussani; William W. Godwin; Kashish Goel; Shifalika Goenka; Ellen M. Goldberg; Philimon N. Gona; Amador Goodridge; Sameer Vali Gopalani; Richard A. Gosselin; Carolyn C. Gotay; Atsushi Goto; Alessandra Carvalho Goulart; Nicholas Graetz; Harish Chander Gugnani; Rajeev Gupta; Prakash C. Gupta; Tanush Gupta; Vipin Gupta; Rahul Gupta; Reyna A. Gutiérrez; Vladimir Hachinski; Nima Hafezi-Nejad; Alemayehu Desalegne Hailu; Gessessew Bugssa Hailu; Randah Ribhi Hamadeh; Samer Hamidi; Mouhanad Hammami; Alexis J. Handal; Graeme J. Hankey; Yuantao Hao; Hilda L. Harb; Habtamu Abera Hareri; Josep Maria Haro; Kimani M. Harun; James Harvey; Mohammad Sadegh Hassanvand; Rasmus Havmoeller; Roderick J. Hay; Mohammad T. Hedayati; Delia Hendrie; Nathaniel J. Henry; Ileana Beatriz Heredia-Pi; Pouria Heydarpour; Hans W. Hoek; Howard J. Hofman; Masako Horino; Nobuyuki Horita; H. Dean Hosgood; Sorin Hostiuc; Peter J. Hotez; Damian G. Hoy; Aung Soe Htet; Guoqing Hu; John J. Huang; Chantal Huynh; Kim Moesgaard Iburg; Ehimario Uche Igumbor; Chad Ikeda; Caleb Mackay Salpeter Irvine; Kathryn H. Jacobsen; Nader Jahanmehr; Mihajlo B. Jakovljevic; Peter James; Simerjot K. Jassal; Mehdi Javanbakht; Sudha P. Jayaraman; Panniyammakal Jeemon; Paul N. Jensen; Vivekanand Jha; Guohong Jiang; Denny John; Catherine O. Johnson; Sarah Charlotte Johnson; Jost B. Jonas; Mikk Jürisson; Zubair Kabir; Rajendra Kadel; Amaha Kahsay; Ritul Kamal; Chittaranjan Kar; Nadim E. Karam; André Karch; Corine Kakizi Karema; Seyed M. Karimi; Chante Karimkhani; Amir Kasaeian; Getachew Mullu Kassa; Nicholas J. Kassebaum; Nigussie Assefa Kassaw; Anshul Kastor; Srinivasa Vittal Katikireddi; Anil Kaul; Norito Kawakami; Peter Njenga Keiyoro; Laura Kemmer; Andre Pascal Kengne; Andre Keren; Chandrasekharan Nair Kesavachandran; Yousef Saleh Khader; Ibrahim A. Khalil; Ejaz Ahmad Khan; Young-Ho Khang; Abdullah T. Khoja; Ardeshir Khosravi; Jagdish Khubchandani; Christian Kieling; Yun Jin Kim; Daniel Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Katarzyna A. Kissimova-Skarbek; Niranjan Kissoon; Mika Kivimaki; Ann Kristin Knudsen; Yoshihiro Kokubo; Dhaval Kolte; Jacek A. Kopec; Soewarta Kosen; Georgios A. Kotsakis; Parvaiz A. Koul; Ai Koyanagi; Michael Kravchenko; Kristopher J. Krohn; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Pushpendra Kumar; Hmwe H. Kyu; Anton Carl Jonas Lager; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Nkurunziza Lambert; Qing Lan; Van C. Lansingh; Anders Larsson; Janet L. Leasher; Paul H. Lee; James Leigh; Cheru Tesema Leshargie; Janni Leung; Ricky Leung; Miriam Levi; Yichong Li; Yongmei Li; Xiaofeng Liang; Misgan Legesse Liben; Stephen S. Lim; Shai Linn; Angela Liu; Patrick Y. Liu; Shiwei Liu; Yang Liu; Rakesh Lodha; Giancarlo Logroscino; Katharine J. Looker; Alan D. Lopez; Stefan Lorkowski; Paulo A. Lotufo; Rafael Lozano; Timothy C. D. Lucas; Raimundas Lunevicius; Ronan A. Lyons; Erlyn Rachelle King Macarayan; Emilie R. Maddison; Hassan Magdy Abd El Razek; Mohammed Magdy Abd El Razek; Carlos Magis-Rodriguez; Mahdi Mahdavi; Marek Majdan; Reza Majdzadeh; Azeem Majeed; Reza Malekzadeh; Rajesh Malhotra; Deborah Carvalho Malta; Abdullah A. Mamun; Helena Manguerra; Treh Manhertz; Lorenzo G. Mantovani; Chabila C. Mapoma; Lyn M. March; Laurie B. Marczak; Jose Martinez-Raga; Paulo Henrique Viegas Martins; Francisco Rogerlândio Martins-Melo; Ira Martopullo; Winfried März; Manu Raj Mathur; Mohsen Mazidi; Colm McAlinden; Madeline McGaughey; John J. McGrath; Martin McKee; Suresh Mehata; Toni Meier; Kidanu Gebremariam Meles; Peter Memiah; Ziad A. Memish; Walter Mendoza; Melkamu Merid Mengesha; Mubarek Abera Mengistie; Desalegn Tadese Mengistu; George A. Mensah; Atte Meretoja; Tuomo J. Meretoja; Haftay Berhane Mezgebe; Renata Micha; Anoushka Millear; Ted R. Miller; Shawn Minnig; Mojde Mirarefn; Erkin M. Mirrakhimov; Awoke Misganaw; Shiva Raj Mishra; Philip B. Mitchell; Karzan Abdulmuhsin Mohammad; Alireza Mohammadi; Shafu Mohammed; Kedir Endris Mohammed; Muktar Sano Kedir Mohammed; Murali B. V. Mohan; Ali H. Mokdad; Sarah K. Mollenkopf; Lorenzo Monasta; Julio Cesar Montañez Hernandez; Marcella Montico; Maziar Moradi-Lakeh; Paula Moraga; Lidia Morawska; Rintaro Mori; Shane D. Morrison; Mark Moses; Clif Mountjoy-Venning; Kalayu Birhane Mruts; Ulrich O. Mueller; Kate Muller; Michele E. Mudoch; Srinivas Murthy; Gudlavalleti Venkata Satyanarayana Murthy; Kamarul Imran Musa; Jean B. Nachega; Gabriele Nagel; Mohsen Naghavi; Aliya Naheed; Kovin S. Naidoo; Vinay Nangia; Jamal T. Nasher; Gopalakrishnan Natarajan; Dumessa Edessa Negasa; Ionut Negoi; Ruxandra Irina Negoi; Charles R. Newton; Josephine Wanjiku Ngunjiri; Cuong Tat Nguyen; Quyen Le Nguyen; Grant Nguyen; Trang Huyen Nguyen; Minh Nguyen; Emma Nichols; Dina Nur Anggraini Ningrum; Vuong Minh Nong; Ole F. Norheim; Bo Norrving; Jean Jacques N. Noubiap; Alypio Nyandwi; Carla Makhlouf Obermeyer; Martin J. O'Donnell; Felix Akpojene Ogbo; In-Hwan Oh; Anselm Okoro; Olanrewaju Oladimeji; Andrew Toyin Olagunju; Tinuke Oluwasefunmi Olagunju; Helen E. Olsen; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Kanyin Ong; John Nelson Opio; Eyal Oren; Alberto Ortiz; Richard H. Osborne; Aaron Osgood-Zimmerman; Majdi Osman; Erika Ota; Mayowa O. Owolabi; Mahesh Pa; Rosana E. Pacella; Basant Kumar Panda; Jeyaraj D. Pandian; Christina Papachristou; Eun-Kee Park; Charles D. Parry; Mahboubeh Parsaeian; Snehal T. Patil; Scott B. Patten; George C. Patton; Deepak Paudel; Katherine Paulson; Neil Pearce; David M. Pereira; Krystle Marie Perez; Norberto Perico; Konrad Pesudovs; Carrie Beth Peterson; William Arthur Petri; Max Petzold; Michael Robert Phillips; Geofrey Phipps; David M. Pigott; Julian David Pillay; Christine Pinho; Michael