Browsing by Author "Sanjay Kumar Saroj"

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A Randomized, Placebo-controlled, Double-blind Clinical Trial of Bacteriophage Cocktails in Chronic Wound Infections
(SAGE Publications Inc., 2024) Subhash Lal Karn; Satyanam Kumar Bhartiya; Arvind Pratap; Sanjay Kumar Saroj; Rajesh Kumar; Minakshi Sahu; Mayank Gangwar; Gopal Nath
Background: Chronic wounds are prevalent globally at endemic proportions. The common features associated with chronic wounds are prolonged inflammatory phase, infection with multidrug-resistant (MDR) bacteria, and subsequent biofilm formation. The present randomized-controlled trial (RCT) study was undertaken on chronic wounds of ≥6 weeks longer duration using customized phages to evaluate the efficacy and safety of bacteriophage therapy. Methods: The study was conducted from December 2021 to August 2023. Thirty patients in each of the arms (placebo and bacteriophage) were recruited with chronic wounds. The patients, both arms, received the conventional treatment of wound debridement, local antiseptics, and local and systemic antibiotics at the discretion of the treating surgeon. However, before applying the customized bacteriophage cocktail or placebo, the wound surface was thoroughly washed to remove the residual antiseptics. The phage cocktails or placebo were applied on alternate days. The wounds were evaluated using the Bates-Jensen Wound Assessment Tool for the progress of wound healing. Results: A total of 93.3% of the wound became sterile in 39 days (median sterility time), followed by complete healing by the end of 90 days in the phage group. Contrary to this, 83.3% of those on placebo therapy remained colonized by original bacteria or additional new bacteria without healing for up to 90 days. Conclusion: With the well-designed RCT, we could conclude that customized bacteriophage therapy using bacteriophage cocktails will definitely cure the chronic wound, irrespective of age, sex, diabetes status, and infection by MDR bacteria. © The Author(s) 2024.
Laparoscopic Repair of Congenital Diaphragmatic Hernia in Adults
(Hindawi Publishing Corporation, 2016) Sanjay Kumar Saroj; Satendra Kumar; Yusuf Afaque; Abhishek Kumar Bhartia; Vishnu Kumar Bhartia
Background, Aims, and Objectives. Congenital diaphragmatic hernia typically presents in childhood but in adults is extremely rare entity. Surgery is indicated for symptomatic and asymptomatic patients who are fit for surgery. It can be done by laparotomy, thoracotomy, thoracoscopy, or laparoscopy. With the advent of minimal access techniques, the open surgical repair for this hernia has decreased and results are comparable with early recovery and less hospital stay. The aim of this study is to establish that laparoscopic repair of congenital diaphragmatic hernia is a safe and effective modality of surgical treatment. Materials and Methods. A retrospective study of laparoscopic diaphragmatic hernia repair done during May 2011 to Oct 2014. Total n=13 (M/F: 11/2) cases of confirmed diaphragmatic hernia on CT scan, 4 cases Bochdalek hernia (BH), 8 cases of left eventration of the diaphragm (ED), and one case of right-sided eventration of the diaphragm (ED) were included in the study. Largest defect found on the left side was 15 × 6 cm and on the right side it was 15 × 8 cm. Stomach, small intestine, transverse colon, and omentum were contents in the hernial sac. The contents were reduced with harmonic scalpel and thin sacs were usually excised. The eventration was plicated and hernial orifices were repaired with interrupted horizontal mattress sutures buttressed by Teflon pieces. A composite mesh was fixed with nonabsorbable tackers. All patients had good postoperative recovery and went home early with normal follow-up and were followed up for 2 years. Conclusion. The laparoscopic repair is a safe and effective modality of surgical treatment for congenital diaphragmatic hernia in experienced hands. © 2016 Sanjay Kumar Saroj et al.
