Browsing by Author "S.S. Chatterjee"

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Antiaggresive activity of standardised extract of Indian Hypericum perforatum L
(2009) G.M. Husain; S.S. Chatterjee; P.N. Singh; Vikas Kumar
The present study was undertaken to evaluate in vivo anti-aggressive potential of standardised extract of Indian Hypericum perforatum (IHp) by using defensive and offensive behavioural models in rodents. Standardised extract of IHp was evaluated for its potential effects against defensive or offensive aggressive behaviour of rodents. IHp extract was orally administered at two dose levels (100 and 200 mg/ kg of body weight) once daily for three consecutive days, lorazepam (2.5 mg/kg, p.o.), was used as standard anti-aggressive agent. Control group animals were given equal volume of vehicle (0.3 % carboxy methyl cellulose). Anti-aggressive activity was evaluated using following validated models of aggression viz. foot shock-induced aggression, isolation-induced aggression, resident-intruder aggression, water competition test and apomorphine induced aggression in rodents. IHp extract has demonstrated dose dependant anti-aggressive activity in the aforementioned validated models of aggression. IHp at both dose levels (100 and 200 mg/kg) have shown promising anti-aggressive activity qualitatively comparable to that of lorazepam.
Hyperforin as a possible antidepressant component of hypericum extracts
(Elsevier Inc., 1998) S.S. Chatterjee; S.K. Bhattacharya; M. Wonnemann; A. Singer; W.E. Müller
We demonstrate that the phloroglucinol derivative hyperforin is not only the major lipophilic chemical constituent of the medicinal plant Hypericum perforatum (St. John's wort) but also a potent uptake inhibitor of serotonin (5-HT), dopamine (DA), noradrenaline (NA), GABA and L-Glutamate with IC50 values of about 0.05-0.10 μg/ml (5-HT, NA, DA, GABA) and about 0.5 μg/ml (L-glutamate) in synaptosomal preparations. Furthermore, potencies of two different hypericum extracts in two conventional pharmacological paradigms useful for the detection of antidepressants (behavioral despair, learned helplessness), closely correlate with their hyperforin contents. In addition, most till now known neuropharmacological properties of the clinically used hypericum extracts can also be demonstrated with pure hyperforin. It appears, therefore, that this non-nitrogenous constituent is a possible major active principle responsible for the observed clinical efficacies of the extract as an antidepressant and that it could also be a starting point for drug discovery projects engaged in the search of psychoactive drugs with novel mode of action.
Note on the polarography of arsenic, antimony and bismuth in lactic acid medium
(Springer-Verlag, 1975) H.S. Mahanti; S.S. Chatterjee; G.S. Deshmukh
[No abstract available]