A. Piradov; Dietrich Plass; Martin A. Pletcher; Svetlana Popova; Richie G. Poulton; Farshad Pourmalek; Dorairaj Prabhakaran; Narayan Prasad; Carrie Purcell; Manorama Purwar; Mostafa Qorbani; Rynaz H. S. Rabiee; Amir Radfar; Anwar Rafay; Kazem Rahimi; Afarin Rahimi-Movaghar; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Muhammad Aziz Rahman; Mohammad Hifz Ur Rahman; Rajesh Kumar Rai; Sasa Rajsic; Usha Ram; Chhabi Lal Ranabhat; Thara Rangaswamy; Zane Rankin; Paturi Vishnupriya Rao; Puja C. Rao; Salman Rawaf; Sarah E. Ray; Robert C. Reiner; Nikolas Reinig; Marissa Reitsma; Giuseppe Remuzzi; Andre M. N. Renzaho; Serge Resnikof; Satar Rezaei; Antonio L. Ribeiro; Hirbo Shore Roba; Stephen R. Robinson; David Rojas-Rueda; Mohammad Bagher Rokni; Luca Ronfani; Gholamreza Roshandel; Gregory A. Roth; Dietrich Rothenbacher; Ambuj Roy; Enrico Rubagotti; George Mugambage Ruhago; Soheil Saadat; Mahdi Safdarian; Saeid Safri; Rajesh Sagar; Ramesh Sahathevan; Mohammad Ali Sahraian; Joseph Salama; Muhammad Muhammad Saleh; Joshua A. Salomon; Sundeep Santosh Salvi; Abdallah M. Samy; Juan Ramon Sanabria; Maria Dolores Sanchez-Niño; Damian Santomauro; João Vasco Santos; Itamar S. Santos; Milena M. Santric Milicevic; Benn Sartorius; Maheswar Satpathy; Monika Sawhney; Sonia Saxena; Kathryn Schelonka; Maria Inês Schmidt; Ione J. C. Schneider; Ben Schöttker; Aletta E. Schutte; David C. Schwebel; Falk Schwendicke; Soraya Seedat; Sadaf G. Sepanlou; Edson E. Servan-Mori; Amira Shaheen; Masood Ali Shaikh; Mansour Shamsipour; Sheikh Mohammed Shariful Islam; Rajesh Sharma; Jayendra Sharma; Jun She; Peilin Shi; Kenji Shibuya; Chloe Shields; Mekonnen Sisay Shiferaw; Mika Shigematsu; Rahman Shiri; Reza Shirkoohi; Shreya Shirude; Kawkab Shishani; Haitham Shoman; Soraya Siabani; Abla Mehio Sibai; Inga Dora Sigfusdottir; Donald H. Silberberg; João Pedro Silva; Diego Augusto Santos Silva; Dayane Gabriele Alves Silveira; Jasvinder A. Singh; Virendra Singh; Om Prakash Singh; Narinder Pal Singh; Dhirendra Narain Sinha; Eirini Skiadaresi; Vegard Skirbekk; Erica Leigh Slepak; David L. Smith; Mari Smith; Badr H. A. Sobaih; Eugene Sobngwi; Michael Soljak; Reed J. D. Sorensen; Tatiane Cristina Moraes Sousa; Luciano A. Sposato; Chandrashekhar T. Sreeramareddy; Vinay Srinivasan; Jefrey D. Stanaway; Vasiliki Stathopoulou; Nicholas Steel; Dan J. Stein; Caitlyn Steiner; Sabine Steinke; Mark Andrew Stokes; Lars Jacob Stovner; Bryan Strub; Michelle Subart; Muawiyyah Babale Sufyan; Rizwan Suliankatchi Abdulkader; Bruno F. Sunguya; Patrick J. Sur; Soumya Swaminathan; Bryan L. Sykes; Dillon Sylte; Cassandra E. I. Szoeke; Rafael Tabarés-Seisdedos; Santosh Kumar Tadakamadla; Getachew Redae Tafere; Jukka S. Takala; Nikhil Tandon; David Tanne; Yihunie L. Tarekegn; Mohammad Tavakkoli; Nuno Taveira; Hugh R. Taylor; Teketo Kassaw Tegegne; Arash Tehrani-Banihashemi; Tesfalidet Tekelab; Girma Temam Shifa; Abdullah Sulieman Terkawi; Dawit Jember Tesfaye; Belay Tesssema; J.S. Thakur; Ornwipa Thamsuwan; Alice M. Theadom; Andrew M. Theis; Katie E. Thomas; Nihal Thomas; Robert Thompson; Amanda G. Thrift; Ruoyan Tobe-Gai; Myriam Tobollik; Marcello Tonelli; Roman Topor-Madry; Miguel Tortajada; Mathilde Touvier; Jeferson Traebert; Bach Xuan Tran; Christopher Troeger; Thomas Truelsen; Derrick Tsoi; Emin Murat Tuzcu; Hayley Tymeson; Stefanos Tyrovolas; Kingsley Nnanna Ukwaja; Eduardo A. Undurraga; Chigozie Jesse Uneke; Rachel Updike; Olalekan A. Uthman; Benjamin S. Chudi Uzochukwu; Job F. M. Van Boven; Santosh Varughese; Tommi Vasankari; Lennert J. Veerman; S. Venkatesh; Narayanaswamy Venketasubramanian; Ramesh Vidavalur; Lakshmi Vijayakumar; Francesco S. Violante; Abhishek Vishnu; Sergey K. Vladimirov; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Theo Vos; Fiseha Wadilo; Tolassa Wakayo; Mitchell T. Wallin; Yuan-Pang Wang; Scott Weichenthal; Elisabete Weiderpass; Robert G. Weintraub; Daniel J. Weiss; Andrea Werdecker; Ronny Westerman; Harvey A. Whiteford; Tissa Wijeratne; Hywel C. Williams; Charles Shey Wiysonge; Belete Getahun Woldeyes; Charles D. A. Wolfe; Rachel Woodbrook; Anthony D. Woolf; Abdulhalik Workicho; Denis Xavier; Gelin Xu; Simon Yadgir; Mohsen Yaghoubi; Bereket Yakob; Lijing L. Yan; Yuichiro Yano; Pengpeng Ye; Mahari Gidey Yihdego; Hassen Hamid Yimam; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Marcel Yotebieng; Mustafa Z. Younis; Chuanhua Yu; Zoubida Zaidi; Maysaa El Sayed Zaki; Elias Asfaw Zegeye; Zerihun Menlkalew Zenebe; Xueying Zhang; Yingfeng Zheng; Maigeng Zhou; Ben Zipkin; Sanjay Zodpey; Leo Zoeckler; Liesl Joanna Zuhlke; Christopher J. L. Murray; I.A. Adedji; M.E. Murdoch; C.E.G. Bryane
Background: Measurement of changes in health across locations is useful to compare and contrast changing epidemiological patterns against health system performance and identify specific needs for resource allocation in research, policy development, and programme decision making. Using the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we drew from two widely used summary measures to monitor such changes in population health: disability-adjusted life-years (DALYs) and healthy life expectancy (HALE). We used these measures to track trends and benchmark progress compared with expected trends on the basis of the Socio-demographic Index (SDI). Methods: We used results from the Global Burden of Diseases, Injuries, and Risk Factors Study 2016 for all-cause mortality, cause-specific mortality, and non-fatal disease burden to derive HALE and DALYs by sex for 195 countries and territories from 1990 to 2016. We calculated DALYs by summing years of life lost and years of life lived with disability for each location, age group, sex, and year. We estimated HALE using age-specific