Browsing by Author "Shivani Pathak"

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A Marine Bioactive Compound Fistularin-3 Against SARS-CoV-2 and the Underlying Mechanism
(Apple Academic Press, 2025) Shivani Pathak; Kalpana Patni; Neha Garg
Severe Acute Respiratory Syndrome (SARS-CoV-2) has made COVID-19 a global concern to public health over the past few years. People are unfavorably impacted by the COVID-19 pandemic, which has led to high rates of mortality and illness in several nations. The study of antiviral compounds has recently become of great interest to researchers due to viral diseases such as SARS-CoV-2. The fast evolution of viruses and their capacity to acquire drug resistance is the force behind the discovery of novel antiviral medications. A number of vaccines can provide protection against SARS-CoV-2. The evolution of new viral variants, inconsistent availability of the vaccine around the world, and vaccine hesitancy make it unreasonable to rely on mass vaccination alone to combat this pandemic. Several lead antiviral compounds have been isolated from marine sponges that have shown the potential to target SARS-CoV-2. One of the potent bioactive marine hexabrominated tyrosine alkaloids, fistularin-3, is recognized to target SARS-CoV-2. It is extracted from sponges such as Aplysina aerophoba and Aplysina caissara. In the present chapter, we discuss the mechanism of action of fistularin-3 and its anti-SARS-CoV-2 potential. © 2026 by Apple Academic Press, Inc.
Biotic factors as key determinants for ovarian and oothecal developmental plasticity of a tortoise beetle
(Elsevier GmbH, 2024) Ruchita Shivprakash Tiwari; Lankesh Yashwant Bhaisare; Shivani Pathak; Bhupendra Kumar; Desh Deepak Chaudhary
Ovarian development in r-selected species is a highly dynamic process widely studied in various insect groups. An array of biotic and abiotic factors may influence it. So, the present investigation was to evaluate the impact of a female's age and mating status on the ovarian development, ootheca formation, body colour polymorphism, and fat content of the tortoise beetle, Aspidomorpha miliaris (Fabricius). Females of a certain age and mating status were dissected to demonstrate changes in their ovarioles, lateral oviduct, accessory gland, elytral colour, fat body content, and body size. It was predicted that age or mating status would not affect the ovarian parameters like length and width of ovarioles, lateral oviducts, accessory glands, body size, fat body content, and elytral colour. However, the ootheca-forming modifications would be initiated by ageing and mating. The current study demonstrated the substantial effect of age and mating status on the growth of the accessory glands and ovarioles. On the other hand, fat body contents declined comparatively in multiply-mated females. Besides this, the beetle exhibits elytral colour polymorphism till sexual maturity. An accessory gland was exclusively detected in multiply-mated females. This discovery opens opportunities for further investigation into the precise function of the gland, which is likely involved in the formation of ootheca. © 2024 Elsevier GmbH
Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis
(Springer Nature, 2025) Shivani Pathak; Vipendra Kumar Singh; Prashant Kumar Gupta; Arun Kumar Mahapatra; Rajanish Giri; Rashmi Sahu; Rohit Sharma; Neha Garg
Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer. Over time, numerous compounds targeting AR have been identified, presenting encouraging avenues for suppressing its hyperactivity. In our investigation, we used the GEPIA tool to study the importance of AR in the context of prostate cancer. This tool integrates the data from TCGA and GTEx in the gene expression pattern analysis and their clinical relevance. This analysis evaluates overall survival, disease-free survival, and transcripts per million (TPM) analysis of AR in PC. We performed docking and simulation for FDA-approved anticancer drugs to assess their potential interactions with the AR. We also conducted a comprehensive analysis of drugs using a quantum calculation (DFT) which provides electronic properties, chemical reactivity, and stability using the HOMO–LUMO energy gap. This study suggests that repurposed synthetic anticancer drugs could be better options for treating prostate cancer by inhibiting AR. In this work, we have shown the potential of pomalidomide, a synthetic anticancer drug, as a potential candidate for androgen-dependent PC treatment. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.
Exploring the role of pomalidomide in androgen-dependent prostate cancer: a computational analysis
(Springer Nature, 2024) Shivani Pathak; Vipendra Kumar Singh; Prashant Kumar Gupta; Arun Kumar Mahapatra; Rajanish Giri; Rashmi Sahu; Rohit Sharma; Neha Garg
Prostate cancer (PC) is among the most prevalent cancers in males. It is the leading cause of death in men, in around 48 out of 185 countries. Increased androgen receptor (AR) activity is the key factor contributing to the development or progression of newly diagnosed cases of prostate cancer. Over time, numerous compounds targeting AR have been identified, presenting encouraging avenues for suppressing its hyperactivity. In our investigation, we used the GEPIA tool to study the importance of AR in the context of prostate cancer. This tool integrates the data from TCGA and GTEx in the gene expression pattern analysis and their clinical relevance. This analysis evaluates overall survival, disease-free survival, and transcripts per million (TPM) analysis of AR in PC. We performed docking and simulation for FDA-approved anticancer drugs to assess their potential interactions with the AR. We also conducted a comprehensive analysis of drugs using a quantum calculation (DFT) which provides electronic properties, chemical reactivity, and stability using the HOMO–LUMO energy gap. This study suggests that repurposed synthetic anticancer drugs could be better options for treating prostate cancer by inhibiting AR. In this work, we have shown the potential of pomalidomide, a synthetic anticancer drug, as a potential candidate for androgen-dependent PC treatment. © The Author(s), under exclusive licence to Springer Nature Switzerland AG 2024.