Status of Contralateral Ear in Patients with Unilateral Chronic Otitis Media
(Springer, 2022) Deepak Kumar Gupta; Ashvanee Kumar Chaudhary; Rajiv Kumar Jain; Vishwambhar Singh; Sanjay Kumar Saroj; Amit Kumar; Shishupal Yadav; Silky Silky
This study was conducted to evaluate the existence of otoscopic abnormality, hearing status and radiological changes in contralateral ear of patients with chronic otitis media. 300 patients having unilateral Chronic Otitis Media attending OPD in the Department of Otorhinolaryngology, Institute of Medical Sciences, Banaras Hindu University, Varanasi during the period of March 2019 to March 2020 were selected. Otoscopy, Pure Tone Audiometry and Bilateral X-ray mastoids (lateral oblique view) and/or HRCT Temporal bone were done. Contralateral ear was affected in more than 30% cases. Out of 188 patients having Mucosal COM, 58 cases (30.9%) had abnormal TM. Out of 112 patients having Squamosal COM, 48 cases (42.9%) had abnormal CLE. Out of 300 cases, 231 (77.0%) of them had normal hearing in contralateral ear. It was followed by 65 cases (21.6%) with conductive hearing loss. Mixed hearing loss and SNHL were seen in 2 patients each. In contralateral ear of Mucosal COM, pneumatic pattern of pneumatisation was seen in 69.1% followed by Diploic pattern (30.9%). In squamosal COM, X-ray mastoid showed pneumatic pattern (64.3%) followed by Diploic pattern (33.9%) in the contralateral ear. Sclerotic pattern was seen in only 1.8% of cases in contralateral ear. Chronic otitis media as a disease is not limited to one ear. The precise and critical evaluation of both ears does not play a role in prognostic evaluation of the patient only, but it can also serve as a guide for early detection of probable evolution of the disease process in a patient in contralateral ear with unilateral chronic otitis media. © 2022, Association of Otolaryngologists of India.
The laparoscopic re-exploration in the management of the gallbladder remnant and the cystic duct stump calculi
(Journal of Clinical and Diagnostic Research, 2016) Sanjay Kumar Saroj; Satendra Kumar; Yusuf Afaque; Abhishek Bhartia; Vishnu Kumar Bhartia
Introduction: The gallbladder remnant and the cystic duct stump calculi are uncommon causes of post-cholecystectomy syndrome. Re-exploration usually needed in the cases where symptom persists. Very few case series and reports are available regarding laparoscopic re-exploration. Aim: To assess the safety and feasibility of Laparoscopic reexploration in the cases of gallbladder remnant and cystic duct stump calculi leading to post cholecystectomy syndromes. Materials and Methods: In this study, laparoscopic reexplorations was done in 22 patients in which 17 patients had gallbladder remnant calculi and 5 had cystic duct stump calculi. The study considered parameters the operative time, conversion rate, post-operative complications, post-operative hospital stay and mortality in these patients. The duration of study was 15 years and the data was retrospectively reviewed. Results: The median operating time was 83 minutes (range 51 to 134 minutes). Only one patient had conversion to open surgery. In postoperative period two patients had bile leak. They were managed conservatively and leak subsided in 8 and 11 days respectively. One patient had postoperative bleeding not requiring blood transfusion. There was no major complication requiring further intervention and no mortality. Patients were discharged on median day 4 (range 2-11) after the surgery. Patients were followed up every 3 months for one year. However, out of these three patients did not turn up for follow-up. Conclusion: In expert hands laparoscopic re-exploration of the gallbladder remnant/cystic duct stump calculi can be performed within a reasonable operating time. The conversion to conventional re–exploration rate was very low with minimal post-operative complications and shorter hospital stay. © 2016, Journal of Clinical and Diagnostic Research. All rights reserved.
To Study the Incidence of Biofilm Formation, its Microbiology and its Effect on the Development of Acute and Chronic Rhinosinusitis- A Prospective Study
(Springer, 2025) Akshat Pandey; Ramraj Yadav; Vivek Mishra; Akanksha Sharma; Sanjay Kumar Saroj; Rahul Yadav; Jeffrey Oswin Rynjah; Srishti Bhansali; Anjalika Sharma; Gundra Chandra Shekar; Sishupal Yadav; Arpit Goyal; Ragini Tilak; Sushil Kumar Aggarwal
Bacterial biofilms are organised complex structures having polymicrobial nature in a single community, which provide protection to bacteria from antibiotics by various means. The aim of our study was to determine the prevalence of biofilm-forming bacteria in clinical isolates of acute and chronic rhinosinusitis (ARS and CRS) patients with sinonasal mucopurulence. To know the incidence of bacterial biofilms in patient with ARS and CRS, to study the microbiology of bacterial biofilms in ARS and CRS, to assess the role and effects of biofilm in ARS and CRS and to correlate the association between the formation of the biofilm and development of rhinosinusitis. This prospective study was carried out at a tertiary care centre in Eastern part of India, in which 60 patients were taken as sample size. All patients of rhinosinusitis between age-group of 10 to70 years, who came to our out-patient department, were taken for our study. Biofilm formation was observed in 50% cases and were absent in 50% cases of chronic rhinosinusitis in our study. 83.3% (50) of patients out of 60 patients got improved after treatment and recurrence was observed in only 16.6% (10) of patients. Recurrence was more at 3 months follow-up as compared to follow-up at 1 month, though it was not statistically significant. Though our study highlighted the incidence and role of biofilms in the development of chronic rhinosinusitis, but few more randomized controlled studies involving larger sample sizes should be done to exactly determine the pathophysiological role of biofilms in the development and recurrence of acute and chronic rhinosinusuitis. © Association of Otolaryngologists of India 2024.