Browsing by Author "S.C. Goel"

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A Probable Explanation for Mild Extra-articular Manifestations in Indian Patients of Rheumatoid Arthritis: A Preliminary Study
(1998) Vibha Agrawal; Usha; S.C. Goel; Ratah Mala Gupta
One hundred four Rheumatoid factor (RF) positive Rheumatoid Arthritis (RA) patients fulfilling ARA criteria were screened for extraarticular manifestations. Rheumatoid nodules were present in 2.8% cases. Other extraarticular manifestations such as pulmonary, cardiac, occular, renal or GI involvement were absent in these cases. However, circulating immune complexes (CICs) were highly significantly raised in all the RA patients (P<0.001). From amongst these cases a limited number (8 cases) have been subjected to qualitative and quantitative analysis of CICs to look for whether there could be any relationship between these and mild extraarticular manifestations that were being noticed in our groups of patients. Finding showed IgG-IgG CICs in. five, IgG-IgM in two and IgG-IgA in one case. Quantitative analysis revealed mean IgG 4.97±1.7 IU/ml, IgM 14.58±5.53 IU/ml and IgA 5.08±1.53 IU/ml on LD Solugen plates. Serum concentration of C3 was not reduced (94.1±8.9 mg/dl). Low IgM contents of CICs and no reduction in complement level is the likely explanation for less severe inflammatory manifestations seen in our study. The conclusion and findings have been discussed in the light of observation reported by the Western, workers.
Allogenic decalbone in glenoplasty for recurrent anterior dislocation of shoulder.
(1995) G.N. Khare; T.P. Singh; S.C. Goel; S.K. Saraf; S.V. Sharma
31 patients of recurrent anterior dislocation of shoulder treated by anterior glenoplasty using allogenic decalbone had good results. It is proposed that generalised congenital or developmental disorder may be an important etiological factor in pathogenesis of recurrence of the dislocation.
Allogenic decalbone in the repair of benign cystic lesions of bone
(Springer-Verlag, 1992) S.C. Goel; S.M. Tuli; H.P. Singh; S.V. Sharma; S.K. Saraf; T.P. Srivastava
Forty-six cases of benign cystic lesions of bone were treated by curettage and compact filling using partially decalcified allogenic bone graft (Decalbone); of these, 35 were available for study. Decalbone was prepared by partial decalcification with 0.6 N hydrochloric acid (HCl) of human bones generally obtained from freshly amputated limbs. The commonest lesions of bone were giant cell tumours (14) and aneurysmal bone cysts (15), and the commonest bones involved were the femur (23) and the tibia (12). There was one failure and four recurrences. Five cases were infected but this did not interfere with healing of the primary lesion. Radiological incorporation of the graft was seen at about 3 months in unicameral bone cysts, at 4-6 months in aneurysmal bone cysts and at 6-9 months in giant cell tumours. There was no recurrence in any case of giant cell tumour, but three aneurysmal bone cysts recurred. There was no clinical immune reaction. © 1992 Springer-Verlag.
Author’s reply
(Springer, 2010) Shivam Sinha; S.C. Goel
[No abstract available]
Author's reply
(2010) Shivam Sinha; S.C. Goel
[No abstract available]
Carbon fibre reinforced epoxy implants for bridging large osteoperiosteal gaps
(1988) R. Prakash; S. Marwah; S.C. Goel; S.M. Tuli
An experimental study was undertaken to evaluate the suitability or otherwise of carbon fibre reinforced epoxy (CFRE) implants for bridging large osteoperiosteal gaps, devoid of periosteum. Using the basic principles of composite mechanics and simple design criteria, CFRE implants were designed and developed. These implants were put in simulated osteoperiosteal gaps in the ulna of healthy mature rabbits. Ten wk postoperative results clearly demonstrated that implants made of CFRE induced callus bone formation (in the form of woven bone) which totally encapsulated the implant thereby providing reunion of the two bone segments. Further follow-up showed formation of lamellar bones and formation in the pores of the implant. Radiological and scanning electron microscopical evidence is presented. © 1988.
