Browsing by Author "Rajesh Verma"

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Coronary artery calcium scoring is a better predictor of cardiac risk in subclinical hypothyroidism patients with low-risk Framingham score
(Medknow Publications, 2016) Rajesh Verma; Ashish Verma; Piyush Gupta; N. Agrawal
Context: Overt hypothyroidism accelerates the cardiovascular disease. Subclinical hypothyroidism (SCH), being considered as a preclinical state, impacts on cardiovascular status is not clear. Aims: This study was aimed at assessing cardiac risk stratification by Framingham risk scoring (FRS) and coronary coronary artery calcium score (CACS) by noncontrast cardiac computed tomography in SCH. Study Design: Observational study. Subjects and Methods: We enrolled thirty treatment-naive SCH patients (aged 30-60 years with no serious concurrent medical conditions), thirty euthyroid (age, sex, and body mass index-matched) controls, and ten healthy controls. All cases were evaluated for coronary artery calcium scoring and Framingham risk score. Statistical Analysis: Qualitative data were analyzed using the Chi-square test. In addition, demographics and CACS are summarized graphically or in a table. Results: SCH cases had higher thyroglobulin, while there was a trend toward an increase in total cholesterol, low-density lipoprotein (LDL), very LDL, and decrease in HDL levels. All participants had low-risk FRS (10-year FRS < 10%). The mean CACS in SCH was significantly higher than simple obese and healthy controls (47.17 vs. 2.67 vs. 0.00). Conclusion: This study suggests that SCH is an independent risk factor for coronary artery disease in apparently healthy controls. The risk of occult coronary artery disease is increased in SCH cases.
EXPLORING THE PSYCHO-SOCIAL IMPACT OF COVID-19: Global Perspectives on Behaviour, Interventions and Future Directions
(Taylor and Francis, 2024) Rajesh Verma; Uzaina; Gyanesh Kumar Tiwari; Leister Sam Sudheer Manickam; Tushar Singh
This comprehensive resource provides a one-stop information repository, exploring all psychological aspects of Covid-19. Divided into three sections, the book covers the psycho-social impact on society and individuals and our collective cooperative behaviour, as well as philanthropic efforts, coping strategies and technological interventions, and how lessons learned will help in preparedness for the future. Including case studies and the latest research from diverse scientific studies across different regions, this book examines how psycho-social paradigms changed as a result of the pandemic, and left their watermark on the human psyche. It also explores the coping strategies adopted to deal with this common aggressor and how the techniques varied in accordance with social, cultural and geographical factors. The final section offers new insights for the future, highlighting the psychological infrastructure required, the type of preparedness and handling strategies necessary to mitigate the impact of any future biogenic pandemics. Combining theory and practical application, this is a valuable reading for academics and researchers as well as practising psychologists, clinical psychologists, and law-makers who are concerned with mental health. © 2024 selection and editorial matter, Dr Rajesh Verma, Dr Uzaina, Dr Tushar Singh, Dr Gyanesh Kumar Tiwari, and Prof Leister Sam Sudheer Manickam.
HPG axis: The central regulator of spermatogenesis and male fertility
(Springer Singapore, 2017) Vertika Singh; Neeraj Kumar Agrawal; Rajesh Verma; Kiran Singh
Pituitary gonadotropins have been established as essential components for the differentiation of the male reproductive organs. Human sexual maturation and spermatogenesis are intricately regulated by the hypothalamic-pituitary-gonadal (HPG) axis, which eventually determines the reproductive potential of an organism. Alterations affecting this fine balance can severely impair sexual development and fertility. These defects may result from mutations, small deletions or polymorphic changes within the regulatory genes involved in the biosynthesis of hormones, hormone receptors, growth factors and their associated signal transduction pathways. This present chapter summarizes the functioning and regulation of the HPG axis, its control over spermatogenesis by means of FSH and LH synthesis, and the impact of endocrine disruptors on this central axis regulating fertility. © Springer Nature Singapore Pte Ltd. 2017. All rights reserved.
Patient with limb girdle dystrophy presenting with dopa-responsive dystonia - A case report
(2003) Rajesh Verma; S. Misra; N.N. Singh; D. Kishore
Dopa-responsive dystonias are rare. We report a 14-year-old male who was diagnosed as a case of limb girdle dystrophy and had features suggestive of dopa-responsive dystonia.
PREFACE
(Taylor and Francis, 2024) Rajesh Verma; Uzaina; Gyanesh Kumar Tiwari; Leister Sam Sudheer Manickam; Tushar Singh
[No abstract available]
Role of ethanolic extract of Bacopa monnieri against 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) induced mice model via inhibition of apoptotic pathways of dopaminergic neurons
(Elsevier Inc., 2017) Babita Singh; Shivani Pandey; Satyndra Kumar Yadav; Rajesh Verma; Surya Pratap Singh; Abbas Ali Mahdi
Parkinson's disease (PD) is a neurodegenerative disease which causes rigidity, resting tremor and postural instability. The neuroprotective effects of an ethanolic extract of Bacopa monnieri (BM) were evaluated in a Parkinsonian mice model induced by the MPTP. The present study investigates the mechanisms of neuroprotection elicited by BM, an herb traditionally recognized by the Indian system of medicine, Ayurveda. An ethanolic extract of BM was co-treated with the MPTP induced mouse model of PD and was shown to significantly rescue the motor behaviour (Rotarod, Grip Strength and Foot Printing test). Furthermore, on biochemical parameters too BM significantly showed protective effect as Catalase, LPO, Nitrite, SOD, GR, GPx parameters showed marked improvement and levels of Dopamine, DOPAC and HVA were enhanced significantly. There was a significant reduction in tyrosine hydroxylase (TH) immunoreactivity in the substantia nigra (SN) in MPTP treated group, which was considerably restored by the use of BM extract. BM also facilitated neuroprotection by creating an anti-apoptotic environment indicated by reduced apoptotic (Bax and caspase-3) and increased levels of anti-apoptotic (Bcl2) protein expression, respectively. Altogether, the present study suggests that BM treatment provides nigrostriatal dopaminergic neuroprotection against MPTP induced Parkinsonism by the modulation of oxidative stress and apoptotic machinery possibly accounting for the behavioural effects. © 2017