Browsing by Author "Theo Vos"

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Age–sex differences in the global burden of lower respiratory infections and risk factors, 1990–2019: results from the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Hmwe Hmwe Kyu; Avina Vongpradith; Sarah Brooke Sirota; Amanda Novotney; Christopher E Troeger; Matthew C Doxey; Rose G Bender; Jorge R Ledesma; Molly H Biehl; Samuel B Albertson; Joseph Jon Frostad; Katrin Burkart; Fiona B Bennitt; Jeff T Zhao; William M Gardner; Hailey Hagins; Dana Bryazka; Regina-Mae Villanueva Dominguez; Semagn Mekonnen Abate; Michael Abdelmasseh; Amir Abdoli; Gholamreza Abdoli; Aidin Abedi; Vida Abedi; Tadesse M Abegaz; Hassan Abidi; Richard Gyan Aboagye; Hassan Abolhassani; Yonas Derso Abtew; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Ahmed Abu-Zaid; Kidist Adamu; Isaac Yeboah Addo; Oyelola A Adegboye; Mohammad Adnan; Qorinah Estiningtyas Sakilah Adnani; Muhammad Sohail Afzal; Saira Afzal; Bright Opoku Ahinkorah; Aqeel Ahmad; Araz Ramazan Ahmad; Sajjad Ahmad; Ali Ahmadi; Sepideh Ahmadi; Haroon Ahmed; Jivan Qasim Ahmed; Tarik Ahmed Rashid; Mostafa Akbarzadeh-Khiavi; Hanadi Al Hamad; Luciana Albano; Mamoon A Aldeyab; Bezatu Mengistie Alemu; Kefyalew Addis Alene; Abdelazeem M Algammal; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Beriwan Abdulqadir Ali; Liaqat Ali; Musa Mohammed Ali; Syed Shujait Ali; Yousef Alimohamadi; Vahid Alipour; Adel Al-Jumaily; Syed Mohamed Aljunid; Sami Almustanyir; Rajaa M Al-Raddadi; Rami H Hani Al-Rifai; Saif Aldeen S AlRyalat; Nelson Alvis-Guzman; Nelson J Alvis-Zakzuk; Edward Kwabena Ameyaw; Javad Javad Aminian Dehkordi; John H Amuasi; Dickson A Amugsi; Etsay Woldu Anbesu; Adnan Ansar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Demelash Areda; Ayele Mamo Argaw; Zeleke Gebru Argaw; Judie Arulappan; Raphael Taiwo Aruleba; Mulusew A Asemahagn; Seyyed Shamsadin Athari; Daniel Atlaw; Engi F Attia; Sameh Attia; Avinash Aujayeb; Tewachew Awoke; Tegegn Mulatu Ayana; Martin Amogre Ayanore; Sina Azadnajafabad; Mohammadreza Azangou-Khyavy; Samad Azari; Amirhossein Azari Jafari; Muhammad Badar; Ashish D Badiye; Nayereh Baghcheghi; Sara Bagherieh; Atif Amin Baig; MacIej Banach; Indrajit Banerjee; Mainak Bardhan; Francesco Barone-Adesi; Hiba Jawdat Barqawi; Amadou Barrow; Azadeh Bashiri; Quique Bassat; Abdul-Monim Mohammad Batiha; Abate Bekele Belachew; Melaku Ashagrie Belete; Uzma Iqbal Belgaumi; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Parth Bhatt; Vijayalakshmi S Bhojaraja; Zulfiqar A Bhutta; Soumitra S Bhuyan; Ali Bijani; Saeid Bitaraf; Belay Boda Abule Bodicha; Nikolay Ivanovich Briko; Danilo Buonsenso; Muhammad Hammad Butt; Jiao Cai; Paulo Camargos; Luis Alberto Cámera; Promit Ananyo Chakraborty; Muluken Genetu Chanie; Jaykaran Charan; Vijay Kumar Chattu; Patrick R Ching; Sungchul Choi; Yuen Yu Chong; Sonali Gajanan Choudhari; Enayet Karim Chowdhury; Devasahayam J Christopher; Dinh-Toi Chu; Natalie L Cobb; Aaron J Cohen; Natália Cruz-Martins; Omid Dadras; Fentaw Teshome Dagnaw; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; An Thi Minh Dao; Sisay Abebe Debela; Biniyam Demisse; Fitsum Wolde Demisse; Solomon Demissie; Diriba Dereje; Hardik Dineshbhai Desai; Abebaw Alemayehu Desta; Belay Desye; Sameer Dhingra; Nancy Diao; Daniel Diaz; Lankamo Ena Digesa; Linh Phuong Doan; Milad Dodangeh; Deepa Dongarwar; Fariba Dorostkar; Wendel Mombaque Dos Santos; Haneil Larson Dsouza; Eleonora Dubljanin; Oyewole Christopher Durojaiye; Hisham Atan Edinur; Elham Ehsani-Chimeh; Ebrahim Eini; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Eman D El Desouky; Iman El Sayed; Maysaa El Sayed Zaki; Muhammed Elhadi; Ahmed Mahmoud Rabie Elkhapery; Amir Emami; Luchuo Engelbert Bain; Ryenchindorj Erkhembayar; Farshid Etaee; Mohamad Ezati Asar; Adeniyi Francis Fagbamigbe; Shahab Falahi; Aida Fallahzadeh; Anwar Faraj; Emerito Jose A Faraon; Ali Fatehizadeh; Pietro Ferrara; Allegra Allegra Ferrari; Getahun Fetensa; Florian Fischer; Joanne Flavel; Masoud Foroutan; Peter Andras Gaal; Abhay Motiramji Gaidhane; Santosh Gaihre; Nasrin Galehdar; Alberto L Garcia-Basteiro; Tushar Garg; Mesfin Damtew Gebrehiwot; Mathewos Alemu Gebremichael; Yibeltal Yismaw Gela; Belete Negese Belete Gemeda; Bradford D Gessner; Melaku Getachew; Asmare Getie; Seyyed-Hadi Ghamari; Mohammad Ghasemi Nour; Ahmad Ghashghaee; Ali Gholamrezanezhad; Abdolmajid Gholizadeh; Rakesh Ghosh; Sherief Ghozy; Pouya Goleij; Mohamad Golitaleb; Giuseppe Gorini; Alessandra C Goulart; Girma Garedew Goyomsa; Habtamu Alganeh Guadie; Zewdie Gudisa; Rashid Abdi Guled; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Alemu Guta; Parham Habibzadeh; Arvin Haj-Mirzaian; Rabih Halwani; Samer Hamidi; Md Abdul Hannan; Mehdi Harorani; Ahmed I Hasaballah; Hamidreza Hasani; Abbas M Hassan; Shokoufeh Hassani; Hossein Hassanian-Moghaddam; Hadi Hassankhani; Khezar Hayat; Behzad Heibati; Mohammad Heidari; Demisu Zenbaba Heyi; Kamal Hezam; Ramesh Holla; Sung Hwi Hong; Nobuyuki Horita; Mohammad-Salar Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Mowafa Househ; Soodabeh Hoveidamanesh; Junjie Huang; Nawfal R Hussein; Ivo Iavicoli; Segun Emmanuel Ibitoye; Kevin S Ikuta; Olayinka Stephen Ilesanmi; Irena M Ilic; Milena D Ilic; Mustapha Immurana; Nahlah Elkudssiah Ismail; Masao Iwagami; Jalil Jaafari; Elham Jamshidi; Sung-In Jang; Amirreza Javadi Mamaghani; Tahereh Javaheri; Fatemeh Javanmardi; Javad Javidnia; Sathish Kumar Jayapal; Umesh Jayarajah; Shubha Jayaram; Alelign Tasew Jema; Wonjeong Jeong; Jost B Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; V. K; Zubair Kabir; Salah Eddine Oussama Kacimi; Vidya Kadashetti; Laleh R Kalankesh; Rohollah Kalhor; Ashwin Kamath; Bhushan Dattatray Kamble; Himal Kandel; Tesfaye K Kanko; Ibraheem M Karaye; André Karch; Samad Karkhah; Bekalu Getnet Kassa; Patrick D M C Katoto; Harkiran Kaur; Rimple Jeet Kaur; Leila Keikavoosi-Arani; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Ejaz Ahmad Khan; Gulfaraz Khan; Imteyaz A Khan; Maseer Khan; Md Nuruzzaman Khan; Moien A B Khan; Yusra H Khan; Moawiah Mohammad Khatatbeh; Mina Khosravifar; Jagdish Khubchandani; Min Seo Kim; Ruth W Kimokoti; Adnan Kisa; Sezer Kisa; Niranjan Kissoon; Luke D Knibbs; Sonali Kochhar; Farzad Kompani; Hamid Reza Koohestani; Vladimir Andreevich Korshunov; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; G Anil Kumar; Om P Kurmi; Ambily Kuttikkattu; Dharmesh Kumar Lal; Judit Lám; Iván Landires; Caterina Ledda; Sang-Woong Lee; Miriam Levi; Sonia Lewycka; Gang Liu; Wei Liu; Rakesh Lodha; László Lorenzovici; Mojgan Lotfi; Joana A Loureiro; Farzan Madadizadeh; Ata Mahmoodpoor; Razzagh Mahmoudi; Marzieh Mahmoudimanesh; Jamal Majidpoor; Alaa Makki; Elaheh Malakan Rad; Ahmad Azam Malik; Tauqeer Hussain Mallhi; Yosef Manla; Clara N Matei; Alexander G Mathioudakis; Richard James Maude; Entezar Mehrabi Nasab; Addisu Melese; Ziad A Memish; Oliver Mendoza-Cano; Alexios-Fotios A Mentis; Tuomo J Meretoja; Mehari Woldemariam Merid; Tomislav Mestrovic; Ana Carolina Micheletti Gomide Nogueira De Sá; Gelana Fekadu Worku Mijena; Le Huu Nhat Minh; Shabir Ahmad Mir; Reza Mirfakhraie; Seyyedmohammadsadeq Mirmoeeni; Agha Zeeshan Mirza; Moonis Mirza; Mohammad Mirza-Aghazadeh-Attari; Abay Sisay Misganaw; Awoke Temesgen Misganaw; Esmaeil Mohammadi; Mokhtar Mohammadi; Arif Mohammed; Shafiu Mohammed; Syam Mohan; Mohammad Mohseni; Nagabhishek Moka; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Md Moniruzzaman; Fateme Montazeri; Catrin E Moore; Abdolvahab Moradi; Lidia Morawska; Jonathan F Mosser; Ebrahim Mostafavi; Majid Motaghinejad; Haleh Mousavi Isfahani; Seyed Ali Mousavi-Aghdas; Sumaira Mubarik; Efrén Murillo-Zamora; Ghulam Mustafa; Sanjeev Nair; Tapas Sadasivan Nair; Houshang Najafi; Atta Abbas Naqvi; Sreenivas Narasimha Swamy; Zuhair S Natto; Biswa Prakash Nayak; Seyed Aria Nejadghaderi; Huy Van Nguyen Nguyen; Robina Khan Niazi; Antonio Tolentino Nogueira De Sá; Hasti Nouraei; Ali Nowroozi; Virginia Nuñez-Samudio; Chimezie Igwegbe Nzoputam; Ogochukwu Janet Nzoputam; Bogdan Oancea; Chimedsuren Ochir; Oluwakemi Ololade Odukoya; Hassan Okati-Aliabad; Akinkunmi Paul Okekunle; Osaretin Christabel Okonji; Andrew T Olagunju; Isaac Iyinoluwa Olufadewa; Ahmed Omar Bali; Emad Omer; Eyal Oren; Erika Ota; Nikita Otstavnov; Abderrahim Oulhaj; P.A. Mahesh; Jagadish Rao Padubidri; Keyvan Pakshir; Reza Pakzad; Tamás Palicz; Anamika Pandey; Suman Pant; Shahina Pardhan; Eun-Cheol Park; Eun-Kee Park; Fatemeh Pashazadeh Kan; Rajan Paudel; Shrikant Pawar; Minjin Peng; Gavin Pereira; Simone Perna; Navaraj Perumalsamy; Ionela-Roxana Petcu; David M Pigott; Zahra Zahid Piracha; Vivek Podder; Roman V Polibin; Maarten J Postma; Hamid Pourasghari; Naeimeh Pourtaheri; Mirza Muhammad Fahd Qadir; Mathieu Raad; Mohammad Rabiee; Navid Rabiee; Saber Raeghi; Alireza Rafiei; Fakher Rahim; Mehran Rahimi; Vafa Rahimi-Movaghar; Azizur Rahman; Md Obaidur Rahman; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Vahid Rahmanian; Pradhum Ram; Kiana Ramezanzadeh; Juwel Rana; Priyanga Ranasinghe; Usha Rani; Sowmya J Rao; Sina Rashedi; Mohammad-Mahdi Rashidi; Azad Rasul; Zubair Ahmed Ratan; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Elrashdy Moustafa Mohamed Redwan; Marissa B Reitsma; Andre M N Renzaho; Mohsen Rezaeian; Abanoub Riad; Reza Rikhtegar; Jefferson Antonio Buendia Rodriguez; Emma L B Rogowski; Luca Ronfani; Kristina E Rudd; Basema Saddik; Erfan Sadeghi; Umar Saeed; Azam Safary; Sher Zaman Safi; Maryam Sahebazzamani; Amirhossein Sahebkar; Sateesh Sakhamuri; Sana Salehi; Muhammad Salman; Hossein Samadi Kafil; Abdallah M Samy; Milena M Santric-Milicevic; Bruno Piassi Sao Jose; Maryam Sarkhosh; Brijesh Sathian; Monika Sawhney; Ganesh Kumar Saya; Abdul-Aziz Seidu; Allen Seylani; Amira A Shaheen; Masood Ali Shaikh; Elaheh Shaker; Hina Shamshad; Mequannent Melaku Sharew; Asaad Sharhani; Azam Sharifi; Purva Sharma; Ali Sheidaei; Suchitra M Shenoy; Jeevan K Shetty; Damtew Solomon Shiferaw; Mika Shigematsu; Jae Il Shin; Hesamaddin Shirzad-Aski; K.M. Shivakumar; Siddharudha Shivalli; Parnian Shobeiri; Wudneh Simegn; Colin R Simpson; Harpreet Singh; Jasvinder A Singh; Paramdeep Singh; Samarjeet Singh Siwal; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Mohammad Sadegh Soltani-Zangbar; Suhang Song; Yimeng Song; Prashant Sood; Chandrashekhar T Sreeramareddy; Paschalis Steiropoulos; Muhammad Suleman; Seyed-Amir Tabatabaeizadeh; Alireza Tahamtan; Majid Taheri; Moslem Taheri Soodejani; Elahe Taki; Iman M Talaat; Mircea Tampa; Sarmila Tandukar; Nathan Y Tat; Vivian Y Tat; Yibekal Manaye Tefera; Gebremaryam Temesgen; Mohamad-Hani Temsah; Azene Tesfaye; Degefa Gomora Tesfaye; Belay Tessema; Rekha Thapar; Jansje Henny Vera Ticoalu; Amir Tiyuri; Imad I Tleyjeh; Munkhsaikhan Togtmol; Marcos Roberto Tovani-Palone; Derara Girma Tufa; Irfan Ullah; Era Upadhyay; Sahel Valadan Tahbaz; Pascual R Valdez; Rohollah Valizadeh; Constantine Vardavas; Tommi Juhani Vasankari; Bay Vo; Linh Gia Vu; Birhanu Wagaye; Yasir Waheed; Yu Wang; Abdul Waris; T Eoin West; Nuwan Darshana Wickramasinghe; Xiaoyue Xu; Sajad Yaghoubi; Gahin Abdulraheem Tayib Yahya; Seyed Hossein Yahyazadeh Jabbari; Dong Keon Yon; Naohiro Yonemoto; Burhan Abdullah Zaman; Alireza Zandifar; Moein Zangiabadian; Heather J Zar; Iman Zare; Zahra Zareshahrabadi; Armin Zarrintan; Mikhail Sergeevich Zastrozhin; Wu Zeng; Mengxi Zhang; Zhi-Jiang Zhang; Chenwen Zhong; Mohammad Zoladl; Alimuddin Zumla; Stephen S Lim; Theo Vos; Mohsen Naghavi; Michael Brauer; Simon I Hay; Christopher J L Murray
Background: The global burden of lower respiratory infections (LRIs) and corresponding risk factors in children older than 5 years and adults has not been studied as comprehensively as it has been in children younger than 5 years. We assessed the burden and trends of LRIs and risk factors across all age groups by sex, for 204 countries and territories. Methods: In this analysis of data for the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019, we used clinician-diagnosed pneumonia or bronchiolitis as our case definition for LRIs. We included International Classification of Diseases 9th edition codes 079.6, 466–469, 470.0, 480–482.8, 483.0–483.9, 484.1–484.2, 484.6–484.7, and 487–489 and International Classification of Diseases 10th edition codes A48.1, A70, B97.4–B97.6, J09–J15.8, J16–J16.9, J20–J21.9, J91.0, P23.0–P23.4, and U04–U04.9. We used the Cause of Death Ensemble modelling strategy to analyse 23 109 site-years of vital registration data, 825 site-years of sample vital registration data, 1766 site-years of verbal autopsy data, and 681 site-years of mortality surveillance data. We used DisMod-MR 2.1, a Bayesian meta-regression tool, to analyse age–sex-specific incidence and prevalence data identified via systematic reviews of the literature, population-based survey data, and claims and inpatient data. Additionally, we estimated age–sex-specific LRI mortality that is attributable to the independent effects of 14 risk factors. Findings: Globally, in 2019, we estimated that there were 257 million (95% uncertainty interval [UI] 240–275) LRI incident episodes in males and 232 million (217–248) in females. In the same year, LRIs accounted for 1·30 million (95% UI 1·18–1·42) male deaths and 1·20 million (1·07–1·33) female deaths. Age-standardised incidence and mortality rates were 1·17 times (95% UI 1·16–1·18) and 1·31 times (95% UI 1·23–1·41) greater in males than in females in 2019. Between 1990 and 2019, LRI incidence and mortality rates declined at different rates across age groups and an increase in LRI episodes and deaths was estimated among all adult age groups, with males aged 70 years and older having the highest increase in LRI episodes (126·0% [95% UI 121·4–131·1]) and deaths (100·0% [83·4–115·9]). During the same period, LRI episodes and deaths in children younger than 15 years were estimated to have decreased, and the greatest decline was observed for LRI deaths in males younger than 5 years (–70·7% [–77·2 to –61·8]). The leading risk factors for LRI mortality varied across age groups and sex. More than half of global LRI deaths in children younger than 5 years were attributable to child wasting (population attributable fraction [PAF] 53·0% [95% UI 37·7–61·8] in males and 56·4% [40·7–65·1] in females), and more than a quarter of LRI deaths among those aged 5–14 years were attributable to household air pollution (PAF 26·0% [95% UI 16·6–35·5] for males and PAF 25·8% [16·3–35·4] for females). PAFs of male LRI deaths attributed to smoking were 20·4% (95% UI 15·4–25·2) in those aged 15–49 years, 30·5% (24·1–36·9) in those aged 50–69 years, and 21·9% (16·8–27·3) in those aged 70 years and older. PAFs of female LRI deaths attributed to household air pollution were 21·1% (95% UI 14·5–27·9) in those aged 15–49 years and 18·2% (12·5–24·5) in those aged 50–69 years. For females aged 70 years and older, the leading risk factor, ambient particulate matter, was responsible for 11·7% (95% UI 8·2–15·8) of LRI deaths. Interpretation: The patterns and progress in reducing the burden of LRIs and key risk factors for mortality varied across age groups and sexes. The progress seen in children younger than 5 years was clearly a result of targeted interventions, such as vaccination and reduction of exposure to risk factors. Similar interventions for other age groups could contribute to the achievement of multiple Sustainable Development Goals targets, including promoting wellbeing at all ages and reducing health inequalities. Interventions, including addressing risk factors such as child wasting, smoking, ambient particulate matter pollution, and household air pollution, would prevent deaths and reduce health disparities. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Alcohol use and burden for 195 countries and territories, 1990-2016: A systematic analysis for the Global Burden of Disease Study 2016
(Lancet Publishing Group, 2018) Max G. Griswold; Nancy Fullman; Caitlin Hawley; Nicholas Arian; Stephanie R. M. Zimsen; Hayley D. Tymeson; Vidhya Venkateswaran; Austin Douglas Tapp; Mohammad H. Forouzanfar; Joseph S. Salama; Kalkidan Hassen Abate; Degu Abate; Solomon M. Abay; Cristiana Abbafati; Rizwan Suliankatchi Abdulkader; Zegeye Abebe; Victor Aboyans; Mohammed Mehdi Abrar; Pawan Acharya; Olatunji O. Adetokunboh; Tara Ballav Adhikari; Jose C. Adsuar; Mohsen Afarideh; Emilie Elisabet Agardh; Gina Agarwal; Sargis Aghasi Aghayan; Sutapa Agrawal; Muktar Beshir Ahmed; Mohammed Akibu; Tomi Akinyemiju; Nadia Akseer; Deena H. Al Asfoor; Ziyad Al-Aly; Fares Alahdab; Khurshid Alam; Ammar Albujeer; Kefyalew Addis Alene; Raghib Ali; Syed Danish Ali; Mehran Alijanzadeh; Syed Mohamed Aljunid; Ala'A Alkerwi; Peter Allebeck; Nelson Alvis-Guzman; Azmeraw T. Amare; Leopold N. Aminde; Walid Ammar; Yaw Ampem Amoako; Gianna Gayle Herrera Amul; Catalina Liliana Andrei; Colin Angus; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Olatunde Aremu; Johan Ärnlöv; Al Artaman; Krishna K. Aryal; Reza Assadi; Marcel Ausloos; Leticia Avila-Burgos; Euripide F. G. A. Avokpaho; Ashish Awasthi; Henok Tadesse Ayele; Rakesh Ayer; Tambe B. Ayuk; Peter S. Azzopardi; Hamid Badali; Alaa Badawi; Maciej Banach; Suzanne Lyn Barker-Collo; Lope H. Barrero; Huda Basaleem; Estifanos Baye; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Yannick Béjot; Abate Bekele Belachew; Saba Abraham Belay; Derrick A. Bennett; Isabela M. Bensenor; Eduardo Bernabe; Robert S. Bernstein; Addisu Shunu Beyene; Tina Beyranvand; Soumyadeeep Bhaumik; Zulfiqar A. Bhutta; Belete Biadgo; Ali Bijani; Nigus Bililign; Sait Mentes Birlik; Charles Birungi; Hailemichael Bizuneh; Peter Bjerregaard; Tone Bjørge; Guilherme Borges; Cristina Bosetti; Soufiane Boufous; Nicola Luigi Bragazzi; Hermann Brenner; Zahid A. Butt; Lucero Cahuana-Hurtado; Bianca Calabria; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Giulia Carreras; Juan J. Carrero; Félix Carvalho; Carlos A. Castañeda-Orjuela; Jacqueline Castillo Rivas; Ferrán Catalá-López; Jung-Chen Chang; Fiona J. Charlson; Aparajita Chattopadhyay; Pankaj Chaturvedi; Rajiv Chowdhury; Devasahayam J. Christopher; Sheng-Chia Chung; Liliana G. Ciobanu; Rafael M. Claro; Sara Conti; Ewerton Cousin; Michael H. Criqui; Berihun Assefa Dachew; Paul I. Dargan; Ahmad Daryani; José Das Neves; Kairat Davletov; Filipa De Castro; Barbora De Courten; Jan-Walter De Neve; Louisa Degenhardt; Gebre Teklemariam Demoz; Don C. Des Jarlais; Subhojit Dey; Rupinder Singh Dhaliwal; Samath Dhamminda Dharmaratne; Meghnath Dhimal; David Teye Doku; Kerrie E. Doyle; Manisha Dubey; Eleonora Dubljanin; Bruce B. Duncan; Hedyeh Ebrahimi; Dumessa Edessa; Maysaa El Sayed Zaki; Sergei Petrovich Ermakov; Holly E. Erskine; Alireza Esteghamati; Mahbobeh Faramarzi; Andrea Farioli; Andre Faro; Maryam S. Farvid; Farshad Farzadfar; Valery L. Feigin; Mariana Santos Felisbino-Mendes; Eduarda Fernandes; Alize J. Ferrari; Cleusa P. Ferri; Daniel Obadare Fijabi; Irina Filip; Jonas David Finger; Florian Fischer; Abraham D. Flaxman; Richard Charles Franklin; Neal D. Futran; Silvano Gallus; Morsaleh Ganji; Fortune Gbetoho Gankpe; Gebremedhin Berhe Gebregergs; Tsegaye Tewelde Gebrehiwot; Johanna M. Geleijnse; Reza Ghadimi; Lilian A. Ghandour; Mamata Ghimire; Paramjit Singh Gill; Ibrahim Abdelmageed Ginawi; Ababi Zergaw Z. Giref; Philimon N. Gona; Sameer Vali Gopalani; Carolyn C. Gotay; Alessandra C. Goulart; Felix Greaves; Giuseppe Grosso; Yuming Guo; Rahul Gupta; Rajeev Gupta; Vipin Gupta; Reyna Alma Gutiérrez; Murthy Gvs; Nima Hafezi-Nejad; Tekleberhan Beyene Hagos; Gessessew Bugssa Hailu; Randah R. Hamadeh; Samer Hamidi; Graeme J. Hankey; Hilda L. Harb; Sivadasanpillai Harikrishnan; Josep Maria Haro; Hamid Yimam Hassen; Rasmus Havmoeller; Simon I. Hay; Behzad Heibati; Andualem Henok; Ileana Heredia-Pi; Norberto Francisco Hernández-Llanes; Claudiu Herteliu; Desalegn Ts Tsegaw Hibstu; Praveen Hoogar; Nobuyuki Horita; H. Dean Hosgood; Mostafa Hosseini; Mihaela Hostiuc; Guoqing Hu; Hsiang Huang; Abdullatif Husseini; Bulat Idrisov; Bogdan Vasile Ileanu; Olayinka Stephen Ilesanmi; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Maria D. Jackson; Mihajlo Jakovljevic; Moti Tolera Jalu; Achala Upendra Jayatilleke; Ravi Prakash Jha; Jost B. Jonas; Jacek Jerzy Jozwiak; Zubair Kabir; Rajendra Kadel; Amaha Kahsay; Umesh Kapil; Amir Kasaeian; Tesfaye D. Dessale Kassa; Srinivasa Vittal Katikireddi; Norito Kawakami; Seifu Kebede; Adane Teshome Kefale; Peter Njenga Keiyoro; Andre Pascal Kengne; Yousef Khader; Morteza Abdullatif Khafaie; Ibrahim A. Khalil; Md Nuruzzaman Khan; Young-Ho Khang; Mona M. Khater; Jagdish Khubchandani; Cho-Il Kim; Daniel Kim; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Mika Kivimäki; Sonali Kochhar; Soewarta Kosen; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Veena S. Kulkarni; Pushpendra Kumar; Alessandra Lafranconi; Arjun Lakshmana Balaji; Ratilal Lalloo; Tea Lallukka; Hilton Lam; Faris Hasan Lami; Qing Lan; Justin J. Lang; Sonia Lansky; Anders O. Larsson; Arman Latifi; Janet L. Leasher; Paul H. Lee; James Leigh; Mall Leinsalu; Janni Leung; Miriam Levi; Yichong Li; Lee-Ling Lim; Shai Linn; Shiwei Liu; Andrea Lobato-Cordero; Alan D. Lopez; Paulo A. Lotufo; Erlyn Rachelle King Macarayan; Isis Eloah Machado; Fabiana Madotto; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Marek Majdan; Reza Majdzadeh; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Chabila Christopher Mapoma; Jose Martinez-Raga; Pallab K. Maulik; Mohsen Mazidi; Martin McKee; Varshil Mehta; Toni Meier; Tesfa Mekonen; Kidanu Gebremariam Meles; Addisu Melese; Peter T. N. Memiah; Walter Mendoza; Desalegn Tadese Mengistu; George A. Mensah; Tuomo J. Meretoja; Haftay Berhane Mezgebe; Tomasz Miazgowski; Ted R. Miller; Gk Mini; Andreea Mirica; Erkin M. Mirrakhimov; Babak Moazen; Karzan Abdulmuhsin Mohammad; Noushin Mohammadifard; Shafiu Mohammed; Lorenzo Monasta; Paula Moraga; Lidia Morawska; Seyyed Meysam Mousavi; Satinath Mukhopadhyay; Kamarul Imran Musa; Aliya Naheed; Gurudatta Naik; Farid Najafi; Vinay Nangia; Jobert Richie Nansseu; Mudavath Siva Durga Prasad Nayak; Chakib Nejjari; Subas Neupane; Sudan Prasad Neupane; Josephine W. Ngunjiri; Cuong Tat Nguyen; Long Hoang Nguyen; Trang Huyen Nguyen; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Jean Jacques Noubiap; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Olanrewaju Oladimeji; Andrew T. Olagunju; Pedro R. Olivares; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Anu Mary Oommen; Eyal Oren; Heather M. Orpana; Doris D. V. Ortega-Altamirano; Justin R. Ortiz; Erika Ota; Mayowa Ojo Owolabi; Abayomi Samuel Oyekale; P.A. Mahesh; Adrian Pana; Eun-Kee Park; Charles D. H. Parry; Hadi Parsian; Ajay Patle; George C. Patton; Deepak Paudel; Max Petzold; Michael R. Phillips; Julian David Pillay; Maarten J. Postma; Farshad Pourmalek; Dorairaj Prabhakaran; Mostafa Qorbani; Amir Radfar; Anwar Rafay; Alireza Rafiei; Fakher Rahim; Afarin Rahimi-Movaghar; Mahfuzar Rahman; Muhammad Aziz Rahman; Rajesh Kumar Rai; Sasa Rajsic; Sree Bhushan Raju; Usha Ram; Saleem M. Rana; Chhabi Lal Ranabhat; David Laith Rawaf; Salman Rawaf; Robert C. Reiner; Cesar Reis; Andre M. N. Renzaho; Mohammad Sadegh Rezai; Leonardo Roever; Luca Ronfani; Robin Room; Gholamreza Roshandel; Ali Rostami; Gregory A. Roth; Ambuj Roy; Yogesh Damodar Sabde; Basema Saddik; Saeid Safiri; Amirhossein Sahebkar; Zikria Saleem; Joshua A. Salomon; Sundeep Santosh Salvi; Juan Sanabria; Maria Dolores Sanchez-Niño; Damian Francesco Santomauro; Itamar S. Santos; Milena M. M. Santric Milicevic; Abdur Razzaque Sarker; Rodrigo Sarmiento-Suárez; Nizal Sarrafzadegan; Benn Sartorius; Maheswar Satpathy; Monika Sawhney; Sonia Saxena; Mete Saylan; Michael P. Schaub; Maria Inês Schmidt; Ione J. C. Schneider; Ben Schöttker; Aletta Elisabeth Schutte; Falk Schwendicke; Sadaf G. Sepanlou; Masood Ali Shaikh; Mehdi Sharif; Jun She; Aziz Sheikh; Jiabin Shen; Mekonnen Sisay Shiferaw; Mika Shigematsu; Rahman Shiri; Kawkab Shishani; Ivy Shiue; Sharvari Rahul Shukla; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Natacha Torres Da Silva; Dayane Gabriele Alves Silveira; Dhirendra Narain Sinha; Freddy Sitas; Adauto Martins Soares Filho; Moslem Soofi; Reed J. D. Sorensen; Joan B. Soriano; Chandrashekhar T. Sreeramareddy; Nadine Steckling; Dan J. Stein; Mu'Awiyyah Babale Sufiyan; Patrick J. Sur; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Takahiro Tabuchi; Mohammad Tavakkoli; Arash Tehrani-Banihashemi; Merhawi Gebremedhin Tekle; Subash Thapa; Nihal Thomas; Roman Topor-Madry; Fotis Topouzis; Bach Xuan Tran; Christopher E. Troeger; Thomas Clement Truelsen; Nikolaos Tsilimparis; Stefanos Tyrovolas; Kingsley Nnanna Ukwaja; Irfan Ullah; Olalekan A. Uthman; Pascual R. Valdez; Job F. M. Van Boven; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Francesco S. Violante; Sergey Konstantinovitch Vladimirov; Vasily Vlassov; Stein Emil Vollset; Theo Vos; Fasil Wagnew Shiferaw Wagnew; Yasir Waheed; Yuan-Pang Wang; Elisabete Weiderpass; Fitsum Weldegebreal; Kidu Gidey Weldegwergs; Andrea Werdecker; Ronny Westerman; Harvey A. Whiteford; Justyna Widecka; Tissa Wijeratne; Grant M. A. Wyper; Gelin Xu; Tomohide Yamada; Yuichiro Yano; Pengpeng Ye; Ebrahim M. Yimer; Paul Yip; Biruck Desalegn Yirsaw; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Marcel Yotebieng; Mustafa Z. Younis; Geevar Zachariah; Zoubida Zaidi; Mohammad Zamani; Xueying Zhang; Sanjay Zodpey; Ali H. Mokdad; Mohsen Naghavi; Christopher J. L. Murray; Emmanuela Gakidou
Background: Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted lifeyears (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older. Methods: Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health. Findings: Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5-3·0) of age-standardised female deaths and 6·8% (5·8-8·0) of agestandardised male deaths. Among the population aged 15-49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2-4·3) of female deaths and 12·2% (10·8-13·6) of male deaths attributable to alcohol use. For the population aged 15-49 years, female attributable DALYs were 2·3% (95% UI 2·0-2·6) and male attributable DALYs were 8·9% (7·8-9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0-1·7] of total deaths), road injuries (1·2% [0·7-1·9]), and self-harm (1·1% [0·6-1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2-33·3) of total alcohol-attributable female deaths and 18·9% (15·3-22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0-0·8) standard drinks per week. Interpretation: Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption. Funding Bill & Melinda Gates Foundation. Copyright © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license.
