Browsing by Author "Smita Jain"

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Corrigendum to “One-pot hydrothermal green synthesis of Polygala tenuifolia mediated graphene quantum dots for acetylcholine esterase inhibitory activity” [J. Drug Deliv. Sci. Technol., 73(2022) 103486] (Journal of Drug Delivery Science and Technology (2022) 73, (S1773224722003963), (10.1016/j.jddst.2022.103486))
(Editions de Sante, 2024) Kajal Tak; Prashansa Sharma; Rekha Sharma; Vivek Dave; Smita Jain; Swapnil Sharma
The authors regret that the original published version of this article is has errors in Fig. 8 entitled Histopathological study of hippocampus tissue of rat and should be replaced with the corrected one provided below.[Formula presented] The authors would like to apologise for any inconvenience caused. © 2024
One-pot hydrothermal green synthesis of Polygala tenuifolia mediated graphene quantum dots for acetylcholine esterase inhibitory activity
(Editions de Sante, 2022) Kajal Tak; Prashansa Sharma; Rekha Sharma; Vivek Dave; Smita Jain; Swapnil Sharma
The present paper reports the synthesis of Donepezil hydrochloride functionalized Graphene quantum dots (DO-ptGQD) for the cure of Alzheimer disease. Graphene quantum dots were synthesized through root extract of Polygala tenuifolia by using one-pot hydrothermal synthesis method. Using UV/Visible spectroscopy, FTIR, SEM, TEM and XPS methods, the synthesized ptGQD was evaluated. Further the formulated DO-ptGQD was evaluated by SEM, TEM, FTIR, XPS techniques and was further evaluated for the encapsulation study, in-vitro study and various in-vivo models. Through behavioural model (Radial arm maze and Water morris maze assay) the learning and memory ability of the formulations was evaluated and the outcomes indicate that the DO-ptGQD markedly decreases the transmission latency to get in the baited arm in 12.19 ± 0.39 s or to the hidden stage in 15.37 ± 0.45 in 7 days. DO-ptGQD show more percentage inhibition of AchE enzyme that is 86.23 ± 1.28 as likened with the drug and ptGQD. DO-ptGQD considerably increases the protein and glutathione level and decreases the nitric oxide and lipid peroxide level. The Histopathological image indicates that DO-ptGQD treats the disorganization of the cell and show more preservation of small pyramidal cells as compared with the other formulations. In conclusion, DO-ptGQD was safe and effective drug delivery system for the treatment of Alzheimer disease and also the root extract of Polygala tenuifolia provide synergistic effect for the treatment of disease. © 2022