Browsing by Author "Sanchit Arora"

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A review on integrated design and application of stimuli-responsive ZIF-8 metal-organic frameworks for breast cancer theranostics
(Elsevier B.V., 2025) Akshay Kumar Jha; Sanchit Arora; Rohan Chand Sahu; Dinesh Kumar; S. Kumar Singh; Ashish Kumar Kumar Agrawal
Breast cancer continues to be a predominant cause of death among women globally, necessitating the development of more effective and targeted treatment strategies. While current therapies have shown efficacy, they are often associated with notable adverse effects and inadequate tumor targeting. This review explores the potential of stimuli-responsive zeolitic imidazole framework-8 (ZIF-8) metal-organic frameworks (MOFs) in the treatment of breast cancer. Composed of zinc ions and imidazolate linkers, ZIF-8’s structure offers pH-sensitive degradation, making it ideal for precise medication delivery in the acidic tumor microenvironment. We investigate various synthesis methods and emphasize the advantages of ZIF-8 in enhancing drug bioavailability and precision targeting. The stimuli-responsive properties of ZIF-8 MOFs—such as responsiveness to pH, light, temperature, ultrasound, redox conditions, and enzymes—enable controlled and site-specific drug release. Furthermore, we examine the integration of ZIF-8 MOFs with existing breast cancer therapies and their applications in diagnostics and imaging. Consideration is also given to the biocompatibility of ZIF-8 to ensure safe and effective clinical use. This review article offers a comprehensive analysis of the function of stimuli-responsive ZIF-8 MOFs in transforming breast cancer therapy and facilitating novel treatment approaches. © 2025 The Authors
Interplay between food-associated oxidative stress and NDG disorders
(Elsevier, 2024) Lakshay Kapil; Vishal Kumar; Sanchit Arora; Simranjit Kaur; Sonima Prasad; Charan Singh; Arti Singh
Food-associated oxidative stress has a significant impact on the pathophysiology of many diseases and is often influenced by dietary patterns, food preferences, and nutrient intake. Unhealthy eating practices also cause the creation of free radicals, which interact with polyunsaturated fatty acids to create lipid peroxides. When these peroxides degrade, a chain of events begins that includes the production of the recognized mutagen malondialdehyde (MDA). Lipid peroxides have been demonstrated to reduce membrane permeability and flexibility, which may lead to cell damage. These changes are probably more pronounced in long-lived, primarily postmitotic cells like neurons, which may result in a variety of illnesses. In the study, several micro- and macronutrients, their origins, and associated dysfunctions are highlighted along with the mechanism underlying food-associated oxidative stress. © 2025 Elsevier Inc. All rights reserved.
Multifunctional Nanocarriers in Bacteriophage Delivery: A Paradigm Shift in Treating Multidrug-Resistant Infections
(John Wiley and Sons Inc, 2025) Rohit Patil; Sanchit Arora; Dinesh Kumar; Ashish Kumar Kumar Agrawal
The rising challenge of antibiotic-resistant bacterial infections poses a severe threat to global health, highlighting the urgent need for innovative treatment strategies. Bacteriophages, viruses specifically targeting and destroying bacteria, have emerged as a promising solution. However, their therapeutic application faces significant hurdles, including sensitivity to the immune system, limited stability, and challenges in effectively reaching infection sites. Multifunctional nanocarriers offer a cutting-edge approach to address these limitations. These nanoscale delivery systems protect bacteriophages from degradation, enhance their stability, and enable precise release at the infection site. Certain nanocarriers are engineered to respond to specific physiological conditions, such as pH or temperature, and can be combined with additional therapies, like antibiotics, for synergistic effects. Moreover, they hold the potential for real-time infection tracking and treatment monitoring, aligning with the goals of personalized medicine. This review highlights the synergistic potential of nanotechnology and bacteriophage therapy in combating antibiotic-resistant bacteria. By overcoming critical barriers to bacteriophage application, multifunctional nanocarriers represent a transformative advancement in the fight against drug-resistant infections. Furthermore, their ability to enhance treatment efficacy and outcomes establishes them as an essential innovation in advancing global health solutions. © 2025 Wiley Periodicals LLC.