Burden of injury along the development spectrum: associations between the Socio-demographic Index and disability-adjusted life year estimates from the Global Burden of Disease Study 2017
(BMJ Publishing Group, 2020) Juanita A. Haagsma; Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Lydia R. Lucchesi; Nicholas L.S. Roberts; Dillon O. Sylte; Oladimeji M. Adebayo; Alireza Ahmadi; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Suliman A. Alghnam; Syed Mohamed Aljunid; Rajaa M. Al-Raddadi; Ubai Alsharif; Khalid Altirkawi; Mina Anjomshoa; Carl Abelardo T. Antonio; Seth Christopher Yaw Appiah; Olatunde Aremu; Amit Arora; Hamid Asayesh; Reza Assadi; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Shivanthi Balalla; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Masoud Behzadifar; Meysam Behzadifar; Corina Benjet; Derrick A. Bennett; Isabela M. Bensenor; Soumyadeep Bhaumik; Zulfiqar A. Bhutta; Ali Bijani; Guilherme Borges; Rohan Borschmann; Dipan Bose; Soufiane Boufous; Alexandra Brazinova; Julio Cesar Campuzano Rincon; Rosario Cárdenas; Juan J. Carrero; Félix Carvalho; Carlos A. Castañeda-Orjuela; Ferrán Catalá-López; Jee-Young J. Choi; Devasahayam J. Christopher; Christopher Stephen Crowe; Koustuv Dalal; Ahmad Daryani; Dragos Virgil Davitoiu; Louisa Degenhardt; Diego De Leo; Jan-Walter De Neve; Kebede Deribe; Getenet Ayalew Dessie; Gabrielle Aline deVeber; Samath Dhamminda Dharmaratne; Linh Phuong Doan; Kate A. Dolan; Tim Robert Driscoll; Manisha Dubey; Ziad El-Khatib; Christian Lycke Ellingsen; Maysaa El Sayed Zaki; Aman Yesuf Endries; Sharareh Eskandarieh; Andre Faro; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Richard Charles Franklin; Takeshi Fukumoto; Kebede Embaye Gezae; Tiffany K. Gill; Alessandra C. Goulart; Ayman Grada; Yuming Guo; Rahul Gupta; Hassan Haghparast Bidgoli; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Josep Maria Haro; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Delia Hendrie; Andualem Henok; Martha Híjar; Michael K. Hole; Enayatollah Homaie Rad; Naznin Hossain; Sorin Hostiuc; Guoqing Hu; Ehimario U. Igumbor; Olayinka Stephen Ilesanmi; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Rebecca Q. Ivers; Kathryn H. Jacobsen; Nader Jahanmehr; Mihajlo Jakovljevic; Achala Upendra Jayatilleke; Ravi Prakash Jha; Jost B. Jonas; Zahra Jorjoran Shushtari; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Rizwan Kalani; Amir Kasaeian; Abraham Getachew Kelbore; Andre Pascal Kengne; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ejaz Ahmad Khan; Abdullah T. Khoja; Aliasghar A. Kiadaliri; Young-Eun Kim; Daniel Kim; Adnan Kisa; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Manasi Kumar; Ratilal Lalloo; Hilton Lam; Faris Hasan Lami; Van C. Lansingh; Janet L. Leasher; Shanshan Li; Shai Linn; Raimundas Lunevicius; Flavia R. Machado; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Reza Malekzadeh; Manzoor Ahmad Malik; Deborah Carvalho Malta; Ana-Laura Manda; Mohammad Ali Mansournia; Benjamin Ballard Massenburg; Pallab K. Maulik; Hailemariam Abiy Alemu Meheretu; Man Mohan Mehndiratta; Addisu Melese; Walter Mendoza; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Tomislav Mestrovic; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Erkin M. Mirrakhimov; Babak Moazen; Naser Mohammad Gholi Mezerji; Roghayeh Mohammadibakhsh; Shafiu Mohammed; Mariam Molokhia; Lorenzo Monasta; Stefania Mondello; Pablo A. Montero-Zamora; Yoshan Moodley; Mahmood Moosazadeh; Ghobad Moradi; Maziar Moradi-Lakeh; Lidia Morawska; Ilais Moreno Velásquez; Shane Douglas Morrison; Marilita M. Moschos; Seyyed Meysam Mousavi; Srinivas Murthy; Kamarul Imran Musa; Gurudatta Naik; Farid Najafi; Vinay Nangia; Bruno Ramos Nascimento; Duduzile Edith Ndwandwe; Ionut Negoi; Trang Huyen Nguyen; Son Hoang Nguyen; Long Hoang Nguyen; Huong Lan Thi Nguyen; Dina Nur Anggraini Ningrum; Yirga Legesse Nirayo; Richard Ofori-Asenso; Felix Akpojene Ogbo; In-Hwan Oh; Olanrewaju Oladimeji; Andrew T. Olagunju; Tinuke O. Olagunju; Pedro R. Olivares; Heather M. Orpana; Stanislav S. Otstavnov; P.A. Mahesh; Smita Pakhale; Eun-Kee Park; George C. Patton; Konrad Pesudovs; Michael R. Phillips; Suzanne Polinder; Swayam Prakash; Amir Radfar; Anwar Rafay; Alireza Rafiei; Siavash Rahimi; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Rajesh Kumar Rai; Kiana Ramezanzadeh; Salman Rawaf; David Laith Rawaf; Andre M.N. Renzaho; Serge Resnikoff; Shahab Rezaeian; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Yogesh Damodar Sabde; Basema Saddik; Payman Salamati; Yahya Salimi; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Maheswar Satpathy; Monika Sawhney; Susan M. Sawyer; Sonia Saxena; Mete Saylan; Ione J.C. Schneider; David C. Schwebel; Soraya Seedat; Sadaf G. Sepanlou; Masood Ali Shaikh; Mehran Shams-Beyranvand; Morteza Shamsizadeh; Mahdi Sharif-Alhoseini; Aziz Sheikh; Jiabin Shen; Mika Shigematsu; Rahman Shiri; Ivy Shiue; João Pedro Silva; Jasvinder A. Singh; Dhirendra Narain Sinha; Adauto Martins Soares Filho; Joan B. Soriano; Sergey Soshnikov; Ireneous N. Soyiri; Vladimir I. Starodubov; Dan J. Stein; Mark A. Stokes; Mu'awiyyah Babale Sufiyan; Jacob E. Sunshine; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Arash Tehrani-Banihashemi; Gizachew Assefa Tessema; Jarnail Singh Thakur; Khanh Bao Tran; Bach Xuan Tran; Lorainne Tudor Car; Olalekan A. Uthman; Benjamin S. Chudi Uzochukwu; Pascual R. Valdez; Elena Varavikova; Ana Maria Nogales Vasconcelos; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Yuan-Pang Wang; Tissa Wijeratne; Andrea Sylvia Winkler; Priyanka Yadav; Yuichiro Yano; Muluken Azage Yenesew; Paul Yip; Engida Yisma; Naohiro Yonemoto; Mustafa Z. Younis; Chuanhua Yu; Shamsa Zafar; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Yong Zhao; Sanjay Zodpey; Simon I. Hay; Alan D. Lopez; Ali H. Mokdad; Theo Vos
Background The epidemiological transition of non-communicable diseases replacing infectious diseases as the main contributors to disease burden has been well documented in global health literature. Less focus, however, has been given to the relationship between sociodemographic changes and injury. The aim of this study was to examine the association between disability-adjusted life years (DALYs) from injury for 195 countries and territories at different levels along the development spectrum between 1990 and 2017 based on the Global Burden of Disease (GBD) 2017 estimates. Methods Injury mortality was estimated using the GBD mortality database, corrections for garbage coding and CODEm-the cause of death ensemble modelling tool. Morbidity estimation was based on surveys and inpatient and outpatient data sets for 30 cause-of-injury with 47 nature-of-injury categories each. The Socio-demographic Index (SDI) is a composite indicator that includes lagged income per capita, average educational attainment over age 15 years and total fertility rate. results For many causes of injury, age-standardised DALY rates declined with increasing SDI, although road injury, interpersonal violence and self-harm did not follow this pattern. Particularly for self-harm opposing patterns were observed in regions with similar SDI levels. For road injuries, this effect was less pronounced. Conclusions The overall global pattern is that of declining injury burden with increasing SDI. However, not all injuries follow this pattern, which suggests multiple underlying mechanisms influencing injury DALYs. There is a need for a detailed understanding of these patterns to help to inform national and global efforts to address injury-related health outcomes across the development spectrum. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Department of Error: Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017 (The Lancet (2020) 395(10239) (1779–1801), (S0140673620301148), (10.1016/S0140-6736(20)30114-8))
(Elsevier B.V., 2020) Robert C. Reiner; Kirsten E. Wiens; Aniruddha Deshpande; Mathew M. Baumann; Paulina A. Lindstedt; Brigette F. Blacker; Christopher E. Troeger; Lucas Earl; Sandra B. Munro; Degu Abate; Hedayat Abbastabar; Foad Abd-Allah; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Getaneh Abebe; Kedir Hussein Abegaz; Lucas Guimarães Abreu; Michael R.M. Abrigo; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Maryam Adabi; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Davoud Adham; Beyene Meressa Adhena; Mohsen Afarideh; Keivan Ahmadi; Mehdi Ahmadi; Anwar E. Ahmed; Muktar Beshir Ahmed; Rushdia Ahmed; Olufemi Ajumobi; Chalachew Genet Akal; Temesgen Yihunie Akalu; Ali S. Akanda; Genet Melak Alamene; Turki M. Alanzi; James R. Albright; Jacqueline Elizabeth Alcalde Rabanal; Birhan Tamene Alemnew; Zewdie Aderaw Alemu; Beriwan Abdulqadir Ali; Muhammad Ali; Mehran Alijanzadeh; Vahid Alipour; Syed Mohamed Aljunid; Ali Almasi; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Khalid Altirkawi; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Azmeraw T. Amare; Saeed Amini; Arianna Maever Loreche Amit; Catalina Liliana Andrei; Masresha Tessema Anegago; Mina Anjomshoa; Fereshteh Ansari; Carl Abelardo T. Antonio; Ernoiz Antriyandarti; Seth Christopher Yaw Appiah; Jalal Arabloo; Olatunde Aremu; Bahram Armoon; Krishna K. Aryal; Afsaneh Arzani; Mohsen Asadi-Lari; Alebachew Fasil Ashagre; Hagos Tasew Atalay; Suleman Atique; Sachin R. Atre; Marcel Ausloos; Leticia Avila-Burgos; Ashish Awasthi; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Asnakew Achaw Ayele; Yared Asmare Aynalem; Samad Azari; Ebrahim Babaee; Alaa Badawi; Shankar M. Bakkannavar; Senthilkumar Balakrishnan; Ayele Geleto Bali; Maciej Banach; Aleksandra Barac; Till Winfried Barnighausen; Huda Basaleem; Quique Bassat; Mohsen Bayati; Neeraj Bedi; Masoud Behzadifar; Meysam Behzadifar; Yibeltal Alemu Bekele; Michelle L. Bell; Derrick A. Bennett; Dessalegn Ajema Berbada; Tina Beyranvand; Anusha Ganapati Bhat; Krittika Bhattacharyya; Suraj Bhattarai; Soumyadeep Bhaumik; Ali Bijani; Boris Bikbov; Raaj Kishore Biswas; Kassawmar Angaw Bogale; Somayeh Bohlouli; Oliver J. Brady; Nicola Luigi Bragazzi; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Sharath Burugina Nagaraja; Zahid A. Butt; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Rosario Cárdenas; Felix Carvalho; Franz Castro; Collins Chansa; Pranab Chatterjee; Vijay Kumar Chattu; Bal Govind Chauhan; Ken Lee Chin; Devasahayam J. Christopher; Dinh-Toi Chu; Rafael M. Claro; Natalie M. Cormier; Vera M. Costa; Giovanni Damiani; Farah Daoud; Lalit Dandona; Rakhi Dandona; Amira Hamed Darwish; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; Tamirat Tesfaye Dasa; Claudio Alberto Davila; Nicole Davis Weaver; Dragos Virgil Davitoiu; Jan-Walter De Neve; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Gebre Teklemariam Demoz; Edgar Denova-Gutierrez; Kebede Deribe; Assefa Desalew; Getenet Ayalew Dessie; Samath Dhamminda Dharmaratne; Preeti Dhillon; Meghnath Dhimal; Govinda Prasad Dhungana; Daniel Diaz; Eric L. Ding; Helen Derara Diro; Shirin Djalalinia; Huyen Phuc Do; David Teye Doku; Christiane Dolecek; Manisha Dubey; Eleonora Dubljanin; Bereket Duko Adema; Susanna J. Dunachie; Andre R. Durães; Senbagam Duraisamy; Andem Effiong; Aziz Eftekhari; Iman El Sayed; Maysaa El Sayed Zaki; Maha El Tantawi; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Hajer Elkout; Aisha Elsharkawy; Shymaa Enany; Aklilu Endalamaw; Daniel Adane Endalew; Sharareh Eskandarieh; Alireza Esteghamati; Arash Etemadi; Tamer H. Farag; Emerito Jose A. Faraon; Mohammad Fareed; Roghiyeh Faridnia; Andrea Farioli; Andre Faro; Hossein Farzam; Ali Akbar Fazaeli; Mehdi Fazlzadeh; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Irina Filip; Florian Fischer; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Joseph Jon Frostad; Takeshi Fukumoto; Reta Tsegaye Gayesa; Kidane Tadesse Gebremariam; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Getnet Azeze Gedefaw; Yilma Chisha Dea Geramo; Birhanu Geta; Kebede Embaye Gezae; Ahmad Ghashghaee; Fariba Ghassemi; Paramjit Singh Gill; Ibrahim Abdelmageed Ginawi; Srinivas Goli; Nelson G.M. Gomes; Sameer Vali Gopalani; Barbara Niegia Garcia Goulart; Ayman Grada; Harish Chander Gugnani; Davide Guido; Rafael Alves Guimarães; Yuming Guo; Rahul Gupta; Rajeev Gupta; Nima Hafezi-Nejad; Michael Tamene Haile; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian James Hall; Demelash Woldeyohannes Handiso; Hamidreza Haririan; Ninuk Hariyani; Ahmed I. Hasaballah; Md. Mehedi Hasan; Amir Hasanzadeh; Hadi Hassankhani; Hamid Yimam Hassen; Desta Haftu Hayelom; Behnam Heidari; Nathaniel J. Henry; Claudiu Herteliu; Fatemeh Heydarpour; Hagos D. de Hidru; Chi Linh Hoang; Praveen Hoogar; Mojtaba Hoseini-Ghahfarokhi; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mowafa Househ; Guoqing Hu; Ayesha Humayun; Syed Ather Hussain; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Milena D. Ilic; Leeberk Raja Inbaraj; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; Chinwe Juliana Iwu; Anelisa Jaca; Nader Jafari Balalami; Nader Jahanmehr; Mihajlo Jakovljevic; Amir Jalali; Achala Upendra Jayatilleke; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Peng Jia; Kimberly B. Johnson; Jost B. Jonas; Jacek Jerzy Jóźwiak; Ali Kabir; Zubair Kabir; Amaha Kahsay; Hamed Kalani; Tanuj Kanchan; Behzad Karami Matin; Andre Karch; Surendra Karki; Amir Kasaeian; Gebremicheal Gebreslassie Kasahun; Gbenga A. Kayode; Ali Kazemi Karyani; Peter Njenga Keiyoro; Daniel Bekele Ketema; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ali Talha Khalil; Ibrahim Khalil; Rovshan Khalilov; Md Nuruzzaman Khan; Ejaz Ahmad Khan; Gulfaraz Khan; Junaid Khan; Khaled Khatab; Amir Khater; Mona M. Khater; Alireza Khatony; Maryam Khayamzadeh; Mohammad Khazaei; Salman Khazaei; Ehsan Khodamoradi; Mohammad Hossein Khosravi; Jagdish Khubchandani; Aliasghar A. Kiadaliri; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Niranjan Kissoon; Shivakumar K.M. Kondlahalli; Margaret N. Kosek; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Nuworza Kugbey; G. Anil Kumar; Manasi Kumar; Pushpendra Kumar; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Aparna Lal; Dharmesh Kumar Lal; Faris Hasan Lami; Van C. Lansingh; Savita Lasrado; Paul H. Lee; Mostafa Leili; Tsegaye Lolaso Lenjebo; Aubrey J. Levine; Sonia Lewycka; Shanshan Li; Shai Linn; Rakesh Lodha; Joshua Longbottom; Platon D. Lopukhov; Sameh Magdeldin; Phetole Walter Mahasha; Narayan Bahadur Mahotra; Deborah Carvalho Malta; Abdullah A. Mamun; Farzad Manafi; Navid Manafi; Ana-Laura Manda; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Dadi Marami; Laurie B. Marczak; Francisco Rogerlandio Martins-Melo; Winfried März; Anthony Masaka; Manu Raj Mathur; Pallab K. Maulik; Benjamin K. Mayala; Colm McAlinden; Man Mohan Mehndiratta; Ravi Mehrotra; Kala M. Mehta; Gebrekiros Gebremichael Meles; Addisu Melese; Ziad A. Memish; Alemayehu Toma Mena; Ritesh G. Menezes; Melkamu Merid Mengesha; Desalegn Tadese Mengistu; Getnet Mengistu; Tuomo J. Meretoja; Bartosz Miazgowski; Kebadnew Mulatu M. Mihretie; Molly K. Miller-Petrie; Edward J. Mills; Seyed Mostafa Mir; Parvaneh Mirabi; Erkin M. Mirrakhimov; Amjad Mohamadi-Bolbanabad; Dara K. Mohammad; Karzan Abdulmuhsin Mohammad; Yousef Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Noushin Mohammadifard; Ammas Siraj Mohammed; Jemal Abdu Mohammed; Shafiu Mohammed; Farnam Mohebi; Ali H. Mokdad; Lorenzo Monasta; Yoshan Moodley; Ghobad Moradi; Masoud Moradi; Mohammad Moradi-Joo; Maziar Moradi-Lakeh; Paula Moraga; Abbas Mosapour; Simin Mouodi; Seyyed Meysam Mousavi; Miliva Mozaffor; Atalay Goshu Muluneh; Moses K. Muriithi; Christopher J.L. Murray; G.V.S. Murthy; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Mohsen Naghavi; Farid Najafi; Vinay Nangia; Javad Nazari; Duduzile Edith Ndwandwe; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; QuynhAnh P. Nguyen; Trang Huyen Nguyen; Dabere Nigatu; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Marzieh Nojomi; Jean Jacques Noubiap; In-Hwan Oh; Oluchi Okpala; Andrew T. Olagunju; Ahmed Omar Bali; Obinna E. Onwujekwe; Doris D.V. Ortega-Altamirano; Osayomwanbo Osarenotor; Frank B. Osei; Mayowa Ojo Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Adrian Pana; Tahereh Pashaei; Sanghamitra Pati; Ajay Patle; George C. Patton; Kebreab Paulos; Veincent Christian Filipino Pepito; Alexandre Pereira; Norberto Perico; Konrad Pesudovs; David M. Pigott; Bakhtiar Piroozi; James A. Platts-Mills; Mario Poljak; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Akram Pourshams; Hossein Poustchi; Sergio I. Prada; Liliana Preotescu; Hedley Quintana; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Alireza Rafiei; Fakher Rahim; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Fatemeh Rajati; Kiana Ramezanzadeh; Saleem M. Rana; Chhabi Lal Ranabhat; Davide Rasella; David Laith Rawaf; Salman Rawaf; Lal Rawal; Giuseppe Remuzzi; Vishnu Renjith; Andre M.N. Renzaho; Melese Abate Reta; Satar Rezaei; Ana Isabel Ribeiro; Jennifer Rickard; Carlos Miguel Rios González; Maria Jesus Rios-Blancas; Leonardo Roever; Luca Ronfani; Elias Merdassa Roro; Ali Rostami; Dietrich Rothenbacher; Enrico Rubagotti; Salvatore Rubino; Anas M. Saad; Siamak Sabour; Ehsan Sadeghi; Saeed Safari; Mahdi Safdarian; Rajesh Sagar; Mohammad Ali Sahraian; S. Mohammad Sajadi; Mohammad Reza Salahshoor; Nasir Salam; Farkhonde Salehi; Saleh Salehi Zahabi; Hosni Salem; Marwa R. Rashad Salem; Yahya Salimi; Hamideh Salimzadeh; Evanson Zondani Sambala; Abdallah M. Samy; Juan Sanabria; Itamar S. Santos; Sivan Yegnanarayana Iyer Saraswathy; Abdur Razzaque Sarker; Benn Sartorius; Brijesh Sathian; Maheswar Satpathy; Alyssa N. Sbarra; Lauren E. Schaeffer; David C. Schwebel; Anbissa Muleta Senbeta; Subramanian Senthilkumaran; Hosein Shabaninejad; Amira A. Shaheen; Masood Ali Shaikh; Ali S. Shalash; Seifadin Ahmed Shallo; Mehran Shams-Beyranvand; Mohammad Bagher Shamsi; Morteza Shamsizadeh; Mehdi Sharif; Muki Shehu Shey; Kenji Shibuya; Wondimeneh Shibabaw Shiferaw; Mika Shigematsu; Apurba Shil; Jae Il Shin; Rahman Shiri; Reza Shirkoohi; Si Si; Soraya Siabani; Jasvinder A. Singh; Narinder Pal Singh; Dhirendra Narain Sinha; Malede Mequanent Sisay; Eirini Skiadaresi; David L. Smith; Mohammad Reza Sobhiyeh; Anton Sokhan; Moslem Soofi; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Chandrashekhar T. Sreeramareddy; Agus Sudaryanto; Mu'awiyyah Babale Sufiyan; Hafiz Ansar Rasul Suleria; Bryan L. Sykes; Koku Sisay Tamirat; Aberash Abay Tassew; Nuno Taveira; Bineyam Taye; Arash Tehrani-Banihashemi; Mohamad-Hani Temsah; Berhe Etsay Tesfay; Fisaha Haile Tesfay; Zemenu Tadesse Tessema; Kavumpurathu Raman Thankappan; Sathish Thirunavukkarasu; Nihal Thomas; Kenean Getaneh Tlaye; Boikhutso Tlou; Marcos Roberto Tovani-Palone; Eugenio Traini; Khanh Bao Tran; Indang Trihandini; Irfan Ullah; Bhaskaran Unnikrishnan; Sahel Valadan Tahbaz; Pascual R. Valdez; Santosh Varughese; Yousef Veisani; Francesco S. Violante; Sebastian Vollmer; Theo Vos; Fiseha Wadilo Wada; Yasir Waheed; Yafeng Wang; Yuan-Pang Wang; Girmay Teklay Weldesamuel; Catherine A. Welgan; Ronny Westerman; Taweewat Wiangkham; Tissa Wijeratne; Charles Shey Wiysonge; Haileab Fekadu Wolde; Dawit Zewdu Wondafrash; Tewodros Eshete Wonde; Ai-Min Wu; Gelin Xu; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Tomohide Yamada; Mehdi Yaseri; Muluken Azage Yenesew; Alex Yeshaneh; Mekdes Tigistu Yilma; Ebrahim M. 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Reiner RC Jr, Hay SI. Mapping geographical inequalities in childhood diarrhoeal morbidity and mortality in low-income and middle-income countries, 2000–17: analysis for the Global Burden of Disease Study 2017. Lancet 2020; 395: 1779–801—In this Article, the author byline has been amended to Local Burden of Disease Diarrhoea Collaborators. This correction has been made to the online version as of June 4, 2020, and the printed version is correct. © 2020 Elsevier Ltd
