Browsing by Author "S.D. Shukla"

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Anti-platelet activating factor property of Rubia cordifolia Linn.
(1993) Y.B. Tripathi; S. Pandey; S.D. Shukla
Rubia cordifolia is clinically used for the purification of blood by the physicians of the Indian System of Medicine. For the first time, the effect of the partially purified fraction of this whole plant has been studied on rabbit platelets. It inhibits the platelet aggregation induced by PAF (platelet activating factor) but not thrombin. It also inhibits the binding of 3H-PAF to the platelets in the dose-dependent manner. Thus it appears that R. cordifolia inhibits action of PAF at its receptor level either by it's blocking or by desensitization.
Intensification of the metabolic acidosis induced under alpha-chloralose anaesthesia with graded increase in the dose
(1983) Rajni Shukla; S.D. Shukla
Surgical anaesthesia between planes 2-3 with alpha-chloralose in dogs induced simultaneous depression of ventilation viz., low oxygen (PaO2) tension, high carbon dioxide (PaCO2) tension and H+ion homeostasis (high base deficit). The anaesthesia on the aforesaid planes could be achieved only by doses not below 100 mg/kg. The progressive increase in the administered dose between 100 and 200 mg/kg did not alter the acid-base profile. Further increase beyond 200 mg/kg dose was followed by a steep increase in the base deficit enhancing H+ion (cH+) concentration. However, the steep fall in PaO2 accompanied by steep rise in PaCO2 was observed only when the dose was above 250 mg/kg. The findings in the present study indicated that depression of H+ion homeostasis under chloralose anaesthesia was induced by neural mechanism independent of respiratory centres. © 1983 The Italian Pharmacological Society.