Browsing by Author "S.K. Bhartiya"

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Adrenal tumors: An experience of 10 years in a single surgical unit
(Medknow Publications, 2015) S. Khanna; R. Priya; S.K. Bhartiya; S. Basu; V.K. Shukla
INTRODUCTION: Most of the adrenal masses are discovered incidentally by imaging techniques for reasons unrelated to adrenal diseases. Treatment is based on various factors such as, nature of adrenal mass, age of presentation, size of tumor, and the functional status of tumor. We report a series of 14 consecutive cases of adrenal tumors treated in a single surgical unit in our hospital. AIM: The aim of this study was to evaluate the clinical profile and outcome of treatment of adrenal tumors treated in a surgical unit. MATERIALS and METHODS: It is a retrospective study data of 14 cases of adrenal tumors treated in a single surgical unit in University Hospital over 10 years have been analyzed. Various parameters such as gender, age, size of tumor, functional status, histopathology, type of management, and outcome have been reviewed. Results: A total of 14 patients with adrenal masses were seen over a 10 year period (1997-2006). All were referred cases, either from endocrinology or medicine wards. There were seven female and seven male patients. Mean age of patients was 48.6 years (range 14-60 years). Mean size of tumor was 8.0 cm (5.9 cm for benign tumors and 9.7 cm for malignant tumors). There were six cases of adrenal carcinoma, four cases of adrenal myelolipoma, two cases of pheochromocytoma, and one each case of adrenal hyperplasia and histoplasmosis. There were only two functional tumors. All, except two malignant cases were treated operatively. A total of 5 year survival was 100% in benign cases and 27% in malignant tumors. CONCLUSION: Adrenal tumors need to be assessed for their functional status and malignant potential prior to treatment. Surgical excision is usually curative for benign lesion. Among malignant tumors the benefits of surgery depend on local extent and metastatic status of tumors.
Congenital thyroid hemiagenesis with thyroid nodules—Role of TI-RADS to prevent long term thyroid replacement therapy
(Elsevier Ltd, 2016) Ashish Verma; S.K. Bhartiya; S.P. Basu; V.K. Shukla; Ram C. Shukla
Background Hemi-agenesis of thyroid is a rare congenital condition with the clinical significance lying only in cases where the remnant tissue is affected by a pathology mandating removal of the gland. Henceforth, the hemi-thyroidectomy technically becomes a total thyroidectomy with a need for long term thyroid replacement therapy. Case summary We present a series of three cases noted over a period of two years where preoperative imaging evaluation confirmed the developmental abnormality. Further presence of a thyroid nodule in each of these cases posed a specific clinical situation whereby characterization of nodule appeared mandatory for a rational management involving life-long thyroid replacement therapy due to an ‘apparent total thyroidectomy’, if the remnant gland is removed. Ultrasound TI-RADS is a new system for evidence based sub-classification of thyroid nodules enabling both the surgeon and patient to take a streamlined decision about the overall approach for management. Conclusion Prospective nodule characterization based on the thyroid image reporting and data system (TI-RADS), enables the surgeon to decide the treatment strategy sparing the patient of the cost and morbidity associated with long term thyroid replacement therapy. © 2016
EPIDEMIOLOGICAL STUDY OF BREAST CANCER PATIENTS AND THEIR ASSOCIATION WITH ABO BLOOD GROUP
(Verduci International, 2020) R. Dixit; S.K. Bhartiya; K.K. Singh; V.K. Shukla
Objective: ABO Blood groups play an important biological role in the immunological system. Studies have reported a strong relationship between ABO and Rhesus (Rh) blood types with various cancers; however, results are contrasting. This study encompasses epidemiology of breast cancer patients in north-eastern Uttar Pradesh region and also investigates the distribution of ABO and Rh blood antigens among breast cancer patients. Patients and Methods: A total of 187 breast cancer patients and 209 controls were enrolled in the study. Blood group, Rh factor, histological type, and different clinicopathological parameters were recorded. The frequencies of the ABO blood group among both the groups were evaluated and compared with different clinical parameters. Results: Frequency of blood group B (40.6%) was comparatively higher in breast cancer patients than other groups (A – 22.5%, AB – 6.4%, O – 30.5%), and the distribution of blood group among cases and controls did not differ significantly. Blood group B (n=53; 69.7%) has been found to be higher in grade II differentiation of breast cancer, but the difference was not significant. Moreover, we did not find any association of blood group with any of the receptor status. Conclusions: Results suggested that blood group B was found to be higher in breast cancer patients, but it did not show any significant role. In addition, we did not find any association between Rh factor and breast cancer. Study findings have shown that breast cancer type, grade, stage, age of menarche (AOM), and hormonal status showed no significant associations with ABO blood group. However, further studies with larger number of patients are needed to clearly establish the role of ABO/Rh blood groups as a prognostic factor in breast cancer patients. © 2020, Verduci International. All rights reserved.
Study of AP endonuclease (APEX1/REF1), a DNA repair enzyme, in gallbladder carcinoma
(2012) V.K. Shukla; P.C. Das; R. Dixit; S.K. Bhartiya; S. Basu; M.J. Raman
Aim: This study investigated the levels of Apurinic/Apyrimidinic Endonuclease (APEX1) in gallbladder carcinoma (CaGB) tissue and co-related these levels with various clinicopathological parameters. Patients and Methods: Twenty cases of CaGB and cholelithiasis were included in the study. Western blot analysis of APEX1 protein was performed using actin as the reference point. Densitometric analysis and the integrated density value (IDV) of APEX1 protein samples were determined. The ratio of IDV of APEX1/actin was determined. Results: The mean IDV ratio of APEX1 in CaGB was 0.63±0.33 and 0.45±0.19 in cholelithiasis. The mean IDV ratio of a variant of APEX1 (ΔAPEX1) in CaGB was 0.50±0.09, whereas it was 0.40±0.16 in cholelithiasis. Calculating the mean IDV ratio of total APEX (APEX1+ΔAPEX1) in CaGB was 1.13±0.31 whereas in cholelithiasis, 0.85±0.23. The differences were statistically significant (p<0.05). Conclusion: A significant correlation was found between the relative expressions of APEX1 in cancer as compared to that in cholelithiasis patients. There was significant association between APEX1 expression and perineural invasion. A variant of APEX1 correlated with tumor infiltration. Hence APEX1 may be of use as a prognostic marker in patients with CaGB.