Diabetes mortality and trends before 25 years of age: an analysis of the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Ewerton Cousin; Bruce B. Duncan; Caroline Stein; Kanyin Liane Ong; Theo Vos; Cristiana Abbafati; Mohsen Abbasi-Kangevari; Michael Abdelmasseh; Amir Abdoli; Rami Abd-Rabu; Hassan Abolhassani; Eman Abu-Gharbieh; Manfred Mario Kokou Accrombessi; Qorinah Estiningtyas Sakilah Adnani; Muhammad Sohail Afzal; Gina Agarwal; Krishna K. Agrawaal; Marcela Agudelo-Botero; Bright Opoku Ahinkorah; Sajjad Ahmad; Tauseef Ahmad; Keivan Ahmadi; Sepideh Ahmadi; Ali Ahmadi; Ali Ahmed; Yusra Ahmed Salih; Wuraola Akande-Sholabi; Tayyaba Akram; Hanadi Al Hamad; Ziyad Al-Aly; Jacqueline Elizabeth Alcalde-Rabanal; Vahid Alipour; Syed Mohamed Aljunid; Rajaa M. Al-Raddadi; Nelson Alvis-Guzman; Saeed Amini; Robert Ancuceanu; Tudorel Andrei; Catalina Liliana Andrei; Ranjit Mohan Anjana; Adnan Ansar; Ippazio Cosimo Antonazzo; Benny Antony; Anayochukwu Edward Anyasodor; Jalal Arabloo; Damian Arizmendi; Benedetta Armocida; Anton A. Artamonov; Judie Arulappan; Zahra Aryan; Samaneh Asgari; Tahira Ashraf; Thomas Astell-Burt; Prince Atorkey; Maha Moh'd Wahbi Atout; Martin Amogre Ayanore; Ashish D. Badiye; Atif Amin Baig; Mohan Bairwa; Jennifer L. Baker; Ovidiu Constantin Baltatu; Palash Chandra Banik; Anthony Barnett; Mark Thomaz Ugliara Barone; Francesco Barone-Adesi; Amadou Barrow; Neeraj Bedi; Rebuma Belete; Uzma Iqbal Belgaumi; Arielle Wilder Bell; Derrick A. Bennett; Isabela M. Bensenor; David Beran; Akshaya Srikanth Bhagavathula; Sonu Bhaskar; Krittika Bhattacharyya; Vijayalakshmi S. Bhojaraja; Ali Bijani; Boris Bikbov; Setognal Birara; Virginia Bodolica; Aime Bonny; Hermann Brenner; Nikolay Ivanovich Briko; Zahid A. Butt; Florentino Luciano Caetano dos Santos; Luis Alberto Cámera; Ismael R. Campos-Nonato; Yin Cao; Chao Cao; Ester Cerin; Promit Ananyo Chakraborty; Joht Singh Chandan; Vijay Kumar Chattu; Simiao Chen; Jee-Young Jasmine Choi; Sonali Gajanan Choudhari; Enayet Karim Chowdhury; Dinh-Toi Chu; Barbara Corso; Omid Dadras; Xiaochen Dai; Albertino Antonio Moura Damasceno; Lalit Dandona; Rakhi Dandona; Claudio Alberto Dávila-Cervantes; Jan-Walter De Neve; Edgar Denova-Gutiérrez; Deepak Dhamnetiya; Daniel Diaz; Sanam Ebtehaj; Hisham Atan Edinur; Sahar Eftekharzadeh; Iman El Sayed; Islam Y. Elgendy; Muhammed Elhadi; Mohamed A. Elmonem; Mohammed Faisaluddin; Umar Farooque; Xiaoqi Feng; Eduarda Fernandes; Florian Fischer; David Flood; Marisa Freitas; Peter Andras Gaal; Mohamed M. Gad; Piyada Gaewkhiew; Lemma Getacher; Mansour Ghafourifard; Reza Ghanei Gheshlagh; Ahmad Ghashghaee; Nermin Ghith; Ghozali Ghozali; Paramjit Singh Gill; Ibrahim Abdelmageed Ginawi; Ekaterina Vladimirovna Glushkova; Mahaveer Golechha; Sameer Vali Gopalani; Rafael Alves Guimarães; Rajat Das Gupta; Rajeev Gupta; Vivek Kumar Gupta; Veer Bala Gupta; Sapna Gupta; Tesfa Dejenie Habtewold; Nima Hafezi-Nejad; Rabih Halwani; Asif Hanif; Graeme J. Hankey; Shafiul Haque; Ahmed I. Hasaballah; Syed Shahzad Hasan; Abdiwahab Hashi; Soheil Hassanipour; Simon I. Hay; Khezar Hayat; Mohammad Heidari; Mohammad Bellal Hossain Hossain; Sahadat Hossain; Mostafa Hosseini; Soodabeh Hoveidamanesh; Junjie Huang; Ayesha Humayun; Rabia Hussain; Bing-Fang Hwang; Segun Emmanuel Ibitoye; Kevin S. Ikuta; Leeberk Raja Inbaraj; Usman Iqbal; Md Shariful Islam; Sheikh Mohammed Shariful Islam; Rakibul M. Islam; Nahlah Elkudssiah Ismail; Gaetano Isola; Ramaiah Itumalla; Masao Iwagami; Ihoghosa Osamuyi Iyamu; Mohammad Ali Jahani; Mihajlo Jakovljevic; Ranil Jayawardena; Ravi Prakash Jha; Oommen John; Jost B. Jonas; Tamas Joo; Ali Kabir; Rohollah Kalhor; Ashwin Kamath; Tanuj Kanchan; Himal Kandel; Neeti Kapoor; Gbenga A. Kayode; Sewnet Adem Kebede; Pedram Keshavarz; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Moien A. B. Khan; Md Nuruzzaman Khan; Maseer Khan; Amir M. Khater; Tawfik Ahmed Muthafer Khoja; Jagdish Khubchandani; Min Seo Kim; Yun Jin Kim; Ruth W. Kimokoti; Sezer Kisa; Adnan Kisa; Mika Kivimäki; Vladimir Andreevich Korshunov; Oleksii Korzh; Ai Koyanagi; Kewal Krishan; Barthelemy Kuate Defo; G. Anil Kumar; Nithin Kumar; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Anders O. Larsson; Savita Lasrado; Wei-Chen Lee; Chiachi Bonnie Lee; Paul H. Lee; Shaun Wen Huey Lee; Ming-Chieh Li; Stephen S. Lim; Lee-Ling Lim; Giancarlo Lucchetti; Azeem Majeed; Ahmad Azam Malik; Borhan Mansouri; Lorenzo Giovanni Mantovani; Santi Martini; Prashant Mathur; Colm McAlinden; Nafiul Mehedi; Teferi Mekonnen; Ritesh G. Menezes; Amanual Getnet Mersha; Junmei Miao Jonasson; Tomasz Miazgowski; Irmina Maria Michalek; Andreea Mirica; Erkin M. Mirrakhimov; Agha Zeeshan Mirza; Prasanna Mithra; Abdollah Mohammadian-Hafshejani; Reza Mohammadpourhodki; Arif Mohammed; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Mohammad Ali Moni; Farhad Moradpour; Rahmatollah Moradzadeh; Ebrahim Mostafavi; Ulrich Otto Mueller; Christopher J. L. Murray; Ahmad Mustafa; Gabriele Nagel; Vinay Nangia; Atta Abbas Naqvi; Biswa Prakash Nayak; Javad Nazari; Rawlance Ndejjo; Ruxandra Irina Negoi; Sandhya Neupane Kandel; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Jean Jacques Noubiap; Christoph Nowak; Bogdan Oancea; Oluwakemi Ololade Odukoya; Ayodipupo Sikiru Oguntade; Temitope T. Ojo; Andrew T. Olagunju; Obinna E. 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Saif-Ur-Rahman; Hamideh Salimzadeh; Mehrnoosh Samaei; Juan Sanabria; Milena M. Santric-Milicevic; Brijesh Sathian; Thirunavukkarasu Sathish; Markus P. Schlaich; Abdul-Aziz Seidu; Mario Šekerija; Nachimuthu Senthil Kumar; Allen Seylani; Masood Ali Shaikh; Hina Shamshad; Md Shajedur Rahman Shawon; Sara Sheikhbahaei; Jeevan K. Shetty; Rahman Shiri; K.M. Shivakumar; Kerem Shuval; Jasvinder A. Singh; Ambrish Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Ahmad Sofi-Mahmudi; Amin Soheili; Jing Sun; Viktória Szerencsés; Miklós Szócska; Rafael Tabarés-Seisdedos; Hooman Tadbiri; Eyayou Girma Tadesse; Md. Tariqujjaman; Kavumpurathu Raman Thankappan; Rekha Thapar; Nihal Thomas; Binod Timalsina; Ruoyan Tobe-Gai; Marcello Tonelli; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Jaya Prasad Tripathy; Lorainne Tudor Car; Biruk Shalmeno Tusa; Riaz Uddin; Era Upadhyay; Sahel Valadan Tahbaz; Pascual R. Valdez; Tommi Juhani Vasankari; Madhur Verma; Victor E. Villalobos-Daniel; Sergey Konstantinovitch Vladimirov; Bay Vo; Giang Thu Vu; Rade Vukovic; Yasir Waheed; Richard G. Wamai; Andrea Werdecker; Nuwan Darshana Wickramasinghe; Andrea Sylvia Winkler; Befikadu Legesse Wubishet; Xiaoyue Xu; Suowen Xu; Seyed Hossein Yahyazadeh Jabbari; Hiroshi Yatsuya; Sanni Yaya; Taklo Simeneh Yazie Yazie; Siyan Yi; Naohiro Yonemoto; Ismaeel Yunusa; Siddhesh Zadey; Sojib Bin Zaman; Maryam Zamanian; Nelson Zamora; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Chenwen Zhong; Mohammad Zmaili; Alimuddin Zumla; Mohsen Naghavi; Maria Inês Schmidt
Background: Diabetes, particularly type 1 diabetes, at younger ages can be a largely preventable cause of death with the correct health care and services. We aimed to evaluate diabetes mortality and trends at ages younger than 25 years globally using data from the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. Methods: We used estimates of GBD 2019 to calculate international diabetes mortality at ages younger than 25 years in 1990 and 2019. Data sources for causes of death were obtained from vital registration systems, verbal autopsies, and other surveillance systems for 1990–2019. We estimated death rates for each location using the GBD Cause of Death Ensemble model. We analysed the association of age-standardised death rates per 100 000 population with the Socio-demographic Index (SDI) and a measure of universal health coverage (UHC) and described the variability within SDI quintiles. We present estimates with their 95% uncertainty intervals. Findings: In 2019, 16 300 (95% uncertainty interval 14 200 to 18 900) global deaths due to diabetes (type 1 and 2 combined) occurred in people younger than 25 years and 73·7% (68·3 to 77·4) were classified as due to type 1 diabetes. The age-standardised death rate was 0·50 (0·44 to 0·58) per 100 000 population, and 15 900 (97·5%) of these deaths occurred in low to high-middle SDI countries. The rate was 0·13 (0·12 to 0·14) per 100 000 population in the high SDI quintile, 0·60 (0·51 to 0·70) per 100 000 population in the low-middle SDI quintile, and 0·71 (0·60 to 0·86) per 100 000 population in the low SDI quintile. Within SDI quintiles, we observed large variability in rates across countries, in part explained by the extent of UHC (r2=0·62). From 1990 to 2019, age-standardised death rates decreased globally by 17·0% (−28·4 to −2·9) for all diabetes, and by 21·0% (–33·0 to −5·9) when considering only type 1 diabetes. However, the low SDI quintile had the lowest decline for both all diabetes (−13·6% [–28·4 to 3·4]) and for type 1 diabetes (−13·6% [–29·3 to 8·9]). Interpretation: Decreasing diabetes mortality at ages younger than 25 years remains an important challenge, especially in low and low-middle SDI countries. Inadequate diagnosis and treatment of diabetes is likely to be major contributor to these early deaths, highlighting the urgent need to provide better access to insulin and basic diabetes education and care. This mortality metric, derived from readily available and frequently updated GBD data, can help to monitor preventable diabetes-related deaths over time globally, aligned with the UN's Sustainable Development Targets, and serve as an indicator of the adequacy of basic diabetes care for type 1 and type 2 diabetes across nations. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Erratum: Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017 (The Lancet (2018) 392(10159) (1736–1788)(S0140673618322037)(10.1016/S0140-6736(18)32203-7))
(Lancet Publishing Group, 2018) Gregory A. Roth; Degu Abate; Kalkidan Hassen Abate; Solomon M. Abay; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Haftom Temesgen Abebe; Molla Abebe; Zegeye Abebe; Ayenew Negesse Abejie; Semaw F. Abera; Olifan Zewdie Abil; Haftom Niguse Abraha; Aklilu Roba Abrham; Laith Jamal Abu-Raddad; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Abdu A. Adamu; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Beyene Meressa Adhena; Mina G. Adib; Amha Admasie; Ashkan Afshin; Gina Agarwal; Kareha M. Agesa; Anurag Agrawal; Sutapa Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Muktar Beshir Ahmed; Sayem Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Mohammad Esmaeil Akbari; Rufus Olusola Akinyemi; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Rajaa M. 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GBD 2017 Causes of Death Collaborators. Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017. Lancet 2018; 392: 1736–88—The bottom row in figure 7 was cut off. This correction has been made to the online version as of Nov 9, 2018, and has been made to the printed Article. © 2018 Elsevier Ltd
Erratum: Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015 (The Lancet (2016) 388(10053) (1725–1774)(S0140673616315756)(10.1016/S0140-6736(16)31575-6))
(Lancet Publishing Group, 2017) Haidong Wang; Zulfiqar A Bhutta; Matthew M Coates; Megan Coggeshall; Lalit Dandona; Khassoum Diallo; Elisabeth Barboza Franca; Maya Fraser; Nancy Fullman; Peter W Gething; Simon I Hay; Yohannes Kinfu; Maaya Kita; Xie Rachel Kulikoff; Heidi J Larson; Juan Liang; Xiaofeng Liang; Stephen S Lim; Margaret Lind; Alan D Lopez; Rafael Lozano; George A Mensah; Joseph B Mikesell; Ali H Mokdad; Meghan D Mooney; Mohsen Naghavi; Grant Nguyen; Ivo Rakovac; Joshua A Salomon; Naris Silpakit; Amber Sligar; Reed J D Sorensen; Theo Vos; Jun Zhu; Amanuel Alemu Abajobir; Kalkidan Hassen Abate; Kaja M Abbas; Foad Abd-Allah; Abdishakur M Abdulle; Semaw Ferede Abera; Victor Aboyans; Biju Abraham; Ibrahim Abubakar; Laith J Abu-Raddad; Niveen M E Abu-Rmeileh; Gebre Yitayih Abyu; Tom Achoki; Akindele Olupelumi Adebiyi; Isaac Akinkunmi Adedeji; Ademola Lukman Adelekan; Arsène Kouablan Adou; Arnav Agarwal; Oluremi N Ajala; Tomi F Akinyemiju; Nadia Akseer; Khurshid Alam; Noore K M Alam; Deena Alasfoor; Robert William Aldridge; Miguel Angel Alegretti; Zewdie Aderaw Alemu; Raghib Ali; Ala’a Alkerwi; François Alla; Rajaa Al-Raddadi; Ubai Alsharif; Khalid A Altirkawi; Elena Alvarez Martin; Nelson Alvis-Guzman; Azmeraw T Amare; Alemayehu Amberbir; Adeladza Kofi Amegah; Emmanuel A Ameh; Walid Ammar; Stephen Marc Amrock; Hjalte H Andersen; Gregory M Anderson; Carl Abelardo T Antonio; Johan Ärnlöv; Al Artaman; Hamid Asayesh; Rana Jawad Asghar; Reza Assadi; Suleman Atique; Euripide Frinel G Arthur Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Umar Bacha; Alaa Badawi; Kalpana Balakrishnan; Amitava Banerjee; Bolanle F Banigbe; Aleksandra Barac; Ryan M Barber; Suzanne L Barker-Collo; Till Bärnighausen; Lope H Barrero; Tigist Assefa Bayou; Yibeltal Tebekaw Bayou; Shahrzad Bazargan-Hejazi; Justin Beardsley; Neeraj Bedi; Tolesa Bekele; Michelle L Bell; Aminu K Bello; Derrick A Bennett; Isabela M Bensenor; Adugnaw Berhane; Eduardo Bernabé; Balem Demtsu Betsu; Addisu Shunu Beyene; Samir Bhatt; Sibhatu Biadgilign; Boris Bikbov; Sait Mentes Birlik; Donal Bisanzio; Espen Bjertness; Jed D Blore; Rupert R A Bourne; Michael Brainin; Alexandra Brazinova; Nicholas J K Breitborde; Alexandria Brown; Geoffrey Colin Buckle; Michael Burch; Zahid A Butt; Ismael Ricardo Campos-Nonato; Julio Cesar Campuzano; Rosario Cárdenas; David O Carpenter; Juan Jesus Carrero; Austin Carter; Daniel C Casey; Carlos A Castañeda-Orjuela; Jacqueline Castillo Rivas; Ruben Estanislao Castro; Ferrán Catalá-López; Kelly Cercy; Hsing-Yi Chang; Jung-Chen Chang; Chioma Ezinne Chibueze; Vesper Hichilombwe Chisumpa; Jee-Young Jasmine Choi; Rajiv Chowdhury; Devasahayam Jesudas Christopher; Liliana G Ciobanu; Samantha M Colquhoun; Cyrus Cooper; Leslie Cornaby; Solomon Abrha Damtew; Hadi Danawi; Rakhi Dandona; José Das Neves; Adrian C Davis; Pieter de Jager; Diego De Leo; Louisa Degenhardt; Kebede Deribe; Amare Deribew; Don C Des Jarlais; Gabrielle A Deveber; Samath D Dharmaratne; Preet K Dhillon; Eric L Ding; Pratik Pinal Doshi; Kerrie E Doyle; Leilei Duan; Manisha Dubey; Hedyeh Ebrahimi; Christian Lycke Ellingsen; Iqbal Elyazar; Aman Yesuf Endries; Sergey Petrovich Ermakov; Babak Eshrati; Alireza Esteghamati; Emerito Jose Aquino Faraon; Talha A Farid; Carla Sofia E Sa Farinha; André Faro; Maryam S Farvid; Farshad Farzadfar; Seyed-Mohammad Fereshtehnejad; Joao C Fernandes; Florian Fischer; Joseph R A Fitchett; Nataliya Foigt; Richard C Franklin; Joseph Friedman; Thomas Fürst; Ketevan Gambashidze; Amiran Gamkrelidze; Parthasarathi Ganguly; Teshome Gebre; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Alemseged Aregay Gebru; Johanna M Geleijnse; Bradford D Gessner; Ibrahim Abdelmageem Mohamed Ginawi; Ababi Zergaw Giref; Melkamu Dedefo Gishu; Hector Gomez-Dantes; Philimon Gona; Amador Goodridge; Sameer Vali Gopalani; Atsushi Goto; Hebe N Gouda; Harish Chander Gugnani; Yuming Guo; Rahul Gupta; Rajeev Gupta; Vipin Gupta; Bishal Gyawali; Juanita A Haagsma; Nima Hafezi-Nejad; Demewoz Haile; Alemayehu Desalegne Hailu; Gessessew Bugssa Hailu; Randah Ribhi Hamadeh; Samer Hamidi; Jamie Hancock; Alexis J Handal; Graeme J Hankey; Hilda L Harb; Sivadasanpillai Harikrishnan; Kimani M Harun; Rasmus Havmoeller; Roderick J Hay; Ileana Beatriz Heredia-Pi; Hans W Hoek; Masako Horino; Nobuyuki Horita; H. Dean Hosgood; Peter J Hotez; Damian G Hoy; Mohamed Hsairi; Guoqing Hu; Cheng Huang; John J Huang; Hsiang Huang; Laetitia Huiart; Chantal Huynh; Kim Moesgaard Iburg; Bulat T Idrisov; Kaire Innos; Kathryn H Jacobsen; Nader Jahanmehr; Mehdi Javanbakht; Achala Upendra Jayatilleke; Sun Ha Jee; Panniyammakal Jeemon; Vivekanand Jha; Guohong Jiang; Ying Jiang; Tariku Jibat; Ye Jin; Jost B Jonas; Zubair Kabir; Yogeshwar Kalkonde; Ritul Kamal; Haidong Kan; Gagandeep Kang; André Karch; Corine Kakizi Karema; Amir Kasaeian; Anil Kaul; Norito Kawakami; Jeanne Françoise Kayibanda; Konstantin Kazanjan; Peter Njenga Keiyoro; Andrew Haddon Kemp; Andre Pascal Kengne; Andre Keren; Maia Kereselidze; Chandrasekharan Nair Kesavachandran; Yousef Saleh Khader; Ibrahim A Khalil; Abdur Rahman Khan; Ejaz Ahmad Khan; Young-Ho Khang; Irma Khonelidze; Jagdish Khubchandani; Cho-Il Kim; Daniel Kim; Yun Jin Kim; Niranjan Kissoon; Miia Kivipelto; Luke D Knibbs; Yoshihiro Kokubo; Soewarta Kosen; Parvaiz A Koul; Ai Koyanagi; Barthelemy Kuate Defo; Burcu Kucuk Bicer; Andreas A Kudom; G. Anil Kumar; Michael J Kutz; Hmwe H Kyu; Dharmesh Kumar Lal; Ratilal Lalloo; Hilton Lam; Jennifer O Lam; Van C Lansingh; Anders Larsson; James Leigh; Ricky Leung; Yichong Li; Yongmei Li; M Patrice Lindsay; Patrick Y Liu; Shiwei Liu; Belinda K Lloyd; Warren D Lo; Giancarlo Logroscino; Nicola Low; Raimundas Lunevicius; Ronan A Lyons; Stefan Ma; Hassan Magdy Abd El Razek; Mohammed Magdy Abd El Razek; Mahdi Mahdavi; Marek Majdan; Azeem Majeed; Reza Malekzadeh; Chabila C Mapoma; Wagner Marcenes; Jose Martinez-Raga; Melvin Barrientos Marzan; Felix Masiye; John J McGrath; Peter A Meaney; Alem Mehari; Man Mohan Mehndiratta; Alemayehu B Mekonnen; Yohannes Adama Melaku; Peter Memiah; Ziad A Memish; Walter Mendoza; Atte Meretoja; Tuomo J Meretoja; Francis Apolinary Mhimbira; Ted R Miller; Edward J Mills; Mojde Mirarefin; Awoke Misganaw; Charles N Mock; Karzan Abdulmuhsin Mohammad; Alireza Mohammadi; Shafiu Mohammed; Lorenzo Monasta; Julio Cesar Montañez Hernandez; Marcella Montico; Ami R Moore; Maziar Moradi-Lakeh; Lidia Morawska; Rintaro Mori; Ulrich O Mueller; Georgina A V Murphy; Srinivas Murthy; Jean B Nachega; Aliya Naheed; Kovin S Naidoo; Luigi Naldi; Devina Nand; Vinay Nangia; Subas Neupane; Charles R Newton; John N Newton; Marie Ng; Frida Namnyak Ngalesoni; Peter Nguhiu; Quyen Le Nguyen; Muhammad Imran Nisar; Patrick Martial Nkamedjie Pete; Ole F Norheim; Rosana E Norman; Felix Akpojene Ogbo; In-Hwan Oh; Foluke Adetola Ojelabi; Pedro R Olivares; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Eyal Oren; Erika Ota; P.A. Mahesh; Eun-Kee Park; Hye-Youn Park; Mahboubeh Parsaeian; Angel J Paternina Caicedo; Scott B Patten; João Mário Pedro; David M Pereira; Norberto Perico; Konrad Pesudovs; Max Petzold; Michael Robert Phillips; Julian David Pillay; Farhad Pishgar; Suzanne Polinder; Daniel Pope; Svetlana Popova; Farshad Pourmalek; Mostafa Qorbani; Rynaz H S Rabiee; Anwar Rafay; Vafa Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Sajjad Ur Rahman; Rajesh Kumar Rai; Murugesan Raju; Usha Ram; Saleem M Rana; Chhabi Lal Ranabhat; Puja Rao; Amany H Refaat; Giuseppe Remuzzi; Serge Resnikoff; Alex Reynolds; David Rojas-Rueda; Luca Ronfani; Gholamreza Roshandel; Gregory A Roth; Ambuj Roy; George Mugambage Ruhago; Rajesh Sagar; Muhammad Muhammad Saleh; Juan R Sanabria; Maria Dolores Sanchez-Niño; Itamar S Santos; João Vasco Santos; Rodrigo Sarmiento-Suarez; Benn Sartorius; Maheswar Satpathy; Miloje Savic; Monika Sawhney; Ione J C Schneider; Ben Schöttker; David C Schwebel; Soraya Seedat; Sadaf G Sepanlou; Edson E Servan-Mori; Tesfaye Setegn; Saeid Shahraz; Masood Ali Shaikh; Marina Shakh-Nazarova; Rajesh Sharma; Jun She; Sara Sheikhbahaei; Jiabin Shen; Kevin N Sheth; Kenji Shibuya; Hwashin Hyun Shin; Min-Jeong Shin; Rahman Shiri; Ivy Shuie; Inga Dora Sigfusdottir; Diego Augusto Santos Silva; Jonathan Silverberg; Edgar P Simard; Shireen Sindi; Abhishek Singh; Jasvinder A Singh; Om Prakash Singh; Prashant Kumar Singh; Virendra Singh; Joan B Soriano; Sergey Soshnikov; Luciano A Sposato; Chandrashekhar T Sreeramareddy; Vasiliki Stathopoulou; Nicholas Steel; Konstantinos Stroumpoulis; Lela Sturua; Bruno F Sunguya; Soumya Swaminathan; Bryan L Sykes; Cassandra E I Szoeke; Rafael Tabarés-Seisdedos; Mohammad Tavakkoli; Bineyam Taye; Bemnet Amare Tedla; Worku Mekonnen Tefera; Tesfaye Tekle; Girma Temam Shifa; Abdullah Sulieman Terkawi; Fisaha Haile Tesfay; Gizachew Assefa Tessema; Kiran Thapa; Alan J Thomson; Andrew L Thorne-Lyman; Ruoyan Tobe-Gai; Marcello Tonelli; Roman Topor-Madry; Fotis Topouzis; Bach Xuan Tran; Christopher Troeger; Thomas Truelsen; Zacharie Tsala Dimbuene; Abera Kenay Tura; Stefanos Tyrovolas; Kingsley N Ukwaja; Chigozie Jesse Uneke; Olalekan A Uthman; Masoud Vaezghasemi; Tommi Vasankari; Ana Maria Nogales Vasconcelos; Narayanaswamy Venketasubramanian; Raj Kumar Verma; Francesco S Violante; Sergey K Vladimirov; Vasiliy Victorovich Vlassov; Stein Emil Vollset; Linhong Wang; Yanping Wang; Scott Weichenthal; Elisabete Weiderpass; Robert G Weintraub; Daniel J Weiss; Andrea Werdecker; Ronny Westerman; Marc-Alain Widdowson; Tissa Wijeratne; Thomas Neil Williams; Charles Shey Wiysonge; Charles D A Wolfe; Ingrid Wolfe; Sungho Won; Mamo Wubshet; Qingyang Xiao; Gelin Xu; Ajit Kumar Yadav; Bereket Yakob; Yuichiro Yano; Mehdi Yaseri; Pengpeng Ye; Henock Gebremedhin Yebyo; Paul Yip; Naohiro Yonemoto; Seok-Jun Yoon; Mustafa Z Younis; Chuanhua Yu; Zoubida Zaidi; Maysaa El Sayed Zaki; Hajo Zeeb; Hao Zhang; Yong Zhao; Yingfeng Zheng; Maigeng Zhou; Sanjay Zodpey; Christopher J L Murray
GBD 2015 Child Mortality Collaborators. Global, regional, national, and selected subnational levels of stillbirths, neonatal, infant, and under-5 mortality, 1980–2015: a systematic analysis for the Global Burden of Disease Study 2015. Lancet 2016; 388: 1725–74—In this Article, Mohsen Naghavi, Michael J Kutz, Chantal Huynh, Samer Hamidi, Addisu Shunu Beyene, and Stephen S Lim should have been listed as authors. The affiliation details for Simon I Hay have been updated. The funding statement for Simon I Hay has been added. These corrections have been made to the online version as of Jan 5, 2017. © 2017 Elsevier Ltd
Estimating global injuries morbidity and mortality: Methods and data used in the Global Burden of Disease 2017 study
(BMJ Publishing Group, 2020) Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Nicholas L. S. Roberts; Dillon O. Sylte; Gregory J. Bertolacci; Matthew Cunningham; Nathaniel J. Henry; Kate E. Legrand; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Aidin Abedi; Kedir Hussein Abegaz; Akine Eshete Abosetugn; Abdelrahman I. Abushouk; Oladimeji M. Adebayo; Jose C. Adsuar; Shailesh M. Advani; Marcela Agudelo-Botero; Tauseef Ahmad; Muktar Beshir Ahmed; Rushdia Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Fahad Mashhour Alanezi; Niguse Meles Alema; Biresaw Wassihun Alemu; Suliman A. Alghnam; Beriwan Abdulqadir Ali; Saqib Ali; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Khalid Altirkawi; Yasser Sami Abdeldayem Amer; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Davood Anvari; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Zohreh Arefi; Olatunde Aremu; Filippo Ariani; Amit Arora; Malke Asaad; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Ghasem Azarian; Alaa Badawi; Ashish D. Badiye; Atif Amin Baig; Mohan Bairwa; Ahad Bakhtiari; Arun Balachandran; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Akbar Barzegar; Mohsen Bayati; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Masoud Behzadifar; Habte Belete; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Sadia Bibi; Ali Bijani; Archith Boloor; Guilherme Borges; Rohan Borschmann; Antonio Maria Borzì; Soufiane Boufous; Dejana Braithwaite; Nikolay Ivanovich Briko; Traolach Brugha; Shyam S. 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Younis; Zabihollah Yousef; Chuanhua Yu; Yong Yu; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Hamed Zandian; Fatemeh Zarei; Zhi-Jiang Zhang; Yunquan Zhang; Arash Ziapour; Sanjay Zodpey; Rakhi Dandona; Samath Dhamminda Dharmaratne; Simon I. Hay; Ali H. Mokdad; David M. Pigott; Robert C. Reiner; Theo Vos
Background: While there is a long history of measuring death and disability from injuries, modern research methods must account for the wide spectrum of disability that can occur in an injury, and must provide estimates with sufficient demographic, geographical and temporal detail to be useful for policy makers. The Global Burden of Disease (GBD) 2017 study used methods to provide highly detailed estimates of global injury burden that meet these criteria. Methods: In this study, we report and discuss the methods used in GBD 2017 for injury morbidity and mortality burden estimation. In summary, these methods included estimating cause-specific mortality for every cause of injury, and then estimating incidence for every cause of injury. Non-fatal disability for each cause is then calculated based on the probabilities of suffering from different types of bodily injury experienced. Results: GBD 2017 produced morbidity and mortality estimates for 38 causes of injury. Estimates were produced in terms of incidence, prevalence, years lived with disability, cause-specific mortality, years of life lost and disability-adjusted life-years for a 28-year period for 22 age groups, 195 countries and both sexes. Conclusions: GBD 2017 demonstrated a complex and sophisticated series of analytical steps using the largest known database of morbidity and mortality data on injuries. GBD 2017 results should be used to help inform injury prevention policy making and resource allocation. We also identify important avenues for improving injury burden estimation in the future. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC B Y. Published by BMJ.
