Browsing by Author "Saurabh Gupta"

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A field-theoretic model for Hodge theory
(2008) Saurabh Gupta; R.P. Malik
We demonstrate that the four-dimensional (4D) ((3+1)-dimensional) free Abelian 2-form gauge theory presents a tractable field-theoretical model for the Hodge theory where the well-defined symmetry transformations correspond to the de Rham cohomological operators of differential geometry. The conserved charges, corresponding to the above continuous symmetry transformations, obey an algebra that is reminiscent of the algebra obeyed by the cohomological operators. The discrete symmetry transformation of the theory represents the realization of the Hodge duality operation that exists in the relationship between the exterior and co-exterior derivatives of differential geometry. Thus, we provide the realizations of all the mathematical quantities, associated with the de Rham cohomological operators, in the language of the symmetries of the present 4D free Abelian 2-form gauge theory. © 2008 Springer-Verlag / Società Italiana di Fisica.
A note on the (anti-)BRST invariant lagrangian densities for the free abelian 2-form gauge theory
(2010) Saurabh Gupta; R.P. Malik
We show that the previously known off-shell nilpotent (s (a)b2 = 0) and absolutely anticommuting (sb sab + sab sb = 0) BecchiRouetStoraTyutin (BRST) transformations (sb) and anti-BRST transformations (sab) are the symmetry transformations of the appropriate Lagrangian densities of a four (3+1)-dimensional (4D) free Abelian 2-form gauge theory which do not explicitly incorporate a very specific constrained field condition through a Lagrange multiplier 4D vector field. The above condition, which is the analogue of the CurciFerrari restriction of the non-Abelian 1-form gauge theory, emerges from the EulerLagrange equations of motion of our present theory and ensures the absolute anticommutativity of the transformations s(a)b. Thus, the coupled Lagrangian densities, proposed in our present investigation, are aesthetically more appealing and more economical. © 2010 World Scientific Publishing Company.
Augmented superfield approach to non-yang-mills symmetries of Jackiw-Pi model: Novel observations
(2013) Saurabh Gupta; R. Kumar
We derive the off-shell nilpotent and absolutely anti-commuting Becchi-Rouet-Stora-Tyutin (BRST) as well as anti-BRST symmetry transformations corresponding to the non-Yang-Mills (NYM) symmetry transformations of (2+1)-dimensional Jackiw-Pi (JP) model within the framework of "augmented" superfield formalism. The Curci-Ferrari (CF) restriction, which is a hallmark of non-Abelian one-form gauge theories, does not appear in this case. One of the novel features of our present investigation is the derivation of proper (anti-)BRST symmetry transformations corresponding to the auxiliary field ρ that cannot be derived by any conventional means. © 2013 World Scientific Publishing Company.
Comparative transcriptomic profiling of High- and Low- grain Zinc and Iron containing Indian wheat genotypes
(Elsevier B.V., 2019) Vinod Kumar Mishra; Saurabh Gupta; Ramesh Chand; Punam Singh Yadav; Satish Kumar Singh; Arun Kumar Joshi; Pritish Kumar Varadwaj
Development of minerals rich grains with stress tolerance response (STR) wheat cultivars will help to eradicate malnutrition problem globally. The current study deals with the comparative transcriptome analysis of 4 High- and 3 Low- grain Zinc (Zn) & Iron (Fe) containing wheat genotypes (HZFWGs, LZFWGs) to elucidate the genes responsible for mineral transportation mechanism and stress tolerance response(STR). Differentially expressed genes (DEGs) and their functional role in metabolic pathways of mineral transportation, as well as other important pathways, have been explored. Gene ontology (GO) and pathways analysis revealed that phenylpropanoid biosynthesis and other associated pathways are mainly involved in plant stress defense mechanism in both genotypes. Chlorophyll synthesis, purine metabolism, Zn & Fe binding, metal ion transport, and ATP-Synthase coupled transport mechanism are highly active in HZFWGs while ribosomal formation, biomolecules binding activities and secondary metabolite biosynthesis in LZFWGs. It was also found that genes accountable for minerals uptake and purine metabolism in HZFWGs are highly enriched. The genes identified in this study may be used for marker-assisted selection and breeding to develop minerals rich crops. © 2019 The Authors
