Browsing by Author "Ramandeep Kaur"

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Genome-Wide Association Study Reveals Novel Powdery Mildew Resistance Loci in Bread Wheat
(Multidisciplinary Digital Publishing Institute (MDPI), 2023) Ramandeep Kaur; Neeraj Kumar Vasistha; Vikas Kumar Ravat; Vinod Kumar Mishra; Sandeep Sharma; Arun Kumar Joshi; Raman Dhariwal
Powdery mildew (PM), caused by the fungal pathogen Blumeria graminis f. sp. tritici (Bgt), significantly threatens global bread wheat production. Although the use of resistant cultivars is an effective strategy for managing PM, currently available wheat cultivars lack sufficient levels of resistance. To tackle this challenge, we conducted a comprehensive genome-wide association study (GWAS) using a diverse panel of 286 bread wheat genotypes. Over three consecutive years (2020–2021, 2021–2022, and 2022–2023), these genotypes were extensively evaluated for PM severity under field conditions following inoculation with virulent Bgt isolates. The panel was previously genotyped using the Illumina 90K Infinium iSelect assay to obtain genome-wide single-nucleotide polymorphism (SNP) marker coverage. By applying FarmCPU, a multilocus mixed model, we identified a total of 113 marker–trait associations (MTAs) located on chromosomes 1A, 1B, 2B, 3A, 3B, 4A, 4B, 5A, 5B, 6B, 7A, and 7B at a significance level of p ≤ 0.001. Notably, four novel MTAs on chromosome 6B were consistently detected in 2020–2021 and 2021–2022. Furthermore, within the confidence intervals of the identified SNPs, we identified 96 candidate genes belonging to different proteins including 12 disease resistance/host–pathogen interaction-related protein families. Among these, protein kinases, leucine-rich repeats, and zinc finger proteins were of particular interest due to their potential roles in PM resistance. These identified loci can serve as targets for breeding programs aimed at developing disease-resistant wheat cultivars. © 2023 His Majesty the King in Right of Canada.
Organocatalytic Asymmetric Tandem α-Aminooxylation–Henry Reactions for the Synthesis of 1,2-Diols: Total Synthesis of (–)-l-threo-Sphinganine
(Wiley-VCH Verlag, 2017) Yuvraj Garg; Ramandeep Kaur; Satyendra Kumar Pandey
A new and rapid asymmetric synthesis of anti- and syn-β,γ-dihydroxynitroalkanes through an organocatalytic tandem α-aminooxylation–Henry reaction is described. The target diol derivatives were synthesized in good yields, with excellent enantioselectivities, and low to moderate diasteroselectivities, under mild conditions. The synthesis of the antineoplastic and antipsoriatic drug (–)-l-threo-sphinganine demonstrates the synthetic utility of the building blocks generated in the developed reaction. © 2017 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.