Estimation of the global prevalence of dementia in 2019 and forecasted prevalence in 2050: an analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Emma Nichols; Jaimie D. Steinmetz; Stein Emil Vollset; Kai Fukutaki; Julian Chalek; Foad Abd-Allah; Amir Abdoli; Ahmed Abualhasan; Eman Abu-Gharbieh; Tayyaba Tayyaba Akram; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Vahid Alipour; Sami Almustanyir; Hubert Amu; Iman Ansari; Jalal Arabloo; Tahira Ashraf; Thomas Astell-Burt; Getinet Ayano; Jose L. Ayuso-Mateos; Atif Amin Baig; Anthony Barnett; Amadou Barrow; Bernhard T. Baune; Yannick Béjot; Woldesellassie M. Mequanint Bezabhe; Yihienew Mequanint Bezabih; Akshaya Srikanth Bhagavathula; Sonu Bhaskar; Krittika Bhattacharyya; Ali Bijani; Atanu Biswas; Srinivasa Rao Bolla; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Richard A. Burns; Luis Alberto Cámera; Chao Cao; Felix Carvalho; Luis F.S. Castro-De-Araujo; Ferrán Catalá-López; Ester Cerin; Prachi P. Chavan; Nicolas Cherbuin; Dinh-Toi Chu; Vera Marisa Costa; Rosa A.S. Couto; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Vanessa De la Cruz-Góngora; Deepak Dhamnetiya; Diana Dias da Silva; Daniel Diaz; Abdel Douiri; David Edvardsson; Michael Ekholuenetale; Iman El Sayed; Shaimaa I. El-Jaafary; Khalil Eskandari; Sharareh Eskandarieh; Saman Esmaeilnejad; Jawad Fares; Andre Faro; Umar Farooque; Valery L. Feigin; Xiaoqi Feng; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Howard Fillit; Florian Fischer; Shilpa Gaidhane; Lucia Galluzzo; Ahmad Ghashghaee; Nermin Ghith; Alessandro Gialluisi; Syed Amir Gilani; Ionela-Roxana Glavan; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Mohammad Rifat Haider; Brian J. Hall; Samer Hamidi; Asif Hanif; Graeme J. Hankey; Shafiul Haque; Risky Kusuma Hartono; Ahmed I. Hasaballah; M. Tasdik Hasan; Amr Hassan; Simon I. Hay; Khezar Hayat; Mohamed I. Hegazy; Golnaz Heidari; Reza Heidari-Soureshjani; Claudiu Herteliu; Mowafa Househ; Rabia Hussain; Bing-Fang Hwang; Licia Iacoviello; Ivo Iavicoli; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Hiroyasu Iso; Masao Iwagami; Roxana Jabbarinejad; Louis Jacob; Vardhmaan Jain; Sathish Kumar Jayapal; Ranil Jayawardena; Ravi Prakash Jha; Jost B. Jonas; Nitin Joseph; Rizwan Kalani; Amit Kandel; Himal Kandel; André Karch; Ayele Semachew Kasa; Gizat M. Kassie; Pedram Keshavarz; Moien A.B. Khan; Mahalaqua Nazli Khatib; Tawfik Ahmed Muthafer Khoja; Jagdish Khubchandani; Min Seo Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Mika Kivimäki; Walter J. Koroshetz; Ai Koyanagi; G. Anil Kumar; Manasi Kumar; Hassan Mehmood Lak; Matilde Leonardi; Bingyu Li; Stephen S. Lim; Xuefeng Liu; Yuewei Liu; Giancarlo Logroscino; Stefan Lorkowski; Giancarlo Lucchetti; Ricardo Lutzky Saute; Francesca Giulia Magnani; Ahmad Azam Malik; João Massano; Man Mohan Mehndiratta; Ritesh G. Menezes; Atte Meretoja; Bahram Mohajer; Norlinah Mohamed Ibrahim; Yousef Mohammad; Arif Mohammed; Ali H. Mokdad; Stefania Mondello; Mohammad Ali Moni; Md Moniruzzaman; Tilahun Belete Mossie; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Sandhya Neupane Kandel; Trang Huyen Nguyen; Bogdan Oancea; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Songhomitra Panda-Jonas; Fatemeh Pashazadeh Kan; Maja Pasovic; Urvish K. Patel; Mona Pathak; Mario F.P. Peres; Arokiasamy Perianayagam; Carrie B. Peterson; Michael R. Phillips; Marina Pinheiro; Michael A. Piradov; Constance Dimity Pond; Michele H. Potashman; Faheem Hyder Pottoo; Sergio I. Prada; Amir Radfar; Alberto Raggi; Fakher Rahim; Mosiur Rahman; Pradhum Ram; Priyanga Ranasinghe; David Laith Rawaf; Salman Rawaf; Nima Rezaei; Aziz Rezapour; Stephen R. Robinson; Michele Romoli; Gholamreza Roshandel; Ramesh Sahathevan; Amirhossein Sahebkar; Mohammad Ali Sahraian; Brijesh Sathian; Davide Sattin; Monika Sawhney; Mete Saylan; Silvia Schiavolin; Allen Seylani; Feng Sha; Masood Ali Shaikh; K.S. Shaji; Mohammed Shannawaz; Jeevan K. Shetty; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Diego Augusto Santos Silva; Joao Pedro Silva; Renata Silva; Jasvinder A. Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amanda E. Smith; Sergey Soshnikov; Emma Elizabeth Spurlock; Dan J. Stein; Jing Sun; Rafael Tabarés-Seisdedos; Bhaskar Thakur; Binod Timalsina; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Gebiyaw Wudie Tsegaye; Sahel Valadan Tahbaz; Pascual R. Valdez; Narayanaswamy Venketasubramanian; Vasily Vlassov; Giang Thu Vu; Linh Gia Vu; Yuan-Pang Wang; Anders Wimo; Andrea Sylvia Winkler; Lalit Yadav; Seyed Hossein Yahyazadeh Jabbari; Kazumasa Yamagishi; Lin Yang; Yuichiro Yano; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Siddhesh Zadey; Mikhail Sergeevich Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Christopher J.L. Murray; Theo Vos
Background: Given the projected trends in population ageing and population growth, the number of people with dementia is expected to increase. In addition, strong evidence has emerged supporting the importance of potentially modifiable risk factors for dementia. Characterising the distribution and magnitude of anticipated growth is crucial for public health planning and resource prioritisation. This study aimed to improve on previous forecasts of dementia prevalence by producing country-level estimates and incorporating information on selected risk factors. Methods: We forecasted the prevalence of dementia attributable to the three dementia risk factors included in the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 (high body-mass index, high fasting plasma glucose, and smoking) from 2019 to 2050, using relative risks and forecasted risk factor prevalence to predict GBD risk-attributable prevalence in 2050 globally and by world region and country. Using linear regression models with education included as an additional predictor, we then forecasted the prevalence of dementia not attributable to GBD risks. To assess the relative contribution of future trends in GBD risk factors, education, population growth, and population ageing, we did a decomposition analysis. Findings: We estimated that the number of people with dementia would increase from 57·4 (95% uncertainty interval 50·4–65·1) million cases globally in 2019 to 152·8 (130·8–175·9) million cases in 2050. Despite large increases in the projected number of people living with dementia, age-standardised both-sex prevalence remained stable between 2019 and 2050 (global percentage change of 0·1% [–7·5 to 10·8]). We estimated that there were more women with dementia than men with dementia globally in 2019 (female-to-male ratio of 1·69 [1·64–1·73]), and we expect this pattern to continue to 2050 (female-to-male ratio of 1·67 [1·52–1·85]). There was geographical heterogeneity in the projected increases across countries and regions, with the smallest percentage changes in the number of projected dementia cases in high-income Asia Pacific (53% [41–67]) and western Europe (74% [58–90]), and the largest in north Africa and the Middle East (367% [329–403]) and eastern sub-Saharan Africa (357% [323–395]). Projected increases in cases could largely be attributed to population growth and population ageing, although their relative importance varied by world region, with population growth contributing most to the increases in sub-Saharan Africa and population ageing contributing most to the increases in east Asia. Interpretation: Growth in the number of individuals living with dementia underscores the need for public health planning efforts and policy to address the needs of this group. Country-level estimates can be used to inform national planning efforts and decisions. Multifaceted approaches, including scaling up interventions to address modifiable risk factors and investing in research on biological mechanisms, will be key in addressing the expected increases in the number of individuals affected by dementia. Funding: Bill & Melinda Gates Foundation and Gates Ventures. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global burden of 87 risk factors in 204 countries and territories, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier B.V., 2020) Cristiana Abbafati; Kaja M. Abbas; Mohsen Abbasi-Kangevari; Foad Abd-Allah; Ahmed Abdelalim; Mohammad Abdollahi; Ibrahim Abdollahpour; Kedir Hussein Abegaz; Hassan Abolhassani; Victor Aboyans; Lucas Guimarães Abreu; Michael R.M. Abrigo; Ahmed Abualhasan; Laith Jamal Abu-Raddad; Abdelrahman I. Abushouk; Maryam Adabi; Victor Adekanmbi; Abiodun Moshood Adeoye; Olatunji O. Adetokunboh; Davoud Adham; Shailesh M. Advani; Ashkan Afshin; Gina Agarwal; Seyed Mohammad Kazem Aghamir; Anurag Agrawal; Tauseef Ahmad; Keivan Ahmadi; Mehdi Ahmadi; Hamid Ahmadieh; Muktar Beshir Ahmed; Temesgen Yihunie Akalu; Rufus Olusola Akinyemi; Tomi Akinyemiju; Blessing Akombi; Chisom Joyqueenet Akunna; Fares Alahdab; Ziyad Al-Aly; Khurshid Alam; Samiah Alam; Tahiya Alam; Fahad Mashhour Alanezi; Turki M. Alanzi; Biresaw Wassihun Alemu; Khalid F. Alhabib; Muhammad Ali; Saqib Ali; Gianfranco Alicandro; Cyrus Alinia; Vahid Alipour; Hesam Alizade; Syed Mohamed Aljunid; François Alla; Peter Allebeck; Amir Almasi-Hashiani; Hesham M. Al-Mekhlafi; Jordi Alonso; Khalid A. Altirkawi; Mostafa Amini-Rarani; Fatemeh Amiri; Dickson A. Amugsi; Robert Ancuceanu; Deanna Anderlini; Jason A. Anderson; Catalina Liliana Andrei; Tudorel Andrei; Colin Angus; Mina Anjomshoa; Fereshteh Ansari; Alireza Ansari-Moghaddam; Ippazio Cosimo Antonazzo; Carl Abelardo T. Antonio; Catherine M. Antony; Ernoiz Antriyandarti; Davood Anvari; Razique Anwer; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Aleksandr Y. Aravkin; Filippo Ariani; Bahram Armoon; Johan Ärnlöv; Afsaneh Arzani; Mehran Asadi-Aliabadi; Ali A. Asadi-Pooya; Charlie Ashbaugh; Michael Assmus; Zahra Atafar; Desta Debalkie Atnafu; Maha Moh'd Wahbi Atout; Floriane Ausloos; Marcel Ausloos; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Ghasem Azarian; Zelalem Nigussie Azene; Alaa Badawi; Ashish D. Badiye; Mohammad Amin Bahrami; Mohammad Hossein Bakhshaei; Ahad Bakhtiari; Shankar M. Bakkannavar; Alberto Baldasseroni; Kylie Ball; Shoshana H. Ballew; Daniela Balzi; Maciej Banach; Srikanta K. Banerjee; Agegnehu Bante Bante; Adhanom Gebreegziabher Baraki; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Celine M. Barthelemy; Lingkan Barua; Sanjay Basu; Bernhard T. Baune; Mohsen Bayati; Jacob S. Becker; Neeraj Bedi; Ettore Beghi; Yannick Béjot; Michelle L. Bell; Fiona B. Bennitt; Isabela M. Bensenor; Kidanemaryam Berhe; Adam E. Berman; Akshaya Srikanth Bhagavathula; Reshmi Bhageerathy; Neeraj Bhala; Dinesh Bhandari; Krittika Bhattacharyya; Zulfiqar A. Bhutta; Ali Bijani; Boris Bikbov; Muhammad Shahdaat Bin Sayeed; Antonio Biondi; Binyam Minuye Birihane; Catherine Bisignano; Raaj Kishore Biswas; Helen Bitew; Somayeh Bohlouli; Mehdi Bohluli; Alexandra S. Boon-Dooley; Guilherme Borges; Antonio Maria Borzì; Shiva Borzouei; Cristina Bosetti; Soufiane Boufous; Dejana Braithwaite; Michael Brauer; Nicholas J.K. Breitborde; Susanne Breitner; Hermann Brenner; Paul Svitil Briant; Andrey Nikolaevich Briko; Nikolay Ivanovich Briko; Gabrielle B. Britton; Dana Bryazka; Blair R. Bumgarner; Katrin Burkart; Richard Thomas Burnett; Sharath Burugina Nagaraja; Zahid A. Butt; Florentino Luciano Caetano Dos Santos; Leah E. Cahill; Luis Alberto Cámera; Ismael R. Campos-Nonato; Rosario Cárdenas; Giulia Carreras; Juan J. Carrero; Felix Carvalho; Joao Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Franz Castro; Kate Causey; Christopher R. Cederroth; Kelly M. Cercy; Ester Cerin; Joht Singh Chandan; Kai-Lan Chang; Fiona J. Charlson; Vijay Kumar Chattu; Sarika Chaturvedi; Nicolas Cherbuin; Odgerel Chimed-Ochir; Daniel Youngwhan Cho; Jee-Young Jasmine Choi; Hanne Christensen; Dinh-Toi Chu; Michael T. Chung; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Thomas Khaled Dwayne Classen; Aaron J. Cohen; Kelly Compton; Owen R. Cooper; Vera Marisa Costa; Ewerton Cousin; Richard G. Cowden; Di H. Cross; Jessica A. Cruz; Saad M.A. Dahlawi; Albertino Antonio Moura Damasceno; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; William James Dangel; Anna-Karin Danielsson; Paul I. Dargan; Aso Mohammad Darwesh; Ahmad Daryani; Jai K. Das; Rajat Das Gupta; José das Neves; Claudio Alberto Dávila-Cervantes; Dragos Virgil Davitoiu; Diego De Leo; Louisa Degenhardt; Marissa DeLang; Robert Paul Dellavalle; Feleke Mekonnen Demeke; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Edgar Denova-Gutiérrez; Nikolaos Dervenis; Govinda Prasad Dhungana; Mostafa Dianatinasab; Diana Dias da Silva; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Shirin Djalalinia; Hoa Thi Do; Klara Dokova; Fariba Dorostkar; Leila Doshmangir; Tim Robert Driscoll; Bruce B. Duncan; Andre Rodrigues Duraes; Arielle Wilder Eagan; David Edvardsson; Nevine El Nahas; Iman El Sayed; Maha El Tantawi; Iffat Elbarazi; Islam Y. Elgendy; Shaimaa I. El-Jaafary; Iqbal R.F. Elyazar; Sophia Emmons-Bell; Holly E. Erskine; Sharareh Eskandarieh; Saman Esmaeilnejad; Alireza Esteghamati; Kara Estep; Arash Etemadi; Atkilt Esaiyas Etisso; Jessica Fanzo; Mohammad Farahmand; Mohammad Fareed; Roghiyeh Faridnia; Andrea Farioli; Andre Faro; Mithila Faruque; Farshad Farzadfar; Nazir Fattahi; Mehdi Fazlzadeh; Valery L. Feigin; Rachel Feldman; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Giannina Ferrara; Alize J. Ferrari; Manuela L. Ferreira; Irina Filip; Florian Fischer; James L. Fisher; Luisa Sorio Flor; Nataliya A. Foigt; Morenike Oluwatoyin Folayan; Artem Alekseevich Fomenkov; Lisa M. Force; Masoud Foroutan; Richard Charles Franklin; Marisa Freitas; Weijia Fu; Takeshi Fukumoto; João M. Furtado; Mohamed M. Gad; Emmanuela Gakidou; Silvano Gallus; Alberto L. Garcia-Basteiro; William M. Gardner; Biniyam Sahiledengle Geberemariyam; Assefa Ayalew Ayalew Ayalew Gebreslassie; Abraham Geremew; Anna Gershberg Hayoon; Peter W. Gething; Maryam Ghadimi; Keyghobad Ghadiri; Fatemeh Ghaffarifar; Mansour Ghafourifard; Farhad Ghamari; Ahmad Ghashghaee; Hesam Ghiasvand; Nermin Ghith; Asadollah Gholamian; Rakesh Ghosh; Paramjit Singh Gill; Themba G. Ginindza; Giorgia Giussani; Elena V. Gnedovskaya; Salime Goharinezhad; Sameer Vali Gopalani; Giuseppe Gorini; Houman Goudarzi; Alessandra C. Goulart; Felix Greaves; Michal Grivna; Giuseppe Grosso; Mohammed Ibrahim Mohialdeen Gubari; Harish Chander Gugnani; Rafael Alves Guimarães; Rashid Abdi Guled; Gaorui Guo; Yuming Guo; Rajeev Gupta; Tarun Gupta; Beatrix Haddock; Nima Hafezi-Nejad; Abdul Hafiz; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Brian J. Hall; Iman Halvaei; Randah R. Hamadeh; Samer Hamidi; Melanie S. Hammer; Graeme J. Hankey; Hamidreza Haririan; Josep Maria Haro; Ahmed I. Hasaballah; Md Mehedi Hasan; Edris Hasanpoor; Abdiwahab Hashi; Soheil Hassanipour; Hadi Hassankhani; Rasmus J. Havmoeller; Simon I. Hay; Khezar Hayat; Golnaz Heidari; Reza Heidari-Soureshjani; Hannah J. Henrikson; Molly E. Herbert; Claudiu Herteliu; Fatemeh Heydarpour; Thomas R. Hird; Hans W. Hoek; Ramesh Holla; Praveen Hoogar; H. Dean Hosgood; Naznin Hossain; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Mowafa Househ; Mohamed Hsairi; Vivian Chia-Rong Hsieh; Guoqing Hu; Kejia Hu; Tanvir M. Huda; Ayesha Humayun; Chantal K. Huynh; Bing-Fang Hwang; Vincent C. Iannucci; Segun Emmanuel Ibitoye; Nayu Ikeda; Kevin S. Ikuta; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Helen Ippolito; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; M. Mofizul Islam; Sheikh Mohammed Shariful Islam; Hiroyasu Iso; Rebecca Q. Ivers; Chidozie C.D. Iwu; Chinwe Juliana Iwu; Ihoghosa Osamuyi Iyamu; Jalil Jaafari; Kathryn H. Jacobsen; Hussain Jafari; Morteza Jafarinia; Mohammad Ali Jahani; Mihajlo Jakovljevic; Farzad Jalilian; Spencer L. James; Hosna Janjani; Tahereh Javaheri; Javad Javidnia; Panniyammakal Jeemon; Ensiyeh Jenabi; Ravi Prakash Jha; Vivekanand Jha; John S. Ji; Lars Johansson; Oommen John; Yetunde O. John-Akinola; Catherine Owens Johnson; Jost B. Jonas; Farahnaz Joukar; Jacek Jerzy Jozwiak; Mikk Jürisson; Ali Kabir; Zubair Kabir; Hamed Kalani; Rizwan Kalani; Leila R. Kalankesh; Rohollah Kalhor; Tanuj Kanchan; Neeti Kapoor; Behzad Karami Matin; André Karch; Mohd Anisul Karim; Getachew Mullu Kassa; Srinivasa Vittal Katikireddi; Gbenga A. Kayode; Ali Kazemi Karyani; Peter Njenga Keiyoro; Cathleen Keller; Laura Kemmer; Parkes J. Kendrick; Nauman Khalid; Mohammad Khammarnia; Ejaz Ahmad Khan; Maseer Khan; Khaled Khatab; Mona M. Khater; Mahalaqua Nazli Khatib; Maryam Khayamzadeh; Salman Khazaei; Christian Kieling; Yun Jin Kim; Ruth W. Kimokoti; Adnan Kisa; Sezer Kisa; Mika Kivimäki; Luke D. Knibbs; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; Jacek A. Kopec; Vladimir Andreevich Korshunov; Parvaiz A. Koul; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Kris J. Krohn; Hans Kromhout; Barthelemy Kuate Defo; G. Anil Kumar; Vivek Kumar; Om P. Kurmi; Dian Kusuma; Carlo La Vecchia; Ben Lacey; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Faris Hasan Lami; Iván Landires; Justin J. Lang; Sinéad M. Langan; Anders O. Larsson; Savita Lasrado; Paolo Lauriola; Jeffrey V. Lazarus; Paul H. Lee; Shaun Wen Huey Lee; Kate E. Legrand; James Leigh; Matilde Leonardi; Haley Lescinsky; Janni Leung; Miriam Levi; Shanshan Li; Lee-Ling Lim; Shai Linn; Shiwei Liu; Simin Liu; Yang Liu; Justin Lo; Alan D. Lopez; Jaifred Christian F. Lopez; Platon D. Lopukhov; Stefan Lorkowski; Paulo A. Lotufo; Alton Lu; Alessandra Lugo; Emilie R. Maddison; Phetole Walter Mahasha; Mokhtar Mahdavi Mahdavi; Morteza Mahmoudi; Azeem Majeed; Afshin Maleki; Shokofeh Maleki; Reza Malekzadeh; Deborah Carvalho Malta; Abdullah A. Mamun; Ana Laura Manda; Helena Manguerra; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Ana M. Mantilla Herrera; Joemer C. Maravilla; Ashley Marks; Randall V. Martin; Santi Martini; Francisco Rogerlândio Martins-Melo; Anthony Masaka; Seyedeh Zahra Masoumi; Manu Raj Mathur; Kunihiro Matsushita; Pallab K. Maulik; Colm McAlinden; John J. McGrath; Martin McKee; Man Mohan Mehndiratta; Fereshteh Mehri; Kala M. Mehta; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Endalkachew Worku Mengesha; Alibek Mereke; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Irmina Maria Michalek; Ted R. Miller; Edward J. Mills; G.K. Mini; Mohammad Miri; Andreea Mirica; Erkin M. Mirrakhimov; Hamed Mirzaei; Maryam Mirzaei; Roya Mirzaei; Mehdi Mirzaei-Alavijeh; Awoke Temesgen Misganaw; Prasanna Mithra; Babak Moazen; Dara K. Mohammad; Yousef Mohammad; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Noushin Mohammadifard; Reza Mohammadpourhodki; Ammas Siraj Mohammed; Hussen Mohammed; Jemal Abdu Mohammed; Shafiu Mohammed; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Meghan D. Mooney; Ghobad Moradi; Masoud Moradi; Maziar Moradi-Lakeh; Rahmatollah Moradzadeh; Paula Moraga; Lidia Morawska; Joana Morgado-Da-Costa; Shane Douglas Morrison; Abbas Mosapour; Jonathan F. Mosser; Simin Mouodi; Seyyed Meysam Mousavi; Amin Mousavi Khaneghah; Ulrich Otto Mueller; Satinath Mukhopadhyay; Erin C. Mullany; Kamarul Imran Musa; Saravanan Muthupandian; Ashraf F. Nabhan; Mehdi Naderi; Ahamarshan Jayaraman Nagarajan; Gabriele Nagel; Mohsen Naghavi; Behshad Naghshtabrizi; Mukhammad David Naimzada; Farid Najafi; Vinay Nangia; Jobert Richie Nansseu; Morteza Naserbakht; Vinod C. Nayak; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Ming Nguyen; Yeshambel T. Nigatu; Rajan Nikbakhsh; Molly R. Nixon; Chukwudi A. Nnaji; Shuhei Nomura; Bo Norrving; Jean Jacques Noubiap; Christoph Nowak; Virginia Nunez-Samudio; Bogdan Oancea; Christopher M. Odell; Felix Akpojene Ogbo; In-Hwan Oh; Emmanuel Wandera Okunga; Morteza Oladnabi; Andrew T. Olagunju; Bolajoko Olubukunola Olusanya; Jacob Olusegun Olusanya; Muktar Omer Omer; Kanyin L. Ong; Obinna E. Onwujekwe; Heather M. Orpana; Alberto Ortiz; Osayomwanbo Osarenotor; Frank B. Osei; Samuel M. Ostroff; Adrian Otoiu; Nikita Otstavnov; Stanislav S. Otstavnov; Simon Øverland; Mayowa O. Owolabi; P.A. Mahesh; Jagadish Rao Padubidri; Raffaele Palladino; Songhomitra Panda-Jonas; Anamika Pandey; Charles D. H. Parry; Maja Pasovic; Deepak Kumar Pasupula; Sangram Kishor Patel; Mona Pathak; Scott B. Patten; George C. Patton; Hamidreza Pazoki Toroudi; Amy E. Peden; Alyssa Pennini; Veincent Christian Filipino Pepito; Emmanuel K. Peprah; David M. Pereira; Konrad Pesudovs; Hai Quang Pham; Michael R. Phillips; Cristiano Piccinelli; Tessa M. Pilz; Michael A. Piradov; Meghdad Pirsaheb; Dietrich Plass; Suzanne Polinder; Kevan R. Polkinghorne; Constance Dimity Pond; Maarten J. Postma; Hadi Pourjafar; Farshad Pourmalek; Anna Poznañska; Sergio I. Prada; V. Prakash; Dimas Ria Angga Pribadi; Elisabetta Pupillo; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Ata Rafiee; Alberto Raggi; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Pradhum Ram; Kiana Ramezanzadeh; Chhabi Lal Ranabhat; Puja C. Rao; Sowmya J. Rao; Vahid Rashedi; Priya Rathi; David Laith Rawaf; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Ramu Rawat; Christian Razo; Sofia Boston Redford; Robert C. Reiner; Marissa Bettay Reitsma; Giuseppe Remuzzi; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Negar Rezaei; Nima Rezaei; Aziz Rezapour; Phoebe-Anne Rhinehart; Seyed Mohammad Riahi; Daniel Cury Ribeiro; Daniela Ribeiro; Jennifer Rickard; Juan A. Rivera; Nicholas L.S. 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Background: Rigorous analysis of levels and trends in exposure to leading risk factors and quantification of their effect on human health are important to identify where public health is making progress and in which cases current efforts are inadequate. The Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019 provides a standardised and comprehensive assessment of the magnitude of risk factor exposure, relative risk, and attributable burden of disease. Methods: GBD 2019 estimated attributable mortality, years of life lost (YLLs), years of life lived with disability (YLDs), and disability-adjusted life-years (DALYs) for 87 risk factors and combinations of risk factors, at the global level, regionally, and for 204 countries and territories. GBD uses a hierarchical list of risk factors so that specific risk factors (eg, sodium intake), and related aggregates (eg, diet quality), are both evaluated. This method has six analytical steps. (1) We included 560 risk–outcome pairs that met criteria for convincing or probable evidence on the basis of research studies. 12 risk–outcome pairs included in GBD 2017 no longer met inclusion criteria and 47 risk–outcome pairs for risks already included in GBD 2017 were added based on new evidence. (2) Relative risks were estimated as a function of exposure based on published systematic reviews, 81 systematic reviews done for GBD 2019, and meta-regression. (3) Levels of exposure in each age-sex-location-year included in the study were estimated based on all available data sources using spatiotemporal Gaussian process regression, DisMod-MR 2.1, a Bayesian meta-regression method, or alternative methods. (4) We determined, from published trials or cohort studies, the level of exposure associated with minimum risk, called the theoretical minimum risk exposure level. (5) Attributable deaths, YLLs, YLDs, and DALYs were computed by multiplying population attributable fractions (PAFs) by the relevant outcome quantity for each age-sex-location-year. (6) PAFs and attributable burden for combinations of risk factors were estimated taking into account mediation of different risk factors through other risk factors. Across all six analytical steps, 30 652 distinct data sources were used in the analysis. Uncertainty in each step of the analysis was propagated into the final estimates of attributable burden. Exposure levels for dichotomous, polytomous, and continuous risk factors were summarised with use of the summary exposure value to facilitate comparisons over time, across location, and across risks. Because the entire time series from 1990 to 2019 has been re-estimated with use of consistent data and methods, these results supersede previously published GBD estimates of attributable burden. Findings: The largest declines in risk exposure from 2010 to 2019 were among a set of risks that are strongly linked to social and economic development, including household air pollution; unsafe water, sanitation, and handwashing; and child growth failure. Global declines also occurred for tobacco smoking and lead exposure. The largest increases in risk exposure were for ambient particulate matter pollution, drug use, high fasting plasma glucose, and high body-mass index. In 2019, the leading Level 2 risk factor globally for attributable deaths was high systolic blood pressure, which accounted for 10·8 million (95% uncertainty interval [UI] 9·51–12·1) deaths (19·2% [16·9–21·3] of all deaths in 2019), followed by tobacco (smoked, second-hand, and chewing), which accounted for 8·71 million (8·12–9·31) deaths (15·4% [14·6–16·2] of all deaths in 2019). The leading Level 2 risk factor for attributable DALYs globally in 2019 was child and maternal malnutrition, which largely affects health in the youngest age groups and accounted for 295 million (253–350) DALYs (11·6% [10·3–13·1] of all global DALYs that year). The risk factor burden varied considerably in 2019 between age groups and locations. Among children aged 0–9 years, the three leading detailed risk factors for attributable DALYs were all related to malnutrition. Iron deficiency was the leading risk factor for those aged 10–24 years, alcohol use for those aged 25–49 years, and high systolic blood pressure for those aged 50–74 years and 75 years and older. Interpretation: Overall, the record for reducing exposure to harmful risks over the past three decades is poor. Success with reducing smoking and lead exposure through regulatory policy might point the way for a stronger role for public policy on other risks in addition to continued efforts to provide information on risk factor harm to the general public. Funding: Bill & Melinda Gates Foundation. © 2020 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global Burden of Cardiovascular Diseases and Risk Factors, 1990-2019: Update From the GBD 2019 Study
