Browsing by Author "Simon Croft"

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Biomedicine and biotechnology: Public health impact
(Hindawi Publishing Corporation, 2014) Nirmal K. Ganguly; Simon Croft; Lalji Singh; Subrata Sinha; Tanjore Balganesh
[No abstract available]
Control of the leishmaniases
(2008) Richard W. Ashford; Caryn Bern; Marleen Boelaert; Anthony Bryceson; François Chappuis; Simon Croft; Jean-Pierre Dedet; Philippe Desjeux; Luigi Gradoni; Robert R. Killick-Kendrick; Elmer Alejandro Llanos-Cuentas; Rogelio López-Vélez; Farrokh Modabber; Suman Rijal; Afif Ben Salah; Poonam Salotra; Nancy Gore Saravia; Jeffrey Jon Shaw; Shyam Sundar; Chandreshwar P. Thakur; Dinesh Mondal; Guilherme L. Werneck
[No abstract available]
Understanding the transmission dynamics of Leishmania donovani to provide robust evidence for interventions to eliminate visceral leishmaniasis in Bihar, India the LCNTDR Collection: Advances in scientific research for NTD control
(BioMed Central Ltd., 2016) Mary M. Cameron; Alvaro Acosta-Serrano; Caryn Bern; Marleen Boelaert; Margriet Den Boer; Sakib Burza; Lloyd A. C. Chapman; Alexandra Chaskopoulou; Michael Coleman; Orin Courtenay; Simon Croft; Pradeep Das; Erin Dilger; Geraldine Foster; Rajesh Garlapati; Lee Haines; Angela Harris; Janet Hemingway; T. Déirdre Hollingsworth; Sarah Jervis; Graham Medley; Michael Miles; Mark Paine; Albert Picado; Richard Poché; Paul Ready; Matthew Rogers; Mark Rowland; Shyam Sundar; Sake J. De Vlas; David Weetman
Visceral Leishmaniasis (VL) is a neglected vector-borne disease. In India, it is transmitted to humans by Leishmania donovani-infected Phlebotomus argentipes sand flies. In 2005, VL was targeted for elimination by the governments of India, Nepal and Bangladesh by 2015. The elimination strategy consists of rapid case detection, treatment of VL cases and vector control using indoor residual spraying (IRS). However, to achieve sustained elimination of VL, an appropriate post elimination surveillance programme should be designed, and crucial knowledge gaps in vector bionomics, human infection and transmission need to be addressed. This review examines the outstanding knowledge gaps, specifically in the context of Bihar State, India. The knowledge gaps in vector bionomics that will be of immediate benefit to current control operations include better estimates of human biting rates and natural infection rates of P. argentipes, with L. donovani, and how these vary spatially, temporally and in response to IRS. The relative importance of indoor and outdoor transmission, and how P. argentipes disperse, are also unknown. With respect to human transmission it is important to use a range of diagnostic tools to distinguish individuals in endemic communities into those who: 1) are to going to progress to clinical VL, 2) are immune/refractory to infection and 3) have had past exposure to sand flies. It is crucial to keep in mind that close to elimination, and post-elimination, VL cases will become infrequent, so it is vital to define what the surveillance programme should target and how it should be designed to prevent resurgence. Therefore, a better understanding of the transmission dynamics of VL, in particular of how rates of infection in humans and sand flies vary as functions of each other, is required to guide VL elimination efforts and ensure sustained elimination in the Indian subcontinent. By collecting contemporary entomological and human data in the same geographical locations, more precise epidemiological models can be produced. The suite of data collected can also be used to inform the national programme if supplementary vector control tools, in addition to IRS, are required to address the issues of people sleeping outside. © 2016 Cameron et al.