Browsing by Author "Sudhir Kumar Jaiswal"

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Effect of organic production system on productive and reproductive performance of cattle
(Agricultural Research Communication Centre, 2020) S.K. Shandilya; A.P. Singh; B.K. Ojha; Alok Mishra; Manu Jaiswal; Sudhir Kumar Jaiswal; Preeti Bisht
The present investigation was carried out with the objective to study the productive and reproductive performances of dairy cattle under organic farming systems. Total 24 medium to high yielding cattle has been selected for the study, out of which 12 were reared under organic management system and 12 under conventional management system. For cows maintained under organic management system, the animals were fed ad lib quality green fodder grown organically and limited quantity (1.5 to 2.0 kg/cows/day) of concentrate mixture. Production and reproduction performance of animals of both the groups were compared. The results revealed that the reproductive performance was better in cows maintained under organic production management system than their conventional counterparts. The study on milk quality in terms of composition revealed significantly (P<0.05) higher fat % of milk, while lower (P<0.05) protein % of milk for the cows maintained under organic system as compared to those under conventional system. It can be concluded that the organic management system of dairy cows can be beneficial as depicted by better reproductive efficiency of cows with higher fat % of the milk. © 2020 Agricultural Research Communication Centre. All rights reserved.
Tocopherol from seeds of Cucurbita pepo against diabetes: Validation by invivo experiments supported by computational docking
(2013) Sudhanshu Kumar Bharti; Amit Kumar; Neeraj Kumar Sharma; Om Prakash; Sudhir Kumar Jaiswal; Supriya Krishnan; Ashok Kumar Gupta; Awanish Kumar
Background/purpose: Tocopherol from raw pumpkin seeds has been reported to be effective in the alleviation of diabetes through its antioxidant activities. This study evaluates the antidiabetic activities of the tocopherol fraction of raw seeds of Cucurbita pepo L. (CPSE) in a diabetic rat model. In addition, the putative action mechanisms of its botanicals were computationally investigated. Methods: Seed water activity (Aw) was assessed. Tocopherol was extracted and quantified from raw seed oil. The effect of CPSE was studied in poloxamer-407 (PX-407)-induced type 2 diabetic Wistar rats. Glycemic, insulinemic, and lipid profiles, as well as lipid peroxidation status, were evaluated. Glucagon like peptide-1 (GLP-1) content in the cecum was evaluated and histopathological analysis of the pancreas was performed. Further, HYBRID and FRED docking were performed for 10 documented CPSE botanicals, for putative action mechanisms concerning three proteins [protein-tyrosine phosphatase 1B (PTP-1B), peroxisome proliferator-activated receptor gamma (PPAR-γ), and dipeptidyl peptidase IV (DPP-IV)] known to have diabetic therapeutic potential. Results: The Aw of raw seeds was found to be 0.544±0.002. Using tocopherol standards, HPLC determination of CPSE revealed the presence of tocopherol isomers (α, β, γ, and δ). The tocopherol content was found to be 107.4±2.9mg/100g of CPSE. When compared to diabetic control (DC) rats, the CPSE-treated diabetic rats presented a significant amelioration of glycemia, insulinemia, and lipid dysmetabolism. A remarkable reduction in oxidative markers and improved cecal and pancreatic characteristics were also observed. Tocopherol isomers have shown a considerable interaction potential with the aforesaid proteins in docking. Conclusion: The results provide pharmacological evidence of CPSE as an antihyperglycemic mediated by the interaction of various botanicals with multiple targets operating in diabetes mellitus (DM). © 2013.