Browsing by Author "Santosh Kumar Maurya"

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Antidiabetic activity of polyherbomineral formulation: Chandrakala rasa
(Medknow Publications, 2016) Alok Kumar Singh; Santosh Kumar Maurya; Damiki Laloo; Narendra Kumar Singh; Ankit Seth
Objective: Chandrakala rasa (CKR), a herbomineral formulation is used to treat diabetes mellitus in ayurvedic system of health care. The present study aims to evaluate the antihyperglycemic potential of CKR in normoglycemic and streptozotocin (STZ)-nicotinamide (NAD)-induced Type 2 diabetic rats. Materials and Methods: Effects of CKR (100, 200 and 400 mg/kg, p.o.) on hypoglycemia as well as on oral glucose tolerance test (OGTT) were evaluated in normoglycemic rats by measuring the blood glucose concentrations. Similarly, blood glucose level was measured after 7, 14 and 21 days in STZ-NAD-induced diabetic rats treated with CKR. Different biochemical parameters such as total cholesterol, triglyceride, low density lipoprotein-cholesterol, and high density lipoprotein-cholesterol were estimated in a blood sample. In vivo antioxidant potential of CKR was measured in isolated liver sample of rats. Results: CKR (400 mg/kg, p.o.) did not show any hypoglycemic effect in normoglycemic rats. In OGTT, it significantly reduced the hike in blood glucose levels within 30-60 min after glucose administration without causing any hypoglycemic effect. Administration of CKR significantly reduced the fasting blood glucose levels on 7th, 14th and 21st days in STZ-NAD-induced diabetic rats. Treatment of rats with CKR reversed plasma lipid profile as well as increases liver glycogen level significantly in STZ-NAD-induced diabetic rats. Treatment with CKR in diabetic rats significantly restored the levels of lipid per-oxidation, superoxide dismutase and catalase as compared to negative control rats. Conclusion: The present study showed that CKR has antidiabetic activity probably because of antioxidant potential.
Clinical efficacy of moringa oleifera lam. Stems bark in urinary tract infections
(Hindawi Limited, 2014) Santosh Kumar Maurya; Anil Kumar Singh
Objective. Urinary tract infections (UTI) are the most common problem in clinical practice. Usually they are asymptomatic and are commonly present with distressing symptoms like pain and burning sensation on urination. Antibiotics are widely used to treat UTIs; however, they have their own limitations like resistance, reinfection, and relapses.The purpose of the current study was to evaluate the value of Moringa oleifera Lam. stem bark as a potential medicine for UTIs. Study Design. 30 patients with UTI were randomly divided into two groups with 15 patients in each group. Shigru bark was given to patients of the first group (trial group) and modern medicines were prescribed to the other group of patients. At least three follow-ups are taken in both groups at the end of every week of treatment. Results. After treatment 66.67 % were cured, 13.33 % improved, 13.33% patients have no change, and 6.67% relapsed in trial group and in control group 46.67% were cured, 26.66% improved, 6.67% patients have no change, and 20% relapsed. Interpretation and Conclusion.The trial drug is significant in the management of UTI. This study needs to be done on a large scale and for a long time. © Copyright 2014 S. K. Maurya and A. K. Singh.
Ethnomedicinal review of Usnakantaka (Echinops echinatus Roxb.)
(Medknow Publications, 2015) Santosh Kumar Maurya; Ashwini Kumar Kushwaha; Ankit Seth
Echinops echinatus Roxb. (E. echinatus), commonly known as "Usnakantaka," is a xerophytic herbaceous plant traditionally used as a stimulant to treat use the term Sexual debility in Indian traditional systems of medicine. The roots, leaves, fruit, and bark are extensively used in folk medicine as well as in Ayurveda. Also, the plant shows a wide range of pharmacological activities such as antifungal, analgesic, diuretic, reproductive, hepatoprotective, antioxidant, anti-inflammatory, wound-healing, antipyretic, and antibacterial properties. Among the several active constituents, apigenin, apigenin-7-O-glucoside, echinaticin, 5,7-dihydroxy-8,4'-dimethoxy-flavanone-5-O-α-L-rhamnopyranosyl-7-O - β-D-arabinopyranosyl-(14)-O-β-D-glucopyranoside are the most important in terms of reported pharmacological activities. The current review focuses on the updated information from various scientific studies and reports available in the context of the phytoconstituents and pharmacology of this plant. This review also provides adequate information about the use of this plant in an Indian system of medicine, Ayurveda.
Pharmacognostic evaluation of Latakaranja (Caesalpinia bonduc [L.] Roxb.)