Deciphering genome-wide WRKY gene family of Triticum aestivum L. and their functional role in response to Abiotic stress
(Genetics Society of Korea, 2019) Saurabh Gupta; Vinod Kumar Mishra; Sunita Kumari; Raavi; Ramesh Chand; Pritish Kumar Varadwaj
WRKY transcription factors (TFs) act in regulating plant growth and development as well as in response to different stress. Some earlier studies done by individual researchers reported different wheat WRKY TFs. Although, the recently released wheat genome has opened an avenue to investigate wheat WRKYs (TaWRKY) TFs. Prime objective of this study to performed genome-wide classifications of TaWRKYs and their functional annotation. The classification of 107 individual identified characterized sequences of TaWRKY (IICS-TaWRKY) and 160 uncharacterized draft sequences of TaWRKY (UDS-TaWRKY), along with their gene structures and motifs analysis was performed. Along with comparative sequence analysis and microarray analysis was performed to mimic out TaWRKYs functions in response to different abiotic stresses, accompanied by in-vitro validation. The comparative phylogenetic analysis and estimation of Ka/Ks ratio with Triticum urartu, illustrate group based clasifications of TaWRKYs and evolutionary divergences. Furthermore, motif-based and protein-DNA interaction analysis of TaWRKYs helps to identify, their putative function in target DNA recognition sites. Subsequently, results of microarray and comparative sequence analysis provides the evidence of TaWRKYs involved in heat and/or drought stress. Further, in-vitro results validates that TaWRKY014, TaWRKY090 are found to participate in response of drought stress, whereas TaWRKY008, TaWRKY122, and WRKY45 are involved in response of heat and drought stress. These findings can be utilized in developing novel heat and drought-tolerant wheat cultivars using marker-assisted breeding and transgenic development. © 2018, The Genetics Society of Korea and Springer Nature B.V.
Extrapolation of hydroxytyrosol and its analogues as potential anti-inflammatory agents
(Taylor and Francis Ltd., 2020) Naresh Kumar; Biswajit Gorai; Saurabh Gupta; Shiva; Nidhi Goel
Discovery of potential lead molecule is a challenging, and complex process which require lots of money, patience, and manpower. Human beings are using natural products, predominantly secondary metabolites, for this purpose since ancient time and they are still working on them as a potent source for drug discovery due to their wide structural diversity. Phenolic phytochemicals such as hydroxytyrosol and tyrosol are natural antioxidant and involved in many biological disease cure. Herein, we have carried out the quantum chemical calculations for conformational analysis, geometry optimization and computation of electronic as well as optical properties of hydroxytyrosol and its analogues (1a–1k) in terms of density functional theory by using Gaussian 09 program suite. The eventual charge transfer within the molecules has been confirmed by the analysis of frontier molecular orbitals. The molecular docking studies of 1a–1k with cyclooxygenase-2 showed the noticeable binding affinity as compared to other nonsteroidal anti-inflammatory drugs viz. aspirin, naproxen and celecoxib. Computation of pharmacokinetics and pharmacological properties confirmed the lead/drug like potential of these screened molecules. Furthermore, the molecular dynamics simulation of best three docked ligands (1f, 1h and 1k)-receptor complex and their binding free energy calculations reveals that these molecules bind in the catalytic cavity of cyclooxygenase-2 and found stable during the 100 ns of simulation. Communicated by Ramaswamy H. Sarma. © 2020, © 2020 Informa UK Limited, trading as Taylor & Francis Group.
