Browsing by Author "Swati Kurtkoti"

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A Therapeutic Approach of Essential Oils based on Aromatic Plants in the Treatment of Leishmaniasis and Vitiligo
(Pharma Book Syndicate, 2023) Subhashree Patra; Meghraj Suryawanshi; Ankita Bhavsar; Swati Kurtkoti; Harsha Patel; Sushil Raut
Aromatic plants possessing medicinal and bioactive features are the optimistic treatments for irremediable diseases like Leishmaniasis and vitiligo. Leishmaniasis, a lethal disease with over 350 million affected people, has made it a growing concern due to its non-effectual drugs and increasing pathogenic resistance. While vitiligo with globally 1% inhabitants suffering from an autoimmune disorder of depigmentation as macules on skin. Both diseases have two common characteristics: affecting the quality of life; chances of relapse due to ineffectiveness and short-lived treatments. For leishmaniasis, pentavalent antimonials in intravenous mode are the propitious large-scale approach; oral drug miltefosine and liposomal amphotericin B have been in use for a long term. Various combination therapies of paromomycin, sitamaquine, and pentamidine with antimonials up to some extent have delimited the degree of reoccurrence. However, the cost-ineffectiveness, short-term, and detrimental side effects are the roots of failure. Treatment via topical drugs, phototherapies, and surgeries has delimited effectiveness for vitiligo. This review studies the therapeutic approach of a total of 16 essential oils from plants in treating Leishmaniasis and vitiligo with efficacy and long-term effects. Among the 6 EOs notable effect of Bergamot oil with nano-lipid formulations manifested potential for permanent repigmentation. This review also noted the promising potentiality of essential oil mono-therapies, its combination utilities with current drugs could be the active and potential approach to treatment. Such as the combination anti-leishmanial effect of Curcumin and eucalyptus essential oil with miltefosine and glucantime respectively. The phenomenal effects of essential oil from Tetradenia riparia suggested notable anti-leishmanial and immunological responses towards Leishmania and could be utilized as an Antileishmanial drug with further insights. © Pharma Book Syndicate. All Rights Reserved.