Browsing by Author "Suryansh Chandra"

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Anti-cancer activities based on ZnII complex of potassium 5-thiophen-2-yl-[1,3,4]-oxadiazole-2-thiolate: Synthesis, crystal structure, photoluminescence study and Hirshfeld analysis
(Elsevier B.V., 2024) Suryansh Chandra; Shubham Jaiswal; Ankit Srivastava; Ram Nayan Gautam; Subash C. Gupta; Ram Dulare; M.K. Bharty
Recent advancements in developing the most suitable drug for humankind to cure cancer have paved the way to synthesize an alternative to platinum-based drugs. Herein, the synthesis of novel polymeric complex [Zn(thot)2]n (1) derived from potassium 5-thiophen-2-yl-[1,3,4]-oxadiazole-2-thiolate (Kthot) is reported. The synthesized ligand and complex were characterized by infrared, NMR, Mass and UV–vis. spectrometry. Moreover, single-crystal X-ray analysis revealed the polymeric nature of the [Zn(thot)2]n (1). Complex 1 is stabilized via various types of intermolecular interactions. The intermolecular interaction found in complex 1 was further investigated through Hirshfeld surface analysis. Emission spectra data showed that complex [Zn(thot)2]n (1) exhibits higher fluorescent intensity than Kthot. The cytotoxicity of complex 1 and Kthot was evaluated against MDA-MB-231 breast cancer cells, which was determined by measuring mitochondrial dehydrogenase activity using MTT as substrate. The result showed that they both suppressed the viability of cancer cells. Moreover, complex 1 was found to be more effective than ligand salt Kthot. The IC50 value for complex 1 was found around 37.43 μM whereas for Kthot it is 69.24 μM which suggests that complex 1 reduces the cell viability more effectively in comparison to the ligand salt. © 2024 Elsevier B.V.
Anticancer evaluation of Co(III) complex derived from 1-isonicotinoyl-4-(4-nitrophenyl)-3-thiosemicarbazide: Structural characterization, photophysical, and Hirshfeld studies
(Elsevier B.V., 2025) Ram Nayan Gautam; Alok Shukla; Suryansh Chandra; Sundeep Kumar; Arbind Acharya; Mamata K. Singh; Ray Jay Butcher; Manoj Kumar Bharty
A new cationic complex, [Co((intph)(en)2]Cl, derived from the 1-isonicotinoyl-4-(4-nitrophenyl)-3-thiosemicarbazide (H2intph), is reported. The synthesized ligand and its corresponding Co(III) complex were successfully characterized by applying FT-IR and UV–visible spectroscopic techniques and single crystal ray diffraction data. Molecular geometries of the ligand and its Co(III) complex were accurately determined from their respective X-ray crystallographic analysis. The ligand and [Co((intph)(en)2]Cl crystallize in Triclinic and monoclinic systems with space groups P-1 and P 21/n, respectively. The crystal structures of H2intph and [Co((intph)(en)2]Cl are stabilized by weak C-H⋯O, N-H⋯O, and C-H⋯Cl hydrogen bonding interactions. Hirshfeld surface analysis was accomplished to investigate intermolecular hydrogen bonding interactions found in ligand H2intph and [Co((intph)(en)2]Cl. The cytotoxicity of the ligand and the complex [Co((intph)(en)2]Cl was assessed for their anticancer potential against human glioblastoma (U87) and Dalton lymphoma (DL) cell lines. The complex exhibited IC50 values of 100 μg/mL for U87 cells and 120 μg/mL for DL cells, indicating the concentration at which 50 % of cell viability was inhibited. In comparison, the ligand was less effective in the MTT assay against both U87 and DL cells. These results suggest that the complex [Co((intph)(en)2]Cl significantly reduces glioblastoma cell viability. Treatment with the complex induced cell death through both apoptotic and necrotic pathways, as evidenced by Hoechst/PI double staining. Additionally, there was an increase in intracellular reactive oxygen species (ROS), highlighting the role of oxidative stress in the anticancer activity of the [Co((intph)(en)2]Cl complex. Furthermore, fluorescence studies were carried out which revealed the order of fluorescence behaviors between the ligand and the Co(III) complex to be Co(III) complex > H2intph. © 2024 Elsevier B.V.
