Browsing by Author "Sonal Sharma"

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Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities
(John Wiley and Sons Inc, 2024) Harshita Tiwari; Swati Singh; Sonal Sharma; Priyamvada Gupta; Ashish Verma; Amrit Chattopadhaya; Brijesh Kumar; Sakshi Agarwal; Rajiv Kumar; Sanjeev Kumar Gupta; Vibhav Gautam
Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due to its invasive nature which is attributed to the absence of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor (HER-2). The heterogenous tumor microenvironment (TME) of TNBC is composed of diverse constituents that intricately interact to evade immune response and facilitate cancer progression and metastasis. Based on molecular gene expression, TNBC is classified into four molecular subtypes: basal-like (BL1 and BL2), luminal androgen receptor (LAR), immunomodulatory (IM), and mesenchymal. TNBC is an aggressive histological variant with adverse prognosis and poor therapeutic response. The lack of response in most of the TNBC patients could be attributed to the heterogeneity of the disease, highlighting the need for more effective treatments and reliable prognostic biomarkers. Targeting certain signaling pathways and their components has emerged as a promising therapeutic strategy for improving patient outcomes. In this review, we have summarized the interactions among various components of the dynamic TME in TNBC and discussed the classification of its molecular subtypes. Moreover, the purpose of this review is to compile and provide an overview of the most recent data about recently discovered novel TNBC biomarkers and targeted therapeutics that have proven successful in treating metastatic TNBC. The emergence of novel therapeutic strategies such as chemoimmunotherapy, chimeric antigen receptor (CAR)-T cells-based immunotherapy, phytometabolites-mediated natural therapy, photodynamic and photothermal approaches have made a significant positive impact and have paved the way for more effective interventions. © 2024 Wiley Periodicals LLC.
Deciphering the landscape of triple negative breast cancer from microenvironment dynamics and molecular insights to biomarker analysis and therapeutic modalities
(John Wiley and Sons Inc, 2025) Harshita Tiwari; Swati Singh; Sonal Sharma; Priyamvada K. Gupta; Ashish Verma; Amrit Chattopadhaya; Brijesh Kumar; Sakshi Agarwal; Rajiv Kumar; Sanjeev Kumar Gupta; Vibhav Gautam
Triple negative breast cancer (TNBC) displays a notable challenge in clinical oncology due to its invasive nature which is attributed to the absence of progesterone receptor (PR), estrogen receptor (ER), and human epidermal growth factor receptor (HER-2). The heterogenous tumor microenvironment (TME) of TNBC is composed of diverse constituents that intricately interact to evade immune response and facilitate cancer progression and metastasis. Based on molecular gene expression, TNBC is classified into four molecular subtypes: basal-like (BL1 and BL2), luminal androgen receptor (LAR), immunomodulatory (IM), and mesenchymal. TNBC is an aggressive histological variant with adverse prognosis and poor therapeutic response. The lack of response in most of the TNBC patients could be attributed to the heterogeneity of the disease, highlighting the need for more effective treatments and reliable prognostic biomarkers. Targeting certain signaling pathways and their components has emerged as a promising therapeutic strategy for improving patient outcomes. In this review, we have summarized the interactions among various components of the dynamic TME in TNBC and discussed the classification of its molecular subtypes. Moreover, the purpose of this review is to compile and provide an overview of the most recent data about recently discovered novel TNBC biomarkers and targeted therapeutics that have proven successful in treating metastatic TNBC. The emergence of novel therapeutic strategies such as chemoimmunotherapy, chimeric antigen receptor (CAR)-T cells-based immunotherapy, phytometabolites-mediated natural therapy, photodynamic and photothermal approaches have made a significant positive impact and have paved the way for more effective interventions. © 2024 Wiley Periodicals LLC.
EDCs exposure-induced alteration in the germination, growth, and physiological trait of the plant
(Elsevier, 2024) Anuj Saraswat; Shri Ram; Sonal Sharma; Rukoo Chawla; Neha Khardia; Deeksha Chauhan; Dinesh Kumar Vishwakarma; Md Basit Raza; Vishnu D. Rajput; Prithwiraj Dey; Ram Swaroop Meena; Biswaranjan Behera
Environmental health is a major concern around the world due to the exponential increase in pollutant discharges into the environment from industrial and agricultural activities. Endocrine-disrupting chemicals (EDCs) are a broad category of natural or synthetic substances with properties that may cause endocrine disruption in an intact organism, its progeny, or (sub)populations. Everyday products such as plastics, personal care products, and cleaning agents, as well as pesticides, herbicides, and industrial chemicals, may contain EDCs. These chemicals can enter the environment through air and water pollution and can accumulate in the food chain, leading to widespread exposure in both humans and wildlife. EDCs can disturb the normal functioning of plants, humans, and animals. These compounds can enter in plant through roots and atmospheric air and hinder the activity of several enzymes and hormones. Several studies showed that EDCs have negatively affected the various physiological processes of plants such as photosynthesis, which are discussed in this chapter. To tackle the challenges posed by EDCs, numerous organizations and governments have urged for enhanced research, regulation, and public awareness of these chemicals. Certain countries have implemented legislation to limit the use of EDCs in specific products, and several manufacturers have voluntarily removed EDCs from their products. Nonetheless, further action is required to minimize exposure to EDCs and safeguard human and environmental health. In summary, EDCs are a complex and prevalent group of environmental pollutants that pose significant risks to human and wildlife health. Thus this chapter will focus on how EDCs exposure induces alteration in the plant’s germination, growth, and physiological trait. © 2024 Elsevier Inc. All rights reserved.