Browsing by Author "Smita Kumari"

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Corrigendum to “PLGA nanoformulation of sparfloxacin enhanced antibacterial activity with photoprotective potential under ambient UV-R exposure” [Int. J. Pharm. 541 (2018) 173–187] (International Journal of Pharmaceutics (2018) 541(1–2) (173–187), (S0378517318301091) (10.1016/j.ijpharm.2018.02.028))
(Elsevier B.V., 2018) Jyoti Singh; Ashish Dwivedi; Lipika Ray; Deepti Chopra; Divya Dubey; Ajeet K. Srivastva; Smita Kumari; Randhir Kumar Yadav; Saroj Kumar Amar; Chandana Haldar; Ratan Singh Ray
The authors regret that mistakes related to image duplication, quality and labeling were found in Fig. 7b Fig. 9 Fig. 10 a. The corrected images are now provided as Figs. 7b, 9c, d and 10a. These mistakes do not change the scientific conclusions of the article in any way. The authors would like to apologise for any inconvenience caused. © 2018 Elsevier B.V.
Corrigendum to “PLGA nanoformulation of sparfloxacin enhanced antibacterial activity with photoprotective potential under ambient UV-R exposure” [Int. J. Pharm. 541 (2018) 173–187](S0378517318301091)(10.1016/j.ijpharm.2018.02.028)
(Elsevier B.V., 2019) Jyoti Singh; Ashish Dwivedi; Lipika Ray; Deepti Chopra; Divya Dubey; Ajeet K. Srivastva; Smita Kumari; Randhir Kumar Yadav; Saroj Kumar Amar; Chandana Haldar; Ratan Singh Ray
The authors regret to inform that there were inadvertent errors in some figures. The corrected images are given below. These corrections are not affecting the results and conclusion of the manuscript. Hence, the text in the original article remains unchanged. The corrected Fig. 8 is as follows: The corrected Fig. 12 is as follows: The authors would like to apologise for any inconvenience caused. © 2019 Elsevier B.V.
Nanomaterials and biochar mediated remediation of emerging contaminants
(Elsevier B.V., 2024) Priyadarshani Rajput; Pradeep Kumar; A.K. Priya; Smita Kumari; Seyede Roghie Ghadirnezhad Shiade; Vishnu D. Rajput; Amin Fathi; Arunava Pradhan; Rubab Sarfraz; Svetlana Sushkova; Saglara Mandzhieva; Tatiana Minkina; Alexander Soldatov; Ming Hung Wong; Christopher Rensing
The unrestricted release of various toxic substances into the environment is a critical global issue, gaining increased attention in modern society. Many of these substances are pristine to various environmental compartments known as contaminants/emerging contaminants (ECs). Nanoparticles and emerging sorbents enhanced remediation is a compelling methodology exhibiting great potential in addressing EC-related issues and facilitating their elimination from the environment, particularly those compounds that demonstrate eco-toxicity and pose considerable challenges in terms of removal. It provides a novel technique enabling the secure and sustainable removal of various ECs, including persistent organic compounds, microplastics, phthalate, etc. This extensive review presents a critical perspective on the current advancements and potential outcomes of nano-enhanced remediation techniques such as photocatalysis, nano-sensing, nano-enhanced sorbents, bio/phyto-remediation, which are applied to clean-up the natural environment. In addition, when dealing with residual contaminants, special attention is paid to both health and environmental implications; therefore, an evaluation of the long-term sustainability of nano-enhanced remediation methods has been considered. The integrated mechanical approaches were thoroughly discussed and presented in graphical forms. Thus, the critical evaluation of the integrated use of most emerging remediation technologies will open a new dimension in environmental safety and clean-up program. © 2024 Elsevier B.V.
PLGA nanoformulation of sparfloxacin enhanced antibacterial activity with photoprotective potential under ambient UV-R exposure
(Elsevier B.V., 2018) Jyoti Singh; Ashish Dwivedi; Lipika Ray; Deepti Chopra; Divya Dubey; Ajeet K. Srivastva; Smita Kumari; Randhir Kumar Yadav; Saroj Kumar Amar; Chandana Haldar; Ratan Singh Ray
Sparfloxacin (SPFX) is a broad spectrum antibiotic which inhibits bacterial DNA gyrase enzyme activity. However, photodegradation in the presence of UVA limits its antibacterial activity and induces phototoxicity. Thus, to encounter this problem, we have developed poly d,l-lactic-co-glycolic acid (PLGA) loaded SPFX nanoparticles. Here, we have performed a comparative antibacterial activity of SPFX and its nanoparticles (NPs) through molecular docking and plate sensitivity assay. Under environmental UVA exposure, photoexcited SPFX significantly generates ROS, DNA damage and mitochondrial mediated cell death in comparison to PLGA-SPFX-NPs (nano SPFX) in human skin cell line (HaCaT). In presence of UVA, bulk SPFX induced cell cycle arrest with appearance of sub-G1 peak showing apoptosis while nano SPFX did not show any change. SPFX triggered apoptosis via alteration in membrane integrity of mitochondria and lysosome in comparison to PLGA-SPFX-NPs. Involvement of mitochondrial mediated cell death was confirmed by down-regulation of anti-apoptotic Bcl-2 and procaspase-3 and upregulation of pro-apoptotic Bax, cytochrome-c and caspase-3 proteins expression. Specific caspase inhibitor, Z-VAD-FMK showed involvement of caspase cascade pathway in apoptosis. Our finding suggests that controlled release of SPFX from PLGA-SPFX-NPs can reduce its side effects and enhance its antibacterial activity. Thus, nanotization of fluoroquinolones will be a significant step to reduce the problem of resistance and phototoxicity of this group. © 2018 Elsevier B.V.