Browsing by Author "Santosh K. Singh"

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Anti-mycobacterial activity of Piper longum L. fruit extracts against multi drug resistant Mycobacterium Spp
(2011) Chandan Singh; Santosh K. Singh; Gopal Nath; N.P. Rai
A long tradition of using pepper as to fight against several ailments by the local tribal people is still in the practice, in many parts of the rural India. So utilizing this tribal knowledge base for this highly medicinal plant, an attempt was made to isolate some novel natural bioactive compounds with potential activity against multidrug resistant (MDR) Mycobacterium. A bioassay guided fractionation of Pippali (Piper longum L.) was performed in five different organic solvents and their activities were monitored against different pathogenic bacteria including MDR Mycobacterium. Different fractions were screened for the bioactivity against Mycobacterium, and the structure of bioactive compound was characterized with H 1 and C 13 NMR. An ethyl acetate fraction of Pippali extract was found active against M. smegmatis (3000μg ml -1) and M. tuberculosis (39 μg ml -1). It also shows very significant activity against other bacterial strains like E.coli (152 μg ml -1), Staphylococcus aureus (14 μg ml-1), Salmonella typhi (180 μg ml -1), Enterococcus faecalis (15 μg ml -1), and Pseudomonas aeruginosa (52 μg ml -1). This fraction of ethyl acetate was then purified and characterized as piperine [5-(1, 3-benzodioxol-5-yl)-1-piperidin-1-ylpenta-2,4-dien-1-one], a well known alkaloid from this plant. Bioactivity guided fractionation concludes that Piperine is the only active ingredients in various fractions of fruit extract evaluated for antibacterial activity. Fraction having piperine has significant activity against multi drug resistant strains of Mycobacterium spp. than other purified fractions of fruit extract. The current finding encourages us to develop new alternative medicine that includes piperine alone and/or in combination with other drugs to fight against the drug resistance among Mycobacterial strains.
Antibiotic Residues in Food: A Global Concern for Human Health
(Springer Singapore, 2020) Avinash Singh; Sonali K. Kalra; Santosh K. Singh; Amit Prasad
Presence of antimicrobial resistance bacteria (ARBs) and antimicrobial resistance genes (ARGs) in food is a potential risk to the public health. Food animals are considered as key reservoirs of ARBs. Food can be contaminated with ARBs, ARGs and antibiotic residues in several ways, i.e. (1) by use of antibiotics during agriculture production, (2) presence of resistance genes in bacteria that are purposely added during the food processing and (3) through cross-contamination with ARBs during food processing. Contaminated food products without undergoing prior processing or preservation can be consumed, which poses a potential risk for transfer of antimicrobial resistance to humans. In this chapter, we are evaluating the food safety concerns related to the presence of antibiotic-resistant bacteria and residues in food, their impact on human health, their detection methods and few recommendations given by international and national agencies. © Springer Nature Singapore Pte Ltd. 2020.
Arsenic exposure to mouse visceral leishmaniasis model through their drinking water linked to the disease exacerbation via modulation in host protective immunity: a preclinical study
(Nature Research, 2023) Ghufran Ahmed; Fauzia Jamal; Ritesh K. Tiwari; Veer Singh; Sachchida Nand Rai; Sanjay K. Chaturvedi; Krishna Pandey; Santosh K. Singh; Ashish Kumar; Shyam Narayan; Emanuel Vamanu
A large body of evidence has shown a direct link between arsenic exposure and drug resistance to Leishmania parasites against antimonial preparations in visceral leishmaniasis (VL) hyper-endemic regions, especially in India and its sub-continent. However, the implicated roles of arsenic on the VL host, pathophysiological changes, and immune function have not yet been clarified, particularly at the reported concentration of arsenic in the VL hyper-endemic area of Bihar, India. Herein, we exposed the mouse VL model to arsenic (0.5 mg/L to 2 mg/L) through their drinking water and analyzed its effect on T cells proliferation, Th1/Th2-mediators, MAPK signaling cascade, and parasite load in preclinical models. Coherently, the parasite count in Giemsa stained spleen imprint has been investigated and found significant positive associations with levels of arsenic exposure. The liver and kidney function tests (AST, ALT, ALP, BUN, Creatinine, Urea, etc.) are apparent to hepatonephric toxicity in arsenic exposed VL mice compared to unexposed. This observation appears to be consistent with the up-regulated expression of immune regulatory Th2 mediators (IL-4, IL-10, TGF-β) and down-regulated expression of Th1 mediators (IL-12, IFN-γ, TNF-α) with a suppressed leishmanicidal function of macrophage (ROS, NO, iNOS). We also established that arsenic exposure modulated the host ERK-1/2 and p38 MAPK signaling cascade, limited T lymphocyte proliferation, and a lower IgG2a/IgG1 ratio to favor the Leishmania parasite survival inside the host. This study suggests that the contorted Th1-subtype and exacerbated Th2-subtype immune responses are involved in the increased susceptibility and pathogenesis of Leishmania parasite among subjects/individuals regularly exposed to arsenic. © 2023, The Author(s).
Berberine: A plant-derived alkaloid with therapeutic potential to combat Alzheimer’s disease
(Bentham Science Publishers, 2019) Anurag K. Singh; Santosh K. Singh; Manmath K. Nandi; Gaurav Mishra; Anand Maurya; Arati Rai; Gopal K. Rai; Rajendra Awasthi; Bhupesh Sharma; Giriraj T. Kulkarni
Berberine (a protoberberine isoquinoline alkaloid) has shown promising pharmacological activities, including analgesic, anti-inflammatory, anticancer, antidiabetic, anti-hyperlipidemic, cardioprotective, memory enhancement, antidepressant, antioxidant, anti-nociceptive, antimicrobial, anti-HIV and cholesterol-lowering effects. It is used in the treatment of the neurodegenerative disorder. It has strong evidence to serve as a potent phytoconstituent in the treatment of various neurodegenerative disorders such as AD. It limits the extracellular amyloid plaques and intracellular neurofibrillary tangles. It has also lipid-glucose lowering ability, hence can be used as a protective agent in atherosclerosis and AD. However, more detailed investigations along with safety assessment of berberine are warranted to clarify its role in limiting various risk factors and AD-related pathologies. This review highlights the pharmacological basis to control oxidative stress, neuroinflammation and protective effect of berberine in AD, which will benefit to the biological scientists in understanding and exploring the new vistas of berberine in combating Alzheimer’s disease. © 2019 Bentham Science Publishers.
Biofabrication of Anisotropic Gold Nanotriangles Using Extract of Endophytic Aspergillus clavatus as a Dual Functional Reductant and Stabilizer
(Springer New York LLC, 2011) Vijay C. Verma; Santosh K. Singh; Ravindra Solanki; Satya Prakash
Biosynthesis of metal and semiconductor nanoparticles using microorganisms has emerged as a more eco-friendly, simpler and reproducible alternative to the chemical synthesis, allowing the generation of rare forms such as nanotriangles and prisms. Here, we report the endophytic fungus Aspergillus clavatus, isolated from surface sterilized stem tissues of Azadirachta indica A. Juss., when incubated with an aqueous solution of chloroaurate ions produces a diverse mixture of intracellular gold nanoparticles (AuNPs), especially nanotriangles (GNT) in the size range from 20 to 35 nm. These structures (GNT) are of special interest since they possess distinct plasmonic features in the visible and IR regions, which equipped them with unique physical and optical properties exploitable in vital applications such as optics, electronics, catalysis and biomedicine. The reaction process was simple and convenient to handle and was monitored using ultraviolet-visible spectroscopy (UV-vis). The morphology and crystalline nature of the GNTs were determined from transmission electron microscopy (TEM), atomic force spectroscopy (AFM) and X-ray diffraction (XRD) spectroscopy. This proposed mechanistic principal might serve as a set of design rule for the synthesis of anisotropic nanostructures with desired architecture and can be amenable for the large scale commercial production and technical applications. © 2010 The Author(s).
