Browsing by Author "Rajesh K. Jha"

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Effect of Hindi, Sanskrit and Urdu medium schooling on spatial language and encoding
(Springer, 2018) Ramesh C. Mishra; Rajesh K. Jha
Spatial cognition refers to the process through which people acquire knowledge of the location of objects in their surrounding environment. Studies suggest that people use different spatial frames of reference to describe the location of objects in space. The present study examines the frames of reference used by 10–15-year-old students attending Hindi, Sanskrit and Urdu medium schools at Varanasi in performing spatial cognitive tasks. Traditional schools, such as Sanskrit and Urdu medium schools, provide substantial experience and training in the use of a geocentric frame of reference based on cardinal directions (i.e., north, south, east and west). In view of this, it was expected that children attending these schools would use a geocentric frame of reference more than those attending Hindi medium school. Using a variety of procedures, the spatial frames of reference used in description and encoding of objects by students in Hindi, Sanskrit and Urdu medium schools were assessed. The results indicated that traditional Sanskrit and Urdu medium school students used more geocentric language for description of spatial objects and they also engaged in greater geocentric encoding of those objects than the students of Hindi medium schools. © 2018, Springer Nature Singapore Pte Ltd.
High Level of APOA1 in Blood and Maternal Fetal Interface Is Associated With Early Miscarriage
(SAGE Publications Inc., 2019) Priyanka Verma; Rohini R. Nair; Suchita Singh; Singh Rajender; Anuradha Khanna; Rajesh K. Jha; Kiran Singh
Early miscarriage (EM) is one of the most devastating obstetrical complications globally affecting the quality of women’s life. In the present study, we aimed to identify proteins that correlate with and could act as biomarkers for EM. We performed 2-dimensional gel electrophoresis in chorionic villi samples followed by mass spectrometry for identification of differential protein expression with EM. Proteomic studies detected a total 124 protein spots, out of which 83 spots were differentially expressed between EM and controls in chorionic villi samples. Matrix assisted laser desorbtion/ionization-time of flight (MALDI-TOF) mass spectrometry analysis revealed Apolipoprotein A1 (APOA1) to be the most upregulated protein in the EM group that was validated by Western blotting and Enzyme-linked immunosorbent assay (ELISA). We found low but not statistically significant level of APOA1 on 21st day of menstruation in comparison to the 7th day. APOA1 level was observed to be the lowest in the first trimester. Hence, this study suggests that low APOA1 expression is critical in establishing pregnancy and elevated APOA1 expression in chorionic villi correlates with EM. Similar observation in serum samples suggests its potential as a marker for the risk of EM. © The Author(s) 2018.