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Teklehaimanot; Mohamad-Hani Temsah; Ayenew K. Tesema; Bhaskar Thakur; Kavumpurathu R. Thankappan; Rekha Thapar; Amanda G. Thrift; Binod Timalsina; Marcello Tonelli; Mathilde Touvier; Marcos R. Tovani-Palone; Avnish Tripathi; Jaya P. Tripathy; Thomas C. Truelsen; Guesh M. Tsegay; Gebiyaw W. Tsegaye; Nikolaos Tsilimparis; Biruk S. Tusa; Stefanos Tyrovolas; Krishna Kishore Umapathi; Brigid Unim; Bhaskaran Unnikrishnan; Muhammad S. Usman; Muthiah Vaduganathan; Pascual R. Valdez; Tommi J. Vasankari; Diana Z. Velazquez; Narayanaswamy Venketasubramanian; Giang T. Vu; Isidora S. Vujcic; Yasir Waheed; Yanzhong Wang; Fang Wang; Jingkai Wei; Robert G. Weintraub; Abrha H. Weldemariam; Ronny Westerman; Andrea S. Winkler; Charles S. Wiysonge; Charles D.A. Wolfe; Befikadu Legesse Wubishet; Gelin Xu; Ali Yadollahpour; Kazumasa Yamagishi; Lijing L. Yan; Srikanth Yandrapalli; Yuichiro Yano; Hiroshi Yatsuya; Tomas Y. Yeheyis; Yigizie Yeshaw; Christopher S. Yilgwan; Naohiro Yonemoto; Chuanhua Yu; Hasan Yusefzadeh; Geevar Zachariah; Sojib Bin Zaman; Muhammed S. Zaman; Maryam Zamanian; Ramin Zand; Alireza Zandifar; Afshin Zarghi; Mikhail S. Zastrozhin; Anasthasia Zastrozhina; Zhi-Jiang Zhang; Yunquan Zhang; Wangjian Zhang; Chenwen Zhong; Zhiyong Zou; Yves Miel H. Zuniga; Christopher J.L. Murray; Valentin Fuster
Cardiovascular diseases (CVDs), principally ischemic heart disease (IHD) and stroke, are the leading cause of global mortality and a major contributor to disability. This paper reviews the magnitude of total CVD burden, including 13 underlying causes of cardiovascular death and 9 related risk factors, using estimates from the Global Burden of Disease (GBD) Study 2019. GBD, an ongoing multinational collaboration to provide comparable and consistent estimates of population health over time, used all available population-level data sources on incidence, prevalence, case fatality, mortality, and health risks to produce estimates for 204 countries and territories from 1990 to 2019. Prevalent cases of total CVD nearly doubled from 271 million (95% uncertainty interval [UI]: 257 to 285 million) in 1990 to 523 million (95% UI: 497 to 550 million) in 2019, and the number of CVD deaths steadily increased from 12.1 million (95% UI:11.4 to 12.6 million) in 1990, reaching 18.6 million (95% UI: 17.1 to 19.7 million) in 2019. The global trends for disability-adjusted life years (DALYs) and years of life lost also increased significantly, and years lived with disability doubled from 17.7 million (95% UI: 12.9 to 22.5 million) to 34.4 million (95% UI:24.9 to 43.6 million) over that period. The total number of DALYs due to IHD has risen steadily since 1990, reaching 182 million (95% UI: 170 to 194 million) DALYs, 9.14 million (95% UI: 8.40 to 9.74 million) deaths in the year 2019, and 197 million (95% UI: 178 to 220 million) prevalent cases of IHD in 2019. The total number of DALYs due to stroke has risen steadily since 1990, reaching 143 million (95% UI: 133 to 153 million) DALYs, 6.55 million (95% UI: 6.00 to 7.02 million) deaths in the year 2019, and 101 million (95% UI: 93.2 to 111 million) prevalent cases of stroke in 2019. Cardiovascular diseases remain the leading cause of disease burden in the world. CVD burden continues its decades-long rise for almost all countries outside high-income countries, and alarmingly, the age-standardized rate of CVD has begun to rise in some locations where it was previously declining in high-income countries. There is an urgent need to focus on implementing existing cost-effective policies and interventions if the world is to meet the targets for Sustainable Development Goal 3 and achieve a 30% reduction in premature mortality due to noncommunicable diseases. © 2020 The Authors
Global injury morbidity and mortality from 1990 to 2017: Results from the global burden of disease study 2017
(BMJ Publishing Group, 2020) Spencer L. James; Chris D. Castle; Zachary V. Dingels; Jack T. Fox; Erin B. Hamilton; Zichen Liu; Nicholas L.S. Roberts; Dillon O. Sylte; Nathaniel J. Henry; Kate E. LeGrand; Ahmed Abdelalim; Amir Abdoli; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Aidin Abedi; Akine Eshete Abosetugn; Abdelrahman I. Abushouk; Oladimeji M. Adebayo; Marcela Agudelo-Botero; Tauseef Ahmad; Rushdia Ahmed; Muktar Beshir Ahmed; Miloud Taki Eddine Aichour; Fares Alahdab; Genet Melak Alamene; Fahad Mashhour Alanezi; Animut Alebel; Niguse Meles Alema; Suliman A. Alghnam; Samar Al-Hajj; Beriwan Abdulqadir Ali; Saqib Ali; Mahtab Alikhani; Cyrus Alinia; Vahid Alipour; Syed Mohamed Aljunid; Amir Almasi-Hashiani; Nihad A. Almasri; Khalid Altirkawi; Yasser Sami Abdeldayem Amer; Saeed Amini; Arianna Maever Loreche Amit; Catalina Liliana Andrei; Alireza Ansari-Moghaddam; Carl Abelardo T. Antonio; Seth Christopher Yaw Appiah; Jalal Arabloo; Morteza Arab-Zozani; Zohreh Arefi; Olatunde Aremu; Filippo Ariani; Amit Arora; Malke Asaad; Babak Asghari; Nefsu Awoke; Beatriz Paulina Ayala Quintanilla; Getinet Ayano; Martin Amogre Ayanore; Samad Azari; Ghasem Azarian; Alaa Badawi; Ashish D. Badiye; Eleni Bagli; Atif Amin Baig; Mohan Bairwa; Ahad Bakhtiari; Arun Balachandran; Maciej Banach; Srikanta K. Banerjee; Palash Chandra Banik; Amrit Banstola; Suzanne Lyn Barker-Collo; Till Winfried Bärnighausen; Lope H. Barrero; Akbar Barzegar; Mohsen Bayati; Bayisa Abdissa Baye; Neeraj Bedi; Masoud Behzadifar; Tariku Tesfaye Bekuma; Habte Belete; Corina Benjet; Derrick A. Bennett; Isabela M. Bensenor; Kidanemaryam Berhe; Pankaj Bhardwaj; Anusha Ganapati Bhat; Krittika Bhattacharyya; Sadia Bibi; Ali Bijani; Muhammad Shahdaat Bin Sayeed; Guilherme Borges; Antonio Maria Borzì; Soufiane Boufous; Alexandra Brazinova; Nikolay Ivanovich Briko; Shyam S. Budhathoki; Josip Car; Rosario Cárdenas; Félix Carvalho; João Mauricio Castaldelli-Maia; Carlos A. Castañeda-Orjuela; Giulio Castelpietra; Ferrán Catalá-López; Ester Cerin; Joht S. Chandan; Wagaye Fentahun Chanie; Soosanna Kumary Chattu; Vijay Kumar Chattu; Irini Chatziralli; Neha Chaudhary; Daniel Youngwhan Cho; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Samantha M. Colquhoun; Maria-Magdalena Constantin; Vera M. Costa; Giovanni Damiani; Ahmad Daryani; Claudio Alberto Dávila-Cervantes; Feleke Mekonnen Demeke; Asmamaw Bizuneh Demis; Gebre Teklemariam Demoz; Desalegn Getnet Demsie; Afshin Derakhshani; Kebede Deribe; Rupak Desai; Mostafa Dianati Nasab; Diana Dias da Silva; Zahra Sadat Dibaji Forooshani; Kerrie E. Doyle; Tim Robert Driscoll; Eleonora Dubljanin; Bereket Duko Adema; Arielle Wilder Eagan; Aziz Eftekhari; Elham Ehsani-Chimeh; Maysaa El Sayed Zaki; Demelash Abewa Elemineh; Shaimaa I. El-Jaafary; Ziad El-Khatib; Christian Lycke Ellingsen; Mohammad Hassan Emamian; Daniel Adane Endalew; Sharareh Eskandarieh; Pawan Sirwan Faris; Andre Faro; Farshad Farzadfar; Yousef Fatahi; Wubalem Fekadu; Tomas Y. Ferede; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Garumma Tolu Feyissa; Irina Filip; Florian Fischer; Morenike Oluwatoyin Folayan; Masoud Foroutan; Joel Msafiri Francis; Richard Charles Franklin; Takeshi Fukumoto; Biniyam Sahiledengle Geberemariyam; Abadi Kahsu Gebre; Ketema Bizuwork Gebremedhin; Gebreamlak Gebremedhn Gebremeskel; Berhe Gebremichael; Getnet Azeze Gedefaw; Birhanu Geta; Mansour Ghafourifard; Farhad Ghamari; Ahmad Ghashghaee; Asadollah Gholamian; Tiffany K. Gill; Alessandra C. Goulart; Ayman Grada; Michal Grivna; Mohammed Ibrahim Mohialdeen Gubari; Rafael Alves Guimarães; Yuming Guo; Gaurav Gupta; Juanita A. Haagsma; Nima Hafezi-Nejad; Hassan Haghparast Bidgoli; Brian James Hall; Randah R. Hamadeh; Samer Hamidi; Josep Maria Haro; Md Mehedi Hasan; Amir Hasanzadeh; Soheil Hassanipour; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Khezar Hayat; Delia Hendrie; Fatemeh Heydarpour; Martha Híjar; Hung Chak Ho; Chi Linh Hoang; Michael K. Hole; Ramesh Holla; Naznin Hossain; Mehdi Hosseinzadeh; Sorin Hostiuc; Guoqing Hu; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena Ilic; Milena D. Ilic; Leeberk Raja Inbaraj; Endang Indriasih; Seyed Sina Naghibi Irvani; Sheikh Mohammed Shariful Islam; M. Mofizul Islam; Rebecca Q. Ivers; Kathryn H. Jacobsen; Mohammad Ali Jahani; Nader Jahanmehr; Mihajlo Jakovljevic; Farzad Jalilian; Sudha Jayaraman; Achala Upendra Jayatilleke; Ravi Prakash Jha; Yetunde O. John-Akinola; Jost B. Jonas; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jürisson; Ali Kabir; Rajendra Kadel; Amaha Kahsay; Leila R. Kalankesh; Rohollah Kalhor; Teshome Abegaz Kamil; Tanuj Kanchan; Neeti Kapoor; Manoochehr Karami; Amir Kasaeian; Hagazi Gebremedhin Kassaye; Taras Kavetskyy; Hafte Kahsay Kebede; Peter Njenga Keiyoro; Abraham Getachew Kelbore; Bayew Kelkay; Yousef Saleh Khader; Morteza Abdullatif Khafaie; Nauman Khalid; Ibrahim A. Khalil; Rovshan Khalilov; Mohammad Khammarnia; Ejaz Ahmad Khan; Maseer Khan; Tripti Khanna; Habibolah Khazaie; Fatemeh Khosravi Shadmani; Roba Khundkar; Daniel N. Kiirithio; Young-Eun Kim; Daniel Kim; Yun Jin Kim; Adnan Kisa; Sezer Kisa; Hamidreza Komaki; Shivakumar K.M. Kondlahalli; Vladimir Andreevich Korshunov; Ai Koyanagi; Moritz U.G. Kraemer; Kewal Krishan; Burcu Kucuk Bicer; Nuworza Kugbey; Vivek Kumar; Nithin Kumar; G. Anil Kumar; Manasi Kumar; Girikumar Kumaresh; Om P. Kurmi; Oluwatosin Kuti; Carlo La Vecchia; Faris Hasan Lami; Prabhat Lamichhane; Justin J. Lang; Van C. Lansingh; Dennis Odai Laryea; Savita Lasrado; Arman Latifi; Paolo Lauriola; Janet L. Leasher; Shaun Wen Huey Lee; Tsegaye Lolaso Lenjebo; Miriam Levi; Shanshan Li; Shai Linn; Xuefeng Liu; Alan D. Lopez; Paulo A. Lotufo; Raimundas Lunevicius; Ronan A. Lyons; Mohammed Madadin; Muhammed Magdy Abd El Razek; Narayan Bahadur Mahotra; Marek Majdan; Azeem Majeed; Jeadran N. Malagon-Rojas; Venkatesh Maled; Reza Malekzadeh; Deborah Carvalho Malta; Navid Manafi; Amir Manafi; Ana-Laura Manda; Narayana Manjunatha; Fariborz Mansour-Ghanaei; Borhan Mansouri; Mohammad Ali Mansournia; Joemer C. Maravilla; Lyn M. March; Amanda J. Mason-Jones; Seyedeh Zahra Masoumi; Benjamin Ballard Massenburg; Pallab K. Maulik; Gebrekiros Gebremichael Meles; Addisu Melese; Zeleke Aschalew Melketsedik; Peter T.N. Memiah; Walter Mendoza; Ritesh G. Menezes; Meresa Berwo Mengesha; Melkamu Merid Mengesha; Tuomo J. Meretoja; Atte Meretoja; Hayimro Edemealem Merie; Tomislav Mestrovic; Bartosz Miazgowski; Tomasz Miazgowski; Ted R. Miller; G.K. Mini; Andreea Mirica; Erkin M. Mirrakhimov; Mehdi Mirzaei-Alavijeh; Prasanna Mithra; Babak Moazen; Masoud Moghadaszadeh; Efat Mohamadi; Yousef Mohammad; Karzan Abdulmuhsin Mohammad; Aso Mohammad Darwesh; Naser Mohammad Gholi Mezerji; Abdollah Mohammadian-Hafshejani; Milad Mohammadoo-Khorasani; Reza Mohammadpourhodki; Shafiu Mohammed; Jemal Abdu Mohammed; Farnam Mohebi; Mariam Molokhia; Lorenzo Monasta; Yoshan Moodley; Mahmood Moosazadeh; Masoud Moradi; Ghobad Moradi; Maziar Moradi-Lakeh; Farhad Moradpour; Lidia Morawska; Ilais Moreno Velásquez; Naho Morisaki; Shane Douglas Morrison; Tilahun Belete Mossie; Atalay Goshu Muluneh; Srinivas Murthy; Kamarul Imran Musa; Ghulam Mustafa; Ashraf F. Nabhan; Ahamarshan Jayaraman Nagarajan; Gurudatta Naik; Mukhammad David Naimzada; Farid Najafi; Vinay Nangia; Bruno Ramos Nascimento; Morteza Naserbakht; Vinod Nayak; Duduzile Edith Ndwandwe; Ionut Negoi; Josephine W. Ngunjiri; Cuong Tat Nguyen; Huong Lan Thi Nguyen; Rajan Nikbakhsh; Dina Nur Anggraini Ningrum; Chukwudi A. Nnaji; Peter S. Nyasulu; Felix Akpojene Ogbo; Onome Bright Oghenetega; In-Hwan Oh; Emmanuel Wandera Okunga; Andrew T. Olagunju; Tinuke O. Olagunju; Ahmed Omar Bali; Obinna E. Onwujekwe; Kwaku Oppong Asante; Heather M. Orpana; Erika Ota; Nikita Otstavnov; Stanislav S. Otstavnov; P.A. Mahesh; Jagadish Rao Padubidri; Smita Pakhale; Keyvan Pakshir; Songhomitra Panda-Jonas; Eun-Kee Park; Sangram Kishor Patel; Ashish Pathak; Sanghamitra Pati; George C. Patton; Kebreab Paulos; Amy E. Peden; Veincent Christian Filipino Pepito; Jeevan Pereira; Hai Quang Pham; Michael R. Phillips; Marina Pinheiro; Roman V. Polibin; Suzanne Polinder; Hossein Poustchi; Swayam Prakash; Dimas Ria Angga Pribadi; Parul Puri; Zahiruddin Quazi Syed; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Anwar Rafay; Ata Rafiee; Alireza Rafiei; Fakher Rahim; Siavash Rahimi; Vafa Rahimi-Movaghar; Muhammad Aziz Rahman; Ali Rajabpour-Sanati; Fatemeh Rajati; Ivo Rakovac; Kavitha Ranganathan; Sowmya J. Rao; Vahid Rashedi; Prateek Rastogi; Priya Rathi; Salman Rawaf; Lal Rawal; Reza Rawassizadeh; Vishnu Renjith; Andre M.N. Renzaho; Serge Resnikoff; Aziz Rezapour; Ana Isabel Ribeiro; Jennifer Rickard; Carlos Miguel Rios González; Luca Ronfani; Gholamreza Roshandel; Anas M. Saad; Yogesh Damodar Sabde; Siamak Sabour; Basema Saddik; Saeed Safari; Roya Safari-Faramani; Hamid Safarpour; Mahdi Safdarian; S. Mohammad Sajadi; Payman Salamati; Farkhonde Salehi; Saleh Salehi Zahabi; Marwa R. Rashad Salem; Hosni Salem; Omar Salman; Inbal Salz; Abdallah M. Samy; Juan Sanabria; Lidia Sanchez Riera; Milena M. Santric Milicevic; Abdur Razzaque Sarker; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Susan M. Sawyer; Sonia Saxena; Mehdi Sayyah; David C. Schwebel; Soraya Seedat; Subramanian Senthilkumaran; Sadaf G. Sepanlou; Seyedmojtaba Seyedmousavi; Feng Sha; Faramarz Shaahmadi; Saeed Shahabi; Masood Ali Shaikh; Mehran Shams-Beyranvand; Morteza Shamsizadeh; Mahdi Sharif-Alhoseini; Hamid Sharifi; Aziz Sheikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Soraya Siabani; Inga Dora Sigfusdottir; Pankaj Kumar Singh; Jasvinder A. Singh; Dhirendra Narain Sinha; Catalin-Gabriel Smarandache; Emma U.R. Smith; Amin Soheili; Bija Soleymani; Ali Reza Soltanian; Joan B. Soriano; Muluken Bekele Sorrie; Ireneous N. Soyiri; Dan J. Stein; Mark A. Stokes; Babale Sufiyan Mu'awiyyah; Hafiz Ansar Rasul Suleria; Bryan L. Sykes; Rafael Tabarés-Seisdedos; Karen M. Tabb; Biruk Wogayehu Taddele; Degena Bahrey Tadesse; Animut Tagele Tamiru; Ingan Ukur Tarigan; Yonatal Mesfin Tefera; Arash Tehrani-Banihashemi; Merhawi Gebremedhin Tekle; Gebretsadkan Hintsa Tekulu; Ayenew Kassie Tesema; Berhe Etsay Tesfay; Rekha Thapar; Asres Bedaso Tilahune; Kenean Getaneh Tlaye; Hamid Reza Tohidinik; Roman Topor-Madry; Bach Xuan Tran; Khanh Bao Tran; Jaya Prasad Tripathy; Alexander C. Tsai; Lorainne Tudor Car; Saif Ullah; Irfan Ullah; Maida Umar; Bhaskaran Unnikrishnan; Era Upadhyay; Olalekan A. Uthman; Pascual R. Valdez; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Francesco S. Violante; Vasily Vlassov; Yasir Waheed; Girmay Teklay Weldesamuel; Andrea Werdecker; Taweewat Wiangkham; Haileab Fekadu Wolde; Dawit Habte Woldeyes; Dawit Zewdu Wondafrash; Temesgen Gebeyehu Wondmeneh; Adam Belay Wondmieneh; Ai-Min Wu; Rajaram Yadav; Ali Yadollahpour; Yuichiro Yano; Sanni Yaya; Vahid Yazdi-Feyzabadi; Paul Yip; Engida Yisma; Naohiro Yonemoto; Seok-Jun Yoon; Yoosik Youm; Mustafa Z. Younis; Zabihollah Yousefi; Yong Yu; Chuanhua Yu; Hasan Yusefzadeh; Telma Zahirian Moghadam; Zoubida Zaidi; Sojib Bin Zaman; Mohammad Zamani; Maryam Zamanian; Hamed Zandian; Ahmad Zarei; Fatemeh Zare; Zhi-Jiang Zhang; Yunquan Zhang; Sanjay Zodpey; Lalit Dandona; Rakhi Dandona; Louisa Degenhardt; Samath Dhamminda Dharmaratne; Simon I. Hay; Ali H. Mokdad; Robert C. Reiner; Benn Sartorius; Theo Vos
Background Past research in population health trends has shown that injuries form a substantial burden of population health loss. Regular updates to injury burden assessments are critical. We report Global Burden of Disease (GBD) 2017 Study estimates on morbidity and mortality for all injuries. methods We reviewed results for injuries from the GBD 2017 study. GBD 2017 measured injury-specific mortality and years of life lost (YLLs) using the Cause of Death Ensemble model. To measure non-fatal injuries, GBD 2017 modelled injury-specific incidence and converted this to prevalence and years lived with disability (YLDs). YLLs and YLDs were summed to calculate disability-adjusted life years (DALYs). Findings In 1990, there were 4 260 493 (4 085 700 to 4 396 138) injury deaths, which increased to 4 484 722 (4 332 010 to 4 585 554) deaths in 2017, while age-standardised mortality decreased from 1079 (1073 to 1086) to 738 (730 to 745) per 100 000. In 1990, there were 354 064 302 (95% uncertainty interval: 338 174 876 to 371 610 802) new cases of injury globally, which increased to 520 710 288 (493 430 247 to 547 988 635) new cases in 2017. During this time, age-standardised incidence decreased non-significantly from 6824 (6534 to 7147) to 6763 (6412 to 7118) per 100 000. Between 1990 and 2017, age-standardised DALYs decreased from 4947 (4655 to 5233) per 100 000 to 3267 (3058 to 3505). Interpretation Injuries are an important cause of health loss globally, though mortality has declined between 1990 and 2017. Future research in injury burden should focus on prevention in high-burden populations, improving data collection and ensuring access to medical care. © Author(s) (or their employer(s)) 2020. Re-use permitted under CC BY. Published by BMJ.
Global mortality from dementia: Application of a newmethod and results from the global burden of disease study 2019
(John Wiley and Sons Inc, 2021) Emma Nichols; Foad Abd-Allah; Amir Abdoli; Akine Eshete Abosetugn; Woldu Aberhe Abrha; Ahmed Abualhasan; Eman Abu-Gharbieh; Rufus Olusola Akinyemi; Fares Alahdab; Fahad Mashhour Alanezi; Vahid Alipour; Iman Ansari; Jalal Arabloo; Amir Ashraf-Ganjouei; Abolfazl Avan; Getinet Ayano; Zaheer-Ud-Din Babar; Atif Amin Baig; Maciej Banach; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Bernhard T. Baune; Akshaya Srikanth Bhagavathula; Krittika Bhattacharyya; Ali Bijani; Antonio Biondi; Tsegaye Adane Birhan; Atanu Biswas; Srinivasa Rao Bolla; Archith Boloor; Carol Brayne; Hermann Brenner; Katrin Burkart; Richard A. Burns; Sharath Burugina Nagaraja; Felix Carvalho; Luis F. S. Castro-De-araujo; Ferrán Catalá-López; Ester Cerin; Achille Cernigliaro; Nicolas Cherbuin; Jee-Young Jasmine Choi; Dinh-Toi Chu; Baye Dagnew; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Daniel Diaz; Zahra Sadat Dibaji Forooshani; Abdel Douiri; Bruce B. Duncan; David Edvardsson; Shaimaa I. El-Jaafary; Khalil Eskandari; Sharareh Eskandarieh; Valery L. Feigin; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Pietro Ferrara; Irina Filip; Florian Fischer; Shilpa Gaidhane; Kidane Zereabruk Gebregzabiher; Ahmad Ghashghaee; Asadollah Gholamian; Elena V. Gnedovskaya; Mahaveer Golechha; Rajeev Gupta; Vladimir Hachinski; Samer Hamidi; Graeme J. Hankey; Josep Maria Haro; Amr Hassan; Simon I. Hay; Golnaz Heidari; Reza Heidari-Soureshjani; Mowafa Househ; Rabia Hussain; Bing-Fang Hwang; Irena M. Ilic; Milena D. Ilic; Seyed Sina Naghibi Irvani; Hiroyasu Iso; Masao Iwagami; Ravi Prakash Jha; Rizwan Kalani; Himal Kandel; André Karch; Ayele Semachew Kasa; Andre Pascal Kengne; Young-Eun Kim; Yun Jin Kim; Sezer Kisa; Adnan Kisa; Mika Kivimäki; Hamidreza Komaki; Aikoyanagi; Walter A. Kukull; G. Anil Kumar; Manasi Kumar; Iván Landires; Matilde Leonardi; Stephen S. Lim; Xuefeng Liu; Giancarlo Logroscino; Alan D. Lopez; Stefan Lorkowski; Clement T. Loy; Hawraz Ibrahim M. Amin; Navid Manafi; Narayana Manjunatha; Man Mohan Mehndiratta; Ritesh G. Menezes; Atte Meretoja; Alexander Merkin; Workua Mekonnen Metekiya; Awoke Temesgen Misganaw; Bahram Mohajer; Norlinah Mohamed Ibrahim; Yousef Mohammad; Archisman Mohapatra; Farnam Mohebi; Ali H. Mokdad; Stefania Mondello; Tilahun Belete Mossie; Anwar Mulugeta; Gabriele Nagel; Muhammad Naveed; Vinod C. Nayak; Sandhya Neupane Kandel; Son Hoang Nguyen; Huong Lan Thi Nguyen; Virginia Nuñez-Samudio; Felix Akpojene Ogbo; Andrew T. Olagunju; Hans Orru; Sergej M. Ostojic; Samuel M. Ostroff; Nikita Otstavnov; Stanislav S. Otstavnov; Mayowa O. Owolabi; Mona Pathak; Hamidreza Pazoki Toroudi; Carrie B. Peterson; Hai Quang Pham; Michael R. Phillips; Michael A. Piradov; Faheem Hyder Pottoo; Sergio I. Prada; Dimas Ria Angga Pribadi; Amir Radfar; Alberto Raggi; Fakher Rahim; Pradhum Ram; Juwel Rana; Vahid Rashedi; Salman Rawaf; David Laith Rawaf; Nickolas Reinig; Nima Rezaei; Stephen R Robinson; Michele Romoli; Perminder S. Sachdev; Ramesh Sahathevan; Amirhossein Sahebkar; Mohammad Ali Sahraian; Davide Sattin; Mete Saylan; Mehdi Sayyah; Silvia Schiavolin; Maria Inês Schmidt; Izza Shahid; Masood Ali Shaikh; Mika Shigematsu; Jae Il Shin; Rahman Shiri; Tariq Jamal Siddiqi; João Pedro Silva; Jasvinder A. Singh; Amin Soheili; Emma Elizabeth Spurlock; Cassandra E. I. Szoeke; Rafael Tabarés-Seisdedos; Biruk Wogayehu Taddele; Bhaskar Thakur; Akhil Soman Thekke Purakkal; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Ravensara S. Travillian; Manjari Tripathi; Gebiyaw Wudie Tsegaye; Muhammad Shariq Usman; Marco Vacante; Diana Zuleika Velazquez; Narayanaswamy Venketasubramanian; Simone Vidale; Vasily Vlassov; Yuan-Pang Wang; Jingkai Wei; Jordan Weiss; Abrha Hailay Weldemariam; Anders Wimo; Chenkai Wu; Ali Yadollahpour; Kazumasa Yamagishi; Yordanos Gizachew Yeshitila; Naohiro Yonemoto; Siddhesh Zadey; Zhi-Jiang Zhang; Christopher J. L. Murray; Theo Vos
Introduction: Dementia is currently one of the leading causes of mortality globally, and mortality due to dementia will likely increase in the future along with corresponding increases in population growth and population aging. However, large inconsistencies in coding practices in vital registration systems over time and between countries complicate the estimation of global dementia mortality. Methods: We meta-analyzed the excess risk of death in those with dementia and multiplied these estimates by the proportion of dementia deaths occurring in those with severe, end-stage disease to calculate the total number of deaths that could be attributed to dementia. Results: We estimated that there were 1.62 million (95% uncertainty interval [UI]: 0.41-4.21) deaths globally due to dementia in 2019. More dementia deaths occurred in women (1.06 million [0.27-2.71]) than men (0.56 million [0.14-1.51]), largely but not entirely due to the higher life expectancy in women (age-standardized female-tomale ratio 1.19 [1.10-1.26]). Due to population aging, there was a large increase in allage mortality rates from dementia between 1990 and 2019 (100.1% [89.1-117.5]). In 2019, deaths due to dementia ranked seventh globally in all ages and fourth among individuals 70 and older compared to deaths from other diseases estimated in the Global Burden of Disease (GBD) study. Discussion: Mortality due to dementia represents a substantial global burden, and is expected to continue to grow into the future as an older, aging population expands globally. © 2021 The Authors.
