Browsing by Author "Raffaele Capasso"

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Diallyl Disulfide: A Bioactive Garlic Compound with Anticancer Potential
(Frontiers Media S.A., 2022) Saikat Mitra; Rajib Das; Talha Bin Emran; Rafiuddin Khan Labib; Noor-E-Tabassum; Fahadul Islam; Rohit Sharma; Islamudin Ahmad; Firzan Nainu; Kumarappan Chidambaram; Fahad A. Alhumaydhi; Deepak Chandran; Raffaele Capasso; Polrat Wilairatana
Cancer is a life-threatening disease caused by the uncontrolled division of cells, which culminates in a solid mass of cells known as a tumor or liquid cancer. It is the leading cause of mortality worldwide, and the number of cancer patients has been increasing at an alarming rate, with an estimated 20 million cases expected by 2030. Thus, the use of complementary or alternative therapeutic techniques that can help prevent cancer has been the subject of increased attention. Garlic, the most widely used plant medicinal product, exhibits a wide spectrum of biological activities, including antibacterial, hypo-lipidemic, antithrombotic, and anticancer effects. Diallyl disulfide (DADS) is a major organosulfur compound contained within garlic. Recently, several experimental studies have demonstrated that DADS exhibits anti-tumor activity against many types of tumor cells, including gynecological cancers (cervical cancer, ovarian cancer), hematological cancers (leukemia, lymphoma), lung cancer, neural cancer, skin cancer, prostate cancer, gastrointestinal tract and associated cancers (esophageal cancer, gastric cancer, colorectal cancer), hepatocellular cancer cell line, etc. The mechanisms behind the anticancer action of DADS include epithelial-mesenchymal transition (EMT), invasion, and migration. This article aims to review the available information regarding the anti-cancer potential of DADS, as well as summarize its mechanisms of action, bioavailability, and pharmacokinetics from published clinical and toxicity studies. Copyright © 2022 Mitra, Das, Emran, Labib, Noor-E-Tabassum, Islam, Sharma, Ahmad, Nainu, Chidambaram, Alhumaydhi, Chandran, Capasso and Wilairatana.
Naturally-occurring Bioactive Molecules with Anti-Parkinson Disease Potential
(Bentham Science Publishers, 2022) Atul Kabra; Kamal Uddin; Rohit Sharma; Ruchika Kabra; Raffaele Capasso; Caridad Ivette Fernandez Verdecia; Christophe Hano; Natália Cruz-Martins; Uttam Singh Baghel
Parkinson's disease (PD) is a complex limiting neurodegenerative disorder, with a rising incidence. Current therapeutic options for PD have multiple limitations, and naturally occurring biomolecules, often known as phytochemicals, with potent neuroprotective activities, have been searched to meet the need. Thus, this chapter encompasses in-depth information on reported anti-PD activities of medicinal plants in light of available pre-clinical and clinical studies and shares the mechanisms of action proposed in fighting PD. Published information from PubMed, Scopus, Science Direct, Springer, Google Scholar, and other allied databases was analyzed. There is rising interest among researchers in investigating medicinal plants and their isolated compounds for their anti-PD efficacy. Scattered information about the anti-PD potential of plants and bioactive compounds is reported in the scientific domain. A total of 92 medicinal plants belonging to 63 families, exhibiting anti-PD activity were discussed. Botanical species have revealed an extreme potential, encouraging future examination. Data discussed here can be used for further research and clinical purposes. © 2022, Bentham Books imprint. All Rights Reserved.