Bioinformatics: How it helps to boost modern biological research
(Indian Academy of Sciences, 2020) Suvakanta Barik; Nilesh Rai; Pradeep Mishra; Santosh K. Singh; Vibhav Gautam
[No abstract available]
Chitosan functionalized recyclable and eco-friendly nanoadsorbent for Pb(II) adsorption from water
(Taylor and Francis Ltd., 2024) Veer Singh; Nidhi Singh; Sachchida Nand Rai; Vivek K. Chaturvedi; Santosh K. Singh; Ashish Kumar; Emanuel Vamanu; Vishal Mishra
In the present study, MnO2 nanoparticles were synthesized using Citrus limetta peels extract and functionalized by chitosan polymer. Surface morphology analysis of chitosan functionalized MnO2 nanoparticles was carried out using a scanning electron microscope (SEM) and transmission electron microscope (TEM), which revealed that the synthesized nanoparticles were spherical, with a size range of 14–24 nm. Energy dispersive X-ray analysis and elemental mapping were used to observe Mn, O, C, H, and N. Fourier-transform infrared spectroscopy confirmed the presence of hydroxyl, carboxyl, and amino groups on the surface of the nanoparticles. The kinetics and isotherms were compared and it was found that the pseudo-second-order and Langmuir isotherm were the best fit, with R2 values of 0.99. The thermodynamic study demonstrated that the adsorption was endothermic and spontaneous. These findings indicate that chitosan functionalized nanoparticles have a better Pb(II) removal efficiency (94.40%), making them an eco-friendly and cost-effective alternative for wastewater treatment. Highlights Chitosan functionalized nanoadsorbent was synthesized through green route. Sorption mechanism explored through isotherm, kinetics, and thermodynamic models. Synthesized adsorbent showed high Pb(II) removal capacity. © 2024 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Cooperative metal-ligand-induced properties of heteroleptic copper(I) xanthate/dithiocarbamate PPh3 complexes
(Wiley-VCH Verlag, 2012) Gunjan Rajput; Vikram Singh; Santosh K. Singh; Lal B. Prasad; Michael G. B. Drew; Nanhai Singh
Four new heteroleptic mononuclear complexes, [Cu(PPh3) 2L1](1) {L1 = (C9H 11O2CS2-), [2-(4-methoxyphenyl) ethyl]xanthate}, [Cu(PPh3)2L2] (2) [L 2 = (C6H7OCS2-), benzylxanthate], [Cu(PPh3)2L3] (3) [L 3 = (C5H9OCS2-), (cyclobutylmethyl)xanthate] and [Cu(PPh3)2L4] (4) [L4 = (NC13H13NCS2-), N-benzyl-N-(4-pyridylmethyl)dithiocarbamate], have been synthesized and characterized by using microanalysis, IR, UV/Vis, 1H, 13C and 31P NMR spectroscopy and X-ray crystallography; their photoluminescent behaviour and molecular electrical conductivity have been investigated. CuI possesses four-coordinate distorted tetrahedral geometry in all the complexes. All are weakly conducting and exhibit semiconductor behaviour in the studied 303-363 K temperature range. Complex 4 shows striking luminescent behaviour emitting bluish green light at 480 nm in CH2Cl2 solution at room temperature. © 2012 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim.
Correction to Biofabrication of anisotropic gold nanotriangles using extract of endophytic Aspergillus clavatus as a dual functional reductant and stabilizer (Nanoscale Research Letters, (2011), 6, (261))
(2011) Vijay C. Verma; Ravindra N. Kharwar; Santosh K. Singh; Ravindra Solanki; Satya Prakash
[No abstract available]
Design, analysis and optimization of permanent magnet synchronous generator
(Institute of Electrical and Electronics Engineers Inc., 2017) Sachin Rastogi; Raja Ram Kumar; Santosh K. Singh
Permanent magnet synchronous generator (PMSG) is eventually making a serious impact on to the direct drive wind power application. The power density of these generators is critically important to ensure the robustness and cost effectiveness of the supporting turbine structure. In this paper, an optimal design procedure is adopted for the investigation of a radial flux surface mounted PMSG. In order to optimize the weight and losses of the machine, the authors applied ∈- constrained differential evolution with gradient based mutation optimization technique. The design constraints in terms of electromagnetic force, torque, stator tooth flux density & rotor tooth flux density define the boundary of this optimization technique. Finally, the Maxwell-Ansys finite element method is used to validate the designed PMSG. © 2016 IEEE.
Energetics of alkaline phosphatase (monoesterase) activity in Antarctic and tropical isolates of a cyanobacterium, Anabaena
(1997) Satya Prakash Shukla; Santosh K. Singh; Arun K. Mishra
The influence of temperature (5-40°C) on the alkaline phosphatase activity (monoesterase) of Antarctic and tropical isolates of a diazotrophic cyanobacterium, Anabaena, was studied. Comparison of results revealed a lower endergonic reaction of alkaline phosphatase activity in the Antarctic isolate which was evident from a 43.02% lower energy of activation (Ea) of this isolate with respect to its tropical counterpart. Results obtained should provide a basis for future comparative studies on the energetics of alkaline phosphatase activity in cyanobacteria.