Global, regional, and national age-sex-specific mortality for 282 causes of death in 195 countries and territories, 1980–2017: a systematic analysis for the Global Burden of Disease Study 2017
(Lancet Publishing Group, 2018) Gregory A. Roth; Degu Abate; Kalkidan Hassen Abate; Solomon M. Abay; Cristiana Abbafati; Nooshin Abbasi; Hedayat Abbastabar; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Ibrahim Abdollahpour; Rizwan Suliankatchi Abdulkader; Haftom Temesgen Abebe; Molla Abebe; Zegeye Abebe; Ayenew Negesse Abejie; Semaw F. Abera; Olifan Zewdie Abil; Haftom Niguse Abraha; Aklilu Roba Abrham; Laith Jamal Abu-Raddad; Manfred Mario Kokou Accrombessi; Dilaram Acharya; Abdu A. Adamu; Oladimeji M. Adebayo; Rufus Adesoji Adedoyin; Victor Adekanmbi; Olatunji O. Adetokunboh; Beyene Meressa Adhena; Mina G. Adib; Amha Admasie; Ashkan Afshin; Gina Agarwal; Kareha M. Agesa; Anurag Agrawal; Sutapa Agrawal; Alireza Ahmadi; Mehdi Ahmadi; Muktar Beshir Ahmed; Sayem Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Mohammad Esmaeil Akbari; Rufus Olusola Akinyemi; Nadia Akseer; Ziyad Al-Aly; Ayman Al-Eyadhy; Rajaa M. Al-Raddadi; Fares Alahdab; Khurshid Alam; Tahiya Alam; Animut Alebel; Kefyalew Addis Alene; Mehran Alijanzadeh; Reza Alizadeh-Navaei; Syed Mohamed Aljunid; Ala'a Alkerwi; Francois Alla; Peter Allebeck; Jordi Alonso; Khalid Altirkawi; Nelson Alvis-Guzman; Azmeraw T. Amare; Leopold N. Aminde; Erfan Amini; Walid Ammar; Yaw Ampem Amoako; Nahla Hamed Anber; Catalina Liliana Andrei; Sofia Androudi; Megbaru Debalkie Animut; Mina Anjomshoa; Hossein Ansari; Mustafa Geleto Ansha; Carl Abelardo T. Antonio; Palwasha Anwari; Olatunde Aremu; Johan Arnlov; Amit Arora; Monika Arora; Al Artaman; Krishna K. Aryal; Hamid Asayesh; Ephrem Tsegay Asfaw; Zerihun Ataro; Suleman Atique; Sachin R. Atre; Marcel Ausloos; Euripide F.G.A. Avokpaho; Ashish Awasthi; Beatriz Paulina Ayala Quintanilla; Yohanes Ayele; Rakesh Ayer; Peter S. Azzopardi; Arefeh Babazadeh; Umar Bacha; Hamid Badali; Alaa Badawi; Ayele Geleto Bali; Katherine E. Ballesteros; Maciej Banach; Kajori Banerjee; Marlena S. Bannick; Joseph Adel Mattar Banoub; Miguel A. Barboza; Suzanne Lyn Barker-Collo; Till Winfried Barnighausen; Simon Barquera; Lope H. Barrero; Quique Bassat; Sanjay Basu; Bernhard T. Baune; Habtamu Wondifraw Baynes; Shahrzad Bazargan-Hejazi; Neeraj Bedi; Ettore Beghi; Masoud Behzadifar; Meysam Behzadifar; Yannick Bejot; Bayu Begashaw Bekele; Abate Bekele Belachew; Ezra Belay; Yihalem Abebe Belay; Michelle L. Bell; Aminu K. Bello; Derrick A. Bennett; Isabela M. Bensenor; Adam E. Berman; Eduardo Bernabe; Robert S. Bernstein; Gregory J. Bertolacci; Mircea Beuran; Tina Beyranvand; Ashish Bhalla; Suraj Bhattarai; Soumyadeeep Bhaumik; Zulfiqar A. Bhutta; Belete Biadgo; Molly H. Biehl; Ali Bijani; Boris Bikbov; Ver Bilano; Nigus Bililign; Muhammad Shahdaat Bin Sayeed; Donal Bisanzio; Tuhin Biswas; Brigette F. Blacker; Berrak Bora Basara; Rohan Borschmann; Cristina Bosetti; Kayvan Bozorgmehr; Oliver J. Brady; Luisa C. Brant; Carol Brayne; Alexandra Brazinova; Nicholas J.K. Breitborde; Hermann Brenner; Paul Svitil Briant; Gabrielle Britton; Traolach Brugha; Reinhard Busse; Zahid A. Butt; Charlton S.K.H. Callender; Ismael R. Campos-Nonato; Julio Cesar Campuzano Rincon; Jorge Cano; Mate Car; Rosario Cardenas; Giulia Carreras; Juan J. Carrero; Austin Carter; Felix Carvalho; Carlos A. Castaneda-Orjuela; Jacqueline Castillo Rivas; Chris D. Castle; Clara Castro; Franz Castro; Ferran Catala-Lopez; Ester Cerin; Yazan Chaiah; Jung-Chen Chang; Fiona J. Charlson; Pankaj Chaturvedi; Peggy Pei-Chia Chiang; Odgerel Chimed-Ochir; Vesper Hichilombwe Chisumpa; Abdulaal Chitheer; Rajiv Chowdhury; Hanne Christensen; Devasahayam J. Christopher; Sheng-Chia Chung; Flavia M. Cicuttini; Liliana G. Ciobanu; Massimo Cirillo; Aaron J. Cohen; Leslie Trumbull Cooper; Paolo Angelo Cortesi; Monica Cortinovis; Ewerton Cousin; Benjamin C. Cowie; Michael H. Criqui; Elizabeth A. Cromwell; Christopher Stephen Crowe; John A. Crump; Matthew Cunningham; Alemneh Kabeta Daba; Abel Fekadu Dadi; Lalit Dandona; Rakhi Dandona; Anh Kim Dang; Paul I. Dargan; Ahmad Daryani; Siddharth K. Das; Rajat Das Gupta; Jose Das Neves; Tamirat Tesfaye Dasa; Aditya Prasad Dash; Adrian C. Davis; Nicole Davis Weaver; Dragos Virgil Davitoiu; Kairat Davletov; Fernando Pio De La Hoz; Jan-Walter De Neve; Meaza Girma Degefa; Louisa Degenhardt; Tizta T. Degfie; Selina Deiparine; Gebre Teklemariam Demoz; Balem Betsu Demtsu; Edgar Denova-Gutierrez; Kebede Deribe; Nikolaos Dervenis; Don C. Des Jarlais; Getenet Ayalew Dessie; Subhojit Dey; Samath D. Dharmaratne; Daniel Dicker; Mesfin Tadese Dinberu; Eric L. Ding; M. Ashworth Dirac; Shirin Djalalinia; Klara Dokova; David Teye Doku; Christl A. Donnelly; E. Ray Dorsey; Pratik P. Doshi; Dirk Douwes-Schultz; Kerrie E. Doyle; Tim R. Driscoll; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Bruce B. Duncan; Andre R. Duraes; Hedyeh Ebrahimi; Soheil Ebrahimpour; Dumessa Edessa; David Edvardsson; Anne Elise Eggen; Charbel El Bcheraoui; Maysaa El Sayed Zaki; Ziad El-Khatib; Hajer Elkout; Christian Lycke Ellingsen; Matthias Endres; Aman Yesuf Endries; Benjamin Er; Holly E. Erskine; Babak Eshrati; Sharareh Eskandarieh; Reza Esmaeili; Alireza Esteghamati; Mahdi Fakhar; Hamed Fakhim; Mahbobeh Faramarzi; Mohammad Fareed; Farzaneh Farhadi; Carla Sofia Esá Farinha; Andre Faro; Maryam S. Farvid; Farshad Farzadfar; Mohammad Hosein Farzaei; Valery L. Feigin; Andrea B. Feigl; Netsanet Fentahun; Seyed-Mohammad Fereshtehnejad; Eduarda Fernandes; Joao C. Fernandes; Alize J. Ferrari; Garumma Tolu Feyissa; Irina Filip; Samuel Finegold; Florian Fischer; Christina Fitzmaurice; Nataliya A. Foigt; Kyle J. Foreman; Carla Fornari; Tahvi D. Frank; Takeshi Fukumoto; John E. Fuller; Nancy Fullman; Thomas Furst; Joao M. Furtado; Neal D. Futran; Silvano Gallus; Alberto L. Garcia-Basteiro; Miguel A. Garcia-Gordillo; William M. Gardner; Abadi Kahsu Gebre; Tsegaye Tewelde Gebrehiwot; Amanuel Tesfay Gebremedhin; Bereket Gebremichael; Teklu Gebrehiwo Gebremichael; Tilayie Feto Gelano; Johanna M. Geleijnse; Ricard Genova-Maleras; Yilma Chisha Dea Geramo; Peter W. Gething; Kebede Embaye Gezae; Mohammad Rasoul Ghadami; Reza Ghadimi; Khalil Ghasemi Falavarjani; Maryam Ghasemi-Kasman; Mamata Ghimire; Katherine B. Gibney; Paramjit Singh Gill; Tiffany K. Gill; Richard F. Gillum; Ibrahim Abdelmageed Ginawi; Maurice Giroud; Giorgia Giussani; Shifalika Goenka; Ellen M. Goldberg; Srinivas Goli; Hector Gomez-Dantes; Philimon N. Gona; Sameer Vali Gopalani; Taren M. Gorman; Atsushi Goto; Alessandra C. Goulart; Elena V. Gnedovskaya; Ayman Grada; Giuseppe Grosso; Harish Chander Gugnani; Andre Luiz Sena Guimaraes; Yuming Guo; Prakash C. Gupta; Rahul Gupta; Rajeev Gupta; Tanush Gupta; Reyna Alma Gutierrez; Bishal Gyawali; Juanita A. Haagsma; Nima Hafezi-Nejad; Tekleberhan B. Hagos; Tewodros Tesfa Hailegiyorgis; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Arya Haj-Mirzaian; Randah R. Hamadeh; Samer Hamidi; Alexis J. Handal; Graeme J. Hankey; Hilda L. Harb; Sivadasanpillai Harikrishnan; Josep Maria Haro; Mehedi Hasan; Hadi Hassankhani; Hamid Yimam Hassen; Rasmus Havmoeller; Roderick J. Hay; Simon I. Hay; Yihua He; Akbar Hedayatizadeh-Omran; Mohamed I. Hegazy; Behzad Heibati; Mohsen Heidari; Delia Hendrie; Andualem Henok; Nathaniel J. Henry; Claudiu Herteliu; Fatemeh Heydarpour; Pouria Heydarpour; Sousan Heydarpour; Desalegn Tsegaw Hibstu; Hans W. Hoek; Michael K. Hole; Enayatollah Homaie Rad; Praveen Hoogar; H. Dean Hosgood; Seyed Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Peter J. Hotez; Damian G. Hoy; Thomas Hsiao; Guoqing Hu; John J. Huang; Abdullatif Husseini; Mohammedaman Mama Hussen; Susan Hutfless; Bulat Idrisov; Olayinka Stephen Ilesanmi; Usman Iqbal; Seyed Sina Naghibi Irvani; Caleb Mackay Salpeter Irvine; Nazrul Islam; Sheikh Mohammed Shariful Islam; Farhad Islami; Kathryn H. Jacobsen; Leila Jahangiry; Nader Jahanmehr; Sudhir Kumar Jain; Mihajlo Jakovljevic; Moti Tolera Jalu; Spencer L. James; Mehdi Javanbakht; Achala Upendra Jayatilleke; Panniyammakal Jeemon; Kathy J. Jenkins; Ravi Prakash Jha; Vivekanand Jha; Catherine O. Johnson; Sarah C. Johnson; Jost B. Jonas; Ankur Joshi; Jacek Jerzy Jozwiak; Suresh Banayya Jungari; Mikk Jurisson; Zubair Kabir; Rajendra Kadel; Amaha Kahsay; Rizwan Kalani; Manoochehr Karami; Behzad Karami Matin; Andre Karch; Corine Karema; Hamidreza Karimi-Sari; Amir Kasaeian; Dessalegn H. Kassa; Getachew Mullu Kassa; Tesfaye Dessale Kassa; Nicholas J. Kassebaum; Srinivasa Vittal Katikireddi; Anil Kaul; Zhila Kazemi; Ali Kazemi Karyani; Dhruv Satish Kazi; Adane Teshome Kefale; Peter Njenga Keiyoro; Grant Rodgers Kemp; Andre Pascal Kengne; Andre Keren; Chandrasekharan Nair Kesavachandran; Yousef Saleh Khader; Behzad Khafaei; Morteza Abdullatif Khafaie; Alireza Khajavi; Nauman Khalid; Ibrahim A. Khalil; Ejaz Ahmad Khan; Muhammad Shahzeb Khan; Muhammad Ali Khan; Young-Ho Khang; Mona M. Khater; Abdullah T. Khoja; Ardeshir Khosravi; Mohammad Hossein Khosravi; Jagdish Khubchandani; Aliasghar A. Kiadaliri; Getiye D. Kibret; Zelalem Teklemariam Kidanemariam; Daniel N. Kiirithio; Daniel Kim; Young-Eun Kim; Yun Jin Kim; Ruth W. Kimokoti; Yohannes Kinfu; Adnan Kisa; Katarzyna Kissimova-Skarbek; Mika Kivimaki; Ann Kristin Skrindo Knudsen; Jonathan M. Kocarnik; Sonali Kochhar; Yoshihiro Kokubo; Tufa Kolola; Jacek A. Kopec; Parvaiz A. Koul; Ai Koyanagi; Michael A. Kravchenko; Kewal Krishan; Barthelemy Kuate Defo; Burcu Kucuk Bicer; G. Anil Kumar; Manasi Kumar; Pushpendra Kumar; Michael J. Kutz; Igor Kuzin; Hmwe Hmwe Kyu; Deepesh P. Lad; Sheetal D. Lad; Alessandra Lafranconi; Dharmesh Kumar Lal; Ratilal Lalloo; Tea Lallukka; Jennifer O. Lam; Faris Hasan Lami; Van C. Lansingh; Sonia Lansky; Heidi J. Larson; Arman Latifi; Kathryn Mei-Ming Lau; Jeffrey V. Lazarus; Georgy Lebedev; Paul H. Lee; James Leigh; Mostafa Leili; Cheru Tesema Leshargie; Shanshan Li; Yichong Li; Juan Liang; Lee-Ling Lim; Stephen S. Lim; Miteku Andualem Limenih; Shai Linn; Shiwei Liu; Yang Liu; Rakesh Lodha; Chris Lonsdale; Alan D. Lopez; Stefan Lorkowski; Paulo A. Lotufo; Rafael Lozano; Raimundas Lunevicius; Stefan Ma; Erlyn Rachelle King Macarayan; Mark T. Mackay; Jennifer H. MacLachlan; Emilie R. Maddison; Fabiana Madotto; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Dhaval P. Maghavani; Marek Majdan; Reza Majdzadeh; Azeem Majeed; Reza Malekzadeh; Deborah Carvalho Malta; Ana-Laura Manda; Luiz Garcia Mandarano-Filho; Helena Manguerra; Mohammad Ali Mansournia; Chabila Christopher Mapoma; Dadi Marami; Joemer C. Maravilla; Wagner Marcenes; Laurie Marczak; Ashley Marks; Guy B. Marks; Gabriel Martinez; Francisco Rogerlandio Martins-Melo; Ira Martopullo; Winfried Marz; Melvin B. Marzan; Joseph R. Masci; Benjamin Ballard Massenburg; Manu Raj Mathur; Prashant Mathur; Richard Matzopoulos; Pallab K. Maulik; Mohsen Mazidi; Colm McAlinden; John J. McGrath; Martin McKee; Brian J. McMahon; Suresh Mehata; Man Mohan Mehndiratta; Ravi Mehrotra; Kala M. Mehta; Varshil Mehta; Tefera C. Mekonnen; Addisu Melese; Mulugeta Melku; Peter T.N. Memiah; Ziad A. Memish; Walter Mendoza; Desalegn Tadese Mengistu; Getnet Mengistu; George A. Mensah; Seid Tiku Mereta; Atte Meretoja; Tuomo J. Meretoja; Tomislav Mestrovic; Haftay Berhane Mezgebe; Bartosz Miazgowski; Tomasz Miazgowski; Anoushka I. Millear; Ted R. Miller; Molly Katherine Miller-Petrie; G.K. Mini; Parvaneh Mirabi; Mojde Mirarefin; Andreea Mirica; Erkin M. Mirrakhimov; Awoke Temesgen Misganaw; Habtamu Mitiku; Babak Moazen; Karzan Abdulmuhsin Mohammad; Moslem Mohammadi; Noushin Mohammadifard; Mohammed A. Mohammed; Shafiu Mohammed; Viswanathan Mohan; Ali H. Mokdad; Mariam Molokhia; Lorenzo Monasta; Ghobad Moradi; Maziar Moradi-Lakeh; Mehdi Moradinazar; Paula Moraga; Lidia Morawska; Ilais Moreno Velasquez; Joana Morgado-Da-Costa; Shane Douglas Morrison; Marilita M. Moschos; Simin Mouodi; Seyyed Meysam Mousavi; Kindie Fentahun Muchie; Ulrich Otto Mueller; Satinath Mukhopadhyay; Kate Muller; John Everett Mumford; Jonah Musa; Kamarul Imran Musa; Ghulam Mustafa; Saravanan Muthupandian; Jean B. 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Ong; Sok King Sk Ong; Eyal Oren; Heather M. Orpana; Alberto Ortiz; Justin R. Ortiz; Stanislav S. Otstavnov; Simon Overland; Mayowa Ojo Owolabi; Raziye Ozdemir; P.A. Mahesh; Rosana Pacella; Smita Pakhale; Abhijit P. Pakhare; Amir H. Pakpour; Adrian Pana; Songhomitra Panda-Jonas; Jeyaraj Durai Pandian; Andrea Parisi; Eun-Kee Park; Charles D.H. Parry; Hadi Parsian; Shanti Patel; Sanghamitra Pati; George C. Patton; Vishnupriya Rao Paturi; Katherine R. Paulson; Alexandre Pereira; David M. Pereira; Norberto Perico; Konrad Pesudovs; Max Petzold; Michael R. Phillips; Frederic B. Piel; David M. Pigott; Julian David Pillay; Meghdad Pirsaheb; Farhad Pishgar; Suzanne Polinder; Maarten J. Postma; Akram Pourshams; Hossein Poustchi; Ashwini Pujar; Swayam Prakash; Narayan Prasad; Caroline A. Purcell; Mostafa Qorbani; Hedley Quintana; D.Alex Quistberg; Kirankumar Waman Rade; Amir Radfar Anwar Rafay; Fakher Rahim; Kazem Rahimi; Afarin Rahimi-Movaghar; Mahfuzar Rahman; Mohammad Hifz Ur Rahman; Muhammad Aziz Rahman; Rajesh Kumar Rai; Sasa Rajsic; Usha Ram; Chhabi Lal Ranabhat; Prabhat Ranjan; Puja C. Rao; David Laith Rawaf; Salman Rawaf; Christian Razo-Garcia; K. Srinath Reddy; Robert C. Reiner; Marissa B. Reitsma; Giuseppe Remuzzi; Andre M.N. Renzaho; Serge Resnikoff; Satar Rezaei; Shahab Rezaeian; Mohammad Sadegh Rezai; Seyed Mohammad Riahi; Antonio Luiz P. Ribeiro; Maria Jesus Rios-Blancas; Kedir Teji Roba; Nicholas L.S. Roberts; Stephen R. Robinson; Leonardo Roever; Luca Ronfani; Gholamreza Roshandel; Ali Rostami; Dietrich Rothenbacher; Ambuj Roy; Enrico Rubagotti; Perminder S. Sachdev; Basema Saddik; Ehsan Sadeghi; Hosein Safari; Mahdi Safdarian; Sare Safi; Saeid Safiri; Rajesh Sagar; Amirhossein Sahebkar; Mohammad Ali Sahraian; Nasir Salam; Joseph S. 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Stokes; Michelle L. Subart; Agus Sudaryanto; Mu'Awiyyah Babale Sufiyan; Patrick John Sur; Ipsita Sutradhar; Bryan L. Sykes; P.N. Sylaja; Dillon O. Sylte; Cassandra E.I. Szoeke; Rafael Tabares-Seisdedos; Takahiro Tabuchi; Santosh Kumar Tadakamadla; Ken Takahashi; Nikhil Tandon; Segen Gebremeskel Tassew; Nuno Taveira; Arash Tehrani-Banihashemi; Tigist Gashaw Tekalign; Merhawi Gebremedhin Tekle; Mohamad-Hani Temsah; Omar Temsah; Abdullah Sulieman Terkawi; Manaye Yihune Teshale; Belay Tessema; Gizachew Assefa Tessema; Kavumpurathu Raman Thankappan; Sathish Thirunavukkarasu; Nihal Thomas; Amanda G. Thrift; George D. Thurston; Binyam Tilahun; Quyen G. To; Ruoyan Tobe-Gai; Marcello Tonelli; Roman Topor-Madry; Anna E. Torre; Miguel Tortajada-Girbes; Mathilde Touvier; Marcos Roberto Tovani-Palone; Bach Xuan Tran; Khanh Bao Tran; Suryakant Tripathi; Christopher E. Troeger; Thomas Clement Truelsen; Nu Thi Truong; Afewerki Gebremeskel Tsadik; Derrick Tsoi; Lorainne Tudor Car; E. Murat Tuzcu; Stefanos Tyrovolas; Kingsley N. Ukwaja; Irfan Ullah; Eduardo A. Undurraga; Rachel L. Updike; Muhammad Shariq Usman; Olalekan A. Uthman; Selen Begum Uzun; Muthiah Vaduganathan; Afsane Vaezi; Gaurang Vaidya; Pascual R. Valdez; Elena Varavikova; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Santos Villafaina; Francesco S. Violante; Sergey Konstantinovitch Vladimirov; Vasily Vlassov; Stein Emil Vollset; Theo Vos; Gregory R. Wagner; Fasil Shiferaw Wagnew; Yasir Waheed; Mitchell Taylor Wallin; Judd L. Walson; Yanping Wang; Yuan-Pang Wang; Molla Mesele Wassie; Elisabete Weiderpass; Robert G. Weintraub; Fitsum Weldegebreal; Kidu Gidey Weldegwergs; Andrea Werdecker; Adhena Ayaliew Werkneh; T. Eoin West; Ronny Westerman; Harvey A. Whiteford; Justyna Widecka
Background: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use of newly available data and improved methods. GBD 2017 provides a comprehensive assessment of cause-specific mortality for 282 causes in 195 countries and territories from 1980 to 2017. Methods: The causes of death database is composed of vital registration (VR), verbal autopsy (VA), registry, survey, police, and surveillance data. GBD 2017 added ten VA studies, 127 country-years of VR data, 502 cancer-registry country-years, and an additional surveillance country-year. Expansions of the GBD cause of death hierarchy resulted in 18 additional causes estimated for GBD 2017. Newly available data led to subnational estimates for five additional countries—Ethiopia, Iran, New Zealand, Norway, and Russia. Deaths assigned International Classification of Diseases (ICD) codes for non-specific, implausible, or intermediate causes of death were reassigned to underlying causes by redistribution algorithms that were incorporated into uncertainty estimation. We used statistical modelling tools developed for GBD, including the Cause of Death Ensemble model (CODEm), to generate cause fractions and cause-specific death rates for each location, year, age, and sex. Instead of using UN estimates as in previous versions, GBD 2017 independently estimated population size and fertility rate for all locations. Years of life lost (YLLs) were then calculated as the sum of each death multiplied by the standard life expectancy at each age. All rates reported here are age-standardised. Findings: At the broadest grouping of causes of death (Level 1), non-communicable diseases (NCDs) comprised the greatest fraction of deaths, contributing to 73·4% (95% uncertainty interval [UI] 72·5–74·1) of total deaths in 2017, while communicable, maternal, neonatal, and nutritional (CMNN) causes accounted for 18·6% (17·9–19·6), and injuries 8·0% (7·7–8·2). Total numbers of deaths from NCD causes increased from 2007 to 2017 by 22·7% (21·5–23·9), representing an additional 7·61 million (7·20–8·01) deaths estimated in 2017 versus 2007. The death rate from NCDs decreased globally by 7·9% (7·0–8·8). The number of deaths for CMNN causes decreased by 22·2% (20·0–24·0) and the death rate by 31·8% (30·1–33·3). Total deaths from injuries increased by 2·3% (0·5–4·0) between 2007 and 2017, and the death rate from injuries decreased by 13·7% (12·2–15·1) to 57·9 deaths (55·9–59·2) per 100 000 in 2017. Deaths from substance use disorders also increased, rising from 284 000 deaths (268 000–289 000) globally in 2007 to 352 000 (334 000–363 000) in 2017. Between 2007 and 2017, total deaths from conflict and terrorism increased by 118·0% (88·8–148·6). A greater reduction in total deaths and death rates was observed for some CMNN causes among children younger than 5 years than for older adults, such as a 36·4% (32·2–40·6) reduction in deaths from lower respiratory infections for children younger than 5 years compared with a 33·6% (31·2–36·1) increase in adults older than 70 years. Globally, the number of deaths was greater for men than for women at most ages in 2017, except at ages older than 85 years. Trends in global YLLs reflect an epidemiological transition, with decreases in total YLLs from enteric infections, respiratory infections and tuberculosis, and maternal and neonatal disorders between 1990 and 2017; these were generally greater in magnitude at the lowest levels of the Socio-demographic Index (SDI). At the same time, there were large increases in YLLs from neoplasms and cardiovascular diseases. YLL rates decreased across the five leading Level 2 causes in all SDI quintiles. The leading causes of YLLs in 1990—neonatal disorders, lower respiratory infections, and diarrhoeal diseases—were ranked second, fourth, and fifth, in 2017. Meanwhile, estimated YLLs increased for ischaemic heart disease (ranked first in 2017) and stroke (ranked third), even though YLL rates decreased. Population growth contributed to increased total deaths across the 20 leading Level 2 causes of mortality between 2007 and 2017. Decreases in the cause-specific mortality rate reduced the effect of population growth for all but three causes: substance use disorders, neurological disorders, and skin and subcutaneous diseases. Interpretation: Improvements in global health have been unevenly distributed among populations. Deaths due to injuries, substance use disorders, armed conflict and terrorism, neoplasms, and cardiovascular disease are expanding threats to global health. For causes of death such as lower respiratory and enteric infections, more rapid progress occurred for children than for the oldest adults, and there is continuing disparity in mortality rates by sex across age groups. Reductions in the death rate of some common diseases are themselves slowing or have ceased, primarily for NCDs, and the death rate for selected causes has increased in the past decade. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national age-specific progress towards the 2020 milestones of the WHO End TB Strategy: a systematic analysis for the Global Burden of Disease Study 2021
(Elsevier Ltd, 2024) Jorge R. Ledesma; Jianing Ma; Meixin Zhang; Ann V. L. Basting; Huong Thi Chu; Avina Vongpradith; Amanda Novotney; Kate E. LeGrand; Yvonne Yiru Xu; Xiaochen Dai; Sneha Ingle Nicholson; Lauryn K. Stafford; Austin Carter; Jennifer M. Ross; Hedayat Abbastabar; Meriem Abdoun; Deldar Morad Abdulah; Richard Gyan Aboagye; Hassan Abolhassani; Woldu Aberhe Abrha; Hiwa Abubaker Ali; Eman Abu-Gharbieh; Salahdein Aburuz; Isaac Yeboah Addo; Abiola Victor Adepoju; Kishor Adhikari; Qorinah Estiningtyas Sakilah Adnani; Saryia Adra; Abel Afework; Shahin Aghamiri; Williams Agyemang-Duah; Bright Opoku Ahinkorah; Danish Ahmad; Sajjad Ahmad; Amir Mahmoud Ahmadzade; Haroon Ahmed; Mohammed Ahmed; Ayman Ahmed; Karolina Akinosoglou; Tareq Mohammed Ali Al-Ahdal; Nazmul Alam; Mohammed Albashtawy; Mohammad T. AlBataineh; Adel Ali Saeed Al-Gheethi; Abid Ali; Endale Alemayehu Ali; Liaqat Ali; Zahid Ali; Syed Shujait Shujait Ali; Kasim Allel; Awais Altaf; Jaffar A. Al-Tawfiq; Nelson Alvis-Guzman; Nelson J. Alvis-Zakzuk; Reza Amani; Ganiyu Adeniyi Amusa; Jimoh Amzat; Jason R. Andrews; Abhishek Anil; Razique Anwer; Aleksandr Y. Aravkin; Damelash Areda; Anton A. Artamonov; Raphael Taiwo Aruleba; Mulusew A. Asemahagn; Sachin R. Atre; Avinash Aujayeb; Davood Azadi; Sina Azadnajafabad; Ahmed Y. Azzam; Muhammad Badar; Ashish D. Badiye; Sara Bagherieh; Saeed Bahadorikhalili; Atif Amin Baig; Maciej Banach; Biswajit Banik; Mainak Bardhan; Hiba Jawdat Barqawi; Zarrin Basharat; Pritish Baskaran; Saurav Basu; Maryam Beiranvand; Melaku Ashagrie Belete; Makda Abate Belew; Uzma Iqbal Belgaumi; Apostolos Beloukas; Paulo J. G. Bettencourt; Akshaya Srikanth Bhagavathula; Nikha Bhardwaj; Pankaj Bhardwaj; Ashish Bhargava; Vivek Bhat; Jasvinder Singh Bhatti; Gurjit Kaur Bhatti; Boris Bikbov; Veera R. Bitra; Vesna Bjegovic-Mikanovic; Danilo Buonsenso; Katrin Burkart; Yasser Bustanji; Zahid A. Butt; Paulo Camargos; Yu Cao; Sinclair Carr; Felix Carvalho; Luca Cegolon; Muthia Cenderadewi; Muge Cevik; Yaacoub Chahine; Vijay Kumar Chattu; Patrick R. Ching; Hitesh Chopra; Eunice Chung; Mareli M. Claassens; Kaleb Coberly; Natália Cruz-Martins; Bashir Dabo; Sriharsha Dadana; Omid Dadras; Isaac Darban; Jiregna Darega Gela; Aso Mohammad Darwesh; Mahmood Dashti; Berecha Hundessa Demessa; Biniyam Demisse; Solomon Demissie; Awoke Masrie Asrat Derese; Kebede Deribe; Hardik Dineshbhai Desai; Vinoth Gnana Chellaiyan Devanbu; Arkadeep Dhali; Kuldeep Dhama; Sameer Dhingra; Thao Huynh Phuong Do; Deepa Dongarwar; Haneil Larson Dsouza; John Dube; Arkadiusz Marian Dziedzic; Abdelaziz Ed-Dra; Ferry Efendi; Diyan Ermawan Effendi; Aziz Eftekharimehrabad; Nopryan Ekadinata; Temitope Cyrus Ekundayo; Muhammed Elhadi; Legesse Tesfaye Elilo; Theophilus I. Emeto; Luchuo Engelbert Bain; Adeniyi Francis Fagbamigbe; Ayesha Fahim; Alireza Feizkhah; Getahun Fetensa; Florian Fischer; Abduzhappar Gaipov; Aravind P. Gandhi; Rupesh K. Gautam; Miglas W. Gebregergis; Mesfin Gebrehiwot; Kahsu Gebrekirstos Gebrekidan; Kazem Ghaffari; Fariba Ghassemi; Ramy Mohamed Ghazy; Amador Goodridge; Anmol Goyal; Shi-Yang Guan; Mesay Dechasa Gudeta; Rashid Abdi Guled; Novianti Br Gultom; Veer Bala Gupta; Vivek Kumar Gupta; Sapna Gupta; Hailey Hagins; Semira Goitom Hailu; Wase Benti Hailu; Samer Hamidi; Asif Hanif; Harapan Harapan; Rumina Syeda Hasan; Shoaib Hassan; Johannes Haubold; Kamal Hezam; Sung Hwi Hong; Nobuyuki Horita; Md Belal Hossain; Mehdi Hosseinzadeh; Mihaela Hostiuc; Sorin Hostiuc; Hong-Han Huynh; Segun Emmanuel Ibitoye; Kevin S. Ikuta; Irena M. Ilic; Milena D. Ilic; Md Rabiul Islam; Nahlah Elkudssiah Ismail; Faisal Ismail; Abdollah Jafarzadeh; Mihajlo Jakovljevic; Mahsa Jalili; Manthan Dilipkumar Janodia; Nabi Jomehzadeh; Jost B. Jonas; Nitin Joseph; Charity Ehimwenma Joshua; Zubair Kabir; Bhushan Dattatray Kamble; Tanuj Kanchan; Himal Kandel; Kehinde Kazeem Kanmodi; Rami S. Kantar; Ibraheem M. Karaye; Arman Karimi Behnagh; Gebrehiwot G. Kassa; Rimple Jeet Kaur; Navjot Kaur; Himanshu Khajuria; Faham Khamesipour; Yusra H. Khan; M. Nuruzzaman Khan; Mahammed Ziauddin Khan Suheb; Khaled Khatab; Fatemeh Khatami; Min Seo Kim; Soewarta Kosen; Parvaiz A. Koul; Sindhura Lakshmi Koulmane Laxminarayana; Kewal Krishan; Burcu Kucuk Bicer; Md Abdul Kuddus; Mukhtar Kulimbet; Nithin Kumar; Dharmesh Kumar Lal; Iván Landires; Kamaluddin Latief; Trang Diep Thanh Le; Thao Thi Thu Le; Caterina Ledda; Munjae Lee; Seung Won Lee; Temesgen L. Lerango; Stephen S. Lim; Chaojie Liu; Xuefeng Liu; Platon D. Lopukhov; Hong Luo; Hengliang Lv; Preetam Bhalchandra Mahajan; Amir Ali Mahboobipour; Azeem Majeed; Elaheh Malakan Rad; Kashish Malhotra; Muhammad Sajeel Ahmed Malik; Lesibana Anthony Malinga; Tauqeer Hussain Mallhi; Aseer Manilal; Bernardo Alfonso Martinez-Guerra; Francisco Rogerlândio Martins-Melo; Roy Rillera Marzo; Hossein Masoumi-Asl; Vasundhara Mathur; Richard James Maude; Ravi Mehrotra; Ziad A. Memish; Walter Mendoza; Ritesh G. Menezes; Muayad Aghali Merza; Tomislav Mestrovic; Laurette Mhlanga; Sanjeev Misra; Arup Kumar Misra; Prasanna Mithra; Babak Moazen; Hussen Mohammed; Ali H. Mokdad; Lorenzo Monasta; Catrin E. Moore; Parsa Mousavi; Francesk Mulita; Fungai Musaigwa; Raman Muthusamy; Ahamarshan Jayaraman Nagarajan; Pirouz Naghavi; Ganesh R. Naik; Gurudatta Naik; Sanjeev Nair; Tapas Sadasivan Nair; Zuhair S. Natto; Biswa Prakash Nayak; Hadush Negash; Dang H. Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Chukwudi A. Nnaji; Lawrence Achilles Nnyanzi; Efaq Ali Noman; Shuhei Nomura; Bogdan Oancea; Kehinde O. Obamiro; Ismail A. Odetokun; Daniel Bogale Odo Odo; Oluwakemi Ololade Odukoya; In-Hwan Oh; Chukwuma O. Okereke; Osaretin Christabel Okonji; Eyal Oren; Edgar Ortiz-Brizuela; Uchechukwu Levi Osuagwu; Amel Ouyahia; P.A. Mahesh Padukudru; Pragyan Paramita Parija; Romil R. Parikh; Seoyeon Park; Ashwaghosha Parthasarathi; Shankargouda Patil; Shrikant Pawar; Minjin Peng; Veincent Christian Filipino Pepito; Prince Peprah; João Perdigão; Norberto Perico; Hoang Tran Pham; Maarten J. Postma; Attur Ravindra Attur Prabhu; Manya Prasad; Akila Prashant; Elton Junio Sady Prates; Fakher Rahim; Mosiur Rahman; Muhammad Aziz Rahman; Masoud Rahmati; Sathish Rajaa; Shakthi Kumaran Ramasamy; Indu Ramachandra Rao; Sowmya J. Rao; Deepthi Rapaka; Ahmed Mustafa Rashid; Zubair Ahmed Ratan; Nakul Ravikumar; Salman Rawaf; Murali Mohan Rama Krishna Reddy; Elrashdy Moustafa Mohamed Redwan; Giuseppe Remuzzi; Luis Felipe Reyes; Nazila Rezaei; Mohsen Rezaeian; Omid Rezahosseini; Mónica Rodrigues; Priyanka Roy; Guilherme de Andrade Ruela; Siamak Sabour; Basema Saddik; Umar Saeed; Sher Zaman Safi; Narjes Saheb Sharif-Askari; Fatemeh Saheb Sharif-Askari; Amirhossein Sahebkar; Biniyam Sahiledengle; Soumya Swaroop Sahoo; Nasir Salam; Afeez Abolarinwa Salami; Samreen Saleem; Mohamed A. Saleh; Hossein Samadi Kafil; Sara Samadzadeh; Yoseph Leonardo Samodra; Rama Krishna Sanjeev; Aswini Saravanan; Susan M. Sawyer; Siddharthan Selvaraj; Sabyasachi Senapati; Subramanian Senthilkumaran; Pritik A. Shah; Samiah Shahid; Masood Ali Shaikh; Sunder Sham; Mohammad Ali Shamshirgaran; Mohd Shanawaz; Medha Sharath; Samendra P. Sherchan; Ranjitha S. Shetty; Hesamaddin Shirzad-Aski; Aminu Shittu; Emmanuel Edwar Siddig; João Pedro Silva; Surjit Singh; Paramdeep Singh; Harpreet Singh; Jasvinder A. Singh; Md Shahjahan Siraj; Siswanto Siswanto; Ranjan Solanki; Yonatan Solomon; Joan B. Soriano; Chandrashekhar T. Sreeramareddy; Vijay Kumar Srivastava; Paschalis Steiropoulos; Chandan Kumar Swain; Takahiro Tabuchi; Mircea Tampa; Jacques J. L. Lukenze Tamuzi; Nathan Y. Tat; Razieh Tavakoli Oliaee; Gebrehiwot Teklay; Edosa Geta Tesfaye; Belay Tessema; Pugazhenthan Thangaraju; Rekha Thapar; Chern Choong Chern Thum; Jansje Henny Vera Ticoalu; Imad M. Tleyjeh; Ruoyan Tobe-Gai; Temesgen Mohammed Toma; Khai Hoan Tram; Aniefiok John Udoakang; Tungki Pratama Umar; Chukwuma David Umeokonkwo; Seyed Mohammad Vahabi; Asokan Govindaraj Vaithinathan; Job F. M. van Boven; Shoban Babu Varthya; Ziyue Wang; Muktar S. A. Warsame; Ronny Westerman; Tewodros Eshete Wonde; Sajad Yaghoubi; Siyan Yi; Vahit Yigit; Dong Keon Yon; Naohiro Yonemoto; Chuanhua Yu; Fathiah Zakham; Moein Zangiabadian; Francis Zeukeng; Haijun Zhang; Yang Zhao; Peng Zheng; Magdalena Zielinska; Joshua A. Salomon; Robert C. Reiner; Mohsen Naghavi; Theo Vos; Simon I. Hay; Christopher J. L. Murray; Hmwe Hmwe Kyu