(Medknow Publications, 2015) Bhavana Mehra; Santosh Kumar Maurya; K.N. Dwivedi
Background: Latakaranja [Caesalpinia bonduc (L.) Roxb. (Caesalpiniaceae)] is a prickly shrub used to cure number of diseases in Ayurveda. Method: The present study has been carried for pharmacognostical and phytochemical standardization of plant material as per WHO guidelines. Result: Seeds of C. bonduc are greenishgrey to bluish grey in color, globous or rounded, smooth, shiny, 1.2 o 2.5 cm in diameter. Powdered seed showed the presence of columnar palisade cells, bone-shaped thick-walled, parenchymatous cells with resinous contents and roundish to polygonal bearer cells. TLC of the seed alcoholic extract was also performed in the present study. Physicochemical standards quantified includes foreign organic matter (1.0% w/w), loss on drying (2.88% w/w), total ash (10.4% w/w), water soluble ash (10.2% w/w), acid insoluble ash (3.2% w/w), water soluble extractive (14.6% w/w), alcohol soluble extractive (26.68% w/w). Phytochemical screening of aqueous extracts showed the presence of alkaloids, carbohydrates, flavonoids, triterpenoids, proteins, saponins, steroids, tannins and glycosides. Safety profile of plant material was established by quantify microbial load, pesticide residue content and heavy metals (Hg, Zn, Cd and Pb) analysis. Total aerobic organisams (cfu/g) was found to be 1.75 × 103 but no visible microbial growths were observed in seed sample. Pesticide residue content and heavy metals were found to be present within the permissible limits. Conclusion: In conclusion, the diagnostic characters obtained from the seed of C. bonduc will provide necessary information in identifying the crude drugs and comparing this plant from other closely related Caesalpinia species.
Standardization and antioxidant activity of an Ayurvedic formulation "Kushavleha"
(Medknow Publications, 2015) Vineet Sharma; Kritika Hem; Seth Ankit; Santosh Kumar Maurya
Background: Kushavleha, an Ayurvedic polyherbal formulation is an effective medicine for urinary calculi and many more. The present study was carried out to standardize the formulation and established its antioxidant activity in vitro. Methods: The formulation was prepared in the laboratory with authenticated plant drugs. The standardization procedure was conducted on the basis of pharmacognostical and phytochemical parameters as directed by World Health Organization guidelines. Results: Powder study of Kushavleha shows several diagnostic characters such as starch with concentric hilum, pitted vessel, stone cells, fiber with oil globules, pollen grains, lignified fiber epidermis of testa, unicellular trichome and stellate trichome. However some major phytoconstituents like flavonoids, phenolics, tannins, steroids, glycosides, alkaloids and amino acids were found to be positive in preliminary phytoconstituent screening of formulation. Total phenolic, tannin, flavonoid and flavonol content were found to be 144.60 ± 0.41 mg/g in gallic acid equivalent, 123 ± 0.53 mg/g in tannic acid equivalent, 69 ± 0.12 mg/g in rutin equivalent and 0.61 ± 0.27 mg/g in rutin equivalent respectively. Moreover, total solid content, fat content, sugar content, reducing sugar and non reducing sugar were found to be 69 % (w/w), 3.08% (w/w), 68.70% (w/w), 14.21% (w/w) and 54.49% (w/w) respectively. The formulation also exhibited potential antioxidant activity in in vitro DPPH scavenging screening with an IC50 of 63.80 μg/mL. Conclusion: The present result will help in the quality control standardization tool for the manufacturing and processing of Kushavleha.
Therapeutic significance and pharmacological activities of antidiarrheal medicinal plants mention in Ayurveda: A review
(eJManager LLC, 2016) Ashish Mishra; Ankit Seth; Santosh Kumar Maurya
Diarrhea is a serious problem affecting 3-5 billion people per year around the world, especially children of below 5 years. 70% of the world population uses traditional and indigenous medicine for their primary health care. The facts of these indigenous remedies are passed verbally and sometimes as documents. Since ancient time, Ayurveda is the main system of healing in South East Asian countries. Indian literature from ayurvedic texts and other books claim the potency of several plants in the treatment of diarrhea. As the global prospective of ayurvedic medicine is increasing, interest regarding the scientific basis of their action is parallely increasing. Researchers are doing experiments to establish the relation between the claimed action and observed pharmacological activities. In the present article, an attempt was made to compile the scientific basis of medicinal plants used to cure diarrhea in Ayurveda. Literature was collected via electronic search (PubMed, ScienceDirect, Medline, and Google Scholar) from published articles that reports antidiarrheal activity of plants that were mentioned in Ayurveda classics. A total of 109 plant species belonging to 58 families were reported for their antidiarrheal activity. Several Indian medicinal plants have demonstrated promising antidiarrheal effects, but the studies on the antidiarrheal potentials of these plants are not taken beyond proof of concept stage. It is hoped that the article would stimulate future clinical studies because of the paucity of knowledge in this area. © SAGEYA.