death rates and years of life lived with disability per capita. We explored how DALYs and HALE difered from expected trends when compared with the SDI: the geometric mean of income per person, educational attainment in the population older than age 15 years, and total fertility rate. Findings: The highest globally observed HALE at birth for both women and men was in Singapore, at 75·2 years (95% uncertainty interval 71·9-78·6) for females and 72·0 years (68·8-75·1) for males. The lowest for females was in the Central African Republic (45·6 years [42·0-49·5]) and for males was in Lesotho (41·5 years [39·0-44·0]). From 1990 to 2016, global HALE increased by an average of 6·24 years (5·97-6·48) for both sexes combined. Global HALE increased by 6·04 years (5·74-6·27) for males and 6·49 years (6·08-6·77) for females, whereas HALE at age 65 years increased by 1·78 years (1·61-1·93) for males and 1·96 years (1·69-2·13) for females. Total global DALYs remained largely unchanged from 1990 to 2016 (-2·3% [-5·9 to 0·9]), with decreases in communicable, maternal, neonatal, and nutritional (CMNN) disease DALYs ofset by increased DALYs due to non-communicable diseases (NCDs). The exemplars, calculated as the fve lowest ratios of observed to expected age-standardised DALY rates in 2016, were Nicaragua, Costa Rica, the Maldives, Peru, and Israel. The leading three causes of DALYs globally were ischaemic heart disease, cerebrovascular disease, and lower respiratory infections, comprising 16·1% of all DALYs. Total DALYs and age-standardised DALY rates due to most CMNN causes decreased from 1990 to 2016. Conversely, the total DALY burden rose for most NCDs; however, age-standardised DALY rates due to NCDs declined globally. Interpretation: At a global level, DALYs and HALE continue to show improvements. At the same time, we observe that many populations are facing growing functional health loss. Rising SDI was associated with increases in cumulative years of life lived with disability and decreases in CMNN DALYs ofset by increased NCD DALYs. Relative compression of morbidity highlights the importance of continued health interventions, which has changed in most locations in pace with the gross domestic product per person, education, and family planning. The analysis of DALYs and HALE and their relationship to SDI represents a robust framework with which to benchmark location-specific health performance. Country-specific drivers of disease burden, particularly for causes with higher-than-expected DALYs, should inform health policies, health system improvement initiatives, targeted prevention eforts, and development assistance for health, including fnancial and research investments for all countries, regardless of their level of sociodemographic development. The presence of countries that substantially outperform others suggests the need for increased scrutiny for proven examples of best practices, which can help to extend gains, whereas the presence of underperforming countries suggests the need for devotion of extra attention to health systems that need more robust support. © The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Global, regional, and national disability-adjusted life-years (DALYs) for 359 diseases and injuries and healthy life expectancy (HALE) for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
(Lancet Publishing Group, 2018) Hmwe Hmwe Kyu; Degu Abate; Kalkidan Hassen Abate; Solomon M. Abay; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Molla Abebe; Zegeye Abebe; Olifan Zewdie Abil; Victor Aboyans; Aklilu Roba Abrham; Laith Jamal Abu-Raddad; Niveen M.E. Abu-Rmeileh; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Pawan Acharya; Ilana N. Ackerman; Abdu A. Adamu; Oladimeji M. Adebayo; Victor Adekanmbi; Zanfina Ademi; Olatunji O. Adetokunboh; Mina G. Adib; Jose C. Adsuar; Kossivi Agbelenko Afanvi; Mohsen Afarideh; Ashkan Afshin; Gina Agarwal; Kareha M. Agesa; Rakesh Aggarwal; Sargis Aghasi Aghayan; Anurag Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Muktar Beshir Ahmed; Sayem Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Tomi Akinyemiju; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Hesham M. Al-Mekhlafi; Rajaa M. Al-Raddadi; Fares Alahdab; Khurshid Alam; Tahiya Alam; Alaa Alashi; Seyed Moayed Alavian; Kefyalew Addis Alene; Mehran Alijanzadeh; Reza Alizadeh-Navaei; Syed Mohamed Aljunid; Ala'A Alkerwi; François Alla; Peter Allebeck; Jordi Alonso; Ubai Alsharif; Khalid Altirkawi; Nelson Alvis-Guzman; Leopold N. Aminde; Erfan Amini; Mohammadreza Amiresmaili; Walid Ammar; Yaw Ampem Amoako; Nahla Hamed Anber; Catalina Liliana Andrei; Sofia Androudi; Megbaru Debalkie Animut; Mina Anjomshoa; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Palwasha Anwari; Jalal Arabloo; Olatunde Aremu; Johan Ärnlöv; Amit Arora; Megha Arora; Al Artaman; Krishna K. Aryal; Hamid Asayesh; Zerihun Ataro; Marcel Ausloos; Leticia Avila-Burgos; Euripide F.G.A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Rakesh Ayer; Peter S. Azzopardi; Arefeh Babazadeh; Hamid Badali; Kalpana Balakrishnan; Ayele Geleto Bali; Maciej Banach; Joseph Adel Mattar Banoub; Aleksandra Barac; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Simon Barquera; Lope H. Barrero; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Bayu Begashaw Bekele; Eyasu Tamru Bekru; Abate Bekele Belachew; Yihalem Abebe Belay; Michelle L. Bell; Aminu K. Bello; Derrick A. Bennett; Isabela M. Bensenor; Adugnaw Berhane; Eduardo Bernabe; Robert S. Bernstein; Mircea Beuran; Tina Beyranvand; Neeraj Bhala; Samir Bhatt; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Belete Biadgo; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Donal Bisanzio; Tone