Concomitant fracture displacement of proximal and distal radial epiphyses - A case report
(1981) S.C. Goel; T.P. Srivastava
A case of concomitant fracture displacement of proximal and distal radial epiphyses with fracture of shaft of ulna has been reported.
Factors influencing the pain relief obtained with epidural methylprednisolone in low-back pain and sciatica
(1994) V. Rastogi; M. Krishna; S.K. Saraf; S.C. Goel; S.B. Singh
One hundred and twenty-four patients suffering from low-back pain were allocated to two groups: a study group comprised of 104 patients to be treated with epidural Depomedrol (methylprednisolone depot) in saline and a control group of 20 patients who were to be given only saline. Seventy-nine patients (75.3 per cent) in the study group showed good relief of pain in comparison with five patients (25 per cent) in the control group, a statistically significant difference (P ≤ 0.05). Patients with localized pathology responded better (86.5 per cent) than those with generalized pathology (65.4 per cent). Response was also better in patients in whom the pain was of an acute (84.6 per cent) rather than chronic (48 per cent) nature (P ≤ 0.05). The caudal route of medication had an edge over the lumbar epidural one as 87 per cent showed good relief. A higher concentration of drug (8 mg/ml) showed slightly better but statistically insignificant (P ≤ 0.05) relief of pain. Thirty-six (34.6 per cent) patients who were given epidural methylprednisolone showed pain relief lasting for more than 1 year.
Immunodiagnosis in Bone and Joint Tuberculosis
(Evangel Publishing, 2000) S.B. Singh; S.C. Goel
Fifty patients of bone and joint tuberculosis (age 15-70 years) and 30 healthy controls were studied for levels of immunoglobulin G (IsG), immunoglobulin A (IsA), immunoglobulin M (IsM), T cells and circulating immune complexes (CICs) in different stages of disease. Levels of IgG, IgA, IgM, T cells and CICs were significantly raised in fresh and healed tuberculosis patients, compared to control.
Implantation of tricalcium phosphate-polyvinyl alcohol filled carbon fibre reinforced polyester resin composites into bone marrow of rabbits
(Elsevier BV, 2007) V.K. Srivastava; A. Rastogi; S.C. Goel; S.K. Chukowry
Biocompatibility of tricalcium phosphate-polyvinyl alcohol filled unidirectional carbon fibre reinforced epoxy resin composites was investigated in rabbits in present study. The materials were implanted for 4, 8, 12, 16, 20, 24 and 32 weeks into bone defects created (osteoperiosteal gap) in the bone marrow of 20 rabbits. The effects of implantation in the rabbits were evaluated with the help of clinical, radiological and histological methods. Cancellous bone formation was observed around the implanted material after implantation for 12-32 weeks without any adverse reaction. The tricalcium phosphate and polyvinyl alcohol filled carbon fibre reinforced polyester resin show combined advantages of better tensile strength, compressive strength, bending strength and biocompatibility than the carbon fibre reinforced polyester resin composites. No morphological abnormality was observed around tissue of the implant. Where as carbon fibre shows high modulus and strength of implanted material without any adverse effects because carbon fibre fully covered through out the length with the layer of tricalcium phosphate and polyvinyl alcohol; thus, these materials may prove to be useful for novel applications in the biomedical field. © 2006 Elsevier B.V. All rights reserved.
Incorporation and biodegradation of hydroxyapatite-tricalcium phosphate implanted in large metaphyseal defects-an animal study
(2008) P. Sunil; S.C. Goel; A. Rastogi; N.C. Aryya
Incorporation and biodegradation of hydroxyapatite(HA)-tricalcium phosphate(TCP) granules implanted in 5 × 5 × 5 mm distal femoral metaphyseal defects created in 18 adult rabbits were studied. In two rabbits, the defects were left to heal spontaneously without any implant. Roentgenographic and histological study by light microscopy was done on silver nitrate stained undecalcified sections as well as haematoxylin-eosin stained decalcified sections. The synthetic HA-TCP was biocompatible and produced no adverse reactions. The implant was osteoconductive and allowed good new bone formation to occur, mainly from periphery to center, but mature trabeculae could be delineated only at 4-6 months. The HA-TCP biomaterial had very low biodegradability with marked amount of intact implant still present at final follow up. Bonding between implant and bone, though a close biological bond, was not uniformly strong. Rate of bone ingrowth was very slow and large areas of implant at center did not show new bone formation at 12 months.
