Browsing by Author "S. Sandhiya"

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In vitro antioxidant and antimicrobial potential of Bambusa arundinacea (Retz.) Willd
(2013) S. Sandhiya; N. Subhasree; Shivapriya Shivakumar; Aruna Agrawal; G.P. Dubey
Objective: Aim of our study is to evaluate the total antioxidant capacity and antibacterial activity of leaf extracts of Bambusa arundinacea (Retz.) Willd. Methods: Bambusa arundinacea leaves were collected, powdered and extracted with hexane, ethyl acetate, ethanol and hydroalcohol (70% ethanol) separately. The extracts were screened for their antibacterial activity by agar well diffusion method and antioxidant activity by hydroxyl radical scavenging activity, ferric thiocyanate method and DPPH assay. Results: Antioxidant potential of hydroalcohol extract tested by DPPH free radical scavenging assay has showed a maximum of 51.41% of percentage inhibition at 100 μg/ml concentration. Conclusion: The results revealed significant activity for hydroalcohol and ethanol extracts. This supports the folkloric usage of the plant and suggests it possess compounds with antibacterial properties that can be used as antimicrobial agents in new drugs for the therapy of infectious diseases.
In vitro assessment of antibacterial and antioxidant activities of fruit rind extracts of Garcinia cambogia. L
(2013) Shivapriya Shivakumar; S. Sandhiya; N. Subhasree; Aruna Agrawal; G.P. Dubey
Background: Garcinia cambogia is a native species of Asia and Indonesia and it is widely distributed in the subtropical region. The plant is well known for its weight reducing property especially in controlling obesity. In the present we have studied the antioxidant and antibacterial activity of G. cambogia. Materials and method: Fruit rind was dried and extracted in four different solvents (hexane, ethyl acetate, ethanol and hydro-alcoholic extracts). Each extract was individually screened for its activity against different human bacterial pathogens by agar well diffusion method. The in vitro antioxidant assay of the four different extracts of G. cambogia was also evaluated and compared to check the extract showing highest activity. Results: The ethyl acetate extract of G. cambogia exhibited better antibacterial activity where as hexane extract showed on activity against any of the test pathogens. Antioxidant assay conclude that the hydro-alcoholic extract of G. cambogia possesses the highest antioxidant activity followed by ethanol, and with hexane having no or least activity. Conclusion: The results indicate that the fruit rind extract of the plant has an excellent antibacterial activity and antioxidant property.
Unveiling the Lipid Paradox in Oral Leukoplakia: Metabolic Signatures of Dysplasia and Disease Progression
(Springer, 2025) Akhilesh Chandra; R. Keerthika; Rahul Agrawal; Anju Gautam; Richik Tripathi; S. Sandhiya
Oral Leukoplakia (OLK) is the most prevalent oral potentially malignant disorder with an increased risk of malignant transformation. Altered lipid metabolism, often driven by tobacco-induced oxidative stress, may contribute to oral carcinogenesis. However, the relationship between serum lipid profiles and OLK remains ambiguous. This study aimed to evaluate lipid profiles across OLK subtypes and their association with dysplasia and tobacco use to their assess diagnostic and prognostic potential. This cross-sectional prospective study included 114 participants, 57 clinically and histologically confirmed OLK cases and 57 healthy controls. OLK cases were categorized into homogeneous OLK, erythroleukoplakia, verrucous OLK, and OLK with oral submucous fibrosis (OSMF) and their dysplastic status was also evaluated. Serum lipid parameters (TC, TG, HDL, LDL, VLDL) were measured. Statistical comparisons were performed using Mann–Whitney U and Kruskal–Wallis tests (p < 0.05). Although OLK patients showed higher mean lipid levels than controls, the differences were not statistically significant (p > 0.05). Among OLK subtypes, significantly elevated levels of TC, TG, LDL, and VLDL were found in homogeneous OLK, while the lowest levels were observed in erythroleukoplakia (p < 0.00). Lipid levels were significantly lower in dysplastic lesions (p < 0.001). Patients with tobacco use > 5 years had higher TC and LDL levels (p < 0.05), whereas habit frequency showed no significant association. Serum lipid alterations, particularly reduced TC, TG, LDL, and VLDL in dysplastic and high-risk OLK variants, may serve as non-invasive prognostic biomarkers for early risk assessment. © Association of Otolaryngologists of India 2025.