Browsing by Author "Stuti Pandey"

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A phytopharmacological review on alternanthera ficoidea
(Advanced Scientific Research, 2019) Stuti Pandey; Ajay K. Pal; Alakh N. Sahu; Manmath K. Nandi
The spine of Ayurveda and other traditional system of medicines is medicinal plants. The medicinal plants and their extracts are rich with minerals, primary metabolites and secondary metabolites, which are the effective against various diseases. India has big biodiversity that rich with medicinal plants and near about 2500 medicinal plants of Indian origin are recommended in traditional treatment for various diseases. In recent decades metabolites derived from the extract of medicinal plants are frequently used by allopathic physicians as cardio-vascular, immunomodulatory, anticancer and antibiotic medicines. One of the Indian medicinal plant, Alternanthera ficoidea (L.) (Synonyms: Alternanthera tenella Colla and Gomphera ficoidea) belongs to family Amaranthaceae. The plant is traditionally used as diuretic, anti-pyretic, antiseptic, anti-inflammatory and anti- diarrheal agent etc. The secondary metabolites like tannins, saponins, phytols, carotenoids and polyphenols are major classes of compounds are identified for the plant. Some phytomolecules are isolated from the extract as vitexin, quercetin, kaempferol, amarantin, betaine, isoamarantin and sterol etc. Pharmacological activities like hypolipidemic, anti-inflammatory, antidiabetic, antibacterial and immunomodulatory activity are also investigated on this plant. This study compile the information related to Alternanthera ficoidea, which will helpful the researchers for further study on this plant. © 2019, Advanced Scientific Research. All rights reserved.
Targeting biosignatures of hyperglycemia and oxidative stress in diabetes comorbid depressive rats: effectiveness of hydroethanolic extract of the whole plant of Ludwigia octovalvis
(TMR Publishing Group, 2023) Stuti Pandey; Pawan Kumar Pandey; Alakh Niranjan Sahu; Himanshu Verma; Manmath Kumar Nandi
Background: The prime objective of the current research was to evaluate the whole plant hydroalcoholic extract of Ludwigia octovalvis (HLO) against hyperglycemia, and oxidative stress biomarkers in rats induced with diabetes comorbid depression, diabetes comorbid depression (streptozotocin-nicotinamide + electric footshocks). Methods: 2,2-Diphenyl-1-picrylhydrazyl assay of HLO versus ascorbic acid was done. Effects of 200 and 400 mg/kg body weight/day HLO doses versus 25 mg/kg body weight/day metformin was studied through insulin, glucose, superoxide dismutase, lipid peroxidation, catalase, and behavioral assessment (forced swim and open field tests). Results: IC50 values of HLO and ascorbic acid were 33.52 and 27.86 µg/mL respectively. Both the HLO doses showed intended results with respect to oxidative stress biomarkers in diabetes comorbid depression rats in comparison to metformin. Open field test showed better results for HLO in diabetes comorbid depression rats. However, hypoglycemic effects, and forced swim test performance of metformin was slightly higher than the 400 mg dose, followed by the 200 mg dose of HLO. Ethyl gallate, gallic acid, β-sitosterol, and quercetin in HLO might resulted in attenuating diabetic as well as depression biomarkers. Conclusion: Inhibition of glucosidase and lipase activity, and AMP-activated protein kinase phosphorylation might be the possible biochemical changes occurred in HLO treated rats. © 2023 By Author(s). Published by TMR Publishing Group Limited.