Browsing by Author "Shashank Mishra"

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Analysis of Non-isotropic Lorentz Invariance Violation for NOνA Experiment in Disappearance Channel
(Springer Science and Business Media Deutschland GmbH, 2024) Saurabh Shukla; Shashank Mishra; Lakhwinder Singh; Venktesh Singh
Lorentz Invariance Violation (LIV) is a trending topic of Beyond Standard Model Physics. Lorentz symmetry is tasted and well established in the low energy realm of Physics. But there are various theories which suggest its violation for Planck scale phenomenon. As neutrinos, having tiny mass, are the particle that are breaking down the barriers of Standard Model, they may be an excellent tool for searching such Planck-suppressed signals. In order to do this study, we have opted for Standard model extension as the theoretical framewok, which contains all Lorentz violating tems in it. We study the non-isotropic LIV which causes the sidereal effect in the neutrino beamline experiment. Neutrino disappearance channel is simulated for the NOνA far detector. We find that NOνA FD is highly sensitive for the LIV and new limits of LIV coefficients are also predicted. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.
Investigating Lorentz invariance violation effects on CP violation and mass hierarchy sensitivity at DUNE
(American Physical Society, 2024) Saurabh Shukla; Shashank Mishra; Lakhwinder Singh; Venktesh Singh
One of the current goals of neutrino experiments is to precisely determine standard unknown oscillation parameters such as the leptonic CP phase and mass hierarchy. Lorentz invariance violation represents a potential physics factor that could influence the experiment's ability to achieve these precise determinations. This study investigates the influence of Lorentz invariance violation on oscillation dynamics, particularly through nonisotropic CPT-violating (aeμX, aeτX, aμτX) and CPT-conserving (ceμXY, ceτXY, cμτXY) parameters within the Deep Underground Neutrino Experiment. We analyze the impact of these parameters on the mass hierarchy (MH) and Dirac CP phase sensitivity measurements. Our findings indicate that while MH sensitivity remains relatively unaffected, only the presence of cμτXY significantly deteriorates MH sensitivity, albeit remaining above the 5σ threshold. Additionally, we observe a substantial compromise in CP sensitivity due to the ceμXY and ceτXY parameters. © 2024 authors. Published by the American Physical Society.
Microbe-mediated remediation of dyes: Current status and future challenges
(Open Science Publishers LLP Inc., 2023) Kriti Akansha; Tanvir Kaur; Ashok Yadav; Divjot Kour; Ashutosh Kumar Rai; Sangram Singh; Shashank Mishra; Lalit Kumar; Kanika Miglani; Karan Singh; Ajar Nath Yadav
An array of industrial dyes most often azo dyes (–N=N–) deployed for different staining purposes, consequently impacting the environment significantly. The increasing pace of dye production often produces enormous wastewater from textile processing. After processing steps, dyes concentration remains left in expelled wastewater, consequently causing water pollution, and triggers negative toxicological impacts. However, remediation or decolorization is necessitating minimizing its negative consequences. Improper treatment of dye-containing waste waters triggers pollution of soil, water bodies, and so on. Numerous biological, physical, and chemical approaches for dye degradation and wastewater decolorization have been established. However, the high cost and practical feasibility of such methodologies remain obstacles in dye-containing wastewater. Microbial-assisted remediation is predominantly resilient to transforming dye compounds and reducing toxicity from water matrices in the ability to cope and provide cost-effective and efficient solutions. To cover the literature gap, and highlighting recent update information on dye remediation, we outlined different azo dyes, and their remediation deploying different physicochemical and microbial-mediated systems. In addition, recent advances in dye degradation, together with concluding remarks and future perspectives, have been pointed out. © 2023 Kriti Akansha, et al.
Organoids and Alzheimer’s Disease
(CRC Press, 2024) Payal Singh; Shashank Mishra; Pradeep Kumar
Alzheimer’s disease (AD) is the primary neurodegenerative condition observed in the elderly population, characterised by cognitive decline, particularly in memory function, resulting in increased reliance on others for daily activities. AD is characterised by the presence of amyloid plaques and neurofibrillary tangles, which are made up of hyperphosphorylated tau and AΒ peptides, respectively. Currently, there is a lack of a definitive cure or efficacious treatment for AD. This phenomenon could be explained, at least in part, by the lack of suitable study models, especially when it comes to animal experimentation. The vast physiological complexity exhibited by the human brain is not entirely captured by the existing models. with the development of stem cells with induced pluripotency. Induced pluripotent stem cells (iPSCs) offer a way around these limitations. But current two-dimensional (2D) culture models are unable to reproduce the situation precisely. The brain has a variety of brain cell types, but its arrangement lacks a three-dimensional (3D) structure. The procurement of three-dimensional cultures, or organoids, offers a new opportunity to overcome the limitations of previous methods. Human cerebral organoids, or hCOs, are a novel model that captures some of the complex features of the human brain in this particular situation. They are becoming more acknowledged for their remarkable role as a paradigm for studying the evolutionary dimensions of the molecular and cellular etiology of Alzheimer’s disease. This chapter provides a succinct overview of the study on AD, with a focus on the most recent developments brought about by the creation and application of stem cells and cerebral organoid technology. © 2025 selection and editorial matter, Sachchida Nand Rai, Sandeep Singh, Santosh Kumar Singh.
