Browsing by Author "S. Devi"

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A cyclopeptide alkaloid from the bark of Zizyphus rugosa
(1988) V.B. Pandey; Y.C. Tripathi; S. Devi; J.-P. Singh; A.H. Shah
Rugosanine-A has been isolated from the stem bark of Zizyphus rugosa. The structure was deduced by spectroscopic methods and chemical degradation. © 1988.
Biologically active cyclopeptide alkaloids from Rhamnaceae plants
(1990) V.B. Pandey; S. Devi
[No abstract available]
Changes in placenta of rat fetuses induced by maternal administration of papain
(1978) S. Devi; S. Singh
[No abstract available]
Content of betulin and betulinic acid, antitumor agents of Zizyphus species
(1989) S.K. Maurya; S. Devi; V.B. Pandey; R.I. Khosa
[No abstract available]
Cyclopeptide alkaloids from zizyphus xylopyra
(1986) V.B. Pandey; S. Devi; J.P. Singh; A.H. Shah
In our continuing search (1–7) for cyclopeptide alkaloids from Ziziyphus species, we report here the isolation and characterization of the cyclopeptide alkaloids mauritine-D and nummularine-B from the bark of Zizyphus xylopyra Willd. These alkaloids have not previously been reported from this source. © 1986, American Chemical Society. All rights reserved.
Effect of maternal administration of papain on rat foetal liver and kidney
(1980) S. Singh; S. Devi
Livers and kidneys obtained from 20 day-old rat fetuses whose mothers were given crude papain orally or ip in single or repeated doses during gestation days 8-17 (sperm+=day 0) were examined and processed for histological study. Gross examination of the livers showed dark patchy areas with haemorrhages which were confirmed histologically. The cytoarchitecture of the liver was lost. The degenerating liver cords revealed loss of basophilia and poor PAS stained material. The sinusoids were dilated showing empty spaces. Besides focal hemorrhages, central veins were dilated, congested and showed rupture of endothelial lining. The kidneys were markedly enlarged in the treated cases and showed subcapsular and deeper hemorrhages. Glomeruli were atrophic and shrunken. The tubules showed marked degeneration with dilated empty spaces.
Effect of papain on foetal chondrogenesis. Result of maternal administration of the enzyme in rats
(1980) S. Singh; S. Devi
[No abstract available]
Maternal administration of papain and its effect on the brain of rat foetuses
(1979) S. Devi; S. Singh
Crude papain was administered to pregnant rats during 8th-17th day of gestation, orally and intraperitoneally, in single or repeated doses, and fetuses were collected on the 20th day. The brain of rat fetuses showed frequent haemorrhages on their external surface. The subdural vessels were unduly dilated resulting in stasis. Increased capillary permeability of the vessels led to the extravasation of plasma and erythrocytes. The cytoarchitecture of the cortex was altered. Strips of focal coagulative necrosis extended through most of the layers of the cortex or were confined to circumscribed areas in the cortex. The neurons and neurological elements appeared to be reduced in number and were distorted. Many of these had pyknotic nuclei. The intercellular spaces were greatly increased indicating edema.
Maternal administration of papain and its influence on peritoneal mast cells
(1979) S. Devi; S. Singh
[No abstract available]
Peptide alkaloids from Zizyphus species
(1987) S. Devi; V.B. Pandey; J.P. Singh; A.H. Shah
The isolation of cyclopeptide alkaloids, frangufoline from Zizyphus jujuba and Z. nummularia, amphibine-H and nummularine-K from Z. xylopyra and nummularine-R, a new 13-membered cyclopeptide alkaloid, from Z. nummularia is reported. The structure of the new alkaloid was elucidated by spectroscopic methods and by chemical degradation. © 1987.
Sativanine-k: An additional N-formyl cyclopeptide alkaloid from Zizyphus sativa
(1987) A.H. Shah; M.A. Al-Yahya; S. Devi; V.B. Pandey
From the bark of Zizyphus sativa a 13-membered N-formyl cyclopeptide alkaloid containing a short side chain has been isolated for the first time. The structure was determined by spectroscopic methods and chemical degradation. © 1987.
Teratogenic and embryotoxic effect of papain in rat
(1978) S. Singh; S. Devi
Crude papain, a proteolytic enzyme, was administered to 100 pregnant rats during 8th-17th day of gestation, orally and intraperitoneally (i.p.) in single or repeated doses and foetuses were collected on the 20th day. Foetal mortality was more marked with i.p. injections than with oral administration and in each case repeated doses were more lethal than single ones. The teratogenic effect was more severe with i.p. administration though there was no significant difference in the incidence of induced defects in the two groups. Repeated oral doses were more teratogenic than single dose. Besides stunted growth observed in most of the foetuses surviving up to the 20th gestation day, subcutaneous haemorrhages and haematomas were seen on various parts of the body. Haemorrhages were also observed on the surface of viscera like liver, kidney and brain and were confirmed histologically. Visceral haemorrhages were twice more common than subcutaneous haemorrhages. Oedema of the body was observed in 8 per cent to 15 per cent of foetuses. Some of the viscera, like brain and kidney were also found oedematous. It appeared that the enzyme could induce teratogenesis through a systemic effect.