Browsing by Author "Shouri Banerjee"

Now showing 1 - 2 of 2

Preparation, characterization and performance of a silica gel bonded molecularly imprinted polymer for selective recognition and enrichment of β-lactam antibiotics
(2003) Bhim Bali Prasad; Shouri Banerjee
A silica gel-bound molecularly imprinted polymer to oxazolone(s) exclusively derived from certain cephalosporins (cefaclor) and penicillins (amoxycillins and ampicillins) was prepared using ethylacetate as a porogen. This was used as a packing material for solid phase extraction in column chromatography. The high selectivity and the quantitative sorption of oxazolone at pH 7.5 and a flow rate of 5.0 ml min-1 in a long (13.0 cm) and wide bore (1.4 cm internal diameter) column have led to efficient clean-up, selective enrichment, and indirect differential pulse adsorptive stripping voltammetric measurement of the β-lactams in the form of corresponding oxazolones either in a larger volume of dilute aqueous systems or in the pharmaceutical formulations, without complications of complex matrices, excipients or column deterioration. © 2003 Elsevier Science B.V. All rights reserved.
Voltammetric studies of an oxazolone derivative of cefaclor in aqueous buffers
(2002) Bhim Bali Prasad; Sandeep Gupta; Shouri Banerjee
Electrochemical properties of cefaclor at a mercury electrode in aqueous solution of varying pH have been studied through tast, pulse (normal and differential), and cyclic voltammetric techniques. For this, the electroinactive cefaclor is transformed into electroactive penicillenate analogue 'oxazolone derivative' under strong acidic hydrolysis condition. The derived oxazolone system underwent two-steps irreversible reductions involving proton-participations (2e-, H+; 4e-, 4H+) when voltammograms scanned cathodically. However, in cyclic voltammetry, a typical wave due to sulphhydryl group oxidation is noticed on scan reversal in anodic direction. The results have been discussed by taking into account the implications of reactant and product adsorptions onto electrode surface during the course of reductions.