Background: Global evaluations of the progress towards the WHO End TB Strategy 2020 interim milestones on mortality (35% reduction) and incidence (20% reduction) have not been age specific. We aimed to assess global, regional, and national-level burdens of and trends in tuberculosis and its risk factors across five separate age groups, from 1990 to 2021, and to report on age-specific progress between 2015 and 2020. Methods: We used the Global Burden of Diseases, Injuries, and Risk Factors Study 2021 (GBD 2021) analytical framework to compute age-specific tuberculosis mortality and incidence estimates for 204 countries and territories (1990–2021 inclusive). We quantified tuberculosis mortality among individuals without HIV co-infection using 22 603 site-years of vital registration data, 1718 site-years of verbal autopsy data, 825 site-years of sample-based vital registration data, 680 site-years of mortality surveillance data, and 9 site-years of minimally invasive tissue sample (MITS) diagnoses data as inputs into the Cause of Death Ensemble modelling platform. Age-specific HIV and tuberculosis deaths were established with a population attributable fraction approach. We analysed all available population-based data sources, including prevalence surveys, annual case notifications, tuberculin surveys, and tuberculosis mortality, in DisMod-MR 2.1 to produce internally consistent age-specific estimates of tuberculosis incidence, prevalence, and mortality. We also estimated age-specific tuberculosis mortality without HIV co-infection that is attributable to the independent and combined effects of three risk factors (smoking, alcohol use, and diabetes). As a secondary analysis, we examined the potential impact of the COVID-19 pandemic on tuberculosis mortality without HIV co-infection by comparing expected tuberculosis deaths, modelled with trends in tuberculosis deaths from 2015 to 2019 in vital registration data, with observed tuberculosis deaths in 2020 and 2021 for countries with available cause-specific mortality data. Findings: We estimated 9·40 million (95% uncertainty interval [UI] 8·36 to 10·5) tuberculosis incident cases and 1·35 million (1·23 to 1·52) deaths due to tuberculosis in 2021. At the global level, the all-age tuberculosis incidence rate declined by 6·26% (5·27 to 7·25) between 2015 and 2020 (the WHO End TB strategy evaluation period). 15 of 204 countries achieved a 20% decrease in all-age tuberculosis incidence between 2015 and 2020, eight of which were in western sub-Saharan Africa. When stratified by age, global tuberculosis incidence rates decreased by 16·5% (14·8 to 18·4) in children younger than 5 years, 16·2% (14·2 to 17·9) in those aged 5–14 years, 6·29% (5·05 to 7·70) in those aged 15–49 years, 5·72% (4·02 to 7·39) in those aged 50–69 years, and 8·48% (6·74 to 10·4) in those aged 70 years and older, from 2015 to 2020. Global tuberculosis deaths decreased by 11·9% (5·77 to 17·0) from 2015 to 2020. 17 countries attained a 35% reduction in deaths due to tuberculosis between 2015 and 2020, most of which were in eastern Europe (six countries) and central Europe (four countries). There was variable progress by age: a 35·3% (26·7 to 41·7) decrease in tuberculosis deaths in children younger than 5 years, a 29·5% (25·5 to 34·1) decrease in those aged 5–14 years, a 15·2% (10·0 to 20·2) decrease in those aged 15–49 years, a 7·97% (0·472 to 14·1) decrease in those aged 50–69 years, and a 3·29% (–5·56 to 9·07) decrease in those aged 70 years and older. Removing the combined effects of the three attributable risk factors would have reduced the number of all-age tuberculosis deaths from 1·39 million (1·28 to 1·54) to 1·00 million (0·703 to 1·23) in 2020, representing a 36·5% (21·5 to 54·8) reduction in tuberculosis deaths compared to those observed in 2015. 41 countries were included in our analysis of the impact of the COVID-19 pandemic on tuberculosis deaths without HIV co-infection in 2020, and 20 countries were included in the analysis for 2021. In 2020, 50 900 (95% CI 49 700 to 52 400) deaths were expected across all ages, compared to an observed 45 500 deaths, corresponding to 5340 (4070 to 6920) fewer deaths; in 2021, 39 600 (38 300 to 41 100) deaths were expected across all ages compared to an observed 39 000 deaths, corresponding to 657 (–713 to 2180) fewer deaths. Interpretation: Despite accelerated progress in reducing the global burden of tuberculosis in the past decade, the world did not attain the first interim milestones of the WHO End TB Strategy in 2020. The pace of decline has been unequal with respect to age, with older adults (ie, those aged >50 years) having the slowest progress. As countries refine their national tuberculosis programmes and recalibrate for achieving the 2035 targets, they could consider learning from the strategies of countries that achieved the 2020 milestones, as well as consider targeted interventions to improve outcomes in older age groups. Funding: Bill & Melinda Gates Foundation. © 2024 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of allergic disorders and their risk factors in 204 countries and territories, from 1990 to 2019: A systematic analysis for the Global Burden of Disease Study 2019
(John Wiley and Sons Inc, 2023) Youn Ho Shin; Jimin Hwang; Rosie Kwon; Seung Won Lee; Min Seo Kim; Jae Il Shin; Dong Keon Yon; Yohannes Habtegiorgis Abate; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Michael Abdelmasseh; Deldar Morad Abdulah; Richard Gyan Aboagye; Hassan Abolhassani; Elissa M. Abrams; Yonas Derso Abtew; Eman Abu-Gharbieh; Denberu Eshetie Adane Adane; Tigist Demssew Adane; Isaac Yeboah Addo; Rishan Adha; Amin Adibi; Qorinah Estiningtyas Sakilah Adnani; Anurag Agrawal; Sohail Ahmad; Ali Ahmadi; Ali Ahmed; Ayman Ahmed; Sayer Al-Azzam; Fadwa Alhalaiqa Naji Alhalaiqa; Sheikh Mohammad Alif; Vahid Alipour; Zaid Altaany; Khalid A. Altirkawi; Nelson Alvis-Guzman; Hany Aly; Adnan Ansar; Judie Arulappan; Mohammad Asghari-Jafarabadi; Tahira Ashraf; Seyyed Shamsadin Athari; Daniel Atlaw; Avinash Aujayeb; Sina Azadnajafabad; Mahsa Babaei; Hassan Babamohamadi; Alaa Badawi; Nayereh Baghcheghi; Sara Bagherieh; Khuloud Bajbouj; Maciej Banach; Mainak Bardhan; Francesco Barone-Adesi; Amadou Barrow; Azadeh Bashiri; Nebiyou Simegnew Bayileyegn; Isabela M. Bensenor; Alemshet Yirga Berhie; Kebede A. Beyene; Akshaya Srikanth Bhagavathula; Pankaj Bhardwaj; Ajay Nagesh Bhat; Vijayalakshmi S. Bhojaraja; Ali Bijani; Andras Bikov; Jiao Cai; Paulo Camargos; Josip Car; Sinclair Carr; Andrea Carugno; Promit Ananyo Chakraborty; Jeffrey Shi Kai Chan; Periklis Charalampous; Mohammadreza Chashmyazdan; Vijay Kumar Chattu; Mohiuddin Ahsanul Kabir Chowdhury; Dinh-Toi Chu; Barbara Corso; Natália Cruz-Martins; Omid Dadras; Xiaochen Dai; Giovanni Damiani; Lalit Dandona; Rakhi Dandona; Dessalegn Demeke; Biniyam Demisse; Daniel Diaz; Mengistie Diress; Deepa Dongarwar; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Muhammed Elhadi; Omar Abdelsadek Abdou Elmeligy; Habtamu Esubalew; Farshid Etaee; Azin Etemadimanesh; Adeniyi Francis Fagbamigbe; Ildar Ravisovich Fakhradiyev; Ali Fatehizadeh; Syeda Anum Fatima Fatima; Xiaoqi Feng; Mohammad Fereidouni; Nuno Ferreira; Getahun Fetensa; Florian Fischer; Masoud Foroutan; Takeshi Fukumoto; Abduzhappar Gaipov; Yibeltal Yismaw Gela; Abera Getachew Obsa; Fataneh Ghadirian; Seyyed-Hadi Ghamari; Sherief Ghozy; Richard F. Gillum; Abraham Tamirat Gizaw; Admasu Belay AB Gizaw; Mohamad Goldust; Mahaveer Golechha; Pouya Goleij; Sapna Gupta; Vivek Kumar Gupta; Arvin Haj-Mirzaian; Rabih Halwani; Samer Hamidi; Md Abdul Hannan; Ahmed I. Hasaballah; Hamidreza Hasani; Abdiwahab Hashi; Mohammed Bheser Hassen; Behzad Heibati; Golnaz Heidari; Mohammad Heidari; Mahsa Heidari-Foroozan; Ramesh Holla; Nobuyuki Horita; Md Shakhaoat Hossain; Salman Hussain; Bing-Fang Hwang; Irena M. Ilic; Milena D. Ilic; Rana Irilouzadian; Nahlah Elkudssiah Ismail; Zhanat Bakhitovna I. Z. B. Ispayeva; Chidozie C. D. Iwu; Linda Merin J; Maziar Jajarmi; Elham Jamshidi; Manthan Dilipkumar Janodia; Shubha Jayaram; Rime Jebai; Jost B. Jonas; Nitin Joseph; Billingsley Kaambwa; Zubair Kabir; Feroze Kaliyadan; Himal Kandel; Rami S. Kantar; Ibraheem M. Karaye; Hanie Karimi; Harkiran Kaur; Leila Keikavoosi-Arani; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Imteyaz A. Khan; Maseer Khan; Moien A. B. Khan; Saval Khanal; Moawiah Mohammad Khatatbeh; Jagdish Khubchandani; Biruk Getahun Kibret; Adnan Kisa; Sezer Kisa; Pavel Kolkhir; Farzad Kompani; Hamid Reza Koohestani; Oleksii Korzh; Parvaiz A. Koul; Ai Koyanagi; Kewal Krishan; Claudia E. Kuehni; G. Anil Kumar; Om P. Kurmi; L. V. Simhachalam Kutikuppala; Ambily Kuttikkattu; Judit Lám; Bagher Larijani; Kamaluddin Latief; Paolo Lauriola; Thao Thi Thu Le; Yo Han Lee; Jacopo Lenzi; Ming-Chieh Li; Shanshan Li; Virendra S. Ligade; Stephen S. Lim; Gang Liu; Wei Liu; Xuefeng Liu; Chun-Han Lo; Graciliana Lopes; Soundarya Mahalingam; Sandeep B. Maharaj; Mansour Adam Mahmoud; Azeem Majeed; Mohammad-Reza Malekpour; Ahmad Azam Malik; Tauqeer Hussain Mallhi; Deborah Carvalho Malta; Abdullah A. Mamun; Seyedeh Zahra Masoumi; Andrea Maugeri; John Robert Carabeo Medina; Ritesh G. Menezes; George A. Mensah; Alexios-Fotios A. Mentis; Tomislav Mestrovic; Irmina Maria Michalek; Le Huu Nhat Minh; Erkin M. Mirrakhimov; Awoke Misganaw; Manish Mishra; Shafiu Mohammed; Ali H. Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Md Moniruzzaman; Temesgen Mulugeta; Daniel Munblit; Efrén Murillo-Zamora; Ghulam Mustafa; Tapas Sadasivan Nair; Vinay Nangia; Sreenivas Narasimha Swamy; Hasan Nassereldine; Zuhair S. Natto; Biswa Prakash Nayak; Javad Nazari; Tze Pin Ng; Dang H. Nguyen; Van Thanh Nguyen; Robina Khan Niazi; Hasti Nouraei; Ogochukwu Janet Nzoputam; Bogdan Oancea; Rahman Md Obaidur; Hassan Okati-Aliabad; Osaretin Christabel Okonji; Patrick Godwin Okwute; Andrew T. Olagunju; Isaac Iyinoluwa Olufadewa; Hans Orru; P.A. Mahesh; Jagadish Rao Padubidri; Anamika Pandey; Shahina Pardhan; Eun-Kee Park; Jay Patel; Shankargouda Patil; Venkata Suresh Patthipati; Uttam Paudel; Marcos Pereira; Renato B. Pereira; Ionela-Roxana Petcu; Indrashis Podder; Vivek Podder; Arash Pour Mohammad; Ibrahim Qattea; Navid Rabiee; Mehran Rahimi; Mosiur Rahman; Muhammad Aziz Rahman; Amir Masoud Rahmani; Shayan Rahmani; Vahid Rahmanian; Prashant Rajput; Pradhum Ram; Premkumar Ramasubramani; Indu Ramachandra Rao; Ahmed Mustafa Rashid; Zubair Ahmed Ratan; Nakul Ravikumar; Salman Rawaf; Lal Rawal; Elrashdy Moustafa Mohamed Redwan; Aavishkar Raj Regmi; Nazila Rezaei; Negar Rezaei; Nima Rezaei; Saeid Rezaei; Mohsen Rezaeian; Jefferson Antonio Buendia Rodriguez; Leonardo Roever; Esperanza Romero-Rodríguez; Luca Ronfani; Aly M. A. Saad; Basema Saddik; Umar Saeed; Dominic Sagoe; Fatemeh Saheb Sharif-Askari; Amirhossein Sahebkar; Harihar Sahoo; Mirza Rizwan Sajid; Joseph W. Sakshaug; Saina Salahi; Sana Salehi; Abdallah M. Samy; Milena M. Santric-Milicevic; Made Ary Sarasmita; Maryam Sarkhosh; Ganesh Kumar Saya; Subramanian Senthilkumaran; Humaira Shah; Masood Ali Shaikh; Mohd Shanawaz; Aziz Sheikh; Shashank Shekhar; Mika Shigematsu; Parnian Shobeiri; Seyed Afshin Shorofi; Migbar Mekonnen Sibhat; Colin R. Simpson; Jasvinder A. Singh; Paramdeep Singh; Surjit Singh; Virendra Singh; Md Shahjahan Siraj; Anna Aleksandrovna Skryabina; Yonatan Solomon; Suhang Song; Sergey Soshnikov; Ireneous N. Soyiri; Paschalis Steiropoulos; Mindy D. Szeto; Iman M. Talaat; Jacques J. L. Lukenze Tamuzi; Ker-Kan Tan; Nathan Y. Tat; Mohamad-Hani Temsah; Dufera Rikitu Terefa; Riki Tesler; Pugazhenthan Thangaraju; Jansje Henny Vera Ticoalu; Tala Tillawi; Mai Thi Ngoc Tran; Biruk Shalmeno Tusa; Irfan Ullah; Saif Ullah; Sana Ullah; Era Upadhyay; Seyed Mohammad Vahabi; Job F. M. van Boven; Tommi Juhani Vasankari; Georgios-Ioannis Verras; Rafael José Vieira; Francesco S. Violante; Theo Vos; Ronny Westerman; Nuwan Darshana Wickramasinghe; Hywel C. Williams; Dereje Y. Yada; Yazachew Yismaw; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Mazyar Zahir; Heather J. Zar; Iman Zare; Mikhail Sergeevich Zastrozhin; Mohammad A. Zeineddine; Getachew Assefa Zenebe; Zhi-Jiang Zhang; Hanqing Zhao; Mohammad Zoladl
Background: Asthma and atopic dermatitis (AD) are chronic allergic conditions, along with allergic rhinitis and food allergy and cause high morbidity and mortality both in children and adults. This study aims to evaluate the global, regional, national, and temporal trends of the burden of asthma and AD from 1990 to 2019 and analyze their associations with geographic, demographic, social, and clinical factors. Methods: Using data from the Global Burden of Diseases (GBD), Injuries, and Risk Factors Study 2019, we assessed the age-standardized prevalence, incidence, mortality, and disability-adjusted life years (DALYs) of both asthma and AD from 1990 to 2019, stratified by geographic region, age, sex, and socio-demographic index (SDI). DALYs were calculated as the sum of years lived with disability and years of life lost to premature mortality. Additionally, the disease burden of asthma attributable to high body mass index, occupational asthmagens, and smoking was described. Results: In 2019, there were a total of 262 million [95% uncertainty interval (UI): 224–309 million] cases of asthma and 171 million [95% UI: 165–178 million] total cases of AD globally; age-standardized prevalence rates were 3416 [95% UI: 2899–4066] and 2277 [95% UI: 2192–2369] per 100,000 population for asthma and AD, respectively, a 24.1% [95% UI: −27.2 to −20.8] decrease for asthma and a 4.3% [95% UI: 3.8–4.8] decrease for AD compared to baseline in 1990. Both asthma and AD had similar trends according to age, with age-specific prevalence rates peaking at age 5–9 years and rising again in adulthood. The prevalence and incidence of asthma and AD were both higher for individuals with higher SDI; however, mortality and DALYs rates of individuals with asthma had a reverse trend, with higher mortality and DALYs rates in those in the lower SDI quintiles. Of the three risk factors, high body mass index contributed to the highest DALYs and deaths due to asthma, accounting for a total of 3.65 million [95% UI: 2.14–5.60 million] asthma DALYs and 75,377 [95% UI: 40,615–122,841] asthma deaths. Conclusions: Asthma and AD continue to cause significant morbidity worldwide, having increased in total prevalence and incidence cases worldwide, but having decreased in age-standardized prevalence rates from 1990 to 2019. Although both are more frequent at younger ages and more prevalent in high-SDI countries, each condition has distinct temporal and regional characteristics. Understanding the temporospatial trends in the disease burden of asthma and AD could guide future policies and interventions to better manage these diseases worldwide and achieve equity in prevention, diagnosis, and treatment. © 2023 EAACI and John Wiley and Sons A/S. Published by John Wiley and Sons Ltd.
Global, regional, and national burden of colorectal cancer and its risk factors, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Rajesh Sharma; Mohsen Abbasi-Kangevari; Rami Abd-Rabu; Hassan Abidi; Eman Abu-Gharbieh; Juan Manuel Acuna; Sangeet Adhikari; Shailesh M. Advani; Muhammad Sohail Afzal; Mohamad Aghaie Meybodi; Bright Opoku Ahinkorah; Sajjad Ahmad; Ali Ahmadi; Sepideh Ahmadi; Haroon Ahmed; Luai A. Ahmed; Muktar Beshir Ahmed; Hanadi Al Hamad; Fares Alahdab; Fahad Mashhour Alanezi; Turki M. Alanzi; Fadwa Alhalaiqa Naji Alhalaiqa; Yousef Alimohamadi; Vahid Alipour; Syed Mohamed Aljunid; Motasem Alkhayyat; Sami Almustanyir; Rajaa M. Al-Raddadi; Saba Alvand; Nelson Alvis-Guzman; Saeed Amini; Robert Ancuceanu; Amir Anoushiravani; Ali Arash Anoushirvani; Alireza Ansari-Moghaddam; Jalal Arabloo; Armin Aryannejad; Mohammad Asghari Jafarabadi; Seyyed Shamsadin Athari; Floriane Ausloos; Marcel Ausloos; Atalel Fentahun Awedew; Mamaru Ayenew Awoke; Tegegn Mulatu Ayana; Sina Azadnajafabad; Hiva Azami; Mohammadreza Azangou-Khyavy; Amirhossein Azari Jafari; Ashish D. Badiye; Sara Bagherieh; Saeed Bahadory; Atif Amin Baig; Jennifer L. Baker; Maciej Banach; Amadou Barrow; Alemshet Yirga Berhie; Sima Besharat; Devidas S. Bhagat; Akshaya Srikanth Bhagavathula; Neeraj Bhala; Krittika Bhattacharyya; Vijayalakshmi S. Bhojaraja; Sadia Bibi; Ali Bijani; Antonio Biondi; Tone Bjørge; Belay Boda Abule Bodicha; Dejana Braithwaite; Hermann Brenner; Daniela Calina; Chao Cao; Yin Cao; Giulia Carreras; Felix Carvalho; Ester Cerin; Raja Chandra Chakinala; William C.S. Cho; Dinh-Toi Chu; Joao Conde; Vera Marisa Costa; Natália Cruz-Martins; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Anna Danielewicz; Feleke Mekonnen Demeke; Getu Debalkie Demissie; Rupak Desai; Deepak Dhamnetiya; Mostafa Dianatinasab; Daniel Diaz; Mojtaba Didehdar; Saeid Doaei; Linh Phuong Doan; Milad Dodangeh; Fatemeh Eghbalian; Debela Debela Ejeta; Michael Ekholuenetale; Temitope Cyrus Ekundayo; Iman El Sayed; Muhammed Elhadi; Daniel Berhanie Enyew; Tahir Eyayu; Rana Ezzeddini; Ildar Ravisovich Fakhradiyev; Umar Farooque; Hossein Farrokhpour; Farshad Farzadfar; Ali Fatehizadeh; Hamed Fattahi; Nima Fattahi; Masood Fereidoonnezhad; Eduarda Fernandes; Getahun Fetensa; Irina Filip; Florian Fischer; Masoud Foroutan; Peter Andras Gaal; Mohamed M. Gad; Silvano Gallus; Tushar Garg; Tamiru Getachew; Seyyed-Hadi Ghamari; Ahmad Ghashghaee; Nermin Ghith; Maryam Gholamalizadeh; Jamshid Gholizadeh Navashenaq; Abraham Tamirat Gizaw; James C. Glasbey; Mahaveer Golechha; Pouya Goleij; Kebebe Bekele Gonfa; Giuseppe Gorini; Avirup Guha; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Rasool Haddadi; Nima Hafezi-Nejad; Arvin Haj-Mirzaian; Rabih Halwani; Shafiul Haque; Sanam Hariri; Ahmed I. Hasaballah; Soheil Hassanipour; Simon I. Hay; Claudiu Herteliu; Ramesh Holla; Mohammad-Salar Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Mowafa Househ; Junjie Huang; Ayesha Humayun; Ivo Iavicoli; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Farhad Islami; Masao Iwagami; Mohammad Ali Jahani; Mihajlo Jakovljevic; Tahereh Javaheri; Ranil Jayawardena; Rime Jebai; Ravi Prakash Jha; Tamas Joo; Nitin Joseph; Farahnaz Joukar; Jacek Jerzy Jozwiak; Ali Kabir; Rohollah Kalhor; Ashwin Kamath; Neeti Kapoor; Ibraheem M. Karaye; Amirali Karimi; Joonas H. Kauppila; Asma Kazemi; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Rovshan Khalilov; Javad Khanali; Maryam Khayamzadeh; Mahmoud Khodadost; Hanna Kim; Min Seo Kim; Adnan Kisa; Sezer Kisa; Ali-Asghar Kolahi; Hamid Reza Koohestani; Jacek A. Kopec; Rajasekaran Koteeswaran; Ai Koyanagi; Yuvaraj Krishnamoorthy; G. Anil Kumar; Manoj Kumar; Vivek Kumar; Carlo La Vecchia; Faris Hasan Lami; Iván Landires; Caterina Ledda; Sang-Woong Lee; Wei-Chen Lee; Yeong Yeh Lee; Elvynna Leong; Bingyu Li; Stephen S. Lim; Stany W. Lobo; Joana A. Loureiro; Raimundas Lunevicius; Farzan Madadizadeh; Ata Mahmoodpoor; Azeem Majeed; Mohammad-Reza Malekpour; Reza Malekzadeh; Ahmad Azam Malik; Fariborz Mansour-Ghanaei; Lorenzo Giovanni Mantovani; Miquel Martorell; Sahar Masoudi; Prashant Mathur; Jitendra Kumar Meena; Entezar Mehrabi Nasab; Walter Mendoza; Alexios-Fotios A. Mentis; Tomislav Mestrovic; Junmei Miao Jonasson; Bartosz Miazgowski; Tomasz Miazgowski; Gelana Fekadu Worku Mijena; Seyyedmohammadsadeq Mirmoeeni; Mohammad Mirza-Aghazadeh-Attari; Hamed Mirzaei; Sanjeev Misra; Karzan Abdulmuhsin Mohammad; Esmaeil Mohammadi; Saeed Mohammadi; Seyyede Momeneh Mohammadi; Abdollah Mohammadian-Hafshejani; Shafiu Mohammed; Teroj Abdulrahman Mohammed; Nagabhishek Moka; Ali H. Mokdad; Zeinab Mokhtari; Mariam Molokhia; Sara Momtazmanesh; Lorenzo Monasta; Ghobad Moradi; Rahmatollah Moradzadeh; Paula Moraga; Joana Morgado-Da-Costa; Sumaira Mubarik; Francesk Mulita; Mohsen Naghavi; Mukhammad David Naimzada; Hae Sung Nam; Zuhair S. Natto; Biswa Prakash Nayak; Javad Nazari; Ehsan Nazemalhosseini-Mojarad; Ionut Negoi; Cuong Tat Nguyen; Son Hoang Nguyen; Nurulamin M. Noor; Maryam Noori; Seyyed Mohammad Ali Noori; Virginia Nuñez-Samudio; Chimezie Igwegbe Nzoputam; Bogdan Oancea; Oluwakemi Ololade Odukoya; Ayodipupo Sikiru Oguntade; Hassan Okati-Aliabad; Andrew T. Olagunju; Tinuke O. Olagunju; Sokking Ong; Samuel M. Ostroff; Alicia Padron-Monedero; Reza Pakzad; Adrian Pana; Anamika Pandey; Fatemeh Pashazadeh Kan; Urvish K. Patel; Uttam Paudel; Renato B. Pereira; Navaraj Perumalsamy; Richard G. Pestell; Zahra Zahid Piracha; Richard Charles G. Pollok; Akram Pourshams; Naeimeh Pourtaheri; Akila Prashant; Mohammad Rabiee; Navid Rabiee; Amir Radfar; Sima Rafiei; Mosiur Rahman; Amir Masoud Rahmani; Vahid Rahmanian; Nazanin Rajai; Aashish Rajesh; Vajiheh Ramezani-Doroh; Kiana Ramezanzadeh; Kamal Ranabhat; Sina Rashedi; Amirfarzan Rashidi; Mahsa Rashidi; Mohammad-Mahdi Rashidi; Mandana Rastegar; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Mohammad Sadegh Razeghinia; Andre M.N. Renzaho; Negar Rezaei; Nima Rezaei; Saeid Rezaei; Mohsen Rezaeian; Sahba Rezazadeh-Khadem; Gholamreza Roshandel; Maha Mohamed Saber-Ayad; Bahar Saberzadeh-Ardestani; Basema Saddik; Hossein Sadeghi; Umar Saeed; Maryam Sahebazzamani; Amirhossein Sahebkar; Amir Salek Farrokhi; Amir Salimi; Hamideh Salimzadeh; Pouria Samadi; Mehrnoosh Samaei; Abdallah M. Samy; Juan Sanabria; Milena M. Santric-Milicevic; Muhammad Arif Nadeem Saqib; Arash Sarveazad; Brijesh Sathian; Maheswar Satpathy; Ione Jayce Ceola Schneider; Mario Šekerija; Sadaf G. Sepanlou; Allen Seylani; Feng Sha; Sayed Mohammad Shafiee; Zahra Shaghaghi; Saeed Shahabi; Elaheh Shaker; Maedeh Sharifian; Javad Sharifi-Rad; Sara Sheikhbahaei; Jeevan K. Shetty; Reza Shirkoohi; Parnian Shobeiri; Sudeep K. Siddappa Malleshappa; Diego Augusto Santos Silva; Guilherme Silva Julian; Achintya Dinesh Singh; Jasvinder A. Singh; Md Shahjahan Siraj; Gholam Reza Sivandzadeh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Bogdan Socea; Marco Solmi; Mohammad Sadegh Soltani-Zangbar; Suhang Song; Viktória Szerencsés; Miklós Szócska; Rafael Tabarés-Seisdedos; Elnaz Tabibian; Majid Taheri; Yasaman Taheri Abkenar; Amir Taherkhani; Iman M. Talaat; Ker-Kan Tan; Abdelghani Tbakhi; Bekele Tesfaye; Amir Tiyuri; Daniel Nigusse Tollosa; Mathilde Touvier; Bach Xuan Tran; Biruk Shalmeno Tusa; Irfan Ullah; Saif Ullah; Marco Vacante; Sahel Valadan Tahbaz; Massimiliano Veroux; Bay Vo; Theo Vos; Cong Wang; Ronny Westerman; Melat Woldemariam; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Fereshteh Yazdanpanah; Chuanhua Yu; Deniz Yuce; Ismaeel Yunusa; Vesna Zadnik; Mazyar Zahir; Iman Zare; Zhi-Jiang Zhang; Mohammad Zoladi
Background: Colorectal cancer is the third leading cause of cancer deaths worldwide. Given the recent increasing trends in colorectal cancer incidence globally, up-to-date information on the colorectal cancer burden could guide screening, early detection, and treatment strategies, and help effectively allocate resources. We examined the temporal patterns of the global, regional, and national burden of colorectal cancer and its risk factors in 204 countries and territories across the past three decades. Methods: Estimates of incidence, mortality, and disability-adjusted life years (DALYs) for colorectal cancer were generated as a part of the Global Burden of Diseases, Injuries and Risk Factors Study (GBD) 2019 by age, sex, and geographical location for the period 1990–2019. Mortality estimates were produced using the cause of death ensemble model. We also calculated DALYs attributable to risk factors that had evidence of causation with colorectal cancer. Findings: Globally, between 1990 and 2019, colorectal cancer incident cases more than doubled, from 842 098 (95% uncertainty interval [UI] 810 408–868 574) to 2·17 million (2·00–2·34), and deaths increased from 518 126 (493 682–537 877) to 1·09 million (1·02–1·15). The global age-standardised incidence rate increased from 22·2 (95% UI 21·3–23·0) per 100 000 to 26·7 (24·6–28·9) per 100 000, whereas the age-standardised mortality rate decreased from 14·3 (13·5–14·9) per 100 000 to 13·7 (12·6–14·5) per 100 000 and the age-standardised DALY rate decreased from 308·5 (294·7–320·7) per 100 000 to 295·5 (275·2–313·0) per 100 000 from 1990 through 2019. Taiwan (province of China; 62·0 [48·9–80·0] per 100 000), Monaco (60·7 [48·5–73·6] per 100 000), and Andorra (56·6 [42·8–71·9] per 100 000) had the highest age-standardised incidence rates, while Greenland (31·4 [26·0–37·1] per 100 000), Brunei (30·3 [26·6–34·1] per 100 000), and Hungary (28·6 [23·6–34·0] per 100 000) had the highest age-standardised mortality rates. From 1990 through 2019, a substantial rise in incidence rates was observed in younger adults (age <50 years), particularly in high Socio-demographic Index (SDI) countries. Globally, a diet low in milk (15·6%), smoking (13·3%), a diet low in calcium (12·9%), and alcohol use (9·9%) were the main contributors to colorectal cancer DALYs in 2019. Interpretation: The increase in incidence rates in people younger than 50 years requires vigilance from researchers, clinicians, and policy makers and a possible reconsideration of screening guidelines. The fast-rising burden in low SDI and middle SDI countries in Asia and Africa calls for colorectal cancer prevention approaches, greater awareness, and cost-effective screening and therapeutic options in these regions. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of hepatitis B, 1990–2019: a systematic analysis for the Global Burden of Disease Study 2019
