Browsing by Author "S.S. Pandey"

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A clinico-epidemiological profile of non-healing wounds in an Indian hospital.
(2000) S.K. Saraf; V.K. Shukla; P. Kaur; S.S. Pandey
One hundred patients with non-healing wounds of more than six weeks' duration were studied for clinico-epidemiological factors and their correlation with healing time. The majority of subjects were aged 30-59 years; those aged 50 and over had significantly delayed healing. Most of the subjects were farmers and physical labourers. Leprosy was the most common cause of non-healing wounds, followed by diabetes, trauma and venous ulcers; the lower limbs were the most common site of involvement. Diabetic wounds were more common in those aged 40 years and above. Diabetic wounds were slower to heal than others. The time to healing was calculated from the day subjects received treatment advice at the wound clinic. Seventy-five of the study group were included for calculation of healing time. The others were lost to follow-up or excluded for other reasons.
A rare presentation of keratosis follicularis spinulosa decalvans in female twins
(Wolters Kluwer Medknow Publications, 2018) Rishabh Kumar Chauhan; Saumya Sankhwar; Ruchika Tripathi; S.S. Pandey
[No abstract available]
A trial to determine the role of placental extract in the treatment of chronic non-healing wounds.
(2004) V.K. Shukla; M.A. Rasheed; M. Kumar; S.K. Gupta; S.S. Pandey
OBJECTIVE: To investigate the effect of topical placental extract in the treatment of non-healing wounds. METHOD: One hundred patients attending the wound clinic at University Hospital, Varanasi, India, with wounds of more than six weeks' duration were recruited. Fifty patients were treated with placental extract, and 50 were controls. Wound biopsy and swab culture and sensitivity were performed and the area surrounding the wound was X-rayed. Wound size was measured and the rate of epithelialisation assessed at weekly follow-ups. In nine cases biopsies were repeated after two weeks of treatment and sent for histopathological examination, including angiogenesis. RESULTS: Thirty patients dropped out, leaving 40 cases in the treatment group and 30 in the control group. Over an eight-week period, 27 patients (67.5%) in the treatment group showed more than 50% epithelialisation, compared with only seven patients (23.3%) in the control group. CONCLUSION: Placental extract has a beneficial role to play as a topical agent in the management of chronic non-healing wounds.
Altered Levels of Serum Zinc and Cadmium in Patients with Chronic Vesiculobullous Hand and Feet Dermatitis
(Hindawi Limited, 2016) Swastika Suvirya; Alpna Thakur; S.S. Pandey; S.K. Tripathi; Durgesh Kumar Dwivedi
Micronutrients serve many important functions in our body and altered levels of heavy and trace metals are associated with cutaneous and systemic disorders. Vesicular palmoplantar eczema is an entity whose etiopathogenesis is a mystery. In this prospective case-noncase study blood levels of Zinc and Cadmium in 37 patients of chronic vesiculobullous hand dermatitis were estimated and compared with 40 noncases with similar age and gender distributions. Low serum Zinc levels were found in patients as compared to noncases. The mean difference of serum Zinc between the case and noncase groups was 27.26; the mean value of serum Zinc between the two groups was statistically significant (p < 0.0001). However, elevated Cadmium levels were detected in only 5 patients and in none of the noncases. The mean concentration of serum Cadmium was 2.32 ± 0.38 μg/dL, with a range of 1.90-2.80 μg/dL for the five cases in whom Cadmium was detected. Various toxic and trace metals can interact by influencing each other's absorption, retention, distribution, and bioavailability in the body. The clinical significance of this finding lies in the possible beneficial role of Zinc supplementation in the therapy of chronic vesiculobullous hand dermatitis. © 2016 Swastika Suvirya et al.
Aqueous extract of Neem leaves in treatment of psoriasis vulgaris
(1994) S.S. Pandey; A.K. Jha; V. Kaur
A double blind clinical drug trial was conducted to see the efficacy of an indigenous drug made up of aqueous extract of Neem leaves in 50 cases of uncomplicated psoriasis taking conventional coal tar regime. Patients taking drug in addition to coal tar had shown a quicker and better response in comparison to placebo group. No any untoward effect was noticed during the period of trial. Probable mode of action is discussed.
Assessment of irritant quality of detergents
(1991) S. Singh; S.S. Pandey; G. Singh
[No abstract available]
Awareness about cause and curability of leprosy among leprosy patients in Eastern UP
(Institute of Medico-Legal Publications, 2016) Sunil Kumar; S.S. Pandey; P. Kaur
To study the awareness about cause and curability of leprosy among leprosy patients. Material & Method: 251 study subjects were selected randomly attending the Skin & VD OPD of S. S. Hospital of IMS, BHU, Varanasi. Questions related to cause and curability were administered to leprosy patients aged 15 years or above by the interviewer himself. Result: Only 6.4% of patients identified the correct cause of leprosy. More than half of the patients (54.6%) identified that leprosy was a curable disease. Nearly one fourth of the patients had heard about MDT. Conclusion: IEC activity should be strengthened with emphasizing message that leprosy is curable and MDT is the only effective treatment. © 2016, Indian Journal of Public Health Research and Development. All rights reserved.