Extrapolation of phenolic compounds as multi-target agents against cancer and inflammation
(Taylor and Francis Ltd., 2019) Naresh Kumar; Saurabh Gupta; Tara Chand Yadav; Vikas Pruthi; Pritish Kumar Varadwaj; Nidhi Goel
Natural products acquire massive structural and chemical diversity, which cannot be coordinated by any synthetic libraries for small molecules and they are continuing to inspire novel discoveries in health sciences. We have performed the computational calculations for geometry optimization and prediction of electronic and structural properties of some plant phenolic compounds through Gaussian 09 program. Energies of molecular orbitals were computed, to mimic out the stabilities arising from charge delocalization and intramolecular interactions. This process indicated the eventual charge transfer within the molecules. The molecular docking and ADMET properties of these compounds with a novel anticancer (HER2) and anti-inflammatory (COX-2) targets revealed that two molecules were capable of inhibiting both the targets, and could be used as multi target inhibitors. Furthermore, molecular dynamics simulation studies were performed to elucidate the binding mechanism and the comparison of inhibitor’s binding mode with diverse biological activities as anticancer and anti-inflammatory agents. A high-quality association was reported among quantum chemical, ADMET, docking, dynamics and MMGBSA results. Communicated By Ramaswamy H. Sarma. © 2018, © 2018 Informa UK Limited, trading as Taylor & Francis Group.
INTENTION to revisit a tourism destination: An empirical study of Bundelkhand, India
(Apple Academic Press, 2017) Saurabh Gupta; Onkar Nath Mishra
As tourism industry becomes more competitive, increasing the frequency of visit to a destination becomes a strategic objective. In such a context, understanding the antecedents of revisit intention can contribute a lot in decision-making processes related to tourism product development. This chapter investigated and presented the results of role of personal characteristics of tourists and purpose of visit in predicting revisit intention for destination Bundelkhand, India. The study indicated that marital status was the only sociodemographic variable that had significant influence on the revisit intention of tourists. Travel-related variables (purpose of visit and touring as a hobby) were found to be statistically significant predictor of revisit intention. © 2018 by Apple Academic Press, Inc.
Measurement scale of tourism destination competitiveness: Supply side perspectives
(SCMS Group of Educational Institutions, 2019) Saurabh Gupta; Anurag Singh
This study is mainly focused on the development and validation of a measurement scale of Tourism Destination Competitiveness from supply side employing a stakeholder's perspective. The study uses primary data to extract the measurement item. It uses confirmatory factor analysis to identify the appropriate dimensions of tourism destination competitiveness. This study has succeeded in developing and validating an TDC scale consisting of eight dimensions i.e., Natural, Culture and Heritage, Tourism Infrastructure, Range of recreational Activities, Shopping, and Entertainment, General Infrastructure and Hospitality. © 2019 SCMS Group of Educational Institutions. All rights reserved.
Molecular targets and therapeutic potential of baicalein: a review
(AboutScience Srl, 2024) Kavita Munjal; Yash Goel; Vinod Kumar Gauttam; Hitesh Chopra; Madhav Singla; Smriti; Saurabh Gupta; Rohit Sharma
Aim: Researchers using herbs and natural products to find new drugs often prefer flavonoids because of their potential as antioxidants and anti-inflammatories. The planned review addressed baicalein research findings in detail. This manuscript provides a complete review of baicalein’s potential pharmacological effects along with several molecular targets for better understanding of its therapeutic activities. Materials and methods: We targeted the review on in vitro and in vivo studies reported on baicalein. For this, the literature is gathered from the database available on search engines like PubMed, ScienceDirect, Scopus, and Google Scholar up to 21 December 2023. The keywords “Scutellaria baicalensis”, “Oroxylum indicum”, “Neuroprotective”, “Cardioprotective”, “Toxicity studies”, and “Baicalein” were used to fetch the content. Results: Baicalein’s molecular receptor binding approach has shown anticancer, antidiabetic, antimicrobial, antiaging, neuroprotective, cardioprotective, respiratory protective, gastroprotective, hepatic protective, and renal protective effects. The synergistic effects of this drug with other selective herbs are also contributed towards significant therapeutic potential. Conclusion: This systematic review article from a contemporary and scientific perspective offers fresh insight into S. baicalensis, O. indicum, and its bioactive component baicalein as a potential complementary medicine. Baicalein may be transformed into more efficacious and acceptable evidence-based medicine. However, we recommend more clinical and mechanistic approaches to confirm safety and efficacy of baicalein. © 2024 The Authors.