Nanotherapeutics in pulmonary infections
(Elsevier, 2025) Sanchit Arora; Archna Panghal; Jayant Kumar; Charan Singh
Pulmonary infections such as pneumonia, tuberculosis, and respiratory virus infections pose serious threats around the world. Systemic delivery of drugs for lung infection treatment is often limited due to inadequate organ distribution, relatively less retention time of active chemicals in the lungs, antimicrobial resistance, and severe side effects. Nanotechnology has made amazing progress over the last few years, providing opportunities to address difficulties in conventional treatment strategies. Nanotherapeutics have the ability to encapsulate compounds with varying solubility, deliver different types of cargo, and particularly target the specific organ, cell, or cellular organelle. Furthermore, many nanotherapeutics can be given locally to the lungs via inhalation, avoiding systemic circulation. The purpose of this chapter is to provide a thorough overview of nanotherapeutics in the realm of pulmonary infections. We investigate the potential applications of nanoscale formulations such as nanoparticles (NPs), liposomes, micelles, and dendrimers in combating pulmonary infections. Furthermore, we emphasize the various approaches used in nanotherapeutics, such as targeted drug delivery, antibacterial strategies, and immunomodulation. In addition, we discuss various challenges related to nanotherapeutics, such as regulatory issues, clinical translation, and long-term toxicity. © 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Piperine loaded metal organic frameworks reverse doxorubicin induced chemobrain in adult zebrafish
(Elsevier B.V., 2023) Sanchit Arora; Vishal Kumar; Lakshay Kapil; Ashish Kumar Agrawal; Arti Singh; Charan Singh
The study's primary goal was to enhance medicinal potential of piperine (PIP)-loaded zeolitic imidazolate frameworks-8 (PIP@ZIF-8) against doxorubicin (DOX)-induced cognitive impairments in zebrafish. Herein, PIP@ZIF-8 was synthesized via easy, economical and reproducible ultrasonication method followed by spray drying technology. ZIF-8's structural integrity has been confirmed by PXRD, and even after PIP was encapsulated, the structure of ZIF-8 remained unchanged. Pure ZIF-8 and PIP@ZIF-8 were subjected to TEM analysis, which revealed hexagonal morphology with a nanosize range. FTIR and UV–Visible spectroscopy studies confirmed the drug loading of ZIF-8. Studies on in vitro release revealed 71.48 ± 7.21% and 34.56 ± 5.35% PIP release from PIP@ZIF-8 and unformulated PIP, respectively in pH 7.4. The highest antioxidant scavenging results were obtained with vitamin C (73.77 ± 6.7%) at an intensity of 200 μg/ml, though it was 65.09 ± 2.5% and 57.99 ± 3.1% for PIP@ZIF-8 and PIP, respectively. In vivo studies on zebrafish showed that DOX administration remarkably impaired cognitive activity in T-Maze, and downregulated spatial memory and locomotor activity in the open field test. In addition, DOX administration caused a downregulation in GSH and SOD levels and increase in LPO, AChE and TNF-α levels compared to the vehicle group along with changes in brain histopathology. Further, PIP@ZIF-8 reversed the DOX-induced cognitive impairments by its antioxidant and neuroprotective properties. It can be concluded that PIP@ZIF-8 has a promising therapeutic potential against the chemotherapy-induced cognitive impairments in zebrafish. © 2023 Elsevier B.V.
Stability Dynamics of Plant-Based Extracellular Vesicles Drug Delivery
(Multidisciplinary Digital Publishing Institute (MDPI), 2025) Satyavati Rawat; Sanchit Arora; Madhukiran R. Dhondale; Mansi Khadilkar; Sanjeev Kumar; Ashish Kumar Kumar Agrawal
Plant-based extracellular vesicles (PBEVs) have been recognized for their wide range of applications in drug delivery however, the extent of their medicinal applicability depends on how well they are preserved and stored. Assessing their physicochemical properties, such as size, particle concentration, shape, and the activity of their cargo, forms the foundation for determining their stability during storage. Moreover, the evaluation of PBEVs is essential to ensure both safety and efficacy, which are critical for advancing their clinical development. Maintaining the biological activity of EVs during storage is a challenging task, similar to the preservation of cells and other cell-derived products like proteins. However, despite limited studies, it is expected that storing drug-loaded EVs may present fewer challenges compared to cell-based therapies, although some limitations are inevitable. This article provides a comprehensive overview of current knowledge on PBEVs preservation and storage methods, particularly focusing on their role as drug carriers. PBEVs hold promise as potential candidates for oral drug administration due to their effective intestinal absorption and ability to withstand both basic and acidic environments. However, maintaining their preservation and stability during storage is critical. Moreover, this review centers on the isolation, characterization, and storage of PBEVs, exploring the potential advantages they offer. Furthermore, it highlights key areas that require further research to overcome existing challenges and enhance the development of effective preservation and storage methods for therapeutic EVs. © 2025 by the authors.