Browsing by Author "Suvakanta Barik"

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Beyond the synthetic drugs: Fungal endophytes derived bioactive compounds in the management of neurodegenerative disorders
(Bentham Science Publishers, 2023) Ashish Verma; Nilesh Rai; Swapnil C. Kamble; Pradeep Mishra; Suvakanta Barik; Rajiv Kumar; Santosh Kumar Singh; Prafull Salvi; Vibhav Gautam
Fungal endophytes are a group of fungi that reside in plant tissues and show a symbiotic relationship with the host plants. They protect against pathogens and increase food availability without causing any harmful effects on the host plant. Fungal endophytes are known to produce a wide range of bioactive compounds with several biological activities, including neuroprotective effects. Neurodegenerative disorders lead to miscommunication between nerve cells, damage or loss in structure and function of the central nervous system (CNS) or peripheral nervous system (PNS). Reactive oxygen species, neuroinflammation, protein degradation or aggregation, familial history, mutation in mitochondrial genes, and aging contribute to neurodegenerative disorders. Plant-associated fungal endophytes produce bioactive compounds, which show anti-neuroinflammatory, antioxidant, and anti-cholinesterase activities. Several pro-inflammatory (TNF-α and NF-κB) and depressant (serotonin, dopamine, and noradrenaline) molecules or neuronal signaling pathways leading to neurodegenerative disorders are known to be inhibited or down-regulated by fungal endophyte-derived bioactive compounds. Therefore, bioactive compounds produced from fungal endophytes could be a promising approach to treating various health ailments. The present chapter discusses selected fungal endophyte-derived potential bioactive compounds with neuroprotective effects for managing neurodegenerative disorders. © 2023 Bentham Science Publishers. All rights reserved.
Bioinformatics: How it helps to boost modern biological research
(Indian Academy of Sciences, 2020) Suvakanta Barik; Nilesh Rai; Pradeep Mishra; Santosh K. Singh; Vibhav Gautam
[No abstract available]
Biological potential of bioactive metabolites derived from fungal endophytes associated with medicinal plants
(Springer Science and Business Media Deutschland GmbH, 2021) Priyanka Kumari Keshri; Nilesh Rai; Ashish Verma; Swapnil C. Kamble; Suvakanta Barik; Pradeep Mishra; Santosh Kumar Singh; Prafull Salvi; Vibhav Gautam
Endophytes are endosymbiotic fungi or bacteria that invade and colonize the plant tissue without harming their respective host. Since fungal endophytes live inside the host tissues, their effective isolation and identification is an important step. Endophytic fungi produce bioactive metabolites with unique chemical structures, which may help in improving the physiological condition of both the plants and endophytes. Endophytic fungi are a potent source of all major classes of secondary metabolites including terpenoids, non-ribosomal peptides, polyketides, and alkaloids. With the increase in the number of diseases and human health problems, an intensive search for new sources and effective metabolites is now in progress. The bioactive metabolites produced by the fungal endophytes are competent and effective against various diseases such as cancer, diabetes, infectious diseases, immunological disorders, and cardiovascular diseases. The present review summarizes the efficient approaches used for the screening of fungal endophytes, extraction, and purification of bioactive metabolites along with OMICS based study of endophytes. Along with this, the pharmaceutical importance of novel bioactive metabolites and their efficient production from fungal endophytes using various approaches like genetic engineering, use of elicitors, and precursor feeding are also discussed. © 2021, German Mycological Society and Springer-Verlag GmbH Germany, part of Springer Nature.
Plant associated fungal endophytes as a source of natural bioactive compounds
(Taylor and Francis Ltd., 2021) Nilesh Rai; Priyanka Kumari Keshri; Ashish Verma; Swapnil C. Kamble; Pradeep Mishra; Suvakanta Barik; Santosh Kumar Singh; Vibhav Gautam
Endophytes are a potent source of bioactive compounds that mimic plant-based metabolites. The relationship of host plant and endophyte is significantly associated with alteration in fungal colonisation and the extraction of endophyte-derived bioactive compounds. Screening of fungal endophytes and their relationship with host plants is essential for the isolation of bioactive compounds. Numerous bioactive compounds with antioxidant, antimicrobial, anticancer, and immunomodulatory properties are known to be derived from fungal endophytes. Bioinformatics tools along with the latest techniques such as metabolomics, next-generation sequencing, and metagenomics multilocus sequence typing can potentially fill the gaps in fungal endophyte research. The current review article focuses on bioactive compounds derived from plant-associated fungal endophytes and their pharmacological importance. We conclude with the challenges and opportunities in the research area of fungal endophytes. © 2021 The Author(s). Published by Informa UK Limited, trading as Taylor & Francis Group.
Probiotics for Management of Gastrointestinal Cancers
(Springer Singapore, 2020) Nilesh Rai; Anurag Kumar Singh; Priyanka Kumari Keshri; Suvakanta Barik; Swapnil C. Kamble; Santosh Kumar Singh; Rajiv Kumar; Pradeep Mishra; Deepak Kotiya; Vibhav Gautam
Probiotics has been used for management of genetically predisposed health disorders associated with gastrointestinal (GI) tract. Administration of specific probiotics in defined doses causes revitalization of healthy gut microflora that can positively modulate immune response within GI tract and hence, aid in the management of inflammation of intestinal mucosa. Thus, it has potential of becoming a durable therapeutic approach to resolve metabolism related disorders including GI cancers. Probiotic-induced competition can exclude and replace pathogenic microorganisms from GI cancer-induced niche in gut. Notably, oral administration of probiotics is a key driving factor for the ease of management of post-operative complications of GI tract cancers. Here, we attempt to summarize the diversified knowledge of probiotics to utilize as therapeutic tool in prevention, progression and treatment of GI tract cancer, current challenges of probiotics in regulating GI cancer progression, and future perspectives. © Springer Nature Singapore Pte Ltd. 2021, corrected publication 2021.
Recent technological advancements in stem cell research for targeted therapeutics
(Springer, 2020) Nilesh Rai; Anurag Kumar Singh; Santosh Kumar Singh; Bhaskar Gaurishankar; Swapnil C. Kamble; Pradeep Mishra; Deepak Kotiya; Suvakanta Barik; Neelam Atri; Vibhav Gautam
Stem cells have characteristic features of self-renewal, pluripotency and differentiation, which are responsible for replenishment of tissue or organ. Stem cells are potentiated as therapeutic tool in drug targeting and regenerative medicine—from curing various neurological diseases and malignancies to congenital diseases. These technological advancements have established stem cells as future of medicine. However, due to ethico-social limitations, the use of embryonic stem cells (ESCs) has been avoided, while physiological availability of adult stem cells (ASCs) and induced pluripotent stem cells (iPSCs) has gained appropriate preference. These iPSCs are very much similar to ESCs in terms of their self-renewal and pluripotency. Here, we have summarized the technologies that have established stem cells isolation, their molecular marker and factors responsible for their maintenance. Different cellular (transcription factors, regulatory proteins, miRNA like miRNA-296, miRNA-145, etc.) and extracellular components transcend stem cell fate. Their identification and characterization involve development and efficient utilization of tools like magnetic activated cell sorting (MACS) and fluorescence activated cell sorting (FACS). Some of the technologies have been patented and spin-off’s based on them have been commercialized. In conclusion, we present the future scope and possibilities that stem cell technologies behold for us. [Figure not available: see fulltext.]. © 2020, Controlled Release Society.