Cd(II) complexes derived from thiazoline, hydrazide and carbodithioate ligands: synthesis, crystal structures and electrochemical sensing of uric acid
(John Wiley and Sons Ltd, 2023) Shubham Jaiswal; Shivendra Kumar Pandey; Jyoti Prajapati; Suryansh Chandra; Mannu Kumar Gond; Manoj Kumar Bharty; Ida Tiwari; Ray J. Butcher
Three novel Cd(II) metal complexes 1–3 have been synthesized with different derivatives of thiazoline, hydrazide and carbodithioate. These metal complexes are abbreviated as [Cd (tht)2]n, [Cd (Hpph)2]n and [Cd (mpps)2]n along with their respective ligands Htht, H2pph and mpps. The developed metal complexes are characterized using X-ray diffraction (XRD) data and other spectroscopic techniques (Infrared [IR], nuclear magnetic resonance [NMR], ultraviolet–visible [UV–vis] and fluorescence). The polymeric nature of these cadmium complexes have been ascertained by single XRD data. Several significant interactions were also revealed, which aid in the stabilization of these complexes' supramolecular architecture. Comparing complex 2 with complexes 1 and 3, the absorption spectra of complex 2 exhibits a greater λmax. On comparing the fluorescence study of these complexes, complex 2 has a higher fluorescence than complexes 1 and 3. The cyclic voltammetry (CV) approach was employed to detect the electrochemical behaviour of these complexes, as well as the sensing of uric acid (UA) by these complexes via modified glassy carbon electrodes (GCEs). According to the conclusions received by CV study, the modified electrode containing complex 3 has admirable UA electro catalytic activity. This UA electrochemical sensing device offers a low detection limit (0.3 μM), fine linear ranges (30–1500 μM), reasonable sensitivity, and a fast reaction time. © 2023 John Wiley & Sons Ltd.
Copper-Based Electrochemical Sensor Derived from Thiosemicarbazide for Selective Detection of Neurotransmitter Dopamine
(American Chemical Society, 2024) Shubham Jaiswal; Suryansh Chandra; Jyoti Prajapati; Ida Tiwari; Manoj Kumar Bharty
This paper presents the synthesis of the ligand 1-picolinoyl-4-cyclohexyl-3-thiosemicarbazide (H2pctc) and new metal complexes [Ni(Hpctc)2] (1), [Cu(Hpctc)Cl] (2), and [Cd(Hpctc)2] (3). The synthesized metal complexes were precisely characterized using single crystal X-ray diffraction (SC-XRD). In addition, complexes 1-3 were also characterized by UV-vis, fluorescence, and infrared spectroscopy. SC-XRD data confirmed the distorted octahedral geometry around the Ni(II) and Cd(II) centers and the distorted square planar geometry around the Cu(II) center. Data derived from the emission spectra depict that higher fluorescence intensity was exhibited by complexes 1, 2, and 3 in comparison to that of the free ligand H2pctc, and complex 3 showed the maximum intensity. Further, these metal complex-modified GCEs (glassy carbon electrodes) were utilized for electrochemical sensing of dopamine (DPM). The electrochemical studies of these complexes were performed using modified glassy carbon electrodes supported by electrical impedance spectroscopy (EIS) and cyclic voltammetry (CV) methods. In contrast to complexes 1 and 3, complex 2 is a superior electrode material with a high effective surface area for the electrochemical oxidation of DPM, according to the electrochemical response results. The derived sensor had a wide linear detection range of 1 to 1400 μM, an acceptable sensitivity of 0.01531 μA cm-2 μM-1, and a low LOD of 0.38 μM. The proposed approach was free of the interfering effects of ascorbic acid, uric acid, aminophenol, and other substances. During the successive scans, no fouling of the electrode surface was observed. The proposed electrochemical sensor had excellent stability, sensitivity, and a low detection limit making it suitable for the analysis of a variety of real samples. Additionally, it was proven to be useful for analyzing biological fluids. © 2024 American Chemical Society.