Engineered Nanomaterials for Purification and Desalination of Palatable Water
(Wiley Blackwell, 2015) Vijay C. Verma; Swechha Anand; Mayank Gangwar; Santosh K. Singh
Despite more than two-thirds of the earth's surface being covered by water, people are facing inadequate access to potable water and are thus forced to use contaminated water from unhygienic sources. A major consequence of using contaminated water for preparing food or other daily uses is acute and chronic illness that is widespread especially in third-world countries. Apart from this, the scarcity of safe drinking water in many parts of the world and the increasing divide between availability and per capita utilization is creating a global problem. Since approximately 97% of water on the earth is saline, recycled water through desalination can help to cope with this problem. In this chapter, we look at the state-of-the art technologies driven with modern nanotechnology for water purification and desalination. The rapid development of nanoscience has enabled the implementation of promising processes for providing improved palatability and hygiene of drinking water. Recent technologies like ultra- and nanofiltration as well as reverse osmosis (RO) create new enthusiasm in the fields of water desalination and purification. Nanomaterials and nanotechnology-based solutions are now an integral part of the research to overcome the ever-growing problems in all aspects of science, and since many traditional approaches of water purification are based on molecule-level separation, it is reasonable to expect novel nano-engineered water treatment approaches. There are several new concepts for the desalination of nonpalatable water using engineered membranes/nanoparticles. Aquaporin nanocomposites, the combination of carbon nanotubes (CNTs) with other metal oxides, and noble metal nanoparticles are some good examples in this field. Despite all these developments, there are still some limitations regarding scalability at an industrial scale. In this chapter, we analyze the recent developments in nanotechnology-based solutions for the purification of water to ensure safe drinking water for all. © 2014 John Wiley & Sons, Inc.
Enhanced light harvesting efficiencies of bis(ferrocenylmethyl)-based sulfur rich sensitizers used in dye sensitized TiO 2 solar cells
(2012) Santosh K. Singh; Ratna Chauhan; Bandana Singh; Kiran Diwan; Gabriele Kociok-Köhn; Lal Bahadur; Nanhai Singh
In this work, the photosensitizing properties of ferrocene (Fc)-based compounds FcCH 2CS 3CH 2Fc (1) and FcCH 2SSCH 2Fc (2) were investigated and significant enhancement in the light harvesting efficiency was observed compared to those achieved with previously reported compounds from our lab. The compounds were fully characterized by spectroscopy and X-ray crystallography, and their electrochemical properties studied. DSSCs based on these dyes display efficiencies comparable to those of a standard cell based on N719 under similar experimental conditions. These studies demonstrate that ferrocenyl-based sulfur rich compounds with proper orientation of the Fc groups assisted via suitable linkers, together with desired redox properties and visible region electronic absorption features could constitute a new class of photosensitizers targeting light driven reactions. © 2012 The Royal Society of Chemistry.
Exploring the Paradox of COVID-19 in Neurological Complications with Emphasis on Parkinson's and Alzheimer's Disease
(Hindawi Limited, 2022) Sachchida Nand Rai; Neeraj Tiwari; Payal Singh; Anurag Kumar Singh; Divya Mishra; Mohd. Imran; Snigdha Singh; Etrat Hooshmandi; Emanuel Vamanu; Santosh K. Singh; Mohan P. Singh
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is a human coronavirus (HCoV) that has created a pandemic situation worldwide as COVID-19. This virus can invade human cells via angiotensin-converting enzyme 2 (ACE2) receptor-based mechanisms, affecting the human respiratory tract. However, several reports of neurological symptoms suggest a neuroinvasive development of coronavirus. SARS-CoV-2 can damage the brain via several routes, along with direct neural cell infection with the coronavirus. The chronic inflammatory reactions surge the brain with proinflammatory elements, damaging the neural cells, causing brain ischemia associated with other health issues. SARS-CoV-2 exhibited neuropsychiatric and neurological manifestations, including cognitive impairment, depression, dizziness, delirium, and