Browsing by Author "Sonam Agrawal"

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A scientific Exploration on Concept of Chronomedicine and Chronotherapy in Ayurveda
(Informatics Publishing Limited, 2019) Sonam Agrawal; Vandana Verma; Sangeeta Gehlot
Human physiology and pathophysiology of diseases have been proved to show rhythmic variation in response to temporal factors. This behavior is intertwined in field of clinical physiology in form of chronomedicine and chronotherapy for the better outcomes of treatment. Ayurveda scholars have also described rhythmic variation in biological entities like Dosha, Agni, Bala, presentation of diseases in relation to diurnal, meal intake and seasonal factors. They have well documented different domain of drug i.e. collection of drug, preparation of medicine, intervention of therapeutic procedures and administration of medicine in accordance to variation in biological entities and time. This article is aimed to summarize all these documented observations of Ayurveda regarding chronomedicine and chronotherapy and discuss in view of contemporary sciences, so that it can be utilized by the researchers of this field to generate evidence based data and may be applied by the physician for the better prognosis and management of the disease. © 2019, Informatics Publishing Limited. All rights reserved.
Ayurveda insights on physiology of sweating and thermoregulation
(Informatics Publishing Limited, 2019) Vandana Verma; Sangeeta Gehlot; Sonam Agrawal
Physiology of sweating and thermoregulation was well conceived by Ancient Ayurveda scholars. The detailed description of Svedavaha Srotas (channels carrying sweat), Sveda (sweat) as Mala (waste), its mechanism of formation on exposure to heat, therapeutic application of heat for inducing sweating under the concept of Svedan Karma (sudation) for purification and balancing the Dosha for management of disorders reflects the deep understanding of Ayurveda scholars about the physiology of sweating and temperature regulation. Keeping these facts in mind a detailed review has been done as an attempt to understand the physiology of sweating and temperature regulation mechanism described in Ayurveda in view of contemporary sciences and recent researches. © 2019, Informatics Publishing Limited. All rights reserved.
Explication on tissue nutrition in prenatal and postnatal life: An Ayurveda perspective
(Elsevier B.V., 2021) Sonam Agrawal; Vandana Verma; Sangeeta Gehlot
Tissue nutrition is the continuous process which is established just after the conception and persists throughout the life. Ayurveda scholars have mentioned that the manner of tissue nutrition is not same in all phases of life. In prenatal life embryo gets nutrition by Upasneha (filtration) and Upasweda (percolation/secretion) and fetus by Garbhanabhinadi (umbilical cord) which is attached with the heart of mother via Rasavahanadi (blood vessels). Thus in intrauterine life the nutrition of embryo is histotrophic, whereas just after the formation of placenta nutrition becomes haemotrophic. In post-natal life nutrition is enteral means nutrients are taken in the form of food via mouth called Aahar. Ayurveda scholars have postulated theories to understand the mechanism of tissue nutrition are Ksheera Dadhi Nyaya (transformation of nutrients), Khale Kapota Nyaya (selective uptake of nutrients), KedariKulya Nyaya (transportation of nutrients via channels), Ek Kala Dhatu Poshan Nyaya (simultaneous supply of nutrients to whole body). The theories of tissue nutrition discussed in Ayurveda suggest that although tissues are nourished and replenished continuously at different rate as per the functional state of Agni by circulating nutrients obtained from Ahara, but tissues are also dependent on each other for their proper nourishment and metabolism. This concept has great implication in management of malnourishment and various other disorders. This manuscript is an attempt to explore the Ayurveda's view on tissue nutrition along with physiological and clinical significance of theories of tissue nutrition in a scientific manner. © 2020 The Authors
Exploration of Ayurveda blueprint on clinical physiology of Meda (adipose tissue) and Majja dhatu (bone marrow) in context to obesity
(J. K. Welfare and Pharmascope Foundation, 2020) Vandana Verma; Sonam Agrawal; Sangeeta Gehlot
The state of health depends on the functional state of Dosha, Dhatu, Mala, Srotas, and Agni. The concept of functional and nutritional interdependence of Dhatu as well as a physiological and pathological aspect of all the seven Dhatu has been described by Ayurveda scholars. The metabolic effect of Meda and Majja Dhatu on other tissues like a muscle (Mamsa Dhatu), bone (Asthi Dhatu), and reproductive tissue (Shukra Dhatu) show their functional interdependence. The Ayurveda compendia, as well as recent research data, shows that obesity is the disorder of nutrition, which depends on lifestyle and diet. The obesity has been discussed in relation to Medovaha Srotodushti and Meda Dhatu Vriddhi. Although the physiology of Vasa, Meda, and Majja tissue has not been elaborated much, their clinical physiology has been described. This article aims to comprehend the pathophysiology of obesity as well as manifestations on the disturbed functional state of Meda and Majja Dhatu, as depicted by Ayurveda scholars in light of contemporary science. This article will be helpful in developing a vision regarding the clinical physiology of Meda and Majja, which will be further helpful in the exploration of pathophysiology and the management of obesity and associated disorders manifested by them. On exhaustive study, it was observed that the clinical physiology of Meda and Majja Dhatu shares quite a resemblance with the outcomes of contemporary researches on adipocytes, but still, some of these are still under the research. © 2020 International Journal of Research in Pharmaceutical Sciences. All rights reserved.
Overlooked contributions of Ayurveda literature to the history of physiology of digestion and metabolism
(Springer Science and Business Media Deutschland GmbH, 2023) Aparna Singh; Sonam Agrawal; Kishor Patwardhan; Sangeeta Gehlot
Ayurveda is a traditional system of healthcare that is native to India and has a rich documented literature of its own. Most of the historians agree that the documentation of core Ayurveda literature took place approximately in between 400 BCE and 200 CE, while acknowledging that the roots of its theoretical framework can be traced back to a much earlier period. For multiple reasons many significant contributions of Ayurveda literature to various streams of biological and medical sciences have remained under-recognized while recounting the historical milestones of development. This is true in the context of the physiology of digestion and metabolism too. In this communication we try to reconstruct a picture of the processes of digestion and metabolism as had been understood by ancient Ayurveda scholars. Though this understanding was primitive and insufficient in many ways, we argue that this deserves to be documented and acknowledged. To help with grasping the importance of these contributions, we juxtapose them with the corresponding insights pertaining to this subject reported by prominent western scientists. The major contributions of Ayurveda that have been recounted in this paper are those related to the description of three distinct phases of digestion (Avasthapaka), multiple sets of transformative entities acting at different levels of metabolism (Agni), and the roles ascribed to various internal and external factors in executing these physiological functions. © 2023, Springer Nature Switzerland AG.