Brooke-Spiegler syndrome: A rare entity
(2012) Kajal Manchanda; Manish Bansal; Aakash Amar Bhayana; S.S. Pandey
Brooke-Spiegler syndrome (BSS) is a rare autosomal dominant disorder characterized by the presence of various adnexal tumors including multiple cylindromas, trichoepitheliomas and spiradenomas. A 35-year-old female presented with multiple asymptomatic nodular lesions over face and scalp since the age of 5 years. There were no complaints suggestive of systemic involvement. Her son, elder sister, younger sister, father, father′s sister, and grandmother had history of similar lesions. On examination, there were multiple asymptomatic skin-colored firm papulonodular lesions measuring from 2 to 8 mm in diameter, with smooth surface mainly affecting central part of face. Scalp showed pinkish, firm, smooth-surfaced, dome-shaped nodules measuring about 1 to 3 cm in size. Histopathological examination was consistent with trichoepitheliomas for the facial lesions and cylindromas for the scalp lesions. The diagnosis of BSS was thus confirmed.
Classification of Gait Abnormalities Using Transfer Learning with EMG Scalogram Features
(Springer Science and Business Media Deutschland GmbH, 2023) Pranshu C. B. S. Negi; S.S. Pandey; Shiru Sharma; Neeraj Sharma
Gait abnormalities can significantly impact the mobility and quality of life of individuals, thus making its early diagnosis crucial for proper treatment planning and rehabilitation. In this study scalograms generated from EMG signals of two important gait abnormalities, rheumatoid arthritis, and prolapsed intervertebral disc are classified using transfer learning. Scalogram has an advantage when dealing with high-noise data with abrupt transitions making it an excellent choice for classifying movement patterns. When classified using only CNN an accuracy of 91.1%, precision of 92.8%, recall of 92.9%, AUC of 0.98, and a PRC of 0.97 were obtained. For transfer learning, VGG16, VGG19, ResNet50, Inceptionv3, InceptionResNet, MobileNet and MobileNetv2, and DenseNet Large were incorporated along with previous CNN. DenseNet Large achieved highest accuracy of 97.5% along with 96.2% precision, 96.2% recall, an AUC of 0.99 and a PRC of 0.99. The use of transfer learning provided a significant boost to performance of the model. The proposed method of using scalograms with transfer learning can be used to accurately diagnose gait abnormalities and allow medical professionals to design treatment and rehabilitation plan. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd 2023.
Clinical mycological and immunological study of tinea capitis
(1981) A. Rajagopal; H.S. Girgla; S.S. Pandey
[No abstract available]
Clofazimine in vitiligo
(1980) P.K. Guha; S.S. Pandey; G. Singh
11 patients with vitiligo were treated with Clofazimine, for a period of 3 months. There was no evidence of repigmentation of the affected areas in any of the patients treated. Exposure to sunlight in addition, did not improve the response.
Comparative measurement of irritant properties of toilet bar soaps on human skin
(1990) S. Singh; G. Singh; S.S. Pandey
[No abstract available]
Cutaneous T-cell lymphomas and their management strategies
(Wolters Kluwer Medknow Publications, 2014) S.S. Pandey; S. Garg; A.N.D. Dwivedi; R. Tripathi; K. Tripathi; M. Bansal
Cutaneous T-cell lymphomas (CTCLs) comprise a heterogeneous group of lymphoproliferative disorders characterized by the proliferation of skin-homing post-thymic T-cells. It is the second most common extranodal non-Hodgekin′s lymphoma. Many variants of mycosis fungoides and CTCLs are known to date, differing in clinical, histological, and immunophenotypic characteristics. Oral involvement has also been reported rarely in CTCLs. Treatment depends on the disease stage or the type of variant. New insights into the disease and the number of emerging novel therapeutic options have made it an interesting area for dermatologists and medical oncologists.
Dyschromatosis universalis
(1985) P.K. Singh; B.V. Ramachandra; S.S. Pandey; G. Singh
[No abstract available]
Effect of duration of application and dosing frequency on the efficacy of topical 0.1% mometasone furoate ointment in psoriasis
(Informa Healthcare, 1998) S. Singh; S.S. Pandey
Duration of application is believed to be an important determinant of efficacy of topical corticosteroids, but clinical studies are lacking. Mometasone furoate is recommended for once-daily use, despite a lack of studies comparing once-daily application with the conventional twice-daily application. We studied the efficacy of 0.1% mometasone furoate ointment in psoriasis with various application durations (randomized, observer-blind, bilateral-paired design), and once- and twice-daily dosing frequencies (randomized, double-blind, vehicle-controlled, bilateral-paired design) in 64 consecutive patients with stable plaque psoriasis having equivalent symmetrical indicator lesions. Mometasone furoate ointment was applied in every patient to six indicator lesions for various application durations daily, and to two lesions with different dosing frequencies for up to 15 days. The main outcome measures were proportion of patients showing complete clearance and Local Psoriasis Severity Index scores on different days. With regard to the duration of application, there were no significant differences between 5 and 10 min, 10 and 15 min, 15 and 30 min, 30 min and 1 h, 1 and 6 h, 6 and 24 h, and 30 min and 24 h (P ≤ 0.2), but a 15-min application was less effective than a 24-h application (P = 0.03). Severity scores on all assessment days with various application durations were not significantly different (P ≤ 0.2). Once- and twice-daily dosing frequencies were equivalent for proportion of clearance (P = 0.17; 95% confidence interval, -5% to 27%) and severity scores on different days (P ≤ 0.09). This study shows that increasing the duration of application from 30 min to 24 h and the dosing frequency from once to twice daily do not increase the efficacy of mometasone furoate ointment in psoriasis.
