Browsing by Author "S. Mohanty"

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A large cirsoid aneurysm of the scalp associated with epilepsy
(BMJ Publishing Group, 1976) S. Mohanty; C.J. Rao
A large cirsoid aneurysm of the scalp that was present since birth in a 1 year old baby For six months the patient had been suffering from generalized seizures and mental After excision of the aneurysm, the patient became seizure free.
Accumulation of serotonin in human cerebral contusion
(1978) S. Mohanty; P.K. Dey; P.C. Sen; A. Ray
Brain tissue from ten patients with gross evidence of brain contusion and edema following trauma was examined for serotonin content by histofluorescent examination. There was evidence of an accumulation of serotonin and its diffusion towards the surrounding tissues in contusions.
An outbreak of infection in neurosurgery ward
(1980) L. Das; S. Mohanty; S.C. Sanyal; K.C. Mukherjee
[No abstract available]
Antibodies to dynorphin A (1-17) attenuate closed head injury induced blood-brain barrier disruption, brain edema formation and brain pathology in the rat
(Springer-Verlag Wien, 2009) H.S. Sharma; R. Patnaik; S. Patnaik; A. Sharma; S. Mohanty; P. Vannemreddy
The potential neuroprotective efficacy of dynorphin A antiserum on BBB dysfunction, edema formation and brain pathology was examined in a closed head injury (CHI) model in the rat. The CHI was produced by an impact of 0.224 N on the right parietal bone under anesthesia by dropping a weight of 114.6 g on the skull from a height of 20 cm through a guide tube. This concussive brain injury resulted in profound BBB disruption as evidenced by leakage of Evans blue and radioiodine in the brain. Edema formation and swelling at 5 h were most pronounced in the contralateral cerebral hemisphere. Pretreatment with dynorphin A antiserum (1:20, monoclonal) infused into the left lateral cerebral ventricle (30 μL in PBS) either 30 min before or 30 min after CHI significantly attenuated BBB dysfunction, brain edema formation, volume swelling and brain pathology. However, no reduction in brain edema, BBB permeability or improved brain pathology was seen when the antiserum was given 60 min post-CHI. These observations are the first to suggest that antiserum to dynorphin when administered into the CSF during early phase of CHI is neuroprotective. Our work further indicates that dynorphin is actively involved in the cellular and molecular mechanisms of edema formation and BBB breakdown in CHI. © 2009 Springer-Verlag Vienna.
Antibodies to serotonin attenuate closed head injury induced blood-brain barrier disruption and brain pathology
(Blackwell Publishing Inc., 2007) H.S. Sharma; R. Patnaik; S. Patnaik; S. Mohanty; A. Sharma; P. Vannemreddy
Closed head injury (CHI) often results in profound brain swelling and instant death of the victims due to compression of the vital centers. However, the neurochemical basis of edema formation in CHI is still obscure. Previous studies from our laboratory show that blockade of serotonin synthesis prior to CHI in a rat model attenuates brain edema, indicating a prominent role for serotonin in head injury. Thus, neutralization of endogenous serotonin activity and/or blocking of its receptors will induce neuroprotection in CHI. Since serotonin has more than 14 receptors and selective serotonin antagonists are still not available, we used serotonin antiserum to neutralize its in vivo effects before or after CHI in a rat model. CHI was produced by an impact of 0.224 N on the right parietal skull bone under Equithesin anesthesia by dropping a weight of 114.6 g from a height of 20 cm through a guide tube. This concussive brain injury resulted in blood-brain barrier (BBB) disruption, brain edema formation, and volume swelling at 5 h that were most pronounced in the contralateral cerebral hemisphere. The plasma and brain serotonin levels were increased several-fold at this time. Intracerebroventricular administration of serotonin antiserum (1:20, monoclonal) into the left lateral cerebral ventricle (30 μL in PBS) 30 min before or 30 min (but not 60 min) after CHI significantly attenuated BBB disruption, brain edema formation, volume swelling, and brain pathology. The plasma and brain serotonin levels continued to remain high. These observations are the first to suggest that antiserum to serotonin when administered into the CSF during the early phase of CHI are capable of inducing neuroprotection. © 2007 New York Academy of Sciences.