Bjorge; Archie Bleyer; Eshetu Mulisa Bobasa; Ibrahim R. Bou-Orm; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Luisa C. Brant; Carol Brayne; Alexandra Brazinova; Nicholas J.K. Breitborde; Hermann Brenner; Paul Svitil Briant; Andrey Nikolaevich Briko; Gabrielle Britton; Traolach Brugha; Rachelle Buchbinder; Reinhard Busse; Zahid A. Butt; Lucero Cahuana-Hurtado; Julio Cesar Campuzano Rincon; Jorge Cano; Rosario Cárdenas; Juan J. Carrero; Austin Carter; Félix Carvalho; Carlos A. Castaneda-Orjuela; Jacqueline Castillo Rivas; Franz Castro; Ferrán Catalá-López; Kelly M. Cercy; Ester Cerin; Yazan Chaiah; Jung-Chen Chang; Fiona J. Charlson; Vijay Kumar Chattu; Peggy Pei-Chia Chiang; Abdulaal Chitheer; Jee-Young J. Choi; Hanne Christensen; Devasahayam J. Christopher; Sheng-Chia Chung; Flavia M. Cicuttini; Massimo Cirillo; Daniel Collado-Mateo; Cyrus Cooper; Paolo Angelo Cortesi; Monica Cortinovis; Ewerton Cousin; Michael H. Criqui; Elizabeth A. Cromwell; Marita Cross; John A. Crump; Alemneh Kabeta Daba; Berihun Assefa Dachew; Abel Fekadu Dadi; Lalit Dandona; Rakhi Dandona; Paul I. Dargan; Ahmad Daryani; Rajat Das Gupta; José Das Neves; Tamirat Tesfaye Dasa; Dragos Virgil Davitoiu; Fernando Pio De La Hoz; Diego De Leo; Jan-Walter De Neve; Hans De Steur; Meaza Girma Degefa; Louisa Degenhardt; Selina Deiparine; Gebre Teklemariam Demoz; Edgar Denova-Gutiérrez; Kebede Deribe; Nikolaos Dervenis; Don C. Des Jarlais; Subhojit Dey; Samath D. Dharmaratne; Meghnath Dhimal; Mesfin Tadese Dinberu; M. Ashworth Dirac; Shirin Djalalinia; Linh Doan; Klara Dokova; David Teye Doku; E. Ray Dorsey; Kerrie E. Doyle; Tim Robert Driscoll; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Bruce B. Duncan; Andre R. Duraes; Hedyeh Ebrahimi; Soheil Ebrahimpour; Michelle M. Echko; Dumessa Edessa; David Edvardsson; Andem Effiong; Anne Elise Eggen; Joshua R. Ehrlich; Charbel El Bcheraoui; Ziad El-Khatib; Iqbal R.F. Elyazar; Ahmadali Enayati; Melese Linger Endalifer; Aman Yesuf Endries; Benjamin Er; Holly E. Erskine; Sharareh Eskandarieh; Alireza Esteghamati; Sadaf Esteghamati; Hamed Fakhim; Mahbobeh Faramarzi; Mohammad Fareed; Farzaneh Farhadi; Talha A. Farid; Carla Sofia E. Sá Farinha; Andrea Farioli; Andre Faro; Farshad Farzadfar; Ali Akbar Fazaeli; Valery L. Feigin; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Joao C. Fernandes; Alize J. Ferrari; Manuela L. Ferreira; Irina Filip; Florian Fischer; Christina Fitzmaurice; Nataliya A. Foigt; Kyle J. Foreman; Tahvi D. Frank; Takeshi Fukumoto; Nancy Fullman; Thomas Fürst; Joao M. Furtado; Emmanuela Gakidou; Seana Gall; Silvano Gallus; Morsaleh Ganji; Alberto L. Garcia-Basteiro; William M. Gardner; Abadi Kahsu Gebre; Amanuel Tesfay Gebremedhin; Teklu Gebrehiwo Gebremichael; Tilayie Feto Gelano; Johanna M. Geleijnse; Ricard Genova-Maleras; Yilma Chisha Dea Geramo; Peter W. Gething; Kebede Embaye Gezae; Mohammad Rasoul Ghadami; Keyghobad Ghadiri; Maryam Ghasemi-Kasman; Mamata Ghimire; Aloke Gopal Ghoshal; Paramjit Singh Gill; Tiffany K. Gill; Ibrahim Abdelmageed Ginawi; Giorgia Giussani; Elena V. Gnedovskaya; Ellen M. Goldberg; Srinivas Goli; Hector Gómez-Dantés; Philimon N. Gona; Sameer Vali Gopalani; Taren M. Gorman; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Giuseppe Grosso; Harish Chander Gugnani; Francis Guillemin; Yuming Guo; Prakash C. Gupta; Rahul Gupta; Rajeev Gupta; Tanush Gupta; Reyna Alma Gutiérrez; Bishal Gyawali; Juanita A. Haagsma; Vladimir Hachinski; Nima Hafezi-Nejad; Hassan Haghparast Bidgoli; Tekleberhan B. Hagos; Tewodros Tesfa Hailegiyorgis; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Alexis J. Handal; Graeme J. Hankey; Yuantao Hao; Hilda L. Harb; Sivadasanpillai Harikrishnan; Hamidreza Haririan; Josep Maria Haro; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Roderick J. Hay; Simon I. Hay; Akbar Hedayatizadeh-Omran; Behzad Heibati; Delia Hendrie; Andualem Henok; Ileana Heredia-Pi; Claudiu Herteliu; Fatemeh Heydarpour; Pouria Heydarpour; Desalegn Tsegaw Hibstu; Hans W. Hoek; Howard J. Hoffman; Michael K. Hole; Enayatollah Homaie Rad; Praveen Hoogar; H. Dean Hosgood; Seyed Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Peter J. Hotez; Damian G. Hoy; Mohamed Hsairi; Aung Soe Htet; John J. Huang; Kim Moesgaard Iburg; Chad Thomas Ikeda; Olayinka Stephen Ilesanmi; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; Sheikh Mohammed Shariful Islam; Farhad Islami; Kathryn H. Jacobsen; Leila Jahangiry; Nader Jahanmehr; Sudhir Kumar Jain; Mihajlo Jakovljevic; Spencer L. James; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Catherine O. Johnson; Jost B. Jonas; Jitendra Jonnagaddala; Zahra Jorjoran Shushtari; Ankur Joshi; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Zubair Kabir; Rajendra Kadel; Amaha Kahsay; Rizwan Kalani; Tanuj Kanchan; Chittaranjan Kar; Manoochehr Karami; Behzad Karami Matin; André Karch; Corine Karema; Narges Karimi; Seyed M. Karimi; Amir Kasaeian; Dessalegn H. Kassa; Getachew Mullu Kassa; Tesfaye Dessale Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Anil Kaul; Norito Kawakami; Zhila Kazemi; Ali Kazemi Karyani; Masoud Masoud Keighobadi; Peter Njenga Keiyoro; Laura Kemmer; Grant Rodgers Kemp; Andre Pascal Kengne; Andre Keren; Yousef Saleh Khader; Behzad Khafaei; Morteza Abdullatif Khafaie; Alireza Khajavi; Nauman Khalid; Ibrahim A. Khalil; Ejaz Ahmad Khan; Muhammad Shahzeb Khan; Muhammad Ali Khan; Young-Ho Khang; Mona M. Khater; Mohammad Khazaei; Abdullah T. Khoja; Ardeshir Khosravi; Mohammad Hossein Khosravi; Aliasghar A. Kiadaliri; Zelalem Teklemariam Kidanemariam; Daniel N. Kiirithio; Cho-Il Kim; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Katarzyna Kissimova-Skarbek; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; Yoshihiro