Isolated fractures of the ulnar shaft
(1991) S.C. Goel; K.B. Raj; T.P. Srivastava
In a prospective study from January 1985 to December 1987, 60 consecutive patients with isolated fractures of the shaft of the ulna were divided into two groups. In group I, 28 patients were treated with plaster-of-Paris cast splintage, while in group II, 32 patients were given an elastic crêpe bandage support and were mobilized early. Average time to union in group I was 10.8 weeks while in group II it was 7.8 weeks. Two fractures in group I did not unite, whereas there was no case of non-union in group II. Isolated fractures of the ulna can be treated successfully with minimal support and early mobilization. © 1991.
Management of sequelae of septic arthritis of hip in infancy
(2003) S.C. Goel; Vivek Logani
[No abstract available]
Myositis ossificans progressiva. A case report
(1991) S.C. Goel; H.P. Singh
[No abstract available]
The bridging of large osteoperiosteal gaps using 'Decalbone'
(Springer-Verlag, 1988) S.M. Tuli; T.P. Srivastava; S.V. Sharma; S.C. Goel; D. Gupta; S. Khanna
'Decalbone' was prepared by partial decalcification of human bones obtained from recently amputated specimens. It was then stored in 80 to 90% ethanol in a domestic refrigerator. The decalbone was used to fill large osteoperiosteal gaps in 25 patients. The commonest lesion was a giant cell tumour (21 cases) and various long bones were affected. There were 6 failures with recurrence of the tumour in 3 and uncontrolled infection in 3. The remaining 19 cases were followed up for from 2 1/2 to 7 years. In 10 the decalbone incorporated well, but further reconstructive procedures were needed in 9. Our studies showed that incorporation began at around 6 to 9 months and was complete at about 2 years in the upper limb and 4 years in the lower limb. There was no clinical evidence of an immune response. © 1988 Springer-Verlag.
The role of stem cells in osteoarthritis: An experimental study in rabbits
(British Editorial Society of Bone and Joint Surgery, 2014) A. Singh; S.C. Goel; K.K. Gupta; M. Kumar; G.R. Arun; H. Patil; V. Kumaraswamy; S. Jha
Introduction: Osteoarthritis (OA) is a progressively debilitating disease that affects mostly cartilage, with associated changes in the bone. The increasing incidence of OA and an ageing population, coupled with insufficient therapeutic choices, has led to focus on the potential of stem cells as a novel strategy for cartilage repair. Methods: In this study, we used scaffold-free mesenchymal stem cells (MSCs) obtained from bone marrow in an experimental animal model of OA by direct intra-articular injection. MSCs were isolated from 2.8 kg white New Zealand rabbits. There were ten in the study group and ten in the control group. OA was induced by unilateral transection of the anterior cruciate ligament of the knee joint. At 12 weeks post-operatively, a single dose of 1 million cells suspended in 1 ml of medium was delivered to the injured knee by direct intra-articular injection. The control group received 1 ml of medium without cells. The knees were examined at 16 and 20 weeks following surgery. Repair was investigated radiologically, grossly and histologically using haematoxylin and eosin, Safranin-O and toluidine blue staining. Results: Radiological assessment confirmed development of OA changes after 12 weeks. Rabbits receiving MSCs showed a lower degree of cartilage degeneration, osteophyte formation, and subchondral sclerosis than the control group at 20 weeks post-operatively. The quality of cartilage was significantly better in the cell-treated group compared with the control group after 20 weeks. Conclusions: Bone marrow-derived MSCs could be promising cell sources for the treatment of OA. Neither stem cell culture nor scaffolds are absolutely necessary for a favourable outcome. ©2014 The British Editorial Society of Bone & Joint Surgery.