Search for Lorentz violations through the sidereal effect at the NOν A experiment
(American Physical Society, 2024) Shashank Mishra; Saurabh Shukla; Lakhwinder Singh; Venktesh Singh
Long-baseline neutrino oscillation experiments offer a unique laboratory to test the fundamental Lorentz symmetry, which is at the heart of both the standard model of particle and general relativity theory. The sidereal modulation in neutrino events will act as the smoking-gun experimental signature of Lorentz and CPT violation. In this study, we investigate the impact of the sidereal effect on standard neutrino oscillation measurements within the context of the NuMI Off-Axis νe Appearance Experiment (NOνA) experiment. Additionally, we assess the sensitivity of the NOνA experiment to detect Lorentz-violating interactions, taking into account the sidereal effect. Furthermore, we highlight the potential of the NOνA experiment to set new constraints on anisotropic Lorentz-violating parameters. © 2024 authors. Published by the American Physical Society. Published by the American Physical Society under the terms of the "https://creativecommons.org/licenses/by/4.0/"Creative Commons Attribution 4.0 International license. Further distribution of this work must maintain attribution to the author(s) and the published article's title, journal citation, and DOI. Funded by SCOAP3.
Structural and functional diversity of plant growth promoting microbiomes for agricultural sustainability
(Open Science Publishers LLP Inc., 2022) Tanvir Kaur; Divjot Kour; Olivia Pericak; Collin Olson; Rajinikanth Mohan; Ashok Yadav; Shashank Mishra; Manish Kumar; Ashutosh Kumar Rai; Ajar Nath Yadav
The plant allied microbes are phyllospheric, endophytic, and rhizospheric that is allied with plants eco-systems. These microbes have are termed as plant growth promoting (PGP) microbes as they have an ability to enhance growth of plant through indirectly or directly PGP mechanisms. The PGP microbes improve the growth and development of plant under both normal and diverse abiotic stresses conditions of temperatures, pH, salinity and drought. The microbes uses subsequent mechanism to stimulate the plant growth like biological nitrogen fixation; solubilization of minerals (P, K and Zn); production of phyto-hormones (Indole acetic acid, cytokinin and gibberellic acid); 1-aminocyclopropane-1-carboxylate deaminase attributes; production of extracellular hydrolytic enzymes (amylase, cellulase, chitanase, pectinase, protease, and xylanase), siderophores, hydrogen cyanide and ammonia. The PGP microbes sorted out from soil and plant associated are belong to several phylum of all three domain, that is, Archaea, Bacteria and Eukarya with predominant species of genera Arthrobacter, Pseudomonas, Aspergillus, Bacillus, Burkholderia, Colletotrichum, Exiguobacterium, Flavobacterium, Fusarium, Halobacillus, Haloferax, Lysinibacillus, Paenibacillus, Penicillium, Psychrobacter, Sediminibacillus, Streptomyces, Trichoderma, and Virgibacillus. In agriculture PGP microbiomes potentiality has increased steadily as it is an effective way to reduce the use of different chemical-based fertilizer, pesticide and other supplements. Present progress on research related to PGP microbial diversity (plant and soil microbiomes), along with their colonizing capability and action’s mechanism should increase their applications for plant growth and disease management of agricultural system toward the agricultural sustainability. Present review deals with the structural and functional diversity of PGP microbiomes for agricultural sustainability. © 2022 Kaur, et al.
The Impact of Sidereal Variation on Time-Independent Probability Analysis in Neutrino Long-Baseline Experiments
(Springer Science and Business Media Deutschland GmbH, 2024) Shashank Mishra; Saurabh Shukla; Lakhwinder Singh; Venktesh Singh
Lorentz invariance is a well-known fundamental symmetry, serving as the pillar of widely accepted theories such as quantum field theory and Einstein theory of relativity, and has deep connections with the charge, parity, and time-reversal symmetry. The search for Lorentz invariance violation (LIV) is getting more attention in recent years due to many theories of beyond standard model (Stochastic space-time foam, quantum loop gravity, string theory, etc.) predicting LIV in high-energy physics. We adopt the non-isotropic model to study the LIV parameters. We compare the impact of LIV in different long-baseline neutrino experiments and shows how they are sensitivity depends on their position and orientation. We have also investigated the effect of the non-isotropic LIV parameter on disappearance channels in time-independent analysis. © The Author(s), under exclusive license to Springer Nature Singapore Pte Ltd. 2024.
Transcriptome and proteome analyses reveal selenium mediated amelioration of arsenic toxicity in rice (Oryza sativa L.)
(Elsevier B.V., 2020) Reshu Chauhan; Surabhi Awasthi; Yuvraj Indoliya; Abhishek Singh Chauhan; Shashank Mishra; Lalit Agrawal; Sudhakar Srivastava; Sanjay Dwivedi; Poonam C. Singh; Shekhar Mallick; Puneet Singh Chauhan; Veena Pande; Debasis Chakrabarty; Rudra Deo Tripathi
Arsenic (As), a chronic poison and non-threshold carcinogen, is a food chain contaminant in rice, posing yield losses as well as serious health risks. Selenium (Se), a trace element, is a known antagonist of As toxicity. In present study, RNA seq. and proteome profiling, along with morphological analyses were performed to explore molecular cross-talk involved in Se mediated As stress amelioration. The repair of As induced structural deformities involving disintegration of cell wall and membranes were observed upon Se supplementation. The expression of As transporter genes viz., NIP1;1, NIP2;1, ABCG5, NRAMP1, NRAMP5, TIP2;2 as well as sulfate transporters, SULTR3;1 and SULTR3;6, were higher in As + Se compared to As alone exposure, which resulted in reduced As accumulation and toxicity. The higher expression of regulatory elements like AUX/IAA, WRKY and MYB TFs during As + Se exposure was also observed. The up-regulation of GST, PRX and GRX during As + Se exposure confirmed the amelioration of As induced oxidative stress. The abundance of proteins involved in photosynthesis, energy metabolism, transport, signaling and ROS homeostasis were found higher in As + Se than in As alone exposure. Overall, present study identified Se responsive pathways, genes and proteins involved to cope-up with As toxicity in rice. © 2020 Elsevier B.V.