Browsing by Author "Remya Jayakumar"

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Ayurvedic supportive therapy in the management of breast cancer
(Elsevier GmbH, 2021) Manoj Kumar Dash; Namrata Joshi; D.N.S Gautam; Remya Jayakumar; Y.B. Tripathi
Introduction: Breast cancer is the second most common cancer among women. Initial signs of cancer start in the lymph nodes located under the arm, within the breast, and near the collarbone. Many promising remedies for breast cancer are included in Ayurveda, the Indian system of medicine. Nowadays, multi-targeted herbal drugs are used as an adjuvant therapy alongside conventional medicine in the management of t0068is type of cancer. The present review concentrates on the available literature found in Ayurveda regarding plants and breast cancer. Methods: Web of Science, PubMed, Google Scholar were searched, resulting in 115 articles, as per the authors study criteria, by using keywords, breast cancer, and medicinal plants, then were able to aggregate 64 therapeutic targets from 35 different plant species in this review article. Result: Seven treatment areas were identified: Anti-inflammatory, Immunomodulatory, Endocrine suppressor, Tumour suppressor, Glut-1 inhibitor, Aromatase inhibitor, and Lectin-containing plants. Among the molecular targets, 51 % (33/64) caused apoptosis and 37 % (24/64) demonstrated cell proliferation activity. The review provides evidence of data suggesting that 17 % therapeutic targets have carcinogen inactivation activity, 10 % have precancerous growth prevention activity, 9% have mutagenesis and gene expression activity, and 4 % regulate toxic metabolism. Conclusion: Ayurvedic herbs that suppress multiple pathways must be chosen for prevention as well as treatment of the disease. It may not only be beneficial in reducing the harms of chemotherapeutic agents but also enhances their efficacy as supportive care. © 2021 Elsevier GmbH
Clinical efficacy of Gojihvadi Kwath, Shirishadi Kwath, Sanjeevani Vati, Panchagavya Ghrita Granules & Shunthi Churna for COVID-19 management, a randomized controlled trial
(National Institute of Science Communication and Policy Research, 2024) Parameswarappa S. Byadgi; Meena Kumari; Vishwambhar Singh; Arun Kumar Dwivedi; Sunil Kumar Mishra; Sushil Kumar Dubey; Ashvanee Kumar Chaudhary; R.N. Chaurasia; Namrata Joshi; Hitesh Jani; Rajeev Kumar Mishra; T.B. Singh; P.S. Arunima; Remya Jayakumar
The obscure disease pattern of COVID-19 have to be evaluated with Ayurvedic interventions and the present clinical trial was a randomized open label parallel three-arm control trial on the major and minor symptomatic patients with the recent pandemic. The patients were recruited from the Super specialty building of Sir Sunderlal hospital, COVID-19 ward and home isolated ones. The Ayurvedic intervention includes the 15 days oral administration (Group A) –Gojihvadi Kwath, Sanjeevani Vati; Panchagavya Ghrit Granules; Shunthi (Dry ginger powder) plus conventional treatment, in (Group B) – Shirishadi Kwath, Sanjeevani Vati; Panchagavya Ghrit Granules; Shunthi (Dry ginger powder) plus conventional treatment and in Group C (control group) only the conventional medicines. Assessment was done based on the RT-PCR reports, signs and symptoms. The results point out the efficacy of trial medicine (that is group A and B) to discharge the patients earlier than those from the control group. The early reduction in the signs and symptoms noted were also observed. Group B showed a faster recovery from dry cough and shortness of breath and improvement in appetite. Home-isolation patients showed faster recovery of clinical symptoms than the hospitalized patients. Ayurvedic interventions can accelerate viral load clearance associated with quicker recovery and concurrently decrease the risk of viral dissemination. Additionally, there were no adverse reactions observed with these trial medicines. © 2024, National Institute of Science Communication and Policy Research. All rights reserved.
Dietary Supplements and Nutraceuticals in the Management of Endocrine Disorders, Endocrinological Challenges in Aging and Nutraceuticals
(CRC Press, 2021) Remya Jayakumar; Namrata Joshi; Manoj Dash
Annath bavanthi boothani… when the gospels from Vedic literature hails food, the subsistence of all material bodies [1], ancient treatise by Sage Kashyapa emphasized the food factor as medicine itself [2]. Hippocrates’s quote “Let food be thy medicine and medicine be thy food” preceded the very concept [3]. The framework of food as medicine gets later highlighted by Stephen de Felice by coining the term NUTRACEUTICAL in 1989 [4]. Nutraceuticals started reverberating the baseline history of food as medicine and nowadays can be seen conjoined with any conventional medical prescription and health concept. The loosened legalities regarding the new trend were the added advantage for the upcoming wave leaving behind the questions of safety. This nutraceutical key to health when thoroughly shuffled might be suiting the antiaging process on a preventive schedule. © 2022 selection and editorial matter, Jayant Nemchand Lokhande, Yashwant Vishnupant Pathak; individual chapters, the contributors CRC Press is an imprint of Taylor & Francis Group, LLC.
