Browsing by Author "Shailesh Singh"

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An Autosomal Recessive Eye Colour Mutant of Melon Fruit Fly, Bactrocera cucurbitae (Coquillett)
(Springer, 2020) Shailesh Singh; Naveen Yadav; A.K. Singh
Bactrocera cucurbitae is commonly known as melon fruit fly. It is a serious pest of several vegetable and fruit plants grown all across the world. The morphological features and damaging nature of this pest species have been well documented. However, the genetics of its any mutation that results into phenotypic variation has not been mentioned at all. While working on this fly, we found a golden brown eye mutant that showed eye colour variation from the wild type flies (bluish green eye coloured). By setting different crosses to get F1 and F2 flies, this has been ascertained that the eye colour mutation is autosomal recessive in nature. The preliminary results of some of the experiments involving mutants clearly depict the pleiotropic effect of this mutant gene. © 2019, Zoological Society, Kolkata, India.
Carcinoma of the gallbladder: Role of sonography in diagnosis and staging
(2000) Manoj Pandey; Bimal P. Sood; Ram C. Shukla; Nakul C. Aryya; Shailesh Singh; Vijay K. Shukla
Purpose. In an attempt to define the sonographic characteristics of gallbladder cancer, we retrospectively analyzed the sonographic findings in 203 cases of gallbladder cancer confirmed by cytology or histopathology. Patients and Methods. Patients with proven gallbladder cancer presenting to a single surgical unit between 1991 and 1995 were identified through a records search. All patients underwent sonographic examination followed by fine- needle aspiration (FNA), biopsy, or laparotomy for establishing the diagnosis. Results. A mass in the gallbladder and gallbladder wall thickening (> 12 mm) were cardinal sonographic findings of carcinoma. Liver infiltration was correctly identified in all patients who had it. Sonography was highly accurate for detecting mass lesions, gallstones, liver infiltration, metastasis, and ascites. However, visualization of lymph nodes, common bile duct infiltration, and peritoneal dissemination was poor. Conclusions. Sonography was found to be a good diagnostic tool for carcinoma of the gallbladder; however, its sensitivity was poor for staging nodal spread of the disease. (C) 2000 John Wiley and Sons, Inc.
Effect of platelet counts and activator in platelet-rich plasma on the treatment of androgenetic alopecia, split-head comparison: A randomised, double-blind study
(Scientific Scholar, 2023) Satyendra K. Singh; Shailesh Singh
Background: Androgenetic alopecia is a common, chronic, non-scarring alopecia. It is characterised by stepwise miniaturisation of the hair follicles, due to alteration in the hair cycle dynamics, leading to the transformation of terminal hair follicles into a vellus ones. Oral finasteride and topical minoxidil are the only approved drugs for treating this condition. Due to a limited number of effective therapies for androgenetic alopecia, platelet-rich plasma may be an effective alternative treatment. Aims: To study the effect of activator in platelet-rich plasma and baseline platelet count in platelet-rich plasma on the treatment of androgenetic alopecia. Methods: A randomised, double-blind split-head comparative study. The sample size was calculated and randomisation was done. Patients with androgenetic alopecia were allocated into two groups; in the first group, autologous activated platelet-rich plasma was injected in the right half of the affected scalp and autologous non-activated platelet-rich plasma was injected in the left half of the affected scalp and vice versa in the second group. Patients were also categorised on the basis of platelet counts in their platelet-rich plasma in three groups; group A (6–8 lakh/mm3), group B (8.1–10 lakh/mm3) and group C (>10 lakh/mm3). Interventions were done monthly for three months and followed up for the next three months. Effects of interventions were assessed by hair density, hair thickness, patient self-assessment and clinical photography. Results: A total of 80 patients were included in the study. Activated platelet-rich plasma produced significant improvement of hair density after four months and hair thickness at 6 months. An increase in platelet count led to a significant increase in hair density and hair thickness after three and four months respectively and a highly significant increase in both parameters at the end of the study. Limitations: Long-term follow-up of cases was not done and no measurement of vellus hair count was done. Conclusion: There is a significant effect of activator and platelet count of the platelet-rich plasma on hair density as well as hair thickness. © 2023 Indian Journal of Dermatology, Venereology and Leprology - Published by Scientific Scholar.
Erythrocyte membrane fatty acid profile and saturation index in gallbladder carcinogenesis: A case-control study
(2003) Manoj Pandey; Lal B. Sharma; Shailesh Singh; Vijay K. Shukla
Background: Gallbladder cancer is a common neoplasm of biliary tract, with an unknown etiology. Patients and methods: This study was carried out to evaluate the changes in the membrane fatty acid profile and saturation index in patients with gallbladder cancer. The study sample consisted of 50 newly diagnosed cases of gallbladder cancer and 50 patients undergoing cholecystectomy for cholelithiasis were recruited as controls. The fatty acid estimation was carried out by high performance liquid chromatography (HPLC). Statistical analysis was carried out by student 't' test and one-way ANOVA. Pearson's correlation coefficient was also obtained. Results: A significant lowering of erythrocyte membrane stearic acid (p = 0.000), arachidonic acid (p = 0.001), and saturation index (p = 0.001) was observed in patients with gallbladder cancer compared to controls. A significant inverse relation was observed between stearic and oleic acid (r = -0.269 p = 0.007). Conclusion: Results of the present study suggest an increase in the delta 9 desaturation in cancer patients compared to controls however, a possible role of biliary stasis due to altered gallbladder motility or derangements of signal transduction secondary to altered membrane lipid bilayer cannot be ruled out. © 2003 Pandey et al; licensee BioMed Central Ltd.
Generalized lichenoid skin lesions: A rare manifestation of secondary syphilis
(Wolters Kluwer Medknow Publications, 2023) Satyendra Singh; Maneesh Meria; Mohammad Ansari; Shailesh Singh
[No abstract available]
Intra nuclear estrogen receptor status and its clinicopathological correlation in breast cancer patients
(1996) Hari D. Khanna; Shailesh Singh; Gaurav Agrawal; Rahul Khanna; Lalan P. Singh; Ranjana Khanna; Sushila Khanna
[No abstract available]
Stage specific feeding attributes and mobilization of nutrients in Mexican beetle, Zygogramma bicolorata Pallister on Parthenium hysterophorus L.
(Elsevier B.V., 2020) Priya Patel; Shailesh Singh; Arvind Kumar Patel; Bhupendra Kumar; Arvind Kumar Singh; Dinesh Kumar
Parthenium hysterophorus L. (Asteraceae) is a toxic weed of agricultural farms, pastures and wastelands with a pan-tropical distribution. The weed causes a reduction in crop production of agricultural fields and severe health problems in humans. The Mexican beetle, Zygogramma bicolorata Pallister (Coleoptera: Chrysomelidae) is among the most promising candidates for the weed biocontrol. However, no previous study has evaluated assimilation of nutrients in this beetle. In the present study, feeding attributes and assimilation of nutrients by larvae of Z. bicolorata were assessed on the weed. Results revealed that the first larval instars of Z. bicolorata exhibited lowest consumption rates, and accumulated minimum concentrations of glucose, proteins and triglycerides in their body. They showed compensatory feeding, and displayed highest food utilization efficiencies and developmental rates. In contrast, the fourth larval instars exhibited higher food consumption rates and conversion efficiencies, but displayed lowest developmental rates. Accumulation of food reserves was also recorded maximum for the fourth larval instars. Overall, the findings may aid current mass-rearing efforts for Z. bicolorata in laboratories, but field trials are still needed to strengthen the present findings. © 2020