Browsing by Author "Sundaram Singh"

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A facile superoxide induced conversion of aromatic amines to azo compounds under microwave irradiation
(Indian Chemical Society, 2011) Sundaram Singh; Krishna Nand Singh
The present report demonstrates an efficient use of tetraethylammonium superoxide under non-aqueous conditions to bring about a mild and convenient transformation of aromatic amines to azo compounds in good yield under mono-mode microwave irradiation.
Anti Cancer Potential of some Indole based Quinoxaline Derivatives against Dalton’s Lymphoma (DL) cells
(Research Journal of Pharmacy and Technology, 2023) Shivam Bajpai; Sundaram Singh
Indole based quinoxaline derivatives (2a-f) were synthesized and the therapeutic potential of the synthesized compounds (2a-f) was investigated against Dalton’s Lymphoma (DL) cells. It was observed that treatment of DL cells with quinoxaline derivatives (2a-f) showed significant decrease in cell viability, altered morphology, nuclear disintegration and DNA fragmentation into low molecular weight DNA fragments and thus characteristic of apoptosis. In this view, the synthesized compounds may be used as potential therapeutic regimen to treat this type of cancer. © RJPT All right reserved.
New D-π-A-Based Coumarin- Derived Fluorescent Theranostic Probes With Broad-Spectrum Antimicrobial Activity
(John Wiley and Sons Inc, 2025) Himanshu Rai; Atul Kumar Tiwari; Aishwarya Nikhil; Ankit Tiwari; Prahalad Singh Bharti; Suresh Kumar Maury; Munesh Kumar Gupta; Sundaram Singh; Saroj Kumar; Gyan Prakash Modi
Understanding how multidrug-resistant (MDR) bacteria and fungi defy the existing antimicrobial agents requires innovative tools and techniques for real-time, in situ exploration of bacterial responses to antibiotics. Fluorescence-tagged antibiotics or dyes with inherent antimicrobial activity can provide a profound understanding of the molecular biology underlying antibiotic action and resistance mechanisms. Cutting-edge research highlights the pursuit of benzo-α-pyrone (coumarin) derivatives due to their excellent pharmacokinetics, diverse pharmacological activities, and innovative fluorescence molecular probes. In this study, donor-π-acceptor-based coumarin dyes were designed and evaluated for antimicrobial efficacy against fungal strains (Candida albicans), Gram-negative pathogens (Escherichia coli), and Gram-positive bacteria (Staphylococcus aureus). I-6 exhibited notable antimicrobial activity against S. aureus and C. albicans compared with E. coli. Conversely, I-9, a congener of I-6, showed a comparable affinity for S. aureus but found poor activity against the remaining tested strains. Mechanistic investigative studies unveiled that the inhibitory efficacy of I-6 can be attributed to its capacity to generate high reactive oxygen species (ROS) formation. Despite the evident antimicrobial potential of I-6 in the data, our future prospects, including real-time visualization to study physiological processes like uptake, distribution, and mechanism of action through fluorescence-based imaging modalities, could enhance the applicability of these probes. © 2025 Deutsche Pharmazeutische Gesellschaft.