Browsing by Author "Shipra Sahai"

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    Dendritic cell therapy in advanced gastric cancer: A promising new hope?
    (2012) Mallika Tewari; Shipra Sahai; Raghvendra R. Mishra; Sunit K. Shukla; Hari S. Shukla
    Advanced gastric cancer carries a very poor prognosis when the tumor becomes unresectable. Even with the best currently available chemotherapy regimens the survival rate remains dismal. A recent breakthrough in the treatment paradigm has been the approval of trastuzumab, a monoclonal antibody, in HER2-positive metastatic gastric cancer. A large number of trials are underway using dendritic cells (DCs) in a number of human malignancies and do show a ray of hope in management of these patients. This review attempts to summarize tumor immunology and the current data regarding use of DCs in gastric cancer therapy. © 2012 Elsevier Ltd. All rights reserved.
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