Browsing by Author "Saheem Ahmad"

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Enzymatic biomethanol production: Future perspective
(Elsevier B.V., 2023) Saif Khan; Gourav Jain; Alka Srivastava; Praveen C. Verma; Veena Pande; Rama S. Dubey; Mahvish Khan; Shafiul Haque; Saheem Ahmad
The need for an alternative, renewable, and environment-friendly fuel is widely recognized across various energy sectors. Methanol emerged as a promising alternative fuel with numerous economic and environmental benefits. Methanol can be produced either synthetically using chemicals as a feedstock or through the utilization of renewable resources like waste biomass. Utilizing different thermochemical and biochemical routes, bio-methanol can be synthesized from waste biomass like agricultural wastes, food wastes, forest litter, clipping, etc. The conversion of waste biomass into biogas, which can then be used for bio-methanol production, relies on the involvement of methanotrophs. Methanotrophs have a specific enzyme known as methane monooxygenase (MMO) that enables the transformation of methane into methanol. Subsequently, methanol dehydrogenase (MDH) converts methanol to formaldehyde. By manipulating the culture media and using specific MDH inhibitors, large-scale production of bio-methanol can be achieved. This review explores the methodologies for utilizing biogas derived from waste biomass as a feedstock for methanol production. Apart from methanotrophs, the Pectin methylesterase (PME) enzyme also produces methanol, by demethylesterifying pectin. Additionally, the review identifies the shortcomings of the present research and prescribes a way for future studies to overcome these limitations and move towards a sustainable generation of eco-friendly bio-methanol. © 2023 Elsevier B.V.
Inhibiting Effect of Zinc Oxide Nanoparticles on Advanced Glycation Products and Oxidative Modifications: a Potential Tool to Counteract Oxidative Stress in Neurodegenerative Diseases
(Humana Press Inc., 2018) Jalaluddin M. Ashraf; Mohammad Azam Ansari; Sana Fatma; Saleh M. S. Abdullah; Johar Iqbal; Aymen Madkhali; Al Hassan Hamali; Saheem Ahmad; Ahmed Jerah; Valentina Echeverria; George E. Barreto; Ghulam Md Ashraf
Advanced glycation end products (AGEs) are implicated in several central nervous system (CNS) pathologies including Alzheimer and Parkinson’s diseases. In the face-off of AGE menace, we have attempted to investigate the zinc oxide nanoparticle (ZnONP) role in inhibition of AGE formation. Synthesized ZnONPs were used to investigate the inhibitory effects on AGE formation. The inhibitory effects of ZnONPs on AGE formation were determined by biophysical immunological and biochemical techniques. The results showed that ZnONP is a potential anti-glycating agent inhibiting AGE formation as well as protecting the protein structure from change. Therefore, our findings suggest ZnONPs may be used as a therapeutic in resolving the AGE role in CNS-related complications. © 2018, Springer Science+Business Media, LLC, part of Springer Nature.