Browsing by Author "Snigdha Mishra"

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Carbohydrate-Based Therapeutics: A Frontier in Drug Discovery and Development
(Elsevier B.V., 2016) Snigdha Mishra; K. Upadhaya; Kunj B. Mishra; Akhilesh K. Shukla; Rama P. Tripathi; Vinod K. Tiwari
Carbohydrates, one of the most abundant classes of biomolecules, are the structural building blocks of genetic materials and vital source of energy. They are integral part of the living cells as they play key roles in many cellular and intracellular interactions in the form of cell surface receptors, signaling molecules, and bacterial adhesives. These roles of carbohydrates underlie their potential as pharmaceutical and diagnostic agents and therefore stimulate the synthetic chemists to develop various facile ways to synthesize diverse eccentric glycoconjugates. Many carbohydrates and their derivatives of natural and synthetic origin are clinically used for treatment of various diseases. The immense structural diversity in terms of functional groups, linkages, and number of rings offers these molecules as a valuable tool for design and development of biologically active glycoconjugates. The promising biological activity of carbohydrate-based entities makes them valuable molecular scaffold after their thorough chemical and biological investigations. The carbohydrate moieties in glycoconjugates impart properties like hydrophilicity and decreased toxicity, which enhance the bioavailability to give the optimum pharmacokinetics. This chapter will abridge the cardinal developments in the synthesis and analysis of biologically significant carbohydrate-based molecules from the leading laboratories, highlighting the certainty of carbohydrates in creating an ideal therapeutic platform for drug discovery and development. © 2016 Elsevier B.V.
N-Acylbenzotriazole as Efficient Ligand in Copper-Catalyzed O-Arylation Leading to Diverse Benzoxazoles
(Wiley-Blackwell, 2017) Anoop S. Singh; Mala Singh; Nidhi Mishra; Snigdha Mishra; Anand K. Agrahari; Vinod K. Tiwari
An establishment of (1H-benzo[d][1,2,3]triazol-1-yl)(2-methoxyphenyl)methanone as ligand was attained in intramolecular C-O cross-coupling of N-(2-halophenyl)aryl/alkylamide derivatives to form 2-Aryl/alkyl benzoxazole derivatives using CuI/K2CO3 as catalytic system. A series of benzoxazoles was developed using this protocol and synthesized compounds were characterized using spectroscopic analysis (IR, MS, 1H & 13C NMR). Salient advantages associated with this pathway include easily available starting materials, cheap catalyst, highly stable ligand, wide substrate scope, smooth reaction, easy work-up and high product yield. © 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim