Browsing by Author "Soma Ghoshal"

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A case of endometriosis in episiotomy scar with anal sphincter involvement and extension into ischiorectal fossa
(Jaypee Brothers Medical Publishers (P) Ltd, 2014) Shuchi Jain; Soma Ghoshal; Mohan Kumar; Madhu Jain
Episiotomy scar endometriosis is characterized by presence of endometrial tissue (glands and stroma) and is a rare condition. It may also extend and involve the anal sphincter. The ideal treatment is wide excision to prevent recurrence but it may cause fecal incontinence, if the anal sphincter is involved. We describe here a case with much deeper extension into ischiorectal fossa. She was treated with wide local excision and primary sphincteroplasty. She has remained free of recurrence up to 12 months follow-up. © 2014, Jaypee Brothers Medical Publishers (P) Ltd. All rights reserved.
Expression profiling of TGF-β receptor and its relation with endometriosis
(Jaypee Brothers Medical Publishers (P) Ltd, 2015) Soma Ghoshal; Nisha Rani Agrawal; Kiran Singh
Study objectives: To measure the transforming growth factorbeta (TGF-β) receptor level in endometriotic tissues in patients selected for surgery in our hospital; and thus to assess its genetic basis in the pathophysiology of endometriosis; and to study its possibility as a potent tissue marker. Design: Observational study (case control study) involving Genetic Laboratory Study. Setting: Tertiary Care Institute, Gynecology Department. Population or sample: Total 100 female patients undergoing surgery in our hospital involved; out of them 50 were cases and 50 controls. Materials and methods: Fifty cases (having endometriosis) and 50 controls (without endometriosis) were taken. During surgery, excised specimen was examined for presence of any endometriotic tissue. The endometrial tissue samples from suspected area were taken and put immediately in RNA-PCR media and sent to Genetics Laboratory where semi-quantitative RT-PCR analysis of TGF-beta was done using primers designed by Primer Blast software (National Center for Biotechnology Information). Main outcome measures: The mean TGF-β receptor level was 0.5886 in cases and the mean TGF-β receptor level in controls was 2.076. Both in extrauterine endometriosis and in adenomyosis, TGF-β receptor was downregulated equally in 80% of cases. Results: Transforming growth factor-beta receptor levels in all types of endometriosis showed a significant down regulation in maximum number of cases. Conclusion: This downregulation of TGF-β receptor level in the endometriotic tissues not only helps in understanding the pathological basis of endometriosis but most importantly, it can be utilized as genetic basis of therapy in endometriosis in near future. © 2015, Jaypee Brothers Medical Publishers (P) Ltd. All Rights Reserved.