disturbed sleep. These symptoms show nervous tissue damage that enhances the occurrence of neurodegenerative disorders and aids dementia. SARS-CoV-2 has been seen in brain necropsy and isolated from the cerebrospinal fluid of COVID-19 patients. The associated inflammatory reaction in some COVID-19 patients has increased proinflammatory cytokines, which have been investigated as a prognostic factor. Therefore, the immunogenic changes observed in Parkinson's and Alzheimer's patients include their pathogenetic role. Inflammatory events have been an important pathophysiological feature of neurodegenerative diseases (NDs) such as Parkinson's and Alzheimer's. The neuroinflammation observed in AD has exacerbated the Aβ burden and tau hyperphosphorylation. The resident microglia and other immune cells are responsible for the enhanced burden of Aβ and subsequently mediate tau phosphorylation and ultimately disease progression. Similarly, neuroinflammation also plays a key role in the progression of PD. Several studies have demonstrated an interplay between neuroinflammation and pathogenic mechanisms of PD. The dynamic proinflammation stage guides the accumulation of α-synuclein and neurodegenerative progression. Besides, few viruses may have a role as stimulators and generate a cross-autoimmune response for α-synuclein. Hence, neurological complications in patients suffering from COVID-19 cannot be ruled out. In this review article, our primary focus is on discussing the neuroinvasive effect of the SARS-CoV-2 virus, its impact on the blood-brain barrier, and ultimately its impact on the people affected with neurodegenerative disorders such as Parkinson's and Alzheimer's. © 2022 Sachchida Nand Rai et al.
Facile in situ copper(ii) mediated C-S bond activation transforming dithiocarbimate to carbamate and thiocarbamate generating Cu(ii) and Cu(i) complexes
(2012) Kiran Diwan; Bandana Singh; Santosh K. Singh; Michael G. B. Drew; Nanhai Singh
Facile in situ Cu(ii) mediated transformation of p- tolylsulfonyldithiocarbimate in conjunction with polypyridyl or phosphine ligands into corresponding carbamate and thiocarbamate led to the formation of new copper complexes with varying nuclearities and geometries, via C-S bond activation of the ligand within identical reaction systems. © 2012 The Royal Society of Chemistry.
FPGA-Based Modulation Technique for Five-to-Three-Phase Ultra Sparse Matrix Converter
(Springer Science and Business Media Deutschland GmbH, 2022) Tannistha Malakar; Vulavakayala Siva; Santosh K. Singh
A five-phase permanent magnet synchronous generator is developed in our lab. To supply the generated five-phase power to the existing three-phase system, a five-to-three-phase variable frequency AC–AC converter is required, where the input would be variable frequency AC and the output side would be fixed line frequency AC. Five-to-three-phase ultra sparse matrix converter (USMC) is proposed to achieve the purpose. In this topology, power can flow from source to load side only. This topology comprises of eleven controlled devices only, and there is no requirement of DC-link capacitor. Hence, the size and cost of the converter are reduced compared to the conventional DC-link converters, and reliability is also increased. The proposed modulation technique has the property of zero current switching. This modulation scheme can produce constant frequency three-phase output from a variable five-phase frequency. The simulation of this modulation scheme is done and verified using XILINX system generator (XSG) toolbox in MATLAB Simulink. Less than 5% output voltage THD is achieved in simulation results. © 2022, The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd.
Geochemical characteristics of post-magmatic alteration and tungsten mineralisation associated with Balda granite, District Sirohi, Rajasthan
(1997) Santosh K. Singh; Satyendra Singh
Balda leucogranite is characterised by high B, F, Li, Rb, W, Sn Nb content & Rb/Sr ratio and low Sr, Ba content & Ba/Rb ratio. In the case of altered and mineralised leucogranite geochemical data indicates variable B, F, Li, Rb, W, Sn, Nb contents and Rb/Sr & Ba/Rb ratios, differing significantly from those of fresh rocks. The Rb/Sr and Ba/Rb ratios as well as B, F, Li and Rb contents are the guiding characteristics of the granitic rocks which have undergone postmagmatic alteration and mineralisation, and they provide valuable clue for searching tungsten mineralisation in this area.
