Browsing by Author "Sandip Kumar Das"

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Iron-Catalyzed Radical Activation Mechanism for Denitrogenative Rearrangement Over C(sp3)–H Amination
(John Wiley and Sons Inc, 2021) Satyajit Roy; Sandip Kumar Das; Hillol Khatua; Subrata Das; Krishna Nand Singh; Buddhadeb Chattopadhyay
An iron-catalyzed denitrogenative rearrangement of 1,2,3,4-tetrazole is developed over the competitive C(sp3)–H amination. This catalytic rearrangement reaction follows an unprecedented metalloradical activation mechanism. Employing the developed method, a wide number of complex-N-heterocyclic product classes have been accessed. The synthetic utility of this radical activation method is showcased with the short synthesis of a bioactive molecule. Collectively, this discovery underlines the progress of radical activation strategy that should find wide application in the perspective of medicinal chemistry, drug discovery and natural product synthesis research. © 2021 Wiley-VCH GmbH