Kokubo; Tufa Kolola; Jacek A. Kopec; Soewarta Kosen; Georgios A. Kotsakis; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Sanjay Krishnaswami; Kristopher J. Krohn; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Manasi Kumar; Igor Kuzin; Deepesh P. Lad; Sheetal D. Lad; Alessandra Lafranconi; Ratilal Lalloo; Tea Lallukka; Faris Hasan Lami; Justin J. Lang; Sinéad M. Langan; Van C. Lansingh; Arman Latifi; Kathryn Mei-Ming Lau; Jeffrey V. Lazarus; Janet L. Leasher; Jorge R. Ledesma; Paul H. Lee; James Leigh; Mostafa Leili; Cheru Tesema Leshargie; Janni Leung; Miriam Levi; Sonia Lewycka; Shanshan Li; Yichong Li; Xiaofeng Liang; Yu Liao; Misgan Legesse Liben; Lee-Ling Lim; Stephen S. Lim; Miteku Andualem Limenih; Shai Linn; Shiwei Liu; Katharine J. Looker; Alan D. Lopez; Stefan Lorkowski; Paulo A. Lotufo; Rafael Lozano; Tim C.D. Lucas; Raimundas Lunevicius; Ronan A. Lyons; Stefan Ma; Erlyn Rachelle King Macarayan; Mark T. Mackay; Emilie R. Maddison; Fabiana Madotto; Dhaval P. Maghavani; Hue Thi Mai; Marek Majdan; Reza Majdzadeh; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Ana-Laura Manda; Helena Manguerra; Mohammad Ali Mansournia; Ana Maria Mantilla Herrera; Lorenzo Giovanni Mantovani; Joemer C. Maravilla; Wagner Marcenes; Ashley Marks; Francisco Rogerlândio Martins-Melo; Ira Martopullo; Winfried März; Melvin B. Marzan; Joao Massano; Benjamin Ballard Massenburg; Manu Raj Mathur; Pallab K. Maulik; Mohsen Mazidi; Colm McAlinden; John J. McGrath; Martin McKee; Brian J. McMahon; Suresh Mehata; Ravi Mehrotra; Kala M. Mehta; Varshil Mehta; Fabiola Mejia-Rodriguez; Tesfa Mekonen; Addisu Melese; Mulugeta Melku; Peter T.N. Memiah; Ziad A. Memish; Walter Mendoza; Getnet Mengistu; George A. Mensah; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Anoushka I. Millear; Ted R. Miller; G.K. Mini; Mojde Mirarefin; Andreea Mirica; Erkin M. Mirrakhimov; Awoke Temesgen Misganaw; Philip B. Mitchell; Habtamu Mitiku; Babak Moazen; Bahram Mohajer; Karzan Abdulmuhsin Mohammad; Moslem Mohammadi; Noushin Mohammadifard; Mousa Mohammadnia-Afrouzi; Mohammed A. Mohammed; Shafiu Mohammed; Farnam Mohebi; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Julio Cesar Montanez; Mahmood Moosazadeh; Ghobad Moradi; Mahmoudreza Moradi; Maziar Moradi-Lakeh; Mehdi Moradinazar; Paula Moraga; Lidia Morawska; Ilais Moreno Velásquez; Joana Morgado-Da-Costa; Shane Douglas Morrison; Marilita M. Moschos; Seyyed Meysam Mousavi; Kalayu Brhane Mruts; Achenef Asmamaw Muche; Kindie Fentahun Muchie; Ulrich Otto Mueller; Oumer Sada Muhammed; Satinath Mukhopadhyay; Kate Muller; John Everett Mumford; G.V.S. Murthy; Kamarul Imran Musa; Ghulam Mustafa; Ashraf F. Nabhan; Chie Nagata; Gabriele Nagel; Mohsen Naghavi; Aliya Naheed; Azin Nahvijou; Gurudatta Naik; Farid Najafi; Hae Sung Nam; Vinay Nangia; Jobert Richie Nansseu; Nahid Neamati; Ionut Negoi; Ruxandra Irina Negoi; Subas Neupane; Charles Richard James Newton; Josephine W. Ngunjiri; Anh Quynh Nguyen; Grant Nguyen; Ha Thu Nguyen; Huong Lan Thi Nguyen; Huong Thanh Nguyen; Long Hoang Nguyen; Minh Nguyen; Nam Ba Nguyen; Son Hoang Nguyen; Emma Nichols; Dina Nur Anggraini Ningrum; Molly R. Nixon; Shuhei Nomura; Mehdi Noroozi; Bo Norrving; Jean Jacques Noubiap; Hamid Reza Nouri; Malihe Nourollahpour Shiadeh; Mohammad Reza Nowroozi; Elaine O. Nsoesie; Peter S. Nyasulu; Christopher M. Odell; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Olanrewaju Oladimeji; Andrew T. Olagunju; Tinuke O. Olagunju; Pedro R. Olivares; Helen Elizabeth Olsen; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Kanyin L. 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Woolf; Grant M.A. Wyper; Denis Xavier; Gelin Xu; Simon Yadgir; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Lijing L. Yan; Yuichiro Yano; Mehdi Yaseri; Yasin Jemal Yasin; Alex Yeshaneh; Ebrahim M. Yimer; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Marcel Yotebieng; Mustafa Z. Younis; Mahmoud Yousefifard; Chuanhua Yu; Vesna Zadnik; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Heather J. Zar; Zerihun Menlkalew Zenebe; Ben Zipkin; Maigeng Zhou; Sanjay Zodpey; Inbar Zucker; Liesl Joanna Zuhlke; Christopher J.L. Murray
Background: How long one lives, how many years of life are spent in good and poor health, and how the population's state of health and leading causes of disability change over time all have implications for policy, planning, and provision of services. We comparatively assessed the patterns and trends of healthy life expectancy (HALE), which quantifies the number of years of life expected to be lived in good health, and the complementary measure of disability-adjusted lifeyears (DALYs), a composite measure of disease burden capturing both premature mortality and prevalence and severityof ill health, for 359 diseases and injuries for 195 countries and territories over the past 28 years. Methods We used data for age-speci?c mortality rates, years of life lost (YLLs) due to premature mortality, and years lived with disability (YLDs) from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2017 to calculate HALE and DALYs from 1990 to 2017. We calculated HALE using age-specific mortality rates and YLDs per capita for each location, age, sex, and year. We calculated DALYs for 359 causes as the sum of YLLs and YLDs. We assessed how observed HALE and DALYs differed by country and sex from expected trends based on Sociodemographic Index (SDI). We also analysed HALE by decomposing years of life gained into years spent in good health and in poor health, between 1990 and 2017, and extra years lived by females compared with males. Findings Globally, from 1990 to 2017, life expectancy at birth increased by 7·4 