Effectiveness of vitiligo therapy in prospective observational study of 250 cases with review of consensus and individualized care perspective
(2013) A.K. Gupta; S.S. Pandey; B.L. Pandey
Patients and methods: Outcomes of six month therapy in 250 patients bearing varying disease profiles and treatment regimens delivered either in conformity or divergence from consensus guidelines were compared. Influence of trait variables of patients and disease on the outcomes was also examined. Results: Consensus approach yielded superior rates of repigmentation and improved quality of life. The latter effect significantly influenced the former. Therapy adhering guidelines did not yield optimal benefit in patients of younger age, with disease of shorter standing and involving resistant sites. Steroids best benefited the localized disease as topical monotherapy. Combination of steroid with photochemotherapy adhering guidelines benefited less in moderate disease extent. Steroid overtreatment in extensive disease compromised the prospects of repigmentation. Conclusions: Localized short duration disease may better be first treated with steroid-alternative immunosuppressants. Wider spread more than 3% body surface may also respond to their combination with steroids, prior applying photochemotherapy. Additive therapies are prudent with steroid/photochemotherapy than injudicious steroid overuse in progressive extensive disease. Strategies to counter steroid unresponsiveness and adverse effects, psychiatric address to stress, nutrient and environmental interventions deserve emphasis.
EMG scalogram-based classification of gait disorders using attention-based CNN: a comparative study of wavelet functions
(Inderscience Publishers, 2024) Pranshu CBS Negi; Balendra; S.S. Pandey; Shiru Sharma; Neeraj Sharma
This study aims to classify gait abnormalities caused by rheumatoid arthritis and prolapsed intervertebral disc using scalograms from the EMG signals. Classifying EMG signals is difficult because of their variability, high dimensionality, and sensor placement. We propose to bridge this gap by using the wavelet transform and attention-based neural networks. The study involved five participants: one with rheumatoid arthritis, two with prolapsed intervertebral disc, and two healthy subjects. The proposed methodology uses four different wavelet functions: complex Gaussian, frequency B Spline, Mexican Hat, and Shannon, to construct scalograms, and an attention-based CNN for classification. A comparison of performance of the proposed algorithm with nine machine learning classifiers: K nearest neighbour, Naïve Bayes, support vector machine, decision tree, logistic regression, random forest, AdaBoost, gradient boost, and XGBoost was conducted. Out of the nine machine learning classifiers that were tested, XGBoost achieved the highest accuracy of 90.38%, however, in comparison to this the performance of the proposed algorithm was much better, with an accuracy of 99% and precision of 99%. These results indicate that this approach is highly effective in accurately categorising EMG signals. Copyright © 2024 Inderscience Enterprises Ltd.
Epidemiology of leprosy in tribals of adhaura plateau
(1988) P. Kaur; U.C. Sharma; S.S. Pandey; G. Singh
A door to door survey was carried out in the Adhaura plateau of Bihar, to find out the magnitude of leprosy problems in that area. Out of a total of 7,521 persons, mostly tribals, 5,476 were examined giving a coverage of 72.8%. Prevalence rate of leprosy was 20.6%/1000 population. Maximum prevalence was seen in the age group of 55 and above. The disease was more common in males and in the literate and educated group. The ratio of tuberculoid was 57.5%, borderline 29.0% and lepromatous 10.0, indeterminate type constituted 3.5%. The population had a poor nutritional status with caloric intake of 1471 cal per day.
Familial incidence of pseudopelade of Brocq
(1993) D.K. Sharma; S.S. Pandey
Pseudopelade of Brocq is an asymptomatic, beginning insiduously with small, white, depressed, bald spots, devoid of normal hair that mark the borders of some of the earlier lesions with atrophy and minimal perifollicular erythema, if at all. We report here a family of 3 members (2 brothers and 1 sister) with similar findings of cicatricial alopecia for more than 10 years duration but without any cause which may lead to scarring and loss of hair of primary type of pseudopelade. To the best of our knowledge no familial incidence of pseudopelade has been reported any where in literature so far.
Familial pityriasis rubra pilaris: A case report
(2013) Manish Bansal; Kajal Manchanda; Anurag; S.S. Pandey
Pityriasis rubra pilaris (PRP) is a rare papulosquamous disorder of unknown etiology characterized by reddish orange plaques with pityriasiform scaling with follicular keratoses, palmoplantar keratoderma, and occasionally erythroderma. We hereby report a family with five members affected with the condition in three successive generations.