(Elsevier Ltd, 2022) Brittney S. Sheena; Lindsey Hiebert; Hannah Han; Helen Ippolito; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Hedayat Abbastabar; Amir Abdoli; Hiwa Abubaker Ali; Mesafint Molla Adane; Oyelola A. Adegboye; Qorinah Estiningtyas Sakilah Adnani; Shailesh M. Advani; Muhammad Sohail Afzal; Saira Afzal; Mohamad Aghaie Meybodi; Bahman Ahadinezhad; Bright Opoku Ahinkorah; Sajjad Ahmad; Tauseef Ahmad; Sepideh Ahmadi; Haroon Ahmed; Muktar Beshir Ahmed; Tarik Ahmed Rashid; Gizachew Taddesse Akalu; Addis Aklilu; Tayyaba Akram; Hanadi Al Hamad; Fares Alahdab; Adugnaw Zeleke Alem; Dejene Tsegaye Alem; Fadwa Alhalaiqa Naji Alhalaiqa; Robert Kaba Alhassan; Liaqat Ali; Muhammad Ashar Ali; Yousef Alimohamadi; Vahid Alipour; Motasem Alkhayyat; Sami Almustanyir; Rajaa M. Al-Raddadi; Haya Altawalah; Saeed Amini; Hubert Amu; Robert Ancuceanu; Catalina Liliana Andrei; Tudorel Andrei; Amir Anoushiravani; Adnan Ansar; Anayochukwu Edward Anyasodor; Jalal Arabloo; Morteza Arab-Zozani; Ayele Mamo Argaw; Zeleke Gebru Argaw; Muhammad Arshad; Anton A. Artamonov; Tahira Ashraf; Daniel Atlaw; Floriane Ausloos; Marcel Ausloos; Sina Azadnajafabad; Mohammadreza Azangou-Khyavy; Amirhossein Azari Jafari; Ghasem Azarian; Sayna Bagheri; Saeed Bahadory; Atif Amin Baig; Maciej Banach; Nastaran Barati; Amadou Barrow; Abdul-Monim Mohammad Batiha; Diana Fernanda Bejarano Ramirez; Uzma Iqbal Belgaumi; Alemshet Yirga Berhie; Devidas S. Bhagat; Nikha Bhardwaj; Pankaj Bhardwaj; Krittika Bhattacharyya; Vijayalakshmi S. Bhojaraja; Ali Bijani; Antonio Biondi; Belay Boda Abule Bodicha; Hunduma Amensisa Bojia; Archith Boloor; Cristina Bosetti; Dejana Braithwaite; Nikolay Ivanovich Briko; Zahid A. Butt; Luis Alberto Cámera; Raja Chandra Chakinala; Promit Ananyo Chakraborty; Jaykaran Charan; Shu Chen; Jee-Young Jasmine Choi; Sonali Gajanan Choudhari; Fazle Rabbi Chowdhury; Dinh-Toi Chu; Sheng-Chia Chung; Paolo Angelo Cortesi; Benjamin C. Cowie; Garland T. Culbreth; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Fernando Pio De La Hoz; Sisay Abebe Debela; Mohammed Gebre Dedefo; Feleke Mekonnen Demeke; Takele Gezahegn G. Demie; Getu Debalkie Demissie; Meseret Derbew Molla; Abebaw Alemayehu Desta; Deepak Dhamnetiya; Mandira Lamichhane Dhimal; Meghnath Dhimal; Mojtaba Didehdar; Linh Phuong Doan; Fariba Dorostkar; Thomas M. Drake; Fatemeh Eghbalian; Michael Ekholuenetale; Iman El Sayed; Maysaa El Sayed Zaki; Muhammed Elhadi; Mohamed A. Elmonem; Aisha Elsharkawy; Shymaa Enany; Daniel Berhanie Enyew; Ryenchindorj Erkhembayar; Sharareh Eskandarieh; Firooz Esmaeilzadeh; Sayeh Ezzikouri; Hossein Farrokhpour; Getahun Fetensa; Florian Fischer; Masoud Foroutan; Mohamed M. Gad; Abhay Motiramji Gaidhane; Shilpa Gaidhane; Natalie C. Galles; Silvano Gallus; Teferi Gebru Gebremeskel; Eyob Alemayehu Gebreyohannes; Keyghobad Ghadiri; Kazem Ghaffari; Mansour Ghafourifard; Seyyed-Hadi Ghamari; Ahmad Ghashghaee; Ali Gholami; Abdolmajid Gholizadeh; Aima Gilani; Amit Goel; Mahaveer Golechha; Pouya Goleij; Davide Golinelli; Giuseppe Gorini; Yitayal Ayalew Goshu; Max G. Griswold; Mohammed Ibrahim Mohialdeen Gubari; Bhawna Gupta; Sapna Gupta; Veer Bala Gupta; Vivek Kumar Gupta; Rasool Haddadi; Rabih Halwani; Saeed S. Hamid; Samer Hamidi; Asif Hanif; Shafiul Haque; Harapan Harapan; Arief Hargono; Sanam Hariri; Ahmed I. Hasaballah; S.M. Mahmudul Hasan; Soheil Hassanipour; Hadi Hassankhani; Simon I. Hay; Khezar Hayat; Golnaz Heidari; Claudiu Herteliu; Demisu Zenbaba Heyi; Kamal Hezam; Ramesh Holla; Mohammad-Salar Hosseini; Mostafa Hosseini; Mehdi Hosseinzadeh; Mihaela Hostiuc; Mowafa Househ; Junjie Huang; Nawfal R. Hussein; Ivo Iavicoli; Segun Emmanuel Ibitoye; Olayinka Stephen Ilesanmi; Irena M. Ilic; Milena D. Ilic; Lalu Muhammad Irham; Jessica Y. Islam; Nahlah Elkudssiah Ismail; Kathryn H. Jacobsen; Farhad Jadidi-Niaragh; Amirreza Javadi Mamaghani; Shubha Jayaram; Ranil Jayawardena; Rime Jebai; Ravi Prakash Jha; Nitin Joseph; Farahnaz Joukar; Billingsley Kaambwa; Ali Kabir; Zubair Kabir; Rohollah Kalhor; Himal Kandel; Tesfaye K. Tesfaye Kanko; Rami S. Kantar; Ibraheem M. Karaye; Bekalu Getnet Kassa; Phillip M. Kemp Bohan; Mohammad Keykhaei; Yousef Saleh Khader; Himanshu Khajuria; Gulfaraz Khan; Imteyaz A. Khan; Junaid Khan; Moien A.B. Khan; Javad Khanali; Amir M. Khater; Mahalaqua Nazli Khatib; Mahmoud Khodadost; Abdullah T. Khoja; Omid Khosravizadeh; Jagdish Khubchandani; Gyu Ri Kim; Hanna Kim; Min Seo Kim; Yun Jin Kim; Jonathan M. Kocarnik; Ali-Asghar Kolahi; Rajasekaran Koteeswaran; G. Anil Kumar; Carlo La Vecchia; Dharmesh Kumar Lal; Iván Landires; Savita Lasrado; Jeffrey V. Lazarus; Caterina Ledda; Doo Woong Lee; Sang-Woong Lee; Yeong Yeh Lee; Miriam Levi; Jiarui Li; Stephen S. Lim; Stany W. Lobo; Platon D. Lopukhov; Joana A. Loureiro; Jennifer H. MacLachlan; Hassan Magdy Abd El Razek; Muhammed Magdy Abd El Razek; Azeem Majeed; Alaa Makki; Mohammad-Reza Malekpour; Reza Malekzadeh; Ahmad Azam Malik; Fariborz Mansour-Ghanaei; Mohammad Ali Mansournia; Francisco Rogerlândio Martins-Melo; Philippa C. Matthews; Walter Mendoza; Ritesh G. Menezes; Tuomo J. Meretoja; Amanual Getnet Mersha; Tomislav Mestrovic; Ted R. Miller; Le Huu Nhat Minh; Andreea Mirica; Seyyedmohammadsadeq Mirmoeeni; Erkin M. Mirrakhimov; Sanjeev Misra; Prasanna Mithra; Babak Moazen; Ashraf Mohamadkhani; Mokhtar Mohammadi; Shafiu Mohammed; Nagabhishek Moka; Ali H. Mokdad; Jalal Moludi; Sara Momtazmanesh; Lorenzo Monasta; Ghobad Moradi; Maliheh Moradzadeh; Rahmatollah Moradzadeh; Paula Moraga; Ebrahim Mostafavi; Sumaira Mubarik; Malaisamy Muniyandi; Christopher J.L. Murray; Mohsen Naghavi; Mukhammad David Naimzada; Sreenivas Narasimha Swamy; Zuhair S. Natto; Biswa Prakash Nayak; Javad Nazari; Ionut Negoi; Serban Mircea Negru; Seyed Aria Nejadghaderi; Sandhya Neupane Kandel; Huong Lan Thi Nguyen; Che Henry Ngwa; Robina Khan Niazi; Chukwudi A. Nnaji; Jean Jacques Noubiap; Ali Nowroozi; Virginia Nuñez-Samudio; Bogdan Oancea; Chimedsuren Ochir; Oluwakemi Ololade Odukoya; In-Hwan Oh; Andrew T. Olagunju; Babayemi Oluwaseun Olakunde; Ahmed Omar Bali; Emad Omer; Stanislav S. Otstavnov; Bilcha Oumer; Jagadish Rao Padubidri; Adrian Pana; Anamika Pandey; Eun-Cheol Park; Fatemeh Pashazadeh Kan; Urvish K. Patel; Uttam Paudel; Ionela-Roxana Petcu; Zahra Zahid Piracha; Richard Charles G. Pollok; Maarten J. Postma; Akram Pourshams; Hossein Poustchi; Mohammad Rabiee; Navid Rabiee; Alireza Rafiei; Sima Rafiei; Pavan Manibettu Raghuram; Mosiur Rahman; Amir Masoud Rahmani; Setyaningrum Rahmawaty; Aashish Rajesh; Priyanga Ranasinghe; Chythra R. Rao; Sowmya J. Rao; Mahsa Rashidi; Mohammad-Mahdi Rashidi; David Laith Rawaf; Salman Rawaf; Reza Rawassizadeh; Negar Rezaei; Aziz Rezapour; Sahba Rezazadeh-Khadem; Jefferson Antonio Buendia Rodriguez; Godfrey M. Rwegerera; Siamak Sabour; Basema Saddik; Mohammad Reza Saeb; Umar Saeed; Amirhossein Sahebkar; K.M. Saif-Ur-Rahman; Sarvenaz Salahi; Hamideh Salimzadeh; Chethan Sampath; Abdallah M. Samy; Juan Sanabria; Francesco Sanmarchi; Milena M. Santric-Milicevic; Arash Sarveazad; Brijesh Sathian; Monika Sawhney; Abdul-Aziz Seidu; Sadaf G. Sepanlou; Allen Seylani; Saeed Shahabi; Masood Ali Shaikh; Elaheh Shaker; Murad Ziyaudinovich Shakhmardanov; Mohammed Shannawaz; Suchitra M. Shenoy; Jeevan K. Shetty; Pavanchand H. Shetty; Kenji Shibuya; Jae Il Shin; Parnian Shobeiri; Migbar Mekonnen Sibhat; Achintya Dinesh Singh; Jasvinder A. Singh; Surjit Singh; Valentin Yurievich Skryabin; Anna Aleksandrovna Skryabina; Amir Ali Sohrabpour; Suhang Song; Seidamir Pasha Tabaeian; Eyayou Girma Tadesse; Majid Taheri; Mircea Tampa; Ker-Kan Tan; Ahmad Tavakoli; Abdelghani Tbakhi; Belay Negash Tefera; Arash Tehrani-Banihashemi; Habtamu Molla Tesfaw; Rekha Thapar; Aravind Thavamani; Seyed Abolfazl Tohidast; Daniel Nigusse Tollosa; Maria Elena Tosti; Marcos Roberto Tovani-Palone; Eugenio Traini; Mai Thi Ngoc Tran; Indang Trihandini; Biruk Shalmeno Tusa; Irfan Ullah; Marco Vacante; Sahel Valadan Tahbaz; Pascual R. Valdez; Shoban Babu Varthya; Bay Vo; Yasir Waheed; Adisu Birhanu Weldesenbet; Melat Woldemariam; Suowen Xu; Seyed Hossein Yahyazadeh Jabbari; Mehdi Yaseri; Yigizie Yeshaw; Vahit Yiǧit; Birhanu Wubale Yirdaw; Naohiro Yonemoto; Chuanhua Yu; Ismaeel Yunusa; Mazyar Zahir; Leila Zaki; Mohammad Zamani; Maryam Zamanian; Mikhail Sergeevich Zastrozhin; Theo Vos; John W. Ward; M. Ashworth Dirac
Background: Combating viral hepatitis is part of the UN Sustainable Development Goals (SDGs), and WHO has put forth hepatitis B elimination targets in its Global Health Sector Strategy on Viral Hepatitis (WHO-GHSS) and Interim Guidance for Country Validation of Viral Hepatitis Elimination (WHO Interim Guidance). We estimated the global, regional, and national prevalence of hepatitis B virus (HBV), as well as mortality and disability-adjusted life-years (DALYs) due to HBV, as part of the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2019. This included estimates for 194 WHO member states, for which we compared our estimates to WHO elimination targets. Methods: The primary data sources were population-based serosurveys, claims and hospital discharges, cancer registries, vital registration systems, and published case series. We estimated chronic HBV infection and the burden of HBV-related diseases, defined as an aggregate of cirrhosis due to hepatitis B, liver cancer due to hepatitis B, and acute hepatitis B. We used DisMod-MR 2.1, a Bayesian mixed-effects meta-regression tool, to estimate the prevalence of chronic HBV infection, cirrhosis, and aetiological proportions of cirrhosis. We used mortality-to-incidence ratios modelled with spatiotemporal Gaussian process regression to estimate the incidence of liver cancer. We used the Cause of Death Ensemble modelling (CODEm) model, a tool that selects models and covariates on the basis of out-of-sample performance, to estimate mortality due to cirrhosis, liver cancer, and acute hepatitis B. Findings: In 2019, the estimated global, all-age prevalence of chronic HBV infection was 4·1% (95% uncertainty interval [UI] 3·7 to 4·5), corresponding to 316 million (284 to 351) infected people. There was a 31·3% (29·0 to 33·9) decline in all-age prevalence between 1990 and 2019, with a more marked decline of 76·8% (76·2 to 77·5) in prevalence in children younger than 5 years. HBV-related diseases resulted in 555 000 global deaths (487 000 to 630 000) in 2019. The number of HBV-related deaths increased between 1990 and 2019 (by 5·9% [–5·6 to 19·2]) and between 2015 and 2019 (by 2·9% [–5·9 to 11·3]). By contrast, all-age and age-standardised death rates due to HBV-related diseases decreased during these periods. We compared estimates for 2019 in 194 WHO locations to WHO-GHSS 2020 targets, and found that four countries achieved a 10% reduction in deaths, 15 countries achieved a 30% reduction in new cases, and 147 countries achieved a 1% prevalence in children younger than 5 years. As of 2019, 68 of 194 countries had already achieved the 2030 target proposed in WHO Interim Guidance of an all-age HBV-related death rate of four per 100 000. Interpretation: The prevalence of chronic HBV infection declined over time, particularly in children younger than 5 years, since the introduction of hepatitis B vaccination. HBV-related death rates also decreased, but HBV-related death counts increased as a result of population growth, ageing, and cohort effects. By 2019, many countries had met the interim seroprevalence target for children younger than 5 years, but few countries had met the WHO-GHSS interim targets for deaths and new cases. Progress according to all indicators must be accelerated to meet 2030 targets, and there are marked disparities in burden and progress across the world. HBV interventions, such as vaccination, testing, and treatment, must be strategically supported and scaled up to achieve elimination. Funding: Bill & Melinda Gates Foundation. © 2022 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of low back pain, 1990–2020, its attributable risk factors, and projections to 2050: a systematic analysis of the Global Burden of Disease Study 2021
(Elsevier Ltd, 2023) Manuela L Ferreira; Katie De Luca; Lydia M Haile; Jaimie D Steinmetz; Garland T Culbreth; Marita Cross; Jacek A Kopec; Paulo H Ferreira; Fiona M Blyth; Rachelle Buchbinder; Jan Hartvigsen; Ai-Min Wu; Saeid Safiri; Anthony D Woolf; Gary S Collins; Kanyin Liane Ong; Stein Emil Vollset; Amanda E Smith; Jessica A Cruz; Kai Glenn Fukutaki; Semagn Mekonnen Abate; Mitra Abbasifard; Mohsen Abbasi-Kangevari; Zeinab Abbasi-Kangevari; Ahmed Abdelalim; Aidin Abedi; Hassan Abidi; Qorinah Estiningtyas Sakilah Adnani; Ali Ahmadi; Rufus Olusola Akinyemi; Abayneh Tadesse Alamer; Adugnaw Zeleke Alem; Yousef Alimohamadi; Mansour Abdullah Alshehri; Mohammed Mansour Alshehri; Hosam Alzahrani; Saeed Amini; Sohrab Amiri; Hubert Amu; Catalina Liliana Andrei; Tudorel Andrei; Benny Antony; Jalal Arabloo; Judie Arulappan; Ashokan Arumugam; Tahira Ashraf; Seyyed Shamsadin Athari; Nefsu Awoke; Sina Azadnajafabad; Till Winfried Bärnighausen; Lope H Barrero; Amadou Barrow; Akbar Barzegar; Lindsay M Bearne; Isabela M Bensenor; Alemshet Yirga Berhie; Bharti Bhandari Bhandari; Vijayalakshmi S Bhojaraja; Ali Bijani; Belay Boda Abule Bodicha; Srinivasa Rao Bolla; Javier Brazo-Sayavera; Andrew M Briggs; Chao Cao; Periklis Charalampous; Vijay Kumar Chattu; Flavia M Cicuttini; Benjamin Clarsen; Sarah Cuschieri; Omid Dadras; Xiaochen Dai; Lalit Dandona; Rakhi Dandona; Azizallah Dehghan; Takele Gezahegn G Demie; Edgar Denova-Gutiérrez; Syed Masudur Rahman Dewan; Samath Dhamminda Dharmaratne; Mandira Lamichhane Dhimal; Meghnath Dhimal; Daniel Diaz; Mojtaba Didehdar; Lankamo Ena Digesa; Mengistie Diress; Hoa Thi Do; Linh Phuong Doan; Michael Ekholuenetale; Muhammed Elhadi; Sharareh Eskandarieh; Shahriar Faghani; Jawad Fares; Ali Fatehizadeh; Getahun Fetensa; Irina Filip; Florian Fischer; Richard Charles Franklin; Balasankar Ganesan; Belete Negese Belete Gemeda; Motuma Erena Getachew; Ahmad Ghashghaee; Tiffany K Gill; Mahaveer Golechha; Pouya Goleij; Bhawna Gupta; Nima Hafezi-Nejad; Arvin Haj-Mirzaian; Pawan Kumar Hamal; Asif Hanif; Netanja I Harlianto; Hamidreza Hasani; Simon I Hay; Jeffrey J Hebert; Golnaz Heidari; Mohammad Heidari; Reza Heidari-Soureshjani; Mbuzeleni Mbuzeleni Hlongwa; Mohammad-Salar Hosseini; Alexander Kevin Hsiao; Ivo Iavicoli; Segun Emmanuel Ibitoye; Irena M Ilic; Milena D Ilic; Sheikh Mohammed Shariful Islam; Manthan Dilipkumar Janodia; Ravi Prakash Jha; Har Ashish Jindal; Jost B Jonas; Gebisa Guyasa Kabito; Himal Kandel; Rimple Jeet Kaur; Vikash Ranjan Keshri; Yousef Saleh Khader; Ejaz Ahmad Khan; Md Jobair Khan; Moien A B Khan; Hamid Reza Khayat Kashani; Jagdish Khubchandani; Yun Jin Kim; Adnan Kisa; Jitka Klugarová; Ali-Asghar Kolahi; Hamid Reza Koohestani; Ai Koyanagi; G Anil Kumar; Narinder Kumar; Tea Lallukka; Savita Lasrado; Wei-Chen Lee; Yo Han Lee; Ata Mahmoodpoor; Jeadran N Malagón-Rojas; Mohammad-Reza Malekpour; Reza Malekzadeh; Narges Malih; Man Mohan Mehndiratta; Entezar Mehrabi Nasab; Ritesh G Menezes; Alexios-Fotios A Mentis; Mohamed Kamal Mesregah; Ted R Miller; Mohammad Mirza-Aghazadeh-Attari; Maryam Mobarakabadi; Yousef Mohammad; Esmaeil Mohammadi; Shafiu Mohammed; Ali H Mokdad; Sara Momtazmanesh; Lorenzo Monasta; Mohammad Ali Moni; Ebrahim Mostafavi; Christopher J L Murray; Tapas Sadasivan Nair; Javad Nazari; Seyed Aria Nejadghaderi; Subas Neupane; Sandhya Neupane Kandel; Cuong Tat Nguyen; Ali Nowroozi; Hassan Okati-Aliabad; Emad Omer; Abderrahim Oulhaj; Mayowa O Owolabi; Songhomitra Panda-Jonas; Anamika Pandey; Eun-Kee Park; Shrikant Pawar; Paolo Pedersini; Jeevan Pereira; Mario F P Peres; Ionela-Roxana Petcu; Mohammadreza Pourahmadi; Amir Radfar; Shahram Rahimi-Dehgolan; Vafa Rahimi-Movaghar; Mosiur Rahman; Amir Masoud Rahmani; Nazanin Rajai; Chythra R Rao; Vahid Rashedi; Mohammad-Mahdi Rashidi; Zubair Ahmed Ratan; David Laith Rawaf; Salman Rawaf; Andre M N Renzaho; Negar Rezaei; Zahed Rezaei; Leonardo Roever; Guilherme De Andrade Ruela; Basema Saddik; Amirhossein Sahebkar; Sana Salehi; Francesco Sanmarchi; Sadaf G Sepanlou; Saeed Shahabi; Shayan Shahrokhi; Elaheh Shaker; Mohammad Bagher Shamsi; Mohammed Shannawaz; Saurab Sharma; Maryam Shaygan; Rahim Ali Sheikhi; Jeevan K Shetty; Rahman Shiri; Siddharudha Shivalli; Parnian Shobeiri; Migbar Mekonnen Sibhat; Ambrish Singh; Jasvinder A Singh; Helen Slater; Marco Solmi; Ranjani Somayaji; Ker-Kan Tan; Rekha Thapar; Seyed Abolfazl Tohidast; Sahel Valadan Tahbaz; Rohollah Valizadeh; Tommi Juhani Vasankari; Narayanaswamy Venketasubramanian; Vasily Vlassov; Bay Vo; Yuan-Pang Wang; Taweewat Wiangkham; Lalit Yadav; Ali Yadollahpour; Seyed Hossein Yahyazadeh Jabbari; Lin Yang; Fereshteh Yazdanpanah; Naohiro Yonemoto; Mustafa Z Younis; Iman Zare; Armin Zarrintan; Mohammad Zoladl; Theo Vos; Lyn M March
Background: Low back pain is highly prevalent and the main cause of years lived with disability (YLDs). We present the most up-to-date global, regional, and national data on prevalence and YLDs for low back pain from the Global Burden of Diseases, Injuries, and Risk Factors Study 2021. Methods: Population-based studies from 1980 to 2019 identified in a systematic review, international surveys, US medical claims data, and dataset contributions by collaborators were used to estimate the prevalence and YLDs for low back pain from 1990 to 2020, for 204 countries and territories. Low back pain was defined as pain between the 12th ribs and the gluteal folds that lasted a day or more; input data using alternative definitions were adjusted in a network meta-regression analysis. Nested Bayesian meta-regression models were used to estimate prevalence and YLDs by age, sex, year, and location. Prevalence was projected to 2050 by running a regression on prevalence rates using Socio-demographic Index as a predictor, then multiplying them by projected population estimates. Findings: In 2020, low back pain affected 619 million (95% uncertainty interval 554–694) people globally, with a projection of 843 million (759–933) prevalent cases by 2050. In 2020, the global age-standardised rate of YLDs was 832 per 100 000 (578–1070). Between 1990 and 2020, age-standardised rates of prevalence and YLDs decreased by 10·4% (10·9–10·0) and 10·5% (11·1–10·0), respectively. A total of 38·8% (28·7–47·0) of YLDs were attributed to occupational factors, smoking, and high BMI. Interpretation: Low back pain remains the leading cause of YLDs globally, and in 2020, there were more than half a billion prevalent cases of low back pain worldwide. While age-standardised rates have decreased modestly over the past three decades, it is projected that globally in 2050, more than 800 million people will have low back pain. Challenges persist in obtaining primary country-level data on low back pain, and there is an urgent need for more high-quality, primary, country-level data on both prevalence and severity distributions to improve accuracy and monitor change. Funding: Bill and Melinda Gates Foundation. © 2023 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license
Global, regional, and national burden of meningitis, 1990–2016: a systematic analysis for the Global Burden of Disease Study 2016
(Elsevier Ltd, 2018) Joseph Raymond Zunt; Nicholas J Kassebaum; Natacha Blake; Linda Glennie; Claire Wright; Emma Nichols; Foad Abd-Allah; Jemal Abdela; Ahmed Abdelalim; Abdu A Adamu; Mina G Adib; Alireza Ahmadi; Muktar Beshir Ahmed; Amani Nidhal Aichour; Ibtihel Aichour; Miloud Taki Eddine Aichour; Nadia Akseer; Rajaa M Al-Raddadi; Fares Alahdab; Kefyalew Addis Alene; Syed Mohamed Aljunid; Mohammad A AlMazora; Khalid; Nelson Alvis-Guzman; Megbaru Debalkie Animut; Mina Anjomshoa; Mustafa Geleto Ansha; Rana Jawad Asghar; Euripide F G A Avokpaho; Ashish Awasthi; Hamid Badali; Aleksandra Barac; Till Winfried Bärnighausen; Quique Bassat; Neeraj Bedi; Abate Bekele Belachew; Krittika Bhattacharyya; Zulfiqar A Bhutta; Ali Bijani; Zahid A Butt; Félix Carvalho; Carlos A Castañeda-Orjuela; Abdulaal Chitheer; Jee-Young J Choi; Devasahayam J Christopher; Anh Kim Dang; Ahmad Daryani; Gebre Teklemariam Demoz; Shirin Djalalinia; Huyen Phuc Do; Manisha Dubey; Eleonora Dubljanin; Eyasu Ejeta Duken; Maysaa El Sayed Zaki; Iqbal Rf Elyazar; Hamed Fakhim; Eduarda Fernandes; Florian Fischer; Takeshi Fukumoto; Morsaleh Ganji; Abadi Kahsu Gebre; Afewerki Gebremeskel; Bradford D Gessner; Sameer Vali Gopalani; Yuming Guo; Rahul Gupta; Gessessew Bugssa Hailu; Arvin Haj-Mirzaian; Samer Hamidi; Simon I Hay; Andualem Henok; Seyed Sina Naghibi Irvani; Ravi Prakash Jha; Mikk Jürisson; Amaha Kahsay; Manoochehr Karami; André Karch; Amir Kasaeian; Getachew Mullu Kassa; Tesfaye Dessale Kassa; Adane Teshome Kefale; Yousef Saleh Khader; Ibrahim A Khalil; Ejaz Ahmad Khan; Young-Ho Khang; Jagdish Khubchandani; Ruth W Kimokoti; Adnan Kisa; Faris Hasan Lami; Miriam Levi; Shanshan Li; Clement T Loy; Marek Majdan; Azeem Majeed; Lorenzo Giovanni Mantovani; Francisco Rogerlândio Martins-Melo; Colm McAlinden; Varshil Mehta; Addisu Melese; Ziad A Memish; Desalegn Tadese Mengistu; Getnet Mengistu; Tomislav Mestrovic; Haftay Berhane Mezgebe; Bartosz Miazgowski; Branko Milosevic; Ali H Mokdad; Lorenzo Monasta; Ghobad Moradi; Paula Moraga; Seyyed Meysam Mousavi; Ulrich Otto Mueller; Srinivas Murthy; Ghulam Mustafa; Mohsen Naghavi; Aliya Naheed; Gurudatta Naik; Charles Richard James Newton; Yirga Legesse Nirayo; Molly R Nixon; Richard Ofori-Asenso; Felix Akpojene Ogbo; Andrew T Olagunju; Tinuke O Olagunju; Bolajoko Olubukunola Olusanya; Justin R Ortiz; Mayowa Ojo Owolabi; Shanti Patel; Gabriel D Pinilla-Monsalve; Maarten J Postma; Mostafa Qorbani; Alireza Rafiei; Vafa Rahimi-Movaghar; Robert C Reiner; Andre M N Renzaho; Mohammad Sadegh Rezai; Kedir Teji Roba; Luca Ronfani; Gholamreza Roshandel; Ali Rostami; Hosein Safari; Saeed Safari; Saeid Safiri; Rajesh Sagar; Abdallah M Samy; Milena M Santric Milicevic; Benn Sartorius; Shahabeddin Sarvi; Monika Sawhney; Sonia Saxena; Azadeh Shafieesabet; Masood Ali Shaikh; Mehdi Sharif; Mika Shigematsu; Si Si; Eirini Skiadaresi; Mari Smith; Ranjani Somayaji; Mu'Awiyyah Babale Sufiyan; Nega Yimer Tawye; Mohamad-Hani Temsah; Miguel Tortajada-Girbés; Bach Xuan Tran; Khanh Bao Tran; Kingsley Nnanna Ukwaja; Irfan Ullah; Isidora S Vujcic; Fasil Wagnew; Yasir Waheed; Kidu Gidey Weldegwergs; Andrea Sylvia Winkler; Alison B Wiyeh; Charles Shey Wiysonge; Grant M A Wyper; Ebrahim M Yimer; Naohiro Yonemoto; Zoubida Zaidi; Zerihun Menlkalew Zenebe; Valery L Feigin; Theo Vos; Christopher J L Murray
Background: Acute meningitis has a high case-fatality rate and survivors can have severe lifelong disability. We aimed to provide a comprehensive assessment of the levels and trends of global meningitis burden that could help to guide introduction, continuation, and ongoing development of vaccines and treatment programmes. Methods: The Global Burden of Diseases, Injuries, and Risk Factors (GBD) 2016 study estimated meningitis burden due to one of four types of cause: pneumococcal, meningococcal, Haemophilus influenzae type b, and a residual category of other causes. Cause-specific mortality estimates were generated via cause of death ensemble modelling of vital registration and verbal autopsy data that were subject to standardised data processing algorithms. Deaths were multiplied by the GBD standard life expectancy at age of death to estimate years of life lost, the mortality component of disability-adjusted life-years (DALYs). A systematic analysis of relevant publications and hospital and claims data was used to estimate meningitis incidence via a Bayesian meta-regression tool. Meningitis deaths and cases were split between causes with meta-regressions of aetiological proportions of mortality and incidence, respectively. Probabilities of long-term impairment by cause of meningitis were applied to survivors and used to estimate years of life lived with disability (YLDs). We assessed the relationship between burden metrics and Socio-demographic Index (SDI), a composite measure of development based on fertility, income, and education. Findings: Global meningitis deaths decreased by 21·0% from 1990 to 2016, from 403 012 (95% uncertainty interval [UI] 319 426–458 514) to 318 400 (265 218–408 705). Incident cases globally increased from 2·50 million (95% UI 2·19–2·91) in 1990 to 2·82 million (2·46–3·31) in 2016. Meningitis mortality and incidence were closely related to SDI. The highest mortality rates and incidence rates were found in the peri-Sahelian countries that comprise the African meningitis belt, with six of the ten countries with the largest number of cases and deaths being located within this region. Haemophilus influenzae type b was the most common cause of incident meningitis in 1990, at 780 070 cases (95% UI 613 585–978 219) globally, but decreased the most (–49·1%) to become the least common cause in 2016, with 397 297 cases (291 076–533 662). Meningococcus was the leading cause of meningitis mortality in 1990 (192 833 deaths [95% UI 153 358–221 503] globally), whereas other meningitis was the leading cause for both deaths (136 423 [112 682–178 022]) and incident cases (1·25 million [1·06–1·49]) in 2016. Pneumococcus caused the largest number of YLDs (634 458 [444 787–839 749]) in 2016, owing to its more severe long-term effects on survivors. Globally in 2016, 1·48 million (1·04—1·96) YLDs were due to meningitis compared with 21·87 million (18·20—28·28) DALYs, indicating that the contribution of mortality to meningitis burden is far greater than the contribution of disabling outcomes. Interpretation: Meningitis burden remains high and progress lags substantially behind that of other vaccine-preventable diseases. Particular attention should be given to developing vaccines with broader coverage against the causes of meningitis, making these vaccines affordable in the most affected countries, improving vaccine uptake, improving access to low-cost diagnostics and therapeutics, and improving support for disabled survivors. Substantial uncertainty remains around pathogenic causes and risk factors for meningitis. Ongoing, active cause-specific surveillance of meningitis is crucial to continue and to improve monitoring of meningitis burdens and trends throughout the world. Funding: Bill & Melinda Gates Foundation. © 2018 The Author(s). Published by Elsevier Ltd. This is an Open Access article under the CC BY 4.0 license