Atlanto-axial dislocation associated with suboccipital cold abscess
(1978) S. Mohanty; S.V. Sharma; T.P. Shrivastav
A case of atlanto-axial dislocation with quadriparesis, diagnosed preoperatively as cranio-vertebral anomaly, was found to have a tubercular cold abscess in the suboccipital region. Literature on cranio-vertebral tuberculosis reveals such presentation to be unusual.
Buprenorphine-soake absorbable gelatin sponge: An alternative method for postlaminectomy pain relief
(2004) L.D. Mishra; S.S. Nath; R.L. Gairola; R.K. Verma; S. Mohanty
There have been several reports of instillation of buprenorphine in the intact epidural space in an attempt to control postoperative pain, but none in which an absorbable gelatin sponge soaked with buprenorphine is placed directly in the epidural space. In the present study, carried out on 30 patients (study group) undergoing noncervical laminectomies, 0.3 mg buprenorphine diluted to 5 mL with normal saline soaked into an absorbable gelatin sponge was placed in the epidural space under direct vision. In 30 other patients (control group) undergoing laminectomies, absorbable gelatin sponge soaked with 5 mL normal saline was placed in the epidural space. Pulse rate, mean arterial pressure, respiratory rate, pain score by visual analog scale, duration of analgesia, and adverse effects, if any, were noted preoperatively and postoperatively at 1, 2, 3, 4, 5, 6, 12, 18, and 24 hours. The presence of any neurologic symptoms was also assessed at these time intervals as well as on the seventh postoperative day. The authors observed that changes in pulse rate, mean arterial pressure, and respiratory rate were not statistically significant between the control and the study groups. The pain relief score, duration of pain relief (14.8 = 0.77 hours in the study group vs. 0.66 ± 0.15 hours in the control group), and sedation were significantly better in the study group. No patient demonstrated any respiratory depression (respiratory rate <12/min), bradycardia, pruritus, or neurologic pressure symptoms, although the incidence of nausea was higher in the study group.
Calvarial plasmacytoma. A case report
(1988) S. Mohanty; S.K. Gupta; P.K. Shukla; S.K. Gupta
[No abstract available]
Cell growth rate of human brain tumors in vitro
(1980) J. Chaurasiya; S. Mohanty; G.C. Prasad
[No abstract available]
Cerebral oedema and blood-brain and blood-CSF barriers in experimental brain trauma: Effect of indomethacin - a prostaglandin synthetase inhibitor
(1980) S. Mohanty; A.K. Ray; P.K. Dey
[No abstract available]
Combined treatment modalities for intracranial tumours
(1978) B. Sanyal; G.C. Pant; K. Subrahmaniyam; K. Sahni; M.S. Agarwal; S. Mohanty; C.J. Rao; P.K. Shukla
[No abstract available]
Compression head injuries caused by cane crushers
(1981) S. Mohanty
40 cases of head injuries from sugar cane crushing machines are reported. The peculiar features and specific complications of this type of head injury are described. The line of management of these injuries is discussed.
Congenital dermoid cyst over the anterior fontanelle
(1981) S. Mohanty; C.J. Rao
[No abstract available]
Contre-coup extradural haematoma: A short report
(2001) A. Mishra; S. Mohanty
An extradural haematoma contralateral to impact site is reported. Review of literature reveals that such phenomenon is extremely rare.
