Browsing by Author "Sachchida N. Rai"

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Commentary: Metformin reverses TRAP1 mutation-associated alterations in mitochondrial function in parkinson’s disease
(Frontiers Media S.A., 2018) Sachchida N. Rai; Saumitra S. Singh; Hareram Birla; Walia Zahra; Aaina S. Rathore; Payal Singh; Surya P. Singh
[No abstract available]
Commentary: Mild endoplasmic reticulum stress ameliorates lpopolysaccharide-induced neuroinflammation and cognitive impairment via regulation of microglial polarization
(Frontiers Media S.A., 2018) Sachchida N. Rai; Walia Zahra; Hareram Birla; Saumitra S. Singh; Surya P. Singh
[No abstract available]
Comparison of quantum, classical, and statistical behavior in dissociating triatomics
(1984) Sachchida N. Rai; Kenneth G. Kay
Time-dependent calculations are presented which compare the dynamics of quantum and classical one-dimensional triatomic systems undergoing intramolecular vibrational energy transfer and dissociation. The purpose of these calculations is to determine whether statistical dissociative behavior in classical systems implies similar behavior in the analogous quantum systems and to test for the presence of quantum mechanical effects that reduce the tendency of the systems to decompose statistically. The intramolecular vibrational energy transfer is monitored by computing the probability for the systems to remain in their initial, coarsely grained states, and the dissociation is followed by calculating the time-dependent decomposition probability and the product distribution. The classical calculations are performed by a version of the quasiclassical technique while the quantum calculations are carried out by an R-matrix method. The results show that the two forms of dynamics usually result in similar intramolecular evolution and unimolecular decay. Since the behavior of the classical systems is statistical in a well-defined sense, it is argued that the behavior of the quantum mechanical systems can likewise be labeled as statistical in these typical cases. Important exceptions to the generally good quantum-classical agreement occur, however, when the systems are prepared with high energy in a dissociable bond and low energy in the other bond. In such cases, the quantum behavior differs significantly from the classical behavior; the quantum dynamics of decomposition is nonstatistical even though the classical dynamics is statistical. It is found that the "quantum trapping" states which lead to the nonstatistical quantum mechanical behavior are associated with narrow Feshbach resonances which accumulate in certain specific energy regions. It is further concluded that these states occupy a significant proportion of the classical phase space available to molecular complexes with energy below the first vibrational threshold. © 1984 American Institute of Physics.
Corrigendum: Effect of chlorogenic acid supplementation in MPTP-intoxicated mouse(Front Pharmacol., (2018), 6, (9757), 10.3389/fphar.2018.00757)
(Frontiers Media S.A., 2023) Saumitra S. Singh; Sachchida N. Rai; Hareram Birla; Walia Zahra; Gaurav Kumar; Mallikarjuna R. Gedda; Neeraj Tiwari; Ranjana Patnaik; Rakesh K. Singh; Surya P. Singh
In the published article, there was an error in Figure 8 as published. The figure panels in Figure 8 were erroneously duplicated. The corrected Figure 8 and its caption appear below. The authors apologize for this error and state that this does not change the scientific conclusions of the article in any way. The original article has been updated. © 2023 Singh, Rai, Birla, Zahra, Kumar, Gedda, Tiwari, Patnaik, Singh and Singh.