Geochemistry and Tungsten Metallogeny of the Balda Granite, Rajasthan, India
(Elsevier Inc., 2001) Santosh K. Singh; Satyendra Singh
Balda granite occurs along the western margin of the middle Proterozoic South Delhi Fold Belt. It is a medium grained leucogranite associated with tungsten mineralisation. Wolframite mineralisation is confined to pneumatolytic quartz veins and greisenised pegmatites located mainly along shear zones within Balda granite and neighbouring metasediments. Geochemistry of Balda granite suggests that it is highly evolved, peraluminous and volatile -rich granite formed from the melt derived by partial melting of metasediments. Borates and fluorides in various complexes favoured the concentration of W in the melt, whereas sodium cations, chlorides and phosphates were the carrier of tungsten in fluid. The shear zones developed within Balda granite and neighbouring metasediments provided the channelways for fluid movement and deposition of wolframite.
Graphene as a chain extender of polyurethanes for biomedical applications
(Royal Society of Chemistry, 2016) Dinesh K. Patel; Rajesh K. Singh; Santosh K. Singh; Vinod K. Aswal; Dipak Rana; Biswajit Ray; Pralay Maiti
Amine-functionalized graphene has been chemically tagged within long-chain polyurethane molecules, using graphene as a chain extender to prepare a nanohybrid, and its novelty has been explored by comparing its properties with those of physically dispersed functionalized graphene in polyurethane based on di-ol as a chain extender. Chemical tagging has been confirmed through NMR studies and the nature of the interaction between the polymer matrix and graphene (nanofiller) is stronger in the chemically tagged nanohybrid compared to a nanohybrid prepared through physical mixture, as revealed from FTIR, UV-visible and PL spectroscopic measurement. A homogeneous dispersion of graphene platelets is achieved through a chemically tagged nanohybrid as against the agglomerated nanostructure found in a physically mixed nanohybrid. Enhancement of thermal properties and toughening of the nanohybrids is observed, whose extent is significantly higher in the chemically tagged nanohybrid due to greater interactions between the components and the uniform dispersion of nanofiller. Graphene-induced self-assembly from the nanometer scale to the micron level (step by step) was investigated through X-ray diffraction, small angle neutron scattering, atomic force microscopy and optical images in the order of nanometer, tens of nanometer, hundreds of nanometer and micron size, respectively. The effects of self-assembly on drug release and the biocompatible nature of the nanohybrids were monitored using HeLa cells, looking at cell viability, cell adhesion and fluorescence imaging. Significant sustained release of an anti-cancer drug was obtained using the chemically tagged nanohybrid and understanding gained of its kinetic behavior and mechanism. The greater biocompatibility of the chemically tagged nanohybrid was revealed through cell adhesion and fluorescence imaging, demonstrating a superior biomaterial which delivers the anti-cancer drug in a sustained manner. Hence, the developed nanohybrid is a potential biomaterial for drug delivery and tissue engineering. This journal is. © The Royal Society of Chemistry 2016.
Highly efficient and recyclable pre-catalysts based on mono- and dinuclear heteroleptic Cu(I) dithio- PPh3 complexes to produce variety of glycoconjugate triazoles
(Elsevier B.V., 2019) Avadhesh K. Singh; Chote Lal Yadav; Kunj Bihari Mishra; Santosh K. Singh; Ajit N. Gupta; Vinod Kumar Tiwari; Michael G.B. Drew; Nanhai Singh
Highly efficient and reusable pre-formed mono- and dinuclear heteroleptic copper(I) dithiocarbamate and dithiocarbimate complex based catalysts, [Cu(PPh3)2(L)] and [Cu2(PPh3)4(L)] (L = N-(4-methylpyridyl)-N-(3-methylpyridyl)dithiocarbamate− L1 1, N-methylfuryl-N-methylthiophenedithiocarbamate- L2 2; 4-chlorobenzenesulfonyl dithiocarbimate2- L3 3, 4-bromobenzenesulfonyldithiocarbimate2- L4 4) have been utilized in the cycloaddition reactions of azide and alkyne to form a variety of glycoconjugate triazoles in Click chemistry. These new pre-catalysts have been characterized by elemental (C, H, N) analysis, IR, UV–vis., 1H, 13C{1H}, and 31P{1H} NMR spectroscopy and their structures have been revealed by X-ray crystallography. In the structures of (1,2)/(3,4) the copper atoms are situated within a four coordinate (P2S2)/(P2NS) distorted tetrahedral geometry. Notably in the dinuclear complexes 3 and 4, the dithiocarbimate ligands are bonded in a S, S- chelating mode to one copper atom and simultaneously bridge the other copper centre via N, S- donor atoms. 1-4 are strongly luminescent in CH2Cl2 solution at room temperature. © 2019 Elsevier B.V.