Browsing by Author "Ruchi Sinha"

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Abdominal scar endometriosis after caesarean section: A rare entity
(Australasian Medical Journal Pty Ltd, 2011) Ruchi Sinha; Mohan Kumar; Manjari Matah
Scar endometriosis is an uncommon entity. It is often misdiagnosed leading to unnecessary referrals. Gynaecologists and general surgeons must be aware of this entity to avoid discomfort to the patient due to delay in diagnosis. We are presenting a case of scar endometriosis which was misdiagnosed initially. Detailed history of cyclic pain and swelling was the key point for the final diagnosis of scar endometriosis. Medical therapy was ineffective. Surgical excision of mass was the treatment for endometriotic lesion. This article is an attempt to create awareness of this condition among gynaecologists and general surgeons.
Altered crosstalk of estradiol and progesterone with Myeloid-derived suppressor cells and Th1/Th2 cytokines in early miscarriage is associated with early breakdown of maternal-fetal tolerance
(Blackwell Publishing Ltd, 2019) Priyanka Verma; Rachna Verma; Rohini R. Nair; Snehil Budhwar; Anuradha Khanna; Nisha Rani Agrawal; Ruchi Sinha; Ruchi Birendra; Singh Rajender; Kiran Singh
Problem: Decline in myeloid-derived suppressor cells (MDSCs) and Th2 cytokines levels lead to early miscarriage (EM) but how the hormonal milieu of the body regulates MDSCs and Th1/Th2 cytokine balance is still a matter of investigation. Method of study: Peripheral blood and decidua samples were collected from 20 EM patients, and 20 healthy pregnant women opted for elective abortion. MDSCs and G-MDSCs levels were analyzed in peripheral blood mononuclear cells, and Th1/Th2 cytokines levels were determined in serum via flow cytometry. Estrogen (E2), Progesterone (P4), and Testosterone levels were measured via ELISA. Further, proliferation and apoptosis in decidual samples were checked via immunoblot/immunohistochemistry of estrogen receptor -α (ER-α), STAT-3/pSTAT-3, and caspase-3, respectively. Results: Our results clearly indicate that in EM patients; decline in E2 and P4 significantly correlates with decline in MDSCs, particularly with subtype granulocytic MDSCs (G-MDSCs) and skewness of the Th1/Th2 cytokines balance toward Th1 response. Downregulation of ER- α and increased caspase-3 expression in endometrium decidua signifies poor endometrial receptivity in EM. STAT-3 activation regulates proliferation, differentiation and suppressive potency of MDSCs. In decidua of EM, significantly lower expression of pSTAT-3 indicates that these processes pertaining to MDSCs are compromised. Conclusion: Altogether, this unfavorable systemic milieu may drive toward early breakdown of maternal-fetal tolerance in EM. Therefore, regulated crosstalk of E2, P4 with MDSCs and balanced Th1/Th2 cytokines is prerequisite for successful pregnancy. © 2019 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd
Feotus papyraceous in a monoamniotic monochorionic pregnancy: A case report
(2010) Ruchi Sinha; Sonali Gupta; Shikha Sachan; Anuradha Khanna
Foetus papyraceous or compress is the compressed, mummified, parchment-like remains of a dead twin which is retained in-utero after intrauterine death in the second trimester. It is an uncommon finding. The incidence of foetus papyraceous is reported as 1 in 17,000 to 1 in 20,000 pregnancies. Incidence of foetus papyraceous in twin pregnancy is 1 in 184 to 1 in 200 pregnancies. A case of foetus papyraceous which was discovered following expulsion of a Twin at 17 weeks and 1 day of gestation with low lying placenta in a monochorionic monoamniotic twin pregnancy is reported here.
Successful outcome in preeclamptic rudimentary horn pregnancy; [Preeklamptik rudimenter boynuz gebeliǧinde başarılı sonuç]
(AVES, 2011) Ruchi Sinha; Shikha Sachan; Anuradha Khanna
Unicornuate uterus with rudimentary horn is an uncommon type of mullerian duct malformation associated with various gynecological and obstetrical complications. Rudimentary horn pregnancy is a rare entity and the majority have rupture of gravid horn leading to maternal and fetal morbidity and mortality. A case of rudimentary horn pregnancy at 32 weeks and 6days with pregnancy induced hypertension is reported where proper management results in successful pregnancy outcome.