Pseudo-Hermitian interactions in dirac theory: Examples
(2010) Bhabani Prasad Mandal; Saurabh Gupta
We consider a couple of examples to study the pseudo-Hermitian interaction in relativistic quantum mechanics. Rasbha interaction, commonly used to study the spin Hall effect, is considered with imaginary coupling. The corresponding Dirac Hamiltonian is shown to be parity pseudo-Hermitian. In the other example we consider parity pseudo-Hermitian scalar interaction with arbitrary parameter in Dirac theory. In both cases we show that the energy spectrum is real and all the other features of nonrelativistic pseudo-Hermitian formulation are present. Using the spectral method, the positive definite metric operator (η) has been calculated explicitly for both the models to ensure positive definite norms for the state vectors. © 2010 World Scientific Publishing Company.
Rigid rotor as a toy model for Hodge theory
(2010) Saurabh Gupta; R.P. Malik
We apply the superfield approach to the toy model of a rigid rotor and show the existence of the nilpotent and absolutely anticommuting Becchi-Rouet-Stora-Tyutin (BRST) and anti-BRST symmetry transformations, under which, the kinetic term and the action remain invariant. Furthermore, we also derive the off-shell nilpotent and absolutely anticommuting (anti-) co-BRST symmetry transformations, under which, the gauge-fixing term and the Lagrangian remain invariant. The anticommutator of the above nilpotent symmetry transformations leads to the derivation of a bosonic symmetry transformation, under which, the ghost terms and the action remain invariant. Together, the above transformations (and their corresponding generators) respect an algebra that turns out to be a physical realization of the algebra obeyed by the de Rham cohomological operators of differential geometry. Thus, our present model is a toy model for the Hodge theory. © 2010 Springer-Verlag / Società Italiana di Fisica.
Social media and business: In search of missing links
(IGI Global, 2017) Saurabh Gupta; Anurag Singh; Punita Duhan
The influence of social media on the various facets of society has attracted a lot of attention of the researchers in the last few years who are probing its multifaceted impact. One important aspect of social media is its role in promoting instant gratification. It has far reaching consequences for evolution of self, which in turn has important implications for society and businesses. Drawing from the conceptual foundations of the theories of identity and social comparison, the researchers tried to develop a model as to how the dual role of social media acts to alter the identity and hence behavior. In this context, the significance of the study lies in exposing the intricate interplay between the attributes of social media and the dynamic self. The study goes a long way in providing a deeper understanding of self-concept in connection to social media, which has immense importance for consumer behavior and can help businesses to fine-tune their strategies with the changing consumer psychology. © 2018, IGI Global.
UNDERSTANDING RESIDENTS’ PERCEPTION OF RURAL TOURISM DEVELOPMENT IN CENTRAL INDIA: AN EMPIRICAL STUDY
(National Institute of Rural Development, 2018) Anurag Singh; Saurabh Gupta
Tourism is a dynamic industry which is continuously evolving in response to the changes in the micro and macro environment. Over the years, new forms of tourism have come up like medical tourism, sports tourism, eco tourism, rural tourism, etc. The development of rural tourism has come to be regarded as a potent tool to foster development of rural communities. It has led to extensive impacts on the local rural communities. It has been widely recognised that tourism development is a double-edged sword for host communities. Not only does it generate benefits, but it also imposes costs. By evaluating these benefits and costs, local residents develop their attitudes toward tourism. Numerous studies have examined how rural residents perceive such impacts in their communities. However, these research findings are often contradictory. As perceptions and attitudes of residents towards tourism are particularly important for the future success of the tourism industry, this study bases it focus on the perception of residents towards the rural tourism development in the central region of India.In the present study, six variables such as age, gender, education level, involvement in tourism, residential proximity and length of residence, were tested. It was found that none of these six variables had a significant difference existing in the perception of rural tourism impacts, both positive and negative. © 2018 National Institute of Rural Development. All rights reserved.