years (95% uncertainty interval 7·1-7·8), from 65·6 years (65·3-65·8) in 1990 to 73·0 years (72·7-73·3) in 2017. The increase in years of life varied from 5·1 years (5·0-5·3) in high SDI countries to 12·0 years (11·3-12·8) in low SDI countries. Of the additional years of life expected at birth, 26·3% (20·1-33·1) were expected to be spent in poor health in high SDI countries compared with 11·7% (8·8-15·1) in low-middle SDI countries. HALE at birth increased by 6·3 years (5·9-6·7), from 57·0 years (54·6-59·1) in 1990 to 63·3 years (60·5-65·7) in 2017. The increase varied from 3·8 years (3·4-4·1) in high SDI countries to 10·5 years (9·8-11·2) in low SDI countries. Even larger variations in HALE than these were observed between countries, ranging from 1·0 year (0·4-1·7) in Saint Vincent and the Grenadines (62·4 years [59·9-64·7] in 1990 to 63·5 years [60·9-65·8] in 2017) to 23·7 years (21·9-25·6) in Eritrea (30·7 years [28·9-32·2] in 1990 to 54·4 years [51·5-57·1] in 2017). In most countries, the increase in HALE was smaller than the increase in overall life expectancy, indicating more years lived in poor health. In 180 of 195 countries and territories, females were expected to live longer than males in 2017, with extra years lived varying from 1·4 years (0·6-2·3) in Algeria to 11·9 years (10·9-12·9) in Ukraine. Of the extra years gained, the proportion spent in poor health varied largely across countries, with less than 20% of additional years spent in poor health in Bosnia and Herzegovina, Burundi, and Slovakia, whereas in Bahrain all the extra years were spent in poor health. In 2017, the highest estimate of HALE at birth was in Singapore for both females (75·8 years [72·4-78·7]) and males (72·6 years [69·8-75·0]) and the lowest estimates were in Central African Republic (47·0 years [43·7-50·2] for females and 42·8 years [40·1-45·6] for males). Globally, in 2017, the ?ve leading causes of DALYs were neonatal disorders, ischaemic heart disease, stroke, lower respiratory infections, and chronic obstructive pulmonary disease. Between 1990 and 2017, age-standardised DALY rates decreased by 41·3% (38·8-43·5) for communicable diseases and by 49·8% (47·9-51·6) for neonatal disorders. For non-communicable diseases, global DALYs increased by 40·1% (36·8-43·0), although age-standardised DALY rates decreased by 18·1% (16·0-20·2). Interpretation With increasing life expectancy in most countries, the question of whether the additional years of life gained are spent in good health or poor health has been increasingly relevant because of the potential policy implications, such as health-care provisions and extending retirement ages. In some locations, a large proportion of those additional years are spent in poor health. Large inequalities in HALE and disease burden exist across countries in different SDI quintiles and between sexes. The burden of disabling conditions has serious implications for health system planning and health-related expenditures. Despite the progress made in reducing the burden of communicable diseases and neonatal disorders in low SDI countries, the speed of this progress could be increased by scaling up proven interventions. The global trends among non-communicable diseases indicate that more effort is needed to maximise HALE, such as risk prevention and attention to upstream determinants of health. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Global, regional, and national incidence, prevalence, and years lived with disability for 354 Diseases and Injuries for 195 countries and territories, 1990-2017: A systematic analysis for the Global Burden of Disease Study 2017
(Lancet Publishing Group, 2018) Spencer L. James; Degu Abate; Kalkidan Hassen Abate; Solomon M. Abay; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Zegeye Abebe; Semaw F. Abera; Olifan Zewdie Abil; Haftom Niguse Abraha; Laith Jamal Abu-Raddad; Niveen M.E. Abu-Rmeileh; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Pawan Acharya; Ilana N. Ackerman; Abdu A. Adamu; Oladimeji M. Adebayo; Victor Adekanmbi; Olatunji O. Adetokunboh; Mina G. Adib; Jose C. Adsuar; Kossivi Agbelenko Afanvi; Mohsen Afarideh; Ashkan Afshin; Gina Agarwal; Kareha M. Agesa; Rakesh Aggarwal; Sargis Aghasi Aghayan; Sutapa Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Muktar Beshir Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Tomi Akinyemiju; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Hesham M. Al-Mekhlafi; Rajaa M. Al-Raddadi; Fares Alahdab; Khurshid Alam; Tahiya Alam; Alaa Alashi; Seyed Moayed Alavian; Kefyalew Addis Alene; Mehran Alijanzadeh; Reza Alizadeh-Navaei; Syed Mohamed Aljunid; Ala'a Alkerwi; François Alla; Peter Allebeck; Mohamed M.L. Alouani; Khalid Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Leopold N. Aminde; Walid Ammar; Yaw Ampem Amoako; Nahla Hamed Anber; Catalina Liliana Andrei; Sofia Androudi; Megbaru Debalkie Animut; Mina Anjomshoa; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Palwasha Anwari; Jalal Arabloo; Antonio Arauz; Olatunde Aremu; Filippo Ariani; Bahram Armoon; Johan Ärnlöv; Amit Arora; Al Artaman; Krishna K. Aryal; Hamid Asayesh; Rana Jawad Asghar; Zerihun Ataro; Sachin R. Atre; Marcel Ausloos; Leticia Avila-Burgos; Euripide F.G.A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Rakesh Ayer; Peter S. Azzopardi; Arefeh Babazadeh; Hamid Badali; Alaa Badawi; Ayele Geleto Bali; Katherine E. Ballesteros; Shoshana H. Ballew; Maciej Banach; Joseph Adel Mattar Banoub; Amrit Banstola; Aleksandra Barac; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Bernhard T. Baune; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Yannick Béjot; Abate Bekele Belachew; Yihalem Abebe Belay; Michelle L. Bell; Aminu