Browsing by Author "Rama Kanta Dube"
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PublicationArticle BLOOD COAGULATION PROFlLE IN INDIAN PATIENTS WITH PRE‐ECLAMPSIA AND ECLAMPSIA(1975) B. Dube; Sulekha Bhattacharya; Rama Kanta DubeTwelve Indian patients with pre‐eclampsia, 15 with eclampsia and 15 with normal pregnancy in the third trimester were investigated. A systemic bleeding diathesis was encountered in two patients with eclampsia and in none with pre‐eclampsia; two patients with pre‐eclampsia, however, had excessive uterine haemorrhage. Coagulation studies showed statistically significant prolongation of thrombin time, elevation of serum fibrinogen degradation products (FDP) and hypofibrino‐ genaemia in patients with pre‐eclampsia as well as eclampsia. In patients with eclampsia, significant thrombocytopenia also occurred. Euglobulin lysis time showed no significant change in patients with pre‐eclampsia and eclampsia. There was no significant difference in the coagulation profile between patients with eclampsia and pre‐eclampsia, except for more hypofibrinogenaemia in the former. The laboratory findings suggest the occurrence of intravascular coagulation Copyright © 1975, Wiley Blackwell. All rights reserved