Browsing by Author "Santoshkumar Biradar"

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Enhanced mechanical properties of hBN-ZrO2 composites and their biological activities on: Drosophila melanogaster: Synthesis and characterization
(Royal Society of Chemistry, 2019) Amarendra Gautam; Chandkiram Gautam; Monalisa Mishra; Vijay Kumar Mishra; Ajaz Hussain; Swetapadma Sahu; Reetuparna Nanda; Bikash Kisan; Santoshkumar Biradar; Rakesh Kumar Gautam
In this study, six compositions in the system [x(h-BN)-(100 - x)ZrO2] (10 ≤ x ≤ 90) were synthesized by a bottom up approach, i.e., the solid-state reaction technique. XRD results showed the formation of a novel and main phase of zirconium oxynitrate ZrO(NO3)2 and SEM exhibited mixed morphology of layered and stacked h-BN nanosheets with ZrO2 grains. The composite sample 10 wt% h-BN + 90 wt% ZrO2 (10B90Z) showed outstanding mechanical properties for different parameters, i.e., density (3.12 g cm-3), Young's modulus (10.10 GPa), toughness (2.56 MJ m-3), and maximum mechanical strength (227.33 MPa). The current study further checked the in vivo toxicity of composite 10B90Z and composite 90B10Z using Drosophila melanogaster. The composite 10B90Z showed less cytotoxicity in this model, while the composite 90B10Z showed higher toxicity in terms of organ development as well as internal damage of the gut mostly at the lower concentrations of 1, 10, and 25 μg mL-1. Altogether, the current study proposes the composite 10B90Z as an ideal compound for applications in biomedical research. This composite 10B90Z displays remarkable mechanical and biological performances, due to which we recommend this composition for various biomedical applications. © ??? The Royal Society of Chemistry.
Synthesis and enhanced mechanical properties of MgO substituted hydroxyapatite: A bone substitute material
(Royal Society of Chemistry, 2016) C.R. Gautam; Sunil Kumar; Santoshkumar Biradar; Sujin Jose; Vijay Kumar Mishra
Hydroxyapatite (HAp) nano-ceramic powder was synthesized successfully via microwave irradiation technique. To study the effect of MgO inclusion on the mechanical properties of pure HAp, its composites with different (0.1, 0.2, 0.3 and 0.5) wt% of MgO were prepared. The influence of sintering temperature on the mechanical properties of pure HAp and its composites with MgO was also observed at 1000, 1100, 1200 and 1300 °C respectively. Samples were characterized by using X-ray diffraction (XRD) to determine the phase stability. The mechanical properties of pure HAp and its composites with MgO were measured using several parameters such as density, Young's modulus, fracture toughness, load bearing capability and porosity. It was revealed that MgO addition significantly enhanced the grain growth as well as the mechanical properties of HAp. The HAp composite modified with 0.5 wt% of MgO sintered at 1200 °C exhibited the best mechanical characteristics. This composite exhibits density of 3.04 g cm-3, Young's modulus of 126.31 GPa, fracture toughness of 178.58 MJ cm-3 and a maximum load bearing capability of 11.61 kN. To authenticate the biocompatibility of prepared biomaterials, the cell viability (MTT assay) was carried out and the mechanically best composite was found to be compatible for biomedical applications. © The Royal Society of Chemistry 2016.