K. Bello; Isabela M. Bensenor; Eduardo Bernabe; Robert S. Bernstein; Mircea Beuran; Tina Beyranvand; Neeraj Bhala; Suraj Bhattarai; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Belete Biadgo; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Donal Bisanzio; Brigette F. Blacker; Fiona M. Blyth; Ibrahim R. Bou-Orm; Soufiane Boufous; Rupert Bourne; Oliver J. Brady; Michael Brainin; Luisa C. Brant; Alexandra Brazinova; Nicholas J.K. Breitborde; Hermann Brenner; Paul Svitil Briant; Andrew M. Briggs; Andrey Nikolaevich Briko; Gabrielle Britton; Traolach Brugha; Rachelle Buchbinder; Reinhard Busse; Zahid A. Butt; Lucero Cahuana-Hurtado; Jorge Cano; Rosario Cárdenas; Juan J. Carrero; Austin Carter; Félix Carvalho; Carlos A. Castañeda-Orjuela; Jacqueline Castillo Rivas; Franz Castro; Ferrán Catalá-López; Kelly M. Cercy; Ester Cerin; Yazan Chaiah; Alex R. Chang; Hsing-Yi Chang; Jung-Chen Chang; Fiona J. Charlson; Aparajita Chattopadhyay; Vijay Kumar Chattu; Pankaj Chaturvedi; Peggy Pei-Chia Chiang; Ken Lee Chin; Abdulaal Chitheer; Jee-Young J. Choi; Rajiv Chowdhury; Hanne Christensen; Devasahayam J. Christopher; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Rafael M. Claro; Daniel Collado-Mateo; Cyrus Cooper; Josef Coresh; Paolo Angelo Cortesi; Monica Cortinovis; Megan Costa; Ewerton Cousin; Michael H. Criqui; Elizabeth A. Cromwell; Marita Cross; John A. Crump; Abel Fekadu Dadi; Lalit Dandona; Rakhi Dandona; Paul I. Dargan; Ahmad Daryani; Rajat Das Gupta; José Das Neves; Tamirat Tesfaye Dasa; Gail Davey; Adrian C. Davis; Dragos Virgil Davitoiu; Barbora De Courten; Fernando Pio De La Hoz; Diego De Leo; Jan-Walter De Neve; Meaza Girma Degefa; Louisa Degenhardt; Selina Deiparine; Robert P. Dellavalle; Gebre Teklemariam Demoz; Kebede Deribe; Nikolaos Dervenis; Don C. Des Jarlais; Getenet Ayalew Dessie; Subhojit Dey; Samath Dhamminda Dharmaratne; Mesfin Tadese Dinberu; M. Ashworth Dirac; Shirin Djalalinia; Linh Doan; Klara Dokova; David Teye Doku; E. Ray Dorsey; Kerrie E. Doyle; Tim Robert Driscoll; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Bruce B. Duncan; Andre R. Duraes; Hedyeh Ebrahimi; Soheil Ebrahimpour; Michelle Marie Echko; David Edvardsson; Andem Effiong; Joshua R. Ehrlich; Charbel El Bcheraoui; Maysaa El Sayed Zaki; Ziad El-Khatib; Hajer Elkout; Iqbal R.F. Elyazar; Ahmadali Enayati; Aman Yesuf Endries; Benjamin Er; Holly E. Erskine; Babak Eshrati; Sharareh Eskandarieh; Alireza Esteghamati; Sadaf Esteghamati; Hamed Fakhim; Vahid Fallah Omrani; Mahbobeh Faramarzi; Mohammad Fareed; Farzaneh Farhadi; Talha A. Farid; Carla Sofia Esá Farinha; Andrea Farioli; Andre Faro; Maryam S. Farvid; Farshad Farzadfar; Valery L. Feigin; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Joao C. Fernandes; Alize J. Ferrari; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Christina Fitzmaurice; Nataliya A. Foigt; Kyle J. Foreman; Jack Fox; Tahvi D. Frank; Takeshi Fukumoto; Nancy Fullman; Thomas Fürst; João M. Furtado; Neal D. Futran; Seana Gall; Morsaleh Ganji; Fortune Gbetoho Gankpe; Alberto L. Garcia-Basteiro; William M. Gardner; Abadi Kahsu Gebre; Amanuel Tesfay Gebremedhin; Teklu Gebrehiwo Gebremichael; Tilayie Feto Gelano; Johanna M. Geleijnse; Ricard Genova-Maleras; Yilma Chisha Dea Geramo; Peter W. Gething; Kebede Embaye Gezae; Keyghobad Ghadiri; Khalil Ghasemi Falavarjani; Maryam Ghasemi-Kasman; Mamata Ghimire; Rakesh Ghosh; Aloke Gopal Ghoshal; Simona Giampaoli; Paramjit Singh Gill; Tiffany K. Gill; Ibrahim Abdelmageed Ginawi; Giorgia Giussani; Elena V. Gnedovskaya; Ellen M. Goldberg; Srinivas Goli; Hector Gómez-Dantés; Philimon N. Gona; Sameer Vali Gopalani; Taren M. Gorman; Alessandra C. Goulart; Bárbara Niegia Garcia Goulart; Ayman Grada; Morgan E. Grams; Giuseppe Grosso; Harish Chander Gugnani; Yuming Guo; Prakash C. Gupta; Rahul Gupta; Rajeev Gupta; Tanush Gupta; Bishal Gyawali; Juanita A. Haagsma; Vladimir Hachinski; Nima Hafezi-Nejad; Hassan Haghparast Bidgoli; Tekleberhan B. Hagos; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Alexis J. Handal; Graeme J. Hankey; Yuantao Hao; Hilda L. Harb; Sivadasanpillai Harikrishnan; Josep Maria Haro; Mehedi Hasan; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Caitlin N. Hawley; Roderick J. Hay; Simon I. Hay; Akbar Hedayatizadeh-Omran; Behzad Heibati; Delia Hendrie; Andualem Henok; Claudiu Herteliu; Sousan Heydarpour; Desalegn Tsegaw Hibstu; Huong Thanh Hoang; Hans W. Hoek; Howard J. Hoffman; Michael K. Hole; Enayatollah Homaie Rad; Praveen Hoogar; H. Dean Hosgood; Seyed Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Peter J. Hotez; Damian G. Hoy; Mohamed Hsairi; Aung Soe Htet; Guoqing Hu; John J. Huang; Chantal K. Huynh; Kim Moesgaard Iburg; Chad Thomas Ikeda; Bogdan Ileanu; Olayinka Stephen Ilesanmi; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; Sheikh Mohammed; Shariful Islam; Farhad Islami; Kathryn H. Jacobsen; Leila Jahangiry; Nader Jahanmehr; Sudhir Kumar Jain; Mihajlo Jakovljevic; Mehdi Javanbakht; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Catherine O. Johnson; Jost B. Jonas; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Zubair Kabir; Rajendra Kadel; Amaha Kahsay; Rizwan Kalani; Tanuj Kanchan; Manoochehr Karami; Behzad Karami Matin; André Karch; Corine Karema; Narges Karimi; Seyed M. Karimi; Amir Kasaeian; Dessalegn H. Kassa; Getachew Mullu Kassa; Tesfaye Dessale Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Norito Kawakami; Ali Kazemi Karyani; Masoud Masoud Keighobadi; Peter Njenga Keiyoro; Laura Kemmer; Grant Rodgers Kemp; Andre Pascal Kengne; Andre Keren; Yousef Saleh Khader; Behzad Khafaei; Morteza Abdullatif Khafaie; Alireza Khajavi; Ibrahim A. Khalil; Ejaz Ahmad Khan; Muhammad Shahzeb Khan; Muhammad