Pharmaceutical characterization and exploration of Arkeshwara rasa in MDA-MB-231 cells
(Elsevier B.V., 2024) Remya Jayakumar; Manoj Kumar Dash; Pankaj Kumar; Shiwakshi Sharma; Saumya Gulati; Akanksha Pandey; Kaushavi Cholke; Zeeshan Fatima; S.K. Trigun; Namrata Joshi
Background: The diverse specificity mode of cancer treatment targets and chemo resistance demands the necessity of drug entities which can address the devastating dynamicity of the disease. Objectives: To check the anti-tumour potential of traditional medicine rich in polyherbal components and metal nanoparticle namely Arkeshwara rasa (AR). Material methods: The AR was prepared in a modified version with reference from Rasaratna Samuchaya and characterized using sophisticated instrumental analysis including XRD, SEM-EDAX, TEM, TGA-DSC, and LC-MS and tested against the MDA-MB-231 cell line to screen cell viability and the cytotoxicity with MTT, SRB and the AO assay. Results: XRD pattern shows cubic tetrahedrite structure with Sb, Cu, S peaks and trace elements like Fe, Mg, etc. The particle size of AR ranges between 20 and 30 nm. The TGA points thermal decomposition at 210 °C and the metal sulphide peaks in DSC. LC-MS analysis reveals the components of the formulation more on the flavonoid portion. The IC50 value of MTT and SRB are 25.28 μg/mL and 31.7 μg/mL respectively. The AO colorimeter substantiated the cell viability and the apoptosis figures of the same cell line. The AR exhibits cytotoxicity and reaffirms the apoptosis fraction with SRB assay. Conclusions: The Hesperidine, Neohesperidin, Rutin components in the phytochemical pool can synergize the anti-tumour potential with either influencing cellular pathways or decreasing chemo resistance to conventional treatment. AR need to be further experimented with reverse transcription, flow cytometry, western blotting, etc. © 2023 The Authors
Preliminary data on cytotoxicity and functional group assessment of a herb-mineral combination against colorectal carcinoma cell line
(Walter de Gruyter GmbH, 2024) Remya Jayakumar; Manoj Kumar Dash; Saumya Gulati; Akanksha Pandey; Surendra Kumar Trigun; Namrata Joshi
Objectives: The invasive screening methods and the late stage diagnosis of colorectal carcinoma (CRC) are contributing for the devastative prognosis. The gradual shift of the disease pattern among younger generations requires the implementation of phytochemicals and traditional medicines. Arkeshwara rasa (AR) is a herb-mineral combination of Tamra bhasma/incinerated copper ashes and Dwigun Kajjali/mercury sulphide levigated with Calotropis procera leaf juice, Plumbago zeylanica root decoction and the decoction of three myrobalans (Terminalia chebula, Terminalia bellerica, Emblica Officinalis decoction)/Triphala decoction. Methods: The SW-480 cell line was checked for the cytotoxicity and the cell viability criteria with MTT(3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2H-tetrazolium bromide) assay. The acridine orange/ethidium bromide (AO/EtBr) assay revealed the depth of apoptosis affected cells in the fluorescent images. The FTIR analysis exhibited the graphical spectrum of functional groups within the compound AR. Results: The IC50 from the 10-7 to 10-3 concentrations against SW-480 cells was 40.4μg/mL. The staining of AO/EtBr was performed to visualize live and dead cells and it is evident from the result that number of apoptotic cells increases at increasing concentration of AR. The single bond with stretch vibrations of O-H and N-H are more concentrated in the 2,500-3,200cm-1 and 3,700-4,000cm-1 of the spectra whereas, the finger print region carries the O-H and S=O type peaks. Conclusions: The AR shows strong cyto-toxicity against the SW-480 cells by inducing apoptosis. It also modulates cellular metabolism with the involvement of functional groups which antagonizes the strong acids. Moreover, these effects need to be analyzed further based in the in vivo and various in vitro models. © 2023 Walter de Gruyter GmbH, Berlin/Boston.