Effect of chlorogenic acid supplementation in MPTP-intoxicated mouse
(Frontiers Media S.A., 2018) Saumitra S. Singh; Sachchida N. Rai; Hareram Birla; Walia Zahra; Gaurav Kumar; Mallikarjuna R. Gedda; Neeraj Tiwari; Ranjana Patnaik; Rakesh K. Singh; Surya P. Singh
Oxidative stress and neuroinflammation play a key role in dopaminergic (DA) neuronal degeneration, which results in the hindrance of normal ongoing biological processes in the case of Parkinson's disease. As shown in several studies, on 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) administration, different behavioral parameters have suggested motor impairment and damage of antioxidant defence. Thus, some specific biological molecules found in medicinal plants can be used to inhibit the DA neuronal degeneration through their antioxidant and anti-inflammatory activities. With this objective, we studied chlorogenic acid (CGA), a naturally occurring polyphenolic compound, for its antioxidant and anti-inflammatory properties in MPTP-intoxicated mice. We observed significant reoccurrence of motor coordination and antioxidant defence on CGA supplementation, which has been in contrast with MPTP-injected mice. Moreover, in the case of CGA-treated mice, the enhanced expression of tyrosine hydroxylase (TH) within the nigrostriatal region has supported its beneficial effect. The activation of glial cells and oxidative stress levels were also estimated using inducible nitric oxide synthase (iNOS) and glial fibrillary acidic protein (GFAP) immunoreactivity within substantia nigra (SN) and striatum of MPTP-injected mice. Administration of CGA has prevented the neuroinflammation in SN by regulating the nuclear factor-κB expression in the MPTP-induced group. The significant release of certain pro-inflammatory mediators such as tumor necrosis factor-α and interleukin (IL)-1β has also been inhibited by CGA with the enhanced expression of anti-inflammatory cytokine IL-10. Moreover, reduced GFAP staining within the nigrostriatal region has supported the fact that CGA has significantly helped in the attenuation of astrocyte activation. Hence, our study has shown that CGA supplementation shows its therapeutic ability by reducing the oxidative stress and neuroinflammation in MPTP-intoxicated mice. © 2018 Singh, Rai, Birla, Zahra, Kumar, Gedda, Tiwari, Patnaik, Singh and Singh.
Mucuna pruriens protects against MPTP intoxicated neuroinflammation in Parkinson's disease through NF-κB/pAKT signaling pathways
(Frontiers Media S.A., 2017) Sachchida N. Rai; Hareram Birla; Saumitra S. Singh; Walia Zahra; Ravishankar R. Patil; Jyoti P. Jadhav; Mallikarjuna R. Gedda; Surya P. Singh
Till date, drugs that have been used to manage Parkinson's disease (PD) have only shown symptomatic relief with several adverse effects besides their inability to prevent neurodegeneration. Neuroinflammation plays an important role in the advancement of PD and can be targeted for its effective treatment. Researchers have suggested that herbal plants exhibiting the anti-inflammatory and anti-oxidant properties are therefore beneficial to human health. Conventionally, Mucuna pruriens (Mp) seeds are used for maintaining male virility in India. Reportedly, Mp is used as a rejuvenator drug having neuroprotective property. Our study aimed to investigate effects of aqueous extract of Mp (100 mg/kgbwt) on neuroinflammation, orally administered to mice intoxicated with 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) as well as the molecular mechanism involved in the progression of PD. In this study, we have observed significant behavioral abnormalities beside decreased antioxidant defense in MPTP intoxicated mice. We have also observed significant increase in inflammatory parameters like Glial Fibrillary Acidic Protein, Inducible Nitric Oxide Synthase, Intercellular Cell Adhesion Molecule, and Tumor Necrosis Factor alpha in substantia nigra pars compacta (SNpc) of parkinsonian mice, while Mp treatment has notably reduced these inflammatory parameters. Mp also inhibited the MPTP induced activation of NF-κB and promoted pAkt1 activity which further prevented the apoptosis of the dopaminergic neurons. Moreover, Mp exhibited significant antioxidant defense by inhibiting the lipid peroxidation and nitrite level, and by improving catalase activity and enhancing GSH level in nigrostriatal region of mouse brain. Mp also recovered the behavioral abnormalities in MPTP treated mice. Additionally, Mp treatment considerably increased the immunoreactivity of Tyrosine Hydroxylase and Dopamine Transporter in SNpc of parkinsonian mice. Our high performance liquid chromatography analysis of the Mp seed extract have shown L-DOPA, gallic acid, phytic acid, quercetin, and catechin equivalents as the major components which might cause neuroprotection in PD mice. Our result suggested that Mp extract treatment containing L-DOPA and a mixture of rich novel phytochemicals significantly alleviates the MPTP induced neurotoxicity by NF-κB and pAkt pathway. The findings observed thereby indicate that Mp extract have suggestively ameliorated MPTP induced neuroinflammation, restored the biochemical and behavioral abnormalities in PD mouse and thus provided a scientific basis for its traditional claim. © 2017 Rai, Birla, Singh, Zahra, Patil, Jadhav, Gedda and Singh.