Ali Khan; Young-Ho Khang; Mohammad Khazaei; Abdullah T. Khoja; Ardeshir Khosravi; Mohammad Hossein Khosravi; Aliasghar A. Kiadaliri; Daniel N. Kiirithio; Cho-Il Kim; Daniel Kim; Pauline Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Katarzyna Kissimova-Skarbek; Mika Kivimäki; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; Yoshihiro Kokubo; Tufa Kolola; Jacek A. Kopec; Soewarta Kosen; Georgios A. Kotsakis; Parvaiz A. Koul; Ai Koyanagi; Michael A. Kravchenko; Kewal Krishan; Kristopher J. Krohn; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Manasi Kumar; Hmwe Hmwe Kyu; Deepesh P. Lad; Sheetal D. Lad; Alessandra Lafranconi; Ratilal Lalloo; Tea Lallukka; Faris Hasan Lami; Van C. Lansingh; Arman Latifi; Kathryn Mei-Ming Lau; Jeffrey V. Lazarus; Janet L. Leasher; Jorge R. Ledesma; Paul H. Lee; James Leigh; Janni Leung; Miriam Levi; Sonia Lewycka; Shanshan Li; Yichong Li; Yu Liao; Misgan Legesse Liben; Lee-Ling Lim; Stephen S. Lim; Shiwei Liu; Rakesh Lodha; Katharine J. Looker; Alan D. Lopez; Stefan Lorkowski; Paulo A. Lotufo; Nicola Low; Rafael Lozano; Tim C.D. Lucas; Lydia R. Lucchesi; Raimundas Lunevicius; Ronan A. 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Background: The Global Burden of Diseases, Injuries, and Risk Factors Study 2017 (GBD 2017) includes a comprehensive assessment of incidence, prevalence, and years lived with disability (YLDs) for 354 causes in 195 countries and territories from 1990 to 2017. Previous GBD studies have shown how the decline of mortality rates from 1990 to 2016 has led to an increase in life expectancy, an ageing global population, and an expansion of the non-fatal burden of disease and injury. These studies have also shown how a substantial portion of the world's population experiences non-fatal health loss with considerable heterogeneity among different causes, locations, ages, and sexes. Ongoing objectives of the GBD study include increasing the level of estimation detail, improving analytical strategies, and increasing the amount of high-quality data. Methods: We estimated incidence and prevalence for 354 diseases and injuries and 3484 sequelae. We used an updated and extensive body of literature studies, survey data, surveillance data, inpatient admission records, outpatient visit records, and health insurance claims, and additionally used results from cause of death models to inform estimates using a total of 68 781 data sources. Newly available clinical data from India, Iran, Japan, Jordan, Nepal, China, Brazil, Norway, and Italy were incorporated, as well as updated claims data from the USA and new claims data from Taiwan (province of China) and Singapore. We used DisMod-MR 2.1, a Bayesian meta-regression tool, as the main method of estimation, ensuring consistency between rates of incidence, prevalence, remission, and cause of death for each condition. YLDs were estimated as the product of a prevalence estimate and a disability weight for health states of each mutually exclusive sequela, adjusted for comorbidity. We updated the Socio-demographic Index (SDI), a summary development indicator of income per capita, years of schooling, and total fertility rate. Additionally, we calculated differences between male and female YLDs to identify divergent trends across sexes. GBD 2017 complies with the Guidelines for Accurate and Transparent Health Estimates Reporting. Findings: Globally, for females, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and haemoglobinopathies and haemolytic anaemias in both 1990 and 2017. For males, the causes with the greatest age-standardised prevalence were oral disorders, headache disorders, and tuberculosis including latent tuberculosis infection in both 1990 and 2017. In terms of YLDs, low back pain, headache disorders, and dietary iron deficiency were the leading Level 3 causes of YLD counts in 1990, whereas low back pain, headache disorders, and depressive disorders were the leading causes in 2017 for both sexes combined. All-cause age-standardised YLD rates decreased by 3·9% (95% uncertainty interval [UI] 3·1-4·6) from 1990 to 2017; however, the all-age YLD rate increased by 7·2% (6·0-8·4) while the total sum of global YLDs increased from 562 million (421-723) to 853 million (642-1100). The increases for males and females were similar, with increases in all-age YLD rates of 7·9% (6·6-9·2) for males and 6·5% (5·4-7·7) for females. We found significant differences between males and females in terms of age-standardised prevalence estimates for multiple causes. The causes with the greatest relative differences between sexes in 2017 included substance use disorders (3018 cases [95% UI 2782-3252] per 100 000 in males vs 1400 [1279-1524] per 100 000 in females), transport injuries (3322 [3082-3583] vs 2336 [2154-2535]), and self-harm and interpersonal violence (3265 [2943-3630] vs 5643 [5057-6302]). Interpretation: Global all-cause age-standardised YLD rates have improved only slightly over a period spanning nearly three decades. However, the magnitude of the non-fatal disease burden has expanded globally, with increasing numbers of people who have a wide spectrum of conditions. A subset of conditions has remained globally pervasive since 1990, whereas other conditions have displayed more dynamic trends, with different ages, sexes, and geographies across the globe experiencing varying burdens and trends of health loss. This study emphasises how global improvements in premature mortality for select conditions have led to older populations with complex and potentially expensive diseases, yet also highlights global achievements in certain domains of disease and injury. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.