Swarna Bhasma reduces the blood concentration of tumor-specific signatures and protects from hepatocellular damages in Ehrlich ascites mice model
(Elsevier B.V., 2025) Namrata Joshi; Pankaj Kumar; Shiwakshi Sharma; Remya Jayakumar; Anand Mishra; V. Harsha; Manoj Kumar Dash
Background: The paradigm shift with alarmingly high rate of global cancer incidences encourages the application of incinerated gold Nano powder, Swarna Bhasma (SB) due to its exceptional potency, affordability, and minimal toxic effects. Previous experimental investigations were unable to provide a biochemical understanding of the anti-carcinogenic properties of SB. Objective: To evaluate the tumour related markers in blood and possible alteration in hepatic parameters due to SB. Methods: EAC (Ehrlich's Ascites Carcinoma) induced tumour was generated in the female Swiss albino mice divided into 6 groups, namely, Vehicle Control (VC), Disease Control (DC), Standard Control (SC), and Treatment Groups with escalating doses (1.95, 3.9, and 7.8 mg/kg body weight) of SB. Blood serum quantified was measured for the levels of CEA (Carcinoembryonic antigen), TNF-α (Tumour Necrosis Factoralpha), IL-6 (Interleukin-6), ALT (Alanine transaminase), and AST (Aspartate aminotransferase). Changes in daily food consumption, body weight, and tumour volume (with Vernier caliper) were coherently studied and analysed. The data was analysed using One-Way ANOVA and Tukey's Honest Significance Test. Result: SB demonstrated effective reduction of CEA levels at higher doses, and TNF-α levels at medium doses. Both moderate and high doses exhibited a noteworthy, dosedependent decrease in IL-6 levels. Furthermore, SB led to a dose-dependent reduction in the AST/ALT ratio. A significant reduction in tumour volume were reported in both the moderate and high doses of SB along with marked improvement in anorexia. The higher doses of SB exhibited the serum validated results in the hepatic, renal and the splenic tissues. Conclusion: The anti-carcinogenic activity of SB appeared to be dose-dependent. The finding also underscored the hepato-protective capability of SB in lower dose by alleviating cancer-related liver damage © 2025 The Authors
The Potential Impact of Ayurvedic Traditional Bhasma on SARS-CoV-2-Induced Pathogenesis
(Bentham Science Publishers, 2023) Pankaj Kumar; Remya Jayakumar; Manoj Kumar Dash; Namrata Joshi
The mass casualties caused by the delta variant and the wave of the newer “Omicron” variant of SARS-COV-2 in India have brought about great concern among healthcare officials. The government and healthcare agencies are seeking effective strategies to counter the pandemic. The application of nanotechnology and repurposing of drugs are reported as promising approaches in the management of COVID-19 disease. It has also immensely boomed the search for productive, re-liable, cost-effective, and bio-assimilable alternative solutions. Since ancient times, the traditional-ly employed Ayurvedic bhasmas have been used for diverse infectious diseases, which are now employed as nanomedicine that could be applied for managing COVID-19-related health anomalies. Like currently engineered metal nanoparticles (NPs), the bhasma nanoparticles (BNPs) are also packed with unique physicochemical properties, including multi-elemental nanocrystalline compo-sition, size, shape, dissolution, surface charge, hydrophobicity, and multi-pathway regulatory as well as modulatory effects. Because of these conformational and configurational-based physico-chemical advantages, Bhasma NPs may have promising potential to manage the COVID-19 pandemic and reduce the incidence of pneumonia-like common lung infections in children as well as age-related inflammatory diseases via immunomodulatory, anti-inflammatory, antiviral, and adju-vant-related properties. © 2023 Bentham Science Publishers.
Transmission modes of COVID-19 disease pandemic in the light of ancient wisdom of Ayurveda medicine: a review
(De Gruyter Open Ltd, 2022) Namrata Joshi; Manoj Kumar Dash; Remya Jayakumar
Human-to-human transmission of the Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) occurs most often when people are in the incubation stage of the disease or are carriers and have no symptoms. SARS-CoV-2 transmission on different levels showed that the cold and dry climate, hot wind and relative humid wind, maximum wind speed, turbulent wind, intensified recirculating flow were causing transmission higher than factors. The role of environmental factors described in Ayurveda like air, water, soil, season, frequent earthquakes, sunlight exposure, frequent thunderstorm with lightening, and factors from arthropods were revalidated in perspective of COVID-19 transmission. The authors searched the information regarding epidemic diseases in Ayurveda textbooks. Pubmed, Science Direct, Wikipedia, Elsevier, Lancet, and Springer were approached for the latest knowledge relating to SARS-CoV-2 and COVID-19. Google Scholar search engine was thoroughly checked upon for scientific evidence regarding the Ayurveda drugs. Various environmental factors like soil, air, water, frequent earthquake disasters, wildlife animals, aquatic birds, space, inevitable disastrous factors, weather or seasonal hazards, violent thunderstorm with lightning, intermediate hosts, sunlight exposure etc. were considered for their role in the genesis of the disease. The Ayurvedic concepts behind the etiology and development of epidemics are the same as modern epidemiological theories. The mysteries of many aspects of the current pandemic might be deciphered by traditional medicine knowledge and thus adding upon to the integrative medicine concept. © 2021 Walter de Gruyter GmbH, Berlin/Boston.