Browsing by Author "Shubhangi"

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Bimetallic Copper/Zinc Metal Organic Framework-MoS2Nanohybrid based Electrochemical Sensor
(Institute of Electrical and Electronics Engineers Inc., 2024) Divya; Shubhangi; Pranjal Chandra
Acetaminophen is a globally used antipyretic analgesic drug to relieve pain. The excess usage of acetaminophen leads to various health implications including cardiovascular ailments, asthma, liver and kidney damage. Bimetallic MOFs are emerging materials in the field of electrochemical sensing domain utilizing the synergistic effect of both the metal ions present within. In this study, we report a sensing matrix comprising of an electrochemically fabricated novel bimetallic MOF (CoZn) conjugated with Mos2nanosheets to form an electroconductive nanocomposite. Layer-by-layer characterization of CoZn-MOF/MoS2modified electrode surface was done through different electrochemical analytical techniques like CV and EIS. The composite (GCE/CoZn-MOF/MoS2) can find its applications in sensing a plethora of analytes based on the catalytic potential of the metal nodes. In this work we have attempted the application of the developed nanocomposite probe in the electrochemical oxidation and thereby detection of acetaminophen. The developed nanocomposite was able to detect acetaminophen with enhancement in signal, proving the improved electroconductivity of the surface due to synergistic effect of CoZn-MOF and Mos2. © 2024 IEEE.
Emerging 3D nanomaterials as electrocatalysts for water splitting reactions
(Elsevier Ltd, 2024) Rohini Kumari; Aditi Sammi; Shubhangi; Ananya Srivastava; Uday Pratap Azad; Pranjal Chandra
Electrochemical water splitting is an ideal alternative to obtain hydrogen, which is a renewable and clean source of energy with a high calorific value. Designing a highly stable and affordable catalyst is a critical need for achieving the desired electrocatalytic efficacy. Three-dimensional (3D) nanomaterials (NMs) have a hierarchical or interconnected network or framework-like structure with commendable mechanical stability. They possess large surface area and electroactive sites, which have garnered immense scientific interest in the past few years. Different 3D NMs that have been used for electrocatalysis of water are the central focus of this review. There are only a handful of reports discussing them in the literature, but none of them comprehensively cover various 3D NMs as water-splitting catalysts. In addition, the basic concepts of hydrogen evolution reaction (HER) and oxygen evolution reaction (OER), as well as various metrics affecting water splitting kinetics, have been highlighted in detail. In the end, hurdles in the design and commercialization of highly stable water-splitting catalysts and their possible remedies have been discussed along with. © 2024 Hydrogen Energy Publications LLC
Engineered Cobalt/Molybedum Bimetallic MOF as Electrochemical Signal Transducer for Uric Acid Detection
(Institute of Electrical and Electronics Engineers Inc., 2024) Shubhangi; Ruchita Chaudhari; S.K. Rai; Pranjal Chandra
Electrochemical signal transduction systems involving metal organic frameworks (MOFs) are new buzz words in sensing due to their astounding functional capabilities and catalytic potential. In this work, creation of one such novel sensing platform comprising of cobalt/molybdenum (Co/Mo) bimetallic MOF has been attempted for the sensitive detection of uric acid (UA) in clinical ranges. Conventionally, UA is detected through an enzyme called uricase which converts UA to allantoin. However, the enzyme-based diagnostic solutions are prone to chemical and thermal instabilities making the process cumbersome and tedious. To eliminate such challenges, the developed non-enzymatic detection system uses a highly catalytic bimetallic sensing module which electrochemically facilitates conversion of UA to allantoin, and yields electrochemical signal outcomes. The developed sensing probe was characterized through physical and electrochemical techniques such as scanning electron microscopy (SEM), Fourier transform infrared spectroscopy (FTIR) and, cyclic voltammetry (CV). Here, UA has been used as the sample target analyte to validate the efficacy of the bimetallic system using differential pulse voltammetry (DPV) and chronoamperometry (CA). The preliminary results hold immense promise for the developed system in application for sensing a wide range of analytes through electrochemical methods in clinical settings. © 2024 IEEE.
MOF-based nanocomposites as transduction matrices for optical and electrochemical sensing
(Elsevier B.V., 2024) Shubhangi; Indrani Nandi; S.K. Rai; Pranjal Chandra
Metal Organic Frameworks (MOFs), a class of crystalline microporous materials have been into research limelight lately due to their commendable physio-chemical properties and easy fabrication methods. They have enormous surface area which can be a working ground for innumerable molecule adhesions and site for potential sensor matrices. Their biocompatibility makes them valuable for in vitro detection systems but a compromised conductivity requires a lot of surface engineering of these molecules for their usage in electrochemical biosensors. However, they are not just restricted to a single type of transduction system rather can also be modified to achieve feat as optical (colorimetry, luminescence) and electro-luminescent biosensors. This review emphasizes on recent advancements in the area of MOF-based biosensors with focus on various MOF synthesis methods and their general properties along with selective attention to electrochemical, optical and opto-electrochemical hybrid biosensors. It also summarizes MOF-based biosensors for monitoring free radicals, metal ions, small molecules, macromolecules and cells in a wide range of real matrices. Extensive tables have been included for understanding recent trends in the field of MOF-composite probe fabrication. The article sums up the future scope of these materials in the field of biosensors and enlightens the reader with recent trends for future research scope. © 2023
Shifting paradigm in electrochemical biosensing matrices comprising metal organic frameworks and their composites in disease diagnosis
(John Wiley and Sons Inc, 2024) Shubhangi; Divya; Sanjay K. Rai; Pranjal Chandra
Metal Organic Frameworks (MOFs) are an evolving category of crystalline microporous materials that have grabbed the research interest for quite some time due to their admirable physio-chemical properties and easy fabrication methods. Their enormous surface area can be a working ground for innumerable molecular adhesions and site for potential sensor matrices. They have been explored in the last decade for incorporation in electrochemical sensor matrices as diagnostic solutions for a plethora of diseases. This review emphasizes on some of the recent advancements in the area of MOF-based electrochemical biosensors with focus on various important diseases and their significance in upgrading the sensor performance. It summarizes MOF-based biosensors for monitoring biomarkers relevant to diabetes, viral and bacterial sepsis infections, neurological disorders, cardiovascular diseases, and cancer in a wide range of real matrices. The discussion has been supplemented with extensive tables elaborating recent trends in the field of MOF-composite probe fabrication strategies with their respective sensing parameters. The article sums up the future scope of these materials in the field of biosensors and enlightens the reader with recent trends for future research scope. This article is categorized under: Diagnostic Tools > Biosensing Diagnostic Tools > Diagnostic Nanodevices. © 2024 Wiley Periodicals LLC.