Design, synthesis, and structural evaluation of metal complexes of azepane-1-carbodithioate for targeting human breast cancer: investigating cytotoxic activity against the MDA-MB-231 cell line
(Royal Society of Chemistry, 2024) Shubham Jaiswal; Nilesh Rai; Suryansh Chandra; Ashish Verma; Vibhav Gautam; Manu Adhikari; Sanjay Singh; M.K. Bharty
In this article, we have reported the synthesis and structural characterization of complexes containing Co(iii), Cu(ii), Zn(ii), and Hg(ii) metal cations. The ligand potassium azepane-1-carbodithioate (acdt) behaves as a monodentate and bidentate and forms complexes with the metals mentioned above. We investigated the electronic and emission spectra of the ligand potassium azepane-1-carbodithioate (acdt) and its metal complexes [Co(acdt)3]·CHCl3 (1), [Cu(acdt)2] (2), [Zn2(μ2-acdt)2(acdt)2] (3), and [PhHg(acdt)] (4). A photoluminescence study was also carried out and the results revealed that all compounds are fluorescent. Furthermore, this synthesized ligand and its complexes are passed through to examine their cytotoxic activity against human breast cancer cell line MDA-MB-231 and results suggested that complex [Co(acdt)3]·CHCl3 has sufficiently better activity than others. Furthermore, we have explored the impact of the synthesized ligand and its transition metal complexes on glucose metabolism within the human breast cancer cell line MDA-MB-231. Inhibiting glucose uptake can induce starvation in cancer cells, potentially resulting in cell death due to energy deprivation. Our results indicate that the Co(iii) complex-treated group exhibited a greater inhibition of glucose uptake compared to groups treated with ligands and other metal complexes such as Cu, Zn, and Hg. Furthermore, we also measured the extracellular NO level in the ligand and its metal complexes of Co(iii), Cu(ii), Zn(ii), and Hg(ii) treated MDA-MB-231 cells and results indicated that the free ligand and its metal complexes induced the production of nitric oxide in MDA-MB-231 cells. Among the four metal complexes, Co-complex 1 elevated the nitric oxide level in MDA-MB-231 cells to 75.91 μM. In contrast, the groups treated with the complexes of Cu(ii) (2), Zn(iii) (3), and Hg(ii) (4) induced NO levels of 62.91, 49.24, and 33.10 μM, respectively. This suggests that complex 1 induces nitric oxide production and enhances oxidative stress in MDA-MB-231 cells more significantly compared to the groups treated with the free ligand as well as with metal complexes 2-4. Overall, the data strongly suggest that complex 1 exhibits significant anticancer activity against the human breast cancer cell line MDA-MB-231, making it a promising candidate for combating breast cancer progression. © 2024 The Royal Society of Chemistry.
Electrochemical sensing of 4-nitrophenol through heteroleptic complexes of Ag(I) and Hg(II) based on 2-thiazoline-2-thiol: Synthesis, crystal structures, and Hirshfeld analysis
(John Wiley and Sons Ltd, 2023) Suryansh Chandra; Jyoti Prajapati; Shubham Jaiswal; Shivendra Kumar Pandey; Ida Tiwari; Lal Bahadur Prasad; Manoj Kumar Bharty
In pursuit of a more effective electro-sensor for environmentally hazardous nitro phenols detection at the trace level, we have developed two novel complexes [Ag(μ-S-thzt)(Hthzt)(PPh3)]2·2CH3CH2OH (1) and [Hg (thzt)2(o-phen)](2) based on 2-thiazoline-2-thiol (Hthzt). In complexes 1 and 2, triphenylphosphine and o-phen were used as co-ligands, respectively. Both the synthesizedcomplexes have been characterized by single crystal X-ray diffraction data,UV–vis., infrared, and NMR spectrometry. Geometry around both the metal ion complexes is distorted tetrahedral. Noticeably, in complex 1, the Hthzt acts as a bridging as well as terminal ligand. The intermolecular interaction found in complexes 1 and 2 have been further investigated through Hirshfeld surface analysis. On comparing fluorescence intensities of Hthzt, complex 1, and complex 2, the order of fluorescence behavior was found to be Hthzt > complex 1 > complex 2. The electrochemical performance of both complexes 1 and 2 and their ability to sense 4-nitrophenol (NP) have been evaluated through modified glassy carbon electrodes and were detected by the differential pulse voltammetry (DPV) and cyclic voltammetry (CV) methods. Based on electrochemical responses, complex 1 shows more effective performance as anelectro-sensor than complex 2. With a relatively low detection limit of 0.19 μM, great selectivity, and acceptable sensitivity, the complex 1/GCE sensor demonstrated an exceptional linear plot between the oxidation peak current and NP concentration in the ranges of 0.5–500 μM. © 2023 John Wiley & Sons Ltd.
