Browsing by Author "Rajendra Dhar Badgaiyan"

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Intracerebroventricular chloride infusion enhances water intake in rats
(1987) Rajendra Dhar Badgaiyan
Central anionic influences on dipsogenic response was studied in 54 euhydrated rats. Quantity of water consumed following third ventricular infusions of equimolar hypertonic chloride and bicarbonate solutions of sodium, potassium, calcium, and barium was compared. Control group (n=6) was given artificial cerebrospinal fluid infusion while rats of the remaining 8 groups (n=6 each) received one of the test solutions. All the chloride solutions, irrespective of the cations to which they were associated, elicited significantly greater dipsogenic response as compared to the control, or the bicarbonate solutions. Response of the bicarbonate solutions was more than the control only in the observation taken 30 min after the infusions. In the later observations, there was no significant difference. Drinking was not affected significantly by the cationic composition of the infusion fluids. Anionic concentration of the solutions has predominantly influenced the dipsogenic response. Enhancement of drinking following infusions of chloride solutions suggests the possibility of the CSF anions exerting active physiological influences over the juxtacerebroventricular sensors. © 1987.
Third ventricular chloride infusions enhance drinking in water deprived rats
(1989) Rajendra Dhar Badgaiyan
The influence of intraventricularly infused anions on drinking was studied in 54 water deprived male rats, divided in 9 equal groups. Stainless steel cannulae were chronically implanted into the anteroventral part of the third ventricle (AV3V) and the animals were water deprived for 24 hr prior to the infusions. Control group (n=6) was given 10 μl of artificial cerebrospinal fluid. The rats of the remaining 8 groups received similar quantity of equiosmolar chloride or bicarbonate solution of either sodium, potassium, calcium or barium. Cumulative quantity of water consumed in 30 min, 1 hr, and 24 hr after the infusion was recorded. All the chloride solutions, irrespective of the associated cation, enhanced drinking. Effects of the bicarbonates were relatively weak and transient. Dipsogenic effects of the solutions depended on their anionic composition. Thus, chlorides of all the cations elicited greater drinking than their bicarbonates. Responses of the similar anionic solutions were comparable. It appears that intraventricularly infused chloride ions stimulate drinking in water deprived rats. © 1989.