Current status of treatment of intracranial gliomas
(1977) S. Mohanty; C.J. Rao
[No abstract available]
Double extradural hematoma: An analysis of 46 cases
(2004) M.F. Huda; S. Mohanty; V. Sharma; Yogesh Tiwari; A. Choudhary; V.P. Singh
Aims: The authors analyze epidemiology, location, clinical profile and outcome of double extradural hematoma (EDH) or EDH at more than one site. Design: A retrospective clinical study. Materials and Methods: 46 cases of double EDH were studied. All the cases were evaluated for their mode of injury, clinical presentation, level of sensorium at the time of injury, CT scan finding and outcome after surgery, and were compared with single EDH cases. Results: Out of 1025 cases 46 cases had 'double' EDH. There was bilateral EDH in 39 cases; multiple EDH in 3 cases and ipsilateral double EDH was present in 4 cases. The most common site was frontal (70%). The majority of the patients (80.3%) were in altered sensorium from the time of injury, similar situation was seen in 52.2% of cases with single EDH. The number of patients having a low GCS score was higher when first examined in the double EDH group and the mortality rate was 34.8% as compared to 9% in the single EDH group. Conclusion: Majority of the double EDH cases presented with a low GCS and there was a relatively quick neurological deterioration in these cases.
Effect of directional selection on spontaneous male recombination in Drosophila ananassae.
(1992) S. Mohanty; B.N. Singh
Artificial selection was carried out for high and low spontaneous male recombination values in D. ananassae for nine generations by using cu b se marker (second chromosome) and wild stocks which were free from heterozygous chromosome inversions. The mean crossing-over frequency of nine generations was 2.22, 0.70 and 1.20% in high, low and control lines respectively. The values of regression coefficient and realized heritability also indicated that male recombination was affected by selection. However, response to selection was more pronounced in high line as compared to low line. This provides evidence that spontaneous male crossing-over in D. ananassae is under polygenic control.
Effects of lesion variables and emotion type on the perception of facial emotion
(1999) Manas K. Mandal; Joan C. Borod; Hari S. Asthana; Aprajita Mohanty; S. Mohanty; Elissa Koff
The purpose of this study was to consider the effects of valence, motoric direction (i.e., approach/withdrawal), and arousal on the perception of facial emotion in patients with unilateral cortical lesions. We also examined the influence of lesion side, site, and size on emotional perception. Subjects were 30 right-hemisphere-damaged (RHD) and 30 left- hemisphere-damaged (LHD) male patients with focal lesions restricted primarily to the frontal, temporal, or parietal lobe. Patient groups were comparable on demographic and clinical neurological variables. Subjects were tested for their ability to match photographs of four facial emotional expressions: happiness, sadness, fear, and anger. Overall, RHD patients were significantly more impaired than LHD patients in perceiving facial emotion. Lesion side, but not site, was associated with motoric direction and valence dimensions. RHD patients had specific deficits relative to LHD patients in processing negative and withdrawal emotions; there were no group differences for positive/approach emotions. Lesion size was not significantly correlated with accuracy of emotional perception.
Emotion-specific processing deficit in focal brain-damaged patients
(Taylor and Francis Ltd., 1996) Manas K. Mandal; Aprajita Mohanty; Rakesh Pandey; S. Mohanty
Focal brain-damaged patients (left hemisphere damage, right hemisphere damage) and hospitalized general medical patients were asked to sort test photographs into target expressions of four facial emotions, happy, sad, fear and anger. In a second task, patients were asked to match neutral photographs with these target emotion expressions in a forced-choice format. Patients were also asked to rate their mood state on a two-dimensional affect grid. Right hemisphere-damaged patients were significantly inaccurate in matching the test-target expressions of facial emotions in comparison to left hemisphere-damaged or general medical patients. Analysis of error scores indicated a bias toward negative emotions by left hemisphere-damaged patients. Congruent to their mood state, left hemisphere-damaged patients also attributed "sadness" on neutral state of expression significantly more often than right hemisphere-damaged patients.
Familial gliomas : A case report
(1999) A.R. Bhatt; S. Mohanty; V. Sharma; P.K. Shukla
Two non-twin brothers were found to have intracranial malignant neoplasms. The age of presentation was third and fourth decade but the onset was simultaneous, at the same time. Diagnosis in each of them was made by computed tomography and confirmed by histopathology. Elder among them had cellular ependymoma and the younger had oligodendroglioma. Both the brothers received radiotherapy post operatively and were surviving asymptomatically without any neurological deficit, leading active life as police constable, 12 months after surgical treatment.