Solvent-dependent crystallization and anti-cancer activities based on Ni(II) and Co(II) complexes of 1-picolinoyl-4-phenyl-3-thiosemicarbazide: Synthesis, crystal structure, and photoluminescence study
(Elsevier B.V., 2023) Suryansh Chandra; Shubham Jaiswal; Alok Shukla; Ankit Kumar Singh; Somenath Garai; A. Bharti; A. Acharya; M.K. Bharty
In search of alternative of platinum-based drugs for the treatment of cancer, lead to the development of other potential metallodrug of transition metal complexes. The efficacious and novel experimental content of this paper reports the synthesis of [Ni(Hppts)2].CHCl3 (1a), [Ni(Hppts)2].(CH3)2SO (1b) and [Co(Hppts)2] (2) complexes of 1-picolinoyl-4-phenyl-3-thiosemicarbazide (H2ppts). The synthesized complexes have been characterized by UV-vis., Infrared, and NMR spectrometry. Furthermore, complexes 1a and 1b were characterized by single-crystal X-ray diffraction data. Emission spectra show that, complex 1a exhibits higher fluorescence intensity as compared to that of ligand H2ppts and complex 2. The order of fluorescence intensity was found as complex 1a > complex 2 > H2ppts. Moreover, Complexes 1a and 1b are stabilized via various types of intermolecular interactions. The cytotoxicity of complexes 1a, 2, and ligand was evaluated against Dalton's Lymphoma cells using standard MTT Assay. The anticancer activity results showed that complex 1a significantly reduced cell viability in a dose-dependent manner, whereas H2ppts and complex 2 did not show significant reduction in cell viability of DL cells when compared with the control. The complex 1a IC50 value was determined to be around 40 µg/mL. The anti-tumor activity concludes that the complex 1a has high anti-neoplastic activity on DL cells at low doses. © 2023 Elsevier B.V.
Synthesis, characterizations, crystal structure and anticancer activity of Mn(II), Co(II) and Ni(II) complexes of N′-cyclohexyl-2-thiophene-carbonyl hydrazine carbothioamide
(Elsevier Ltd, 2023) Shubham Jaiswal; Lokesh Yadav; Shivendra Kumar Pandey; Suryansh Chandra; M.K. Bharty; L.B. Prasad; A. Acharya
The current century has witnessed continuous and exponential increase in the number of patients suffering from different types of sarcomas. To cure these sarcomas, there are continuous efforts to develop more efficient and less cytotoxic anti-cancerous and antitumor drugs. A thiosemicarbazide derived N-cyclohexyl-2-thiophene-carbonyl hydrazine carbothioamide (Htach) and its metal complexes [Mn(tach)2(o-phen)] (1), [Co(tach)2(o-phen)] (2), [Ni(tach)2(o-phen)] (3) were synthesized and reported here. In these complexes, o-phen was used as secondary ligand for coordinatively saturation of metal ions. The synthesized ligand and complexes are well characterized with different elemental analysis FT-IR, and UV–visible and HR-MS spectroscopy. Further, Complex 1 was characterized by single XRD and crystallized in monoclinic system with space group P 21/n. The anti-proliferative potential of ligand and its complexes were evaluated against Dalton's lymphoma (DL) cancer cell lines through MTT, AO/EtBr and DAPI based assays. The effect of these metal complexes on normal cell lines (splenocyte) has been also investigated. Our investigation reveals that metal–ligand complexes have significant strong anticancer activity against tumor cells in a dose-dependent mode, whereas minimal effect on normal cell lines. For ligand and complexes 1–3, the IC50 values were found as 20, 10, 20 and 5 µM, respectively. These results suggest that among Mn, Co and Ni complexes, nickel complex will be more effective for